Abstract: The effective aperture of an ultrasound imaging probe can be increased by including more than one transducer array and using the transducer elements of all of the arrays to render an image can greatly improve the lateral resolution of the generated image. In order to render an image, the relative positions of all of the elements must be known precisely. Systems and methods for accurately calibrating and adjusting a multi-aperture ultrasound system are disclosed. The relative positions of the transducer elements can be computed and aligned prior to and during probe assembly.

Abstract: A memory system and a method for managing the system is described. The system is configured such a plurality of system controllers, which may be RAID controllers, receive requests from the external environment and distribute the requests to a plurality of memory modules such that data may be stored in the memory modules. A global sequence number is assigned to the data of a data stripe so that the operations related to the data stripe are performed in an ordered manner so that the data remains consistent. A plurality of system controllers may comprise a domain and access a plurality of memory controllers and a plurality of domains may include at least one common memory module.

Abstract: A memory system and a method for managing the system is described. The system is configured such a plurality of system controllers, which may be RAID controllers, receive requests from the external environment and distribute the requests to a plurality of memory modules such that data may be stored in the memory modules. A global sequence number is assigned to the data of a data stripe so that the operations related to the data stripe are performed in an ordered manner so that the data remains consistent. A plurality of system controllers may comprise a domain and access a plurality of memory controllers and a plurality of domains may include at least one common memory module. A plurality of groups of controllers may communicate with a switch or with a representative controller so as to coordinate the assignment of global sequence numbers.

Abstract: The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.

Abstract: A method of calibrating an ultrasound probe includes mounting an ultrasound probe onto a calibration system, transmitting an ultrasound test signal from an element of the probe through a test medium of the calibration system, and receiving the test signal on a matrix of hydrophones such that an element's position relative to other elements and other arrays within the same probe can be computed. Further, the system described herein is configured to detect the acoustic performance of elements of a probe and report the results to an end user or service provider.

Abstract: Systems and methods of M-mode ultrasound imaging allows for M-mode imaging along user-defined paths. In various embodiments, the user-defined path can be a non-linear path or a curved path. In some embodiments, a system for M-mode ultrasound imaging can comprise a multi-aperture probe with at least a first transmitting aperture and a second receiving aperture. The receiving aperture can be separate from the transmitting aperture. In some embodiments, the transmitting aperture can be configured to transmit an unfocused, spherical, ultrasound ping signal into a region of interest. The user-defined path can define a structure of interest within the region of interest.

Abstract: A memory system and a method for managing the system is described. The system is configured such a plurality of system controllers, which may be RAID controllers, receive requests from the external environment and distribute the requests to a plurality of memory modules such that data may be stored in the memory modules. A global sequence number is assigned to the data of a data stripe so that the operations related to the data stripe are performed in an ordered manner so that the data remains consistent. A plurality of system controllers may comprise a domain and access a plurality of memory controllers and a plurality of domains may include at least one common memory module.

Abstract: A Multiple Aperture Ultrasound Imaging (MAUI) probe or transducer is uniquely capable of simultaneous imaging of a region of interest from separate apertures of ultrasound arrays. Some embodiments provide systems and methods for designing, building and using ultrasound probes having continuous arrays of ultrasound transducers which may have a substantially continuous concave curved shape in two or three dimensions (i.e., concave relative to an object to be imaged). Other embodiments herein provide systems and methods for designing, building and using ultrasound imaging probes having other unique configurations, such as adjustable probes and probes with variable configurations.

Abstract: A method of calibrating an ultrasound probe includes mounting an ultrasound probe onto a calibration system, transmitting an ultrasound test signal from an element of the probe through a test medium of the calibration system, and receiving the test signal on a matrix of hydrophones such that an element's position relative to other elements and other arrays within the same probe can be computed. Further, the system described herein is configured to detect the acoustic performance of elements of a probe and report the results to an end user or service provider.

Abstract: Systems and methods of M-mode ultrasound imaging allows for M-mode imaging along user-defined paths. In various embodiments, the user-defined path can be a non-linear path or a curved path. In some embodiments, a system for M-mode ultrasound imaging can comprise a multi-aperture probe with at least a first transmitting aperture and a second receiving aperture. The receiving aperture can be separate from the transmitting aperture. In some embodiments, the transmitting aperture can be configured to transmit an unfocused, spherical, ultrasound ping signal into a region of interest. The user-defined path can define a structure of interest within the region of interest.

Abstract: A communication plate extends along and is sandwiched between cylindrical communication manifolds of a first heat exchanger assembly and a second heat exchanger assembly. The communication plate includes a saddling surface arcuate in one direction and a saddling surface arcuate in the opposite direction for engaging in saddle-like fashion the cylindrical shape of the manifolds. The communication plate defines a plurality of communication plate orifices disposed along the communication plate and aligned co-axial with a plurality of communication orifices disposed along the manifolds to seal the communication orifices of the manifolds and establish distributed and sealed fluid communication between the heat exchanger assemblies.

Abstract: A Multiple Aperture Ultrasound Imaging (MAUI) probe or transducer is uniquely capable of simultaneous imaging of a region of interest from separate apertures of ultrasound arrays. Some embodiments provide systems and methods for designing, building and using ultrasound probes having continuous arrays of ultrasound transducers which may have a substantially continuous concave curved shape in two or three dimensions (i.e. concave relative to an object to be imaged). Other embodiments herein provide systems and methods for designing, building and using ultrasound imaging probes having other unique configurations, such as adjustable probes and probes with variable configurations.

Abstract: A method has been described for making an electrical structure having an air dielectric and includes forming a first subunit including a sacrificial substrate, an electrically conductive layer including a first metal on the sacrificial substrate, and a sacrificial dielectric layer on the sacrificial substrate and the electrically conductive layer. The method further includes forming a second subunit including a dielectric layer and an electrically conductive layer thereon including the first metal, and coating a second metal onto the first metal of one or more of the first and second subunits. The method also includes aligning the first and second subunits together, heating and pressing the aligned first and second subunits to form an intermetallic compound of the first and second metals bonding adjacent metal portions together, and removing the sacrificial substrate and sacrificial dielectric layer to thereby form the electrical structure having the air dielectric.

Abstract: A Multiple Aperture Ultrasound Imaging (MAUI) probe or transducer is uniquely capable of simultaneous imaging of a region of interest from separate apertures of ultrasound arrays. Some embodiments provide systems and methods for designing, building and using ultrasound probes having continuous arrays of ultrasound transducers which may have a substantially continuous concave curved shape in two or three dimensions (i.e., concave relative to an object to be imaged). Other embodiments herein provide systems and methods for designing, building and using ultrasound imaging probes having other unique configurations, such as adjustable probes and probes with variable configurations.

Abstract: Increasing the effective aperture of an ultrasound imaging probe by including more than one probe head and using the elements of all of the probes to render an image can greatly improve the lateral resolution of the generated image. In order to render an image, the relative positions of all of the elements must be known precisely. A calibration fixture is described in which the probe assembly to be calibrated is placed above a test block and transmits ultrasonic pulses through the test block to an ultrasonic sensor. As the ultrasonic pulses are transmitted though some or all of the elements in the probe to be tested, the differential transit times of arrival of the waveform are measured precisely. From these measurements the relative positions of the probe elements can be computed and the probe can be aligned.

Abstract: A method is for making an electrical inductor. The method includes forming a first subunit having a sacrificial substrate, and an electrically conductive layer defining the electrical inductor and including a first metal on the sacrificial substrate. The method includes forming a second subunit having a dielectric layer and an electrically conductive layer thereon defining electrical inductor terminals and having the first metal, and coating a second metal onto the first metal of one of the first and second subunits. The method includes aligning the first and second subunits together, heating and pressing the aligned first and second subunits to form an intermetallic compound of the first and second metals bonding adjacent metal portions together, and removing the sacrificial substrate.

Abstract: A communication plate extends along and is sandwiched between cylindrical communication manifolds of a first heat exchanger assembly and a second heat exchanger assembly. The communication plate includes a saddling surface arcuate in one direction and a saddling surface arcuate in the opposite direction for engaging in saddle-like fashion the cylindrical shape of the manifolds. The communication plate defines a plurality of communication plate orifices disposed along the communication plate and aligned co-axial with a plurality of communication orifices disposed along the manifolds to seal the communication orifices of the manifolds and establish distributed and sealed fluid communication between the heat exchanger assemblies.

Abstract: A method has been described for making an electrical structure having an air dielectric and includes forming a first subunit including a sacrificial substrate, an electrically conductive layer including a first metal on the sacrificial substrate, and a sacrificial dielectric layer on the sacrificial substrate and the electrically conductive layer. The method further includes forming a second subunit including a dielectric layer and an electrically conductive layer thereon including the first metal, and coating a second metal onto the first metal of one or more of the first and second subunits. The method also includes aligning the first and second subunits together, heating and pressing the aligned first and second subunits to form an intermetallic compound of the first and second metals bonding adjacent metal portions together, and removing the sacrificial substrate and sacrificial dielectric layer to thereby form the electrical structure having the air dielectric.

Abstract: A Multiple Aperture Ultrasound Imaging (MAUI) probe or transducer is uniquely capable of simultaneous imaging of a region of interest from separate apertures of ultrasound arrays. Some embodiments provide systems and methods for designing, building and using ultrasound probes having continuous arrays of ultrasound transducers which may have a substantially continuous concave curved shape in two or three dimensions (i.e., concave relative to an object to be imaged). Other embodiments herein provide systems and methods for designing, building and using ultrasound imaging probes having other unique configurations, such as adjustable probes and probes with variable configurations.

Abstract: A Multiple Aperture Ultrasound Imaging (MAUI) probe or transducer is uniquely capable of simultaneous imaging of a region of interest from separate physical apertures. Construction of probes can vary by medical application. That is, a general radiology probe can contain multiple transducers that maintain separate physical points of contact with the patient's skin, allowing multiple physical apertures. A cardiac probe may contain only two transmitters and receivers where the probe fits simultaneously between two or more intracostal spaces. An intracavity version of the probe can space transmit and receive transducers along the length of the wand, while an intravenous version can allow transducers to be located on the distal length the catheter and separated by mere millimeters. Algorithms can solve for variations in tissue speed of sound, thus allowing the probe apparatus to be used virtually anywhere in or on the body.