Abstract: A hair holding device including hingedly connected first and second body members each including hair gripping portions adapted to be squeezed by a user whereby the hair gripping portions come into contact with gathered strands of a user's hair. The device further includes a friction-type adjustment mechanism coaxially arranged with respect to the hinge for causing the hair gripping portions to remain at a point at which the hair gripping portions are squeezed together by a user. Optionally, the device may include squeezable release handles or other release mechanism, as well as a torsion spring for biasing the hair gripping portions into either an open or a closed position.

Abstract: A hair holding device including hingedly connected first and second body members each including hair gripping portions adapted to be squeezed by a user whereby the hair gripping portions come into contact with gathered strands of a user's hair. The device further includes a friction-type adjustment mechanism coaxially arranged with respect to the hinge for causing the hair gripping portions to remain at a point at which the hair gripping portions are squeezed together by a user. Optionally, the device may include squeezable release handles or other release mechanism, as well as a torsion spring for biasing the hair gripping portions into either an open or a closed position.

Abstract: Disclosed are methods for reliably detecting the presence of proteins, especially proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided.

Abstract: Disclosed are methods for reliably detecting the presence of proteins, especially proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided.

Abstract: The present invention relates to novel classes of compounds which are inhibitors of interleukin-1? converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against interleukin-1 mediated diseases, including inflammatory diseases, autoimmune diseases and neurodegenerative diseases. This invention also relates to methods for inhibiting ICE activity and methods for treating interleukin-1 mediated diseases using the compounds and compositions of this invention.

Abstract: A boat hull is described that includes a plurality of features to improve stability and tracking. Any one or more of the features can be provided in a watercraft having displacement and planing characteristics. The hull features improve tracking and stability of the hull when in displacement mode and planing mode.

Abstract: The present invention relates to novel classes of compounds which are inhibitors of interleukin-1? converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against IL-1-, apoptosis-, IGIF-, and IFN-?-mediated diseases, inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, degenerative diseases, and necrotic diseases. This invention also relates to methods for inhibiting ICE activity, for treating interleukin-1-, apoptosis-, IGIF- and IFN-?-mediated diseases and decreasing IGIF and IFN-? production using the compounds and compositions of this invention.

Abstract: Sirtuin modulators, particularly sirtuin activators, are useful in treating vision impairment. In general, the sirtuin modulators inhibit the progression of vision impairment resulting from various eye disorders. The invention also includes pharmaceutically acceptable formulations of sirtuin modulators, particular ophthalmically acceptable formulations.

Abstract: An autonomous robotic system and method for removing pests from a specific location. The robotic system of the invention preferably comprises a means for attracting pests to at least one specific location; and a robotic means for collecting and/or exterminating pests attracted to the specified location. In certain embodiments, the robotic means comprises a mobile robot and a means for navigating the robotic means. In operation, pests are attracted to at least one location by an attracting means, and these pests are then collected and/or exterminated by a mobile, autonomous robot of the invention.

Abstract: A ratchet-type buckle (100) is disclosed for use with a ladder strap (80), wherein the buckle includes a toothed, barrel-shaped strap engagement member (140) that is rotatably mounted between oppositely disposed sidewalls (130) that are pivotally coupled to a base (110). The engagement member is positioned to drivably engage and hold the strap. A holding pawl (160) allows forward rotation and hinders backward rotation of the engagement member. A driving pawl (180) is incorporated into a lever assembly (170), which is pivotally coupled to the sidewalls, the driving pawl positioned to engage and rotate the engagement member teeth when the lever assembly is pivoted in a forward direction. The pivotal coupling of the sidewalls to the base permit the engagement member to be lifted away from the base, to release the strap. The sidewalls are preferably biased towards the base.

Abstract: The invention provides methods for identifying compounds that can be used to modify transcriptional responses to hypoxia, and use of such compounds in therapeutic and diagnostic methods.

Abstract: An apparatus, program product and method of mapping defects on a data storage medium analyze one or more previously-identified defects on a storage medium to detect any growth in those defects over time, such that any detected growth of a previously-identified defect can be accommodated for through the dynamic remapping of additional surface area adjacent the defect to one or more replacement regions located elsewhere on the storage medium. As such, any buffer regions defined around pre-existing defects are effectively maintained as those defects grow over time, thus maintaining suitable protection from data loss that would otherwise result from an attempt to store information in a region that has been impinged upon as a result of the growth of an adjacent defect.

Abstract: Embodiments of the present invention are directed to a method and apparatus for automatic health monitoring. In one embodiment, a regularly accessed device is equipped with an access detection unit. In one embodiment, a regularly accessed device is a temperature controlled compartment. In one embodiment, a timer is started when the access detection unit detects an access to the temperature controlled compartment. In one embodiment, a determination unit determines whether a second access is made within a time interval of a first access. In one embodiment, the time interval is determined using the patient's recommended medication regimen. In one embodiment, when a determination unit determines that a second access is not made within a time interval of a first access, a signal generator generates a signal. In one embodiment, the signal is transmitted to a healthcare provider. In one embodiment, the signal is transmitted via a computer network.

Abstract: The present invention relates to novel classes of compounds which are inhibitors of interleukin-1? converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against IL-1-, apoptosis-, IGIF-, and IFN-?-mediated diseases, inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, degenerative diseases, and necrotic diseases. This invention also relates to methods for inhibiting ICE activity, for treating interleukin-1-, apoptosis-, IGIF- and IFN-?-mediated diseases and decreasing IGIF and IFN-? production using the compounds and compositions of this invention.

Abstract: A ratchet-type buckle (100) is disclosed for use with a ladder strap (80), wherein the buckle includes a toothed, barrel-shaped strap engagement member (140) that is rotatably mounted between oppositely disposed sidewalls (130) that are pivotally coupled to a base (110). The engagement member is positioned to drivably engage and hold the strap. A holding pawl (160) allows forward rotation and hinders backward rotation of the engagement member. A driving pawl (180) is incorporated into a lever assembly (170), which is pivotally coupled to the sidewalls, the driving pawl positioned to engage and rotate the engagement member teeth when the lever assembly is pivoted in a forward direction. The pivotal coupling of the sidewalls to the base permit the engagement member to be lifted away from the base, to release the strap. The sidewalls are preferably biased towards the base.

Abstract: A hair holding device including hingedly connected first and second body members each including hair gripping portions adapted to be squeezed by a user whereby the hair gripping portions come into contact with gathered strands of a user's hair. The device further includes a friction-type adjustment mechanism coaxially arranged with respect to the hinge for causing the hair gripping portions to remain at a point at which the hair gripping portions are squeezed together by a user. Optionally, the device may include squeezable release handles or other release mechanism, as well as a torsion spring for biasing the hair gripping portions into either an open or a closed position.

Abstract: A hair holding device including hingedly connected first and second body members each including hair gripping portions adapted to be squeezed by a user whereby the hair gripping portions come into contact with gathered strands of a user's hair. The device further includes a friction-type adjustment mechanism coaxially arranged with respect to the hinge for causing the hair gripping portions to remain at a point at which the hair gripping portions are squeezed together by a user. Optionally, the device may include squeezable release handles or other release mechanism, as well as a torsion spring for biasing the hair gripping portions into either an open or a closed position.

Abstract: A hair holding device including hingedly connected first and second body members each including hair gripping portions adapted to be squeezed by a user whereby the hair gripping portions come into contact with gathered strands of a user's hair. The device further includes a friction-type adjustment mechanism coaxially arranged with respect to the hinge for causing the hair gripping portions to remain at a point at which the hair gripping portions are squeezed together by a user. Optionally, the device may include squeezable release handles or other release mechanism, as well as a torsion spring for biasing the hair gripping portions into either an open or a closed position.

Abstract: Disclosed are methods for reliably detecting the presence of proteins, especially proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided.

Abstract: A hair holding device and spring concealment mechanism including a pair of opposed, hingedly connected body members adapted to pivot about a hinge axis between closed and open positions. A torsion biasing spring biases the device into a predetermined position. The spring is concealed in multiple casings, which are unattached to either body member of the hair holding device. The casings do not bear any torque exerted by the spring and do not encase the entireties of the spring's first and second projecting arms. Consequently, they can be made relatively thin-walled and compact to closely conform to the size and shape of the coil portion of the spring. The thin walls and small diameter of the spring casings minimize the extent to which the casings protrude from the hair holding device, thereby improving its aesthetic appeal.