Patents by Inventor David M. Cox

David M. Cox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250051341
    Abstract: Provided are novel Pyrazolopyrimidine Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are as defined herein. Also provided are compositions comprising at least one Pyrazolopyrimidine Derivative, and methods of using the Pyrazolopyrimidine Derivatives for treating or preventing a herpesvirus infection in a patient.
    Type: Application
    Filed: December 13, 2022
    Publication date: February 13, 2025
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Kira A. Armacost, Andrew J. Cooke, Christopher Douglas Cox, Brendan M. Crowley, Marc A. Labroli, Michael A. Plotkin, Izzat T. Raheem, Kelly-Ann S. Schlegel, Anthony W. Shaw, David M. Tellers
  • Publication number: 20250043342
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Application
    Filed: October 18, 2024
    Publication date: February 6, 2025
    Inventors: Philip WAGGONER, James A. BALL, Michael L. MINTO, David M. COX, Wolfgang HINZ, Alexander MASTROIANNI, Jeremy GRAY, Marc GLAZER, Scott PARKER, Kimberly GORRELL
  • Patent number: 12191132
    Abstract: Before a sample is introduced into a liquid sample delivery device, an ion source device receives aqueous mobile phase solution from the liquid sample delivery device and ionizes compounds of the aqueous mobile phase solution, producing an ion beam. A tandem mass spectrometer performs a first neutral loss scan of the ion beam with a first neutral loss value set to a molecular weight of a first known solvent, producing a first intensity, and performs a second neutral loss scan of the ion beam with a second neutral loss value set to a molecular weight of a second known solvent, producing a second intensity. A ratio of the first intensity to the second intensity is calculated. It is determined if the aqueous mobile phase solution is properly being delivered by the liquid sample delivery device based on the ratio.
    Type: Grant
    Filed: August 22, 2020
    Date of Patent: January 7, 2025
    Assignee: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
    Inventors: Yves Le Blanc, David M. Cox
  • Patent number: 12139758
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Grant
    Filed: January 8, 2024
    Date of Patent: November 12, 2024
    Assignee: Life Technologies Corporation
    Inventors: Philip Waggoner, James A. Ball, Michael L. Minto, David M. Cox, Wolfgang Hinz, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Scott Parker, Kimberly Gorrell
  • Publication number: 20240355611
    Abstract: An ion mass filter for use in a mass spectrometer is disclosed, which includes a plurality of rods arranged in a multipole configuration to provide a passageway through which ions can travel, said plurality of rods being configured for application of RF voltages thereto to generate an electromagnetic field within the passageway for providing radial confinement of the ions and further configured for application of a DC voltage thereto, and at least two pairs of auxiliary electrodes interspersed between the plurality of multipole rods, where one pair forms a first pole of the auxiliary electrodes and the other pair forms a second pole of the auxiliary electrodes. A controller can provide one or more control signals to the DC voltage source so as to switch the polarity of the DC voltage differential between the two poles according to a predefined criterion.
    Type: Application
    Filed: August 23, 2022
    Publication date: October 24, 2024
    Inventors: David M. COX, Mircea GUNA, Yang KANG, Mircea MANOLESCU, Andrei SONOC
  • Publication number: 20240355612
    Abstract: In one aspect, an ion filter for use in a mass spectrometer is disclosed, which includes a plurality of rods arranged in a multipole configuration to provide a passageway through which ions can travel, said plurality of rods being configured for application of RF voltages thereto to provide an electromagnetic field within the passageway for providing radial confinement of the ions and further configured for application of a DC voltage thereto. At least two pairs of auxiliary electrodes are interspersed between the plurality of rods and are configured for application of a DC bias voltage with one polarity to one of said pairs and a DC bias voltage with an opposite polarity to the other one of said pairs to provide a DC potential difference between the auxiliary electrodes and the plurality of rods.
    Type: Application
    Filed: August 23, 2022
    Publication date: October 24, 2024
    Inventors: David M. COX, Manuel FAUR, Mircea GUNA, Yang KANG, Andrei SONOC
  • Publication number: 20240309443
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Application
    Filed: January 8, 2024
    Publication date: September 19, 2024
    Inventors: Philip WAGGONER, James A. BALL, Michael L. MINTO, David M. COX, Wolfgang HINZ, Alexander MASTROIANNI, Jeremy GRAY, Marc GLAZER, Scott PARKER, Kimberly GORRELL
  • Patent number: 11953478
    Abstract: Each of one or more unknown compounds are separated from a sample over a separation time period. Separated compounds are ionized, producing one or more compound precursor ions for each of the unknown compounds and a plurality of background precursor ions. A precursor ion mass spectrum is measured for the combined compound and background precursor ions at each time step of a plurality of time steps spread across the separation time period, producing a plurality of precursor ion mass spectra. One or more background precursor ions are selected from the plurality of precursor ion mass spectra that have a resolving power in a range below a threshold expected resolving power. A separation time is detected for an unknown compound when a decrease in an intensity measurement of the selected background precursor ions over a time period exceeds a threshold decrease in intensity with respect to time.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: April 9, 2024
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Nic G. Bloomfield, Lyle Lorrence Burton, John Lawrence Campbell, David M. Cox, Eva Duchoslav, Adam San-Ho Lau
  • Patent number: 11879156
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Grant
    Filed: August 10, 2022
    Date of Patent: January 23, 2024
    Assignee: Life Technologies Corporation
    Inventors: Phil Waggoner, James A. Ball, Wolfgang Hinz, Michael L. Minto, Scott Parker, David M. Cox, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Kimberly Gorrell
  • Publication number: 20230377865
    Abstract: A tandem mass spectrometer may be operative to receive sample ions and to monitor a MS scan for a sentinel ion. Upon detection of the sentinel ion in MS1, the mass spectrometer switches to a group of at least one MS/MS scan associated with the sentinel ion to fragment incoming sample ions and to mass analyze resulting product ions of the fragmentation.
    Type: Application
    Filed: October 7, 2021
    Publication date: November 23, 2023
    Inventors: Yves Le Blanc, David M. Cox
  • Publication number: 20230238232
    Abstract: An ADE device identifies an identifiable sequence of one or more ejections from at least one sample using a different value or pattern of values for one or more ADE parameters. The identifiable one or more ejections are performed to produce one or more mass peaks that have a different feature value or pattern of feature values for one or more peak features than other mass peaks produced. Ejection times are stored. One or more detected peaks with the different feature values or pattern of feature values are identified as produced by the identifiable one or more ejections. A delay time is calculated from the time of the identifiable ejections and the time of the identified detected peaks and the peaks are aligned with samples using delay time, stored times, and order of the samples.
    Type: Application
    Filed: May 21, 2021
    Publication date: July 27, 2023
    Inventors: David M. Cox, Chang Liu, Stephen A. Tate
  • Publication number: 20230230825
    Abstract: Each sample of a series of samples is ejected at an ejection time and according to a sample order. Each ejected sample of the series is ionized, producing ion beam. A list of different sets of MRM transitions is received. Each set of the list corresponds to a different sample. A group of one or more different sets is selected from the list. Initially, each set selected for the group corresponds to a different sample of one or more first samples of the series. A mass spectrometer is instructed to execute each transition of each set of the group on the ion beam until a transition of a set of the group is detected, upon which, one or more next sets are selected from the list to be monitored using the set of the detected transition and the sample order.
    Type: Application
    Filed: May 21, 2021
    Publication date: July 20, 2023
    Inventors: David M. Cox, Chang Liu
  • Publication number: 20230037531
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Application
    Filed: August 10, 2022
    Publication date: February 9, 2023
    Inventors: Phil Waggoner, James A. Ball, Wolfgang Hinz, Michael L. Minto, Scott Parker, David M. Cox, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Kimberly Gorrell
  • Publication number: 20220359181
    Abstract: Before a sample is introduced into a liquid sample delivery device, an ion source device receives aqueous mobile phase solution from the liquid sample delivery device and ionizes compounds of the aqueous mobile phase solution, producing an ion beam. A tandem mass spectrometer performs a first neutral loss scan of the ion beam with a first neutral loss value set to a molecular weight of a first known solvent, producing a first intensity, and performs a second neutral loss scan of the ion beam with a second neutral loss value set to a molecular weight of a second known solvent, producing a second intensity. A ratio of the first intensity to the second intensity is calculated. It is determined if the aqueous mobile phase solution is properly being delivered by the liquid sample delivery device based on the ratio.
    Type: Application
    Filed: August 22, 2020
    Publication date: November 10, 2022
    Inventors: Yves Le Blanc, David M. Cox
  • Patent number: 11441178
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: September 13, 2022
    Assignee: Life Technologies Corporation
    Inventors: Phil Waggoner, James A. Ball, Wolfgang Hinz, Michael L. Minto, Scott Parker, David M. Cox, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Kimberly Gorrell
  • Publication number: 20220187260
    Abstract: Each of one or more unknown compounds are separated from a sample over a separation time period. Separated compounds are ionized, producing one or more compound precursor ions for each of the unknown compounds and a plurality of background precursor ions. A precursor ion mass spectrum is measured for the combined compound and background precursor ions at each time step of a plurality of time steps spread across the separation time period, producing a plurality of precursor ion mass spectra. One or more background precursor ions are selected from the plurality of precursor ion mass spectra that have a resolving power in a range below a threshold expected resolving power. A separation time is detected for an unknown compound when a decrease in an intensity measurement of the selected background precursor ions over a time period exceeds a threshold decrease in intensity with respect to time.
    Type: Application
    Filed: March 10, 2020
    Publication date: June 16, 2022
    Inventors: Nic G. Bloomfield, Lyle Lorrence Burton, John Lawrence Campbell, David M. Cox, Eva Duchoslav, Adam San-Ho Lau
  • Publication number: 20220033896
    Abstract: Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure.
    Type: Application
    Filed: October 19, 2021
    Publication date: February 3, 2022
    Applicant: APPLIED BIOSYSTEMS, LLC
    Inventors: Linda G. LEE, Sam L. WOO, Congcong MA, Richard T. REEL, Mark F. OLDHAM, David M. COX, Benjamin G. SCHROEDER, Jon M. SORENSON, Willy WIYATNO
  • Patent number: 11162137
    Abstract: Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: November 2, 2021
    Assignee: APPLIED BIOSYSTEMS LLC
    Inventors: Linda G. Lee, Sam L. Woo, Congcong Ma, Richard T. Reel, Mark F. Oldham, David M. Cox, Benjamin G. Schroeder, Jon M. Sorenson, Willy Wiyatno
  • Patent number: 10724086
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: July 28, 2020
    Assignee: Life Technologies Corporation
    Inventors: Phil Waggoner, James A. Ball, Wolfgang Hinz, Michael L. Minto, Scott Parker, David M. Cox, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Kimberly Gorrell
  • Publication number: 20200216893
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Application
    Filed: March 20, 2020
    Publication date: July 9, 2020
    Inventors: Phil Waggoner, James A. Ball, Wolfgang Hinz, Michael L. Minto, Scott Parker, David M. Cox, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Kimberly Gorrell