Patents by Inventor David M. Cox

David M. Cox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10528702
    Abstract: Mechanisms are provided for communicating with a patient. The mechanisms generate a patient registry comprising a plurality of patient registry records, each patient registry record being associated with a corresponding patient and comprising personal and medical information about the corresponding patient. The mechanisms collect, for each patient registry record, first data regarding treatment of the corresponding patient and second data regarding communications made with the corresponding patient. The mechanisms determine, based on analysis of the first data and second data associated with each of the patient registry records, a mode of communication that is most likely to result in a successful treatment of patients. The mechanisms initiate a communication with a patient of interest using the determined mode of communication based on the results of the determination.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: January 7, 2020
    Assignee: International Business Machines Corporation
    Inventors: James S. Cox, Jacob R. Danks, Anthony J. DiGiorgio, Alan C. Edwards, David J. Gattis, Jonathan M. Harmon, Charles W. Hill, Tushar Kumar Jayantilal, William R. Patterson, James A. Sexton
  • Publication number: 20190307735
    Abstract: This invention relates to the treatment of chronic kidney disease, including diabetic nephropathy, focal segmental glomerulosclerosis (FSGS), nephrotic syndrome, non-diabetic chronic kidney disease, renal fibrosis or acute kidney injury by the administration of an RGD mimetic integrin receptor antagonist, either as a single agent or in combination with other agents.
    Type: Application
    Filed: June 18, 2019
    Publication date: October 10, 2019
    Applicant: MERCK SHARP & DOHME CORP
    Inventors: Jason M. Cox, Lijun Ma, Xiaoyan Zhou, Robin E. Haimbach, Paul J. Coleman, Haihong Zhou, David E. Kelley, Selwyn Aubrey Stoch, Le T. Duong, Maarten Hoek
  • Publication number: 20190275357
    Abstract: A portable positive air filtration device including a respiration component and a harness component. The harness component being connected with the respiration component so as to secure the respiration component against the face of a user and covering the mouth and nostril of the user. One or more fans or air-moving components, one or more filters and at least one power supply provide filtered air to the user at a positive pressure. In some examples, the device includes a mask housing, a filter, a fan and an electronics control system. One or more batteries are provided for powering the device. The electronic control system can be connected with an electronic device for real time monitoring and control.
    Type: Application
    Filed: March 11, 2019
    Publication date: September 12, 2019
    Applicants: P&B Innovations LLC, AUBURN UNIVERSITY
    Inventors: Melvin Merri PALMER, JR., Jerry Dwayne BRITTON, David F. DYER, John A. KLINNER, Adam L. LOGAN, Corey M. COX, Morgan I. COOPER, Thomas J. BRACKIN, Ritu SINGH, Christopher L. BRIGHT, Evans A. CARR, Landon B. CARTWRIGHT, Sangyun GO, Michael T. JONES, Brandon M. WEAVER
  • Publication number: 20190233887
    Abstract: Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than about 100 ?l). The system can also include an automated reagent delivery mechanism configured to reversibly couple with the inlet port corresponding to a target reaction chamber thereby placing allowing for reagent to be accurately moved from a storage container to the reaction chamber with minimal reagent waste. The flowcells can include a plurality of reaction chambers (e.g., 6) thereby allowing for parallel analysis of multiple samples. Various methods of analyzing a biomolecule are also provided herein.
    Type: Application
    Filed: December 19, 2018
    Publication date: August 1, 2019
    Inventors: Jon A. HOSHIZAKI, Joon Mo YANG, Maryam SHARIATI, David M. COX, Kirk M. HIRANO, John BRIDGHAM, George Stefan GOLDA, Sam Lee WOO
  • Patent number: 10309930
    Abstract: Systems and methods are provided for providing a DMS precursor ion survey scan. An ion source configured to receive a sample is instructed to ionize the sample using a processor. A DMS device configured to receive ions from the ion source is instructed to separate precursor ions received from the ion source and transmit precursor ions using two or more CoVs using the processor. A mass analyzer configured to receive transmitted precursor ions from the DMS device is instructed to measure the m/z intensities of the transmitted precursor ions across an m/z range at each CoV of the two or more CoVs using the processor. The measured m/z intensities of the transmitted precursor ions received from the mass analyzer are stored as a function of m/z value and CoV using the processor. This produces a stored two-dimensional mapping of m/z intensities of the precursor ions of the sample.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: June 4, 2019
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: John Lawrence Campbell, Eva Duchoslav, Yves Le Blanc, David M. Cox
  • Publication number: 20190085387
    Abstract: Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure.
    Type: Application
    Filed: August 3, 2018
    Publication date: March 21, 2019
    Inventors: Linda G. Lee, Sam L. Woo, Congcong Ma, Richard T. Reel, Mark F. Oldham, David M. Cox, Benjamin G. Schroeder, Jon M. Sorenson, Willy Wiyatno
  • Publication number: 20190071723
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Application
    Filed: November 6, 2018
    Publication date: March 7, 2019
    Inventors: Phil WAGGONER, James A. BALL, Wolfgang HINZ, Michael L. MINTO, Scott PARKER, David M. COX, Alexander MASTROIANNI, Jeremy GRAY, Marc GLAZER, Kimberly GORRELL
  • Patent number: 10204770
    Abstract: Systems and methods are provided for enabling or disabling a DMS device during an IDA method. Each cycle of the method includes a survey scan step, producing a precursor ion mass spectrum, and an MS/MS scan step. During the MS/MS scan step, one or more user-defined MS/MS scans are performed that correspond to compounds of interest found in the precursor ion mass spectrum. With each user-defined MS/MS scan, a DMS enable parameter that determines if the DMS device is enabled or disabled and one or more DMS parameters necessary to enable the DMS device for the corresponding compound of interest are received. During the MS/MS scan step, for each user-defined MS/MS scan, the DMS device is enabled or disabled according to the DMS enable parameter and one or more parameters of the DMS device are set according to the one or more DMS parameters.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: February 12, 2019
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Michael Jarvis, Yves Le Blanc, David M. Cox
  • Publication number: 20180269048
    Abstract: Systems and methods are provided for enabling or disabling a DMS device during an IDA method. Each cycle of the method includes a survey scan step, producing a precursor ion mass spectrum, and an MS/MS scan step. During the MS/MS scan step, one or more user-defined MS/MS scans are performed that correspond to compounds of interest found in the precursor ion mass spectrum. With each user-defined MS/MS scan, a DMS enable parameter that determines if the DMS device is enabled or disabled and one or more DMS parameters necessary to enable the DMS device for the corresponding compound of interest are received. During the MS/MS scan step, for each user-defined MS/MS scan, the DMS device is enabled or disabled according to the DMS enable parameter and one or more parameters of the DMS device are set according to the one or more DMS parameters.
    Type: Application
    Filed: August 9, 2016
    Publication date: September 20, 2018
    Inventors: Michael Jarvis, Yves Le Blanc, David M. Cox
  • Patent number: 10041113
    Abstract: Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: August 7, 2018
    Assignee: Applied Biosystems, LLC
    Inventors: Linda G. Lee, Sam L. Woo, Congcong Ma, Richard T. Reel, Mark F. Oldham, David M. Cox, Benjamin G. Schroeder, Jon M. Sorenson, Willy Wiyatno
  • Patent number: 9818590
    Abstract: Systems and methods are provided for identifying missing product ions after demultiplexing product ion spectra produced by overlapping precursor ion transmission windows in sequential windowed acquisition tandem mass spectrometry. Overlapping sequential windowed acquisition is performed on a sample. A first precursor mass window and the corresponding first product ion spectrum are selected from a plurality of overlapping stepped precursor mass windows and their corresponding product ion spectra. A product ion spectrum is demultiplexed for each overlapped portion of the first precursor mass window producing two or more demultiplexed first product ion spectra for the first precursor mass window. The two or more demultiplexed first product ion spectra are added together producing a reconstructed summed demultiplexed first product ion spectrum.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: November 14, 2017
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: David M. Cox, Stephen A. Tate, Lyle Burton
  • Publication number: 20170248548
    Abstract: Systems and methods are provided for providing a DMS precursor ion survey scan. An ion source configured to receive a sample is instructed to ionize the sample using a processor. A DMS device configured to receive ions from the ion source is instructed to separate precursor ions received from the ion source and transmit precursor ions using two or more CoVs using the processor. A mass analyzer configured to receive transmitted precursor ions from the DMS device is instructed to measure the m/z intensities of the transmitted precursor ions across an m/z range at each CoV of the two or more CoVs using the processor. The measured m/z intensities of the transmitted precursor ions received from the mass analyzer are stored as a function of m/z value and CoV using the processor. This produces a stored two-dimensional mapping of m/z intensities of the precursor ions of the sample.
    Type: Application
    Filed: September 21, 2015
    Publication date: August 31, 2017
    Applicant: DH Technologies Development Pte. Ltd.
    Inventors: John Lawrence Campbell, Eva Duchoslav, Yves Le Blanc, David M. Cox
  • Patent number: 9733214
    Abstract: MRM triggered MRM, where the triggered MRM transitions make use of mobility device parameter values for the same compound, is performed. A plurality of primary MRM transitions are received and stored together with a mobility device parameter value for each transition as an MRM cycle list. Control information instructs a mobility device and a mass spectrometer to interrogate each MRM transition on the MRM cycle list within an MRM cycle of the mass spectrometer. If a product ion intensity value of an MRM transition exceeds a threshold value for a primary MRM transition, a plurality of secondary MRM transitions of the primary MRM transition with different mobility device parameter values are added to the MRM cycle list. The intensities of the measured secondary MRM transitions provide information on the optimum mobility device parameter for each compound.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: August 15, 2017
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Christie L. Hunter, David M. Cox
  • Patent number: 9583323
    Abstract: Systems and methods identify a product ion that does not include an interference. A full product ion spectrum for a mass range of an analyte in a sample is received from a tandem mass spectrometer. A first set of one or more peak parameters is calculated for a product ion in the full product ion spectrum using a first XIC window width. A second set of one or more peak parameters is calculated for the product ion using a second XIC window width. The product ion is identified as not including an interference, if the first set of one or more peak parameters and the second set of one or more peak parameters are substantially the same. The product ion is further confirmed or determined to be from the analyte and not from a matrix of the sample by correlating the product to a precursor ion of the analyte.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: February 28, 2017
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Stephen A. Tate, David M. Cox
  • Patent number: 9527084
    Abstract: A vertical clamping device is provided that supports a flow cell component in a vertical configuration in which the flow cell is on an opposite side of the vertical support from the electronic interface. The clamp includes a vertical setting to receive the flow cell component and provides an electronic interface on a vertical surface of the vertical setting. A block supports the fluidics interface and can move in a horizontal direction bringing the fluidics interface into contact with the flow cell component.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: December 27, 2016
    Assignee: Life Technologies Corporation
    Inventor: David M. Cox
  • Patent number: 9513232
    Abstract: Methods and systems are provided for triggering an information dependent mass spectrometry scan in real time. A mass spectrometry scan of a separating sample mixture is performed by a mass spectrometer at each time interval of a time period. The mass spectrometer receives the separating sample mixture from a separation device. It is determined at a certain time interval that a received mass spectrometry scan at the time interval and one or more preceding received mass spectrometry scans include two or more time-varying ion signals that represent two or more fragment ion transitions of a known compound. If a characteristic of the two or more time-varying ion signals meets a selection criterion, the mass spectrometer is instructed to perform a dependent mass spectrometry scan of the separating sample mixture for a precursor ion of the known compound at the time interval.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: December 6, 2016
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: David M. Cox, Stephen A. Tate, Matthias Glueckmann
  • Publication number: 20160349210
    Abstract: MRM triggered MRM, where the triggered MRM transitions make use of mobility device parameter values for the same compound, is performed. A plurality of primary MRM transitions are received and stored together with a mobility device parameter value for each transition as an MRM cycle list. Control information instructs a mobility device and a mass spectrometer to interrogate each MRM transition on the MRM cycle list within an MRM cycle of the mass spectrometer. If a product ion intensity value of an MRM transition exceeds a threshold value for a primary MRM transition, a plurality of secondary MRM transitions of the primary MRM transition with different mobility device parameter values are added to the MRM cycle list. The intensities of the measured secondary MRM transitions provide information on the optimum mobility device parameter for each compound.
    Type: Application
    Filed: February 10, 2015
    Publication date: December 1, 2016
    Inventors: Christie L. Hunter, David M. Cox
  • Patent number: D866239
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: November 12, 2019
    Assignee: Sterno Products, LLC
    Inventors: David Amirault, Andrew B. Mendenhall, Dennis M. Turner, Steven L. Cox
  • Patent number: D866241
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: November 12, 2019
    Assignee: Sterno Products, LLC.
    Inventors: David Amirault, Andrew B. Mendenhall, Dennis M. Turner, Steven L. Cox
  • Patent number: D873066
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: January 21, 2020
    Assignee: Sterno Products, LLC.
    Inventors: David Amirault, Andrew B. Mendenhall, Dennis M. Turner, Steven L. Cox