Abstract: The present invention is related to an oral dosage form comprising an effective amount of an alkalizing agent and an azithromycin multiparticulate wherein said multiparticulate comprises azithromycin, a glyceride which comprises glyceryl monobehenate, glyceryl dibehenate, glyceryl tribehenate, or a mixture thereof and a poloxamer. Typically, the oral dosage form includes any suitable oral dosing means such as a powder for oral suspension, a unit dose packet or sachet, a tablet or a capsule.

Abstract: The present invention is related to an oral dosage form comprising an effective amount of an alkalizing agent and an azithromycin multiparticulate wherein said multiparticulate comprises azithromycin, a glyceride which comprises glyceryl monobehenate, glyceryl dibehenate, glyceryl tribehenate, or a mixture thereof and a poloxamer. Typically, the oral dosage form includes any suitable oral dosing means such as a powder for oral suspension, a unit dose packet or sachet, a tablet or a capsule.

Abstract: A cementitious composite article incorporating a powder coating on at least one surface is provided. The composite article includes a surface treatment adapted to facilitate application of the powder coating onto the article. The surface treatment can include modifications to surface porosity, surface, and/or application of a sealer to the surface so as to make the cementitious surface more conducive to powder coating. One method of manufacturing the cementitious composite article includes first applying a sealer coating to a surface of a fiber cement substrate, partially curing the substrate to a gel-like state, applying a powder coating to the article, processing the article to a curing device in which the powder coating and sealer coating are co-cured to form a hardened film.

Abstract: A composite building article is configured with one or more subsurface interfacial zones provided to improve the durability of the article. Each subsurface interfacial zone is made of a matrix of fiber cement and radiation curable material. The radiation curable material forms an interlocking network with the fiber cement to provide a interfacial zone against ingress of environmental agents that can degrade the article. The number, configuration and distribution of the subsurface interfacial zones can vary dependent on the desired characteristics of the final product. The subsurface interfacial zones also improves the adhesion between exterior coatings and the substrate as the interfacial zones can be integrally formed with the substrate as well as exterior coating layer.

Abstract: An apparatus and method for modifying the appearance of a flame to maximize the size of the flame for a given amount of fuel, increase a burn rate efficiency of the flame, or change the shape of the flame. The shape and size of the flame may be modified by applying a secondary source of fluid to the flame. The secondary source of fluid may cause turbulent fluid flow within the combustion chamber enclosure in which the flame is produced to change the appearance of the flame. The secondary source of fluid may be generated by a blower or fan and may include, for example, a source of fresh combustion air, additional flammable gas such as natural gas, or other fluid additives for enhancement of the flame color, shape, and size.

Abstract: An adjustable surround for use with a fireplace. The surround includes first and second top members arranged end to end in a generally horizontal orientation to define a width of the surround. The first and second top members are movable relative to each other to alter the width of the surround. The surround also includes first and second side members that extend generally vertically on opposing sides of a combustion chamber enclosure of the fireplace, and first and second overlap members configured to be coupled to respective first and second side members. Relative movement between the first and second side members and respective first and second overlap member adjusts a height of the surround.

Abstract: A hydronic heating system that includes a liquid-filled conduit and a combustion chamber enclosure having a plurality of panels that define a combustion chamber for the combustion of fuel to generate heat. At least one of the panels and a portion of the liquid-filled conduits are integrally formed together. The at least one panel absorbs heat generated in the combustion chamber and transfers the absorbed heat to the liquid in the conduit. The heated liquid may be transferred to a remote location where the heat is removed from the liquid using a heat exchanger. The at least one panel and the portion of the liquid-filled conduit may be integrally formed using a moldable material such as a ceramic fiber and a binder, and molded using such processes as compression molding or vacuum molding. The use of moldable may reduce condensation in or around the combustion chamber enclosure.

Abstract: Reduced levels of drug degradation in drug-containing multiparticulates are obtained by an extrusion/melt-congeal process.

Abstract: A multiparticulate for controlled release of a drug comprises crystalline drug, a glyceride having at least one alkylate substituent of at least 16 carbon atoms, and a poloxamer, wherein at least 70 wt % of the drug in the multiparticulate is crystalline.

Abstract: A method of forming articles made of an inorganic fiber material using compression molding. In one respect, a method of forming an article, wherein the method includes providing a molding composition comprising inorganic fiber and an inorganic binder, and compression molding the molding composition into the article. In another respect, the method including providing a molding composition comprising inorganic fibers and a binder, and compression molding the molding composition into the article, wherein at least 75% by weight of the molded article is inorganic material. In some embodiments the cured binder is capable of withstanding temperatures of at least 600° F. without significant degradation or deterioration due to heat. Articles made by the use of such methods and a molding composition for use in compression molding an article are also included.

Abstract: Azithromycin multiparticulates containing acceptably low concentrations of azithromycin esters are formed by a melt-congeal process.

Abstract: A lenticular fireplace and methods for simulating a fire within a fireplace. In one respect, a fire is simulated with a lenticular screen. The lenticular screen includes a lenticular lens layer and an image layer, wherein the image layer comprises one or more images of a fire. A device is coupled to the lenticular screen that moves the lenticular screen to alter a viewed image of the fire. In another respect, the lenticular screen is disposed within a fireplace enclosure. In another respect, a fireplace includes a convertible heated glass apparatus. The apparatus is used in a front wall of an enclosure.

Abstract: Pharmaceutical compositions of crystalline azithromycin-containing multiparticulates having low concentrations of azithromycin ester degradants and exhibiting controlled release of the drug are achieved by inclusion of dissolution enhancers having low concentrations of acid and ester substituents.

Abstract: The present invention relates to pharmaceutical compositions comprising amorphous (4R)—N-allyl-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, or a pharmaceutically acceptable salt or solvate thereof, their methods of preparation, their use in inhibiting the HIV protease enzyme, and their use in treating HIV-infected mammals, such as humans.

Abstract: An oral dosage form comprising azithromycin and an effective amount of an alkalizing agent. Preferably, said oral dosage form comprises an effective amount of an alkalizing agent and an azithromycin multiparticulate wherein said multiparticulate comprises azithromycin, a mixture of glyceryl monobehenate, glyceryl dibehenate and glyceryl tribehenate, and a poloxamer. Typically, the oral dosage form includes any suitable oral dosing means such as a powder for oral suspension, a unit dose packet or sachet, a tablet or a capsule. Additionally disclosed is an oral suspension comprising azithromycin, an effective amount of an alkalizing agent and a vehicle. Preferably, the azithromycin is in multiparticulate form wherein said multiparticulate comprises azithromycin, a mixture of glyceryl monobehenate, glyceryl dibehenate and glyceryl tribehenate, and a poloxamer.

Abstract: Liquid-based processes are disclosed for forming azithromycin multiparticulates having minimal amounts of azithromycin esters.

Abstract: A method of forming articles made of an inorganic fiber material using compression molding. In one respect, a method of forming an article, wherein the method includes providing a molding composition comprising inorganic fiber and an inorganic binder, and compression molding the molding composition into the article. In another respect, the method including providing a molding composition comprising inorganic fibers and a binder, and compression molding the molding composition into the article, wherein at least 75% by weight of the molded article is inorganic material. In some embodiments the cured binder is capable of withstanding temperatures of at least 600° F. without significant degradation or deterioration due to heat. Articles made by the use of such methods and a molding composition for use in compression molding an article are also included.

Abstract: A fireplace includes an outer enclosure having a front panel defining a front of the fireplace, and a combustion chamber enclosure defining a combustion chamber and including a front surface. The combustion chamber enclosure is positioned within the outer enclosure at a location spaced rearward from the front panel of the outer enclosure. The fireplace includes a glass panel secured to the front surface of the combustion chamber enclosure, and a surround member adapted and configured to be positioned between the front panel of the outer enclosure and the glass panel to cover the glass frame from view. Controls for the fireplace are positioned between the outer enclosure and the combustion chamber enclosure.

Abstract: A trimmable surround and methods for creating the surround for a heat generating device. The trimmable surround includes a molded portion having a ceramic fiber and a binder and an attachment portion. A portion of the molded member is removable to alter a size of the molded member. An attachment portion coupled to the molded portion allows attachment of the trimmable surround to the heat generating device.

Abstract: The invention generally relates to a fireplace surround for attachment to a fireplace. The surround may include first and second side members formed from a molded material, and a top member formed from the molded material that extends between the first and second side members. The top member defines a cavity that is in fluid communication with a vent of the fireplace to collect heated air from the fireplace. An opening formed in the top member facilitates movement of heated air collected in the cavity to pass through the cavity. The surround may also include a shield member that direct the heated air from the fireplace vent to the exhaust opening in the top member, and an insulating member that dissipates heat in the top member.