Abstract: The present disclosure provides compounds, pharmaceutical compositions, and methods for the treatment of cancer and fibrosis. The disclosed pharmaceutical compositions may include one or more pyrazolyl-containing compounds, or a derivative thereof.

Abstract: A hybrid edge and cloud system for detecting and identifying bird vocalizations including an edge device having an edge neural network. The edge neural network is trained with audio samples for making predictions about identification of the bird vocalizations. The system includes an audio sensor connected to the edge neural network for sending sound information to the edge neural network. The system includes a cloud computing system having a cloud neural network for processing the sound information, a first storage service, a second storage service, and a hit table which stores metadata about sound detections. The edge neural network generates a score for each of the trained audio samples based on predictions made from a sound audio clip and selects a top scoring audio sample. The hybrid edge and cloud system includes a browsing device having access to the cloud computing system and may request information from the hit table.

Abstract: A vacuum exhaust system includes a plurality of turbo pumps that evacuate a plurality of vacuum chambers. A plurality of chamber valves are positioned between the turbo pumps and the plurality of vacuum chambers. A plurality of branch channels are each connected to a corresponding exhaust of the plurality of turbo pumps and a main channel is formed from a confluence of the branch channels. A booster vacuum pump is connected to the main channel. A backing vacuum pump is connected to an exhaust of the booster vacuum pump. A plurality of bypass channels, each having a valve, provide a fluid communication path between at least some of the plurality of vacuum chambers and the booster vacuum pump.

Abstract: Compositions and methods useful for delivery of targeted therapies for pulmonary arterial hypertension, sepsis, cancer and cachexia. The compositions and methods are based on peptide pharmacophores that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. Peptide pharmacophores may selectively target tumor vasculature, regenerating tissue, wounded tissue, inflamed tissue, fibrotic tissue, remodeled tissue, tissue characterized by elevated heparanase levels, and have the ability to internalize into such diseased cells.

Abstract: Compositions and methods useful for delivery of targeted therapies for pulmonary arterial hypertension, sepsis, cancer and cachexia. The compositions and methods are based on peptide pharmacophores that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. Peptide pharmacophores may selectively target tumor vasculature, regenerating tissue, wounded tissue, inflamed tissue, fibrotic tissue, remodeled tissue, tissue characterized by elevated heparanase levels, and have the ability to internalize into such diseased cells.

Abstract: A conjugate for treating an individual suffering from a disease, wherein the conjugate is comprised of: a targeting peptide comprising a sequence substantially identical to CAR, or a variant thereof; and at least one therapeutic molecule and methods for making and administering same. Also disclosed is a combination product for use in the treatment of a disease, wherein the combination product comprises: (a) a targeting peptide comprising a sequence substantially identical to CAR, or a variant thereof; (b) a liposome, wherein the targeting peptide is encapsulated within the liposome; and (c) an effective amount of an anti-inflammatory agent and methods for making and administering same.

Abstract: Disclosed are compositions and methods useful for oral delivery of targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. The disclosed targeting is useful for oral delivery of therapeutic and detectable agents to diseased tissue in an animal.

Abstract: A lifting device (1, 14, 18, 28, 31, 36, 46, 50) has three booms (2, 19) of adjustable length, which in each case have a first end section (4, 20) and a second end section (5, 21) opposite the first end section (4, 20). While the first end sections (4, 20) of all booms (2, 19) are articulatedly connected to one another, the second end sections (5, 21) are articulatedly and rotatably mounted in respective bearings (7, 24, 29). The bearings (7, 24, 29) are thereby arranged at fixed positions relative to one another. Furthermore, in each boom (2, 19) at least the first end section (4, 20) can be rotated about the longitudinal axis of the boom (2, 19) with respect to the second end section (5, 21). In particular, the booms (2, 19) always form a tripod, which is characterized by a high stability. The lifting device (1, 14, 18, 28, 31, 36, 46, 50) is therefore suitable for lifting very heavy loads, wherein greater ranges can be achieved compared to known lifting devices.

Abstract: A vacuum exhaust system includes a plurality of low pressure vacuum pumps that operate in a molecular flow region and evacuate a plurality of vacuum chambers. A plurality of chamber valves are positioned between the low pressure vacuum pumps and the plurality of vacuum chambers. A plurality of branch channels are each connected to a corresponding exhaust of the plurality of low pressure vacuum pumps and a main channel is formed from a confluence of the branch channels. An intermediate vacuum pump is connected to the main channel and operates in a viscous flow region. A higher pressure vacuum pump operates in a higher pressure viscous flow region and is connected to an exhaust of the intermediate pressure vacuum pump. A plurality of bypass channels, each having a valve, provide a fluid communication path between at least some of the plurality of vacuum chambers and a higher pressure vacuum pump.

Abstract: An attenuator for high pressure fluid systems includes a shielding stud including first and second ends and a cylindrical space extending therebetween. The attenuator comprises a cylindrical, attenuator body disposed within the cylindrical space and defining a pressure chamber therein. First and second seal heads are positioned within first and second ends of said shielding stud and coupled to the attenuator body using a tensioner assembly and a plug threadingly coupled to first and second inner threaded surfaces of the shielding stud in first and second ends thereof.

Abstract: Disclosed are compositions and methods for triggering disease selective macropinocytosis. The compositions can serve as a marker of disease activity and as a trigger of enhanced macropinocytosis in tissues undergoing disease remodeling such as wound healing, cancer, PAH, inflammation, diabetes, Crohn's disease, ulcerative colitis, ankylosing spondylitis, diseases of the endometrium, psoriasis, irritable bowel syndrome, arthritis, fibrotic disorders, interstitial cystitis, autoimmune diseases, asthma, acute lung injury, and adult respiratory distress syndrome. The compositions can also serve as a receptor for disease selective cell penetrating peptides in the cells and extracellular matrix of diseased tissues.

Abstract: Disclosed are compositions and methods useful for oral delivery of targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. The disclosed targeting is useful for oral delivery of therapeutic and detectable agents to diseased tissue in an animal.

Abstract: Provided are methods, vectors and gene constructs for enhancing expression of a recombinant nucleic acid sequence in transgenic plants and plant tissues. According to the present invention, nucleic acid sequences are obtained and/or derived from the 3? untranslated regions of Zea mays chlorophyll a/b binding protein gene and engineered to flank respective portions of a selected coding region of a vector. The vector construct may be introduced into plants and/or plant tissues through conventional or gene targeting procedures, resulting in enhanced expression of the selected coding region. In some embodiments, the selected coding region is a chimeric gene or gene fragment expressing one or more proteins known to impart a level of insecticidal activity to a transgenic plant and/or plant tissue.

Abstract: This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a Zea mays KN1 gene. Some embodiments relate to a promoter from a Zea mays KN1 gene that functions in plants to promote transcription of operably linked nucleotide sequences.

Abstract: A method and system for setting a performance event includes collecting information from fans regarding their interest in a performance, and determining whether or not to set the performance and/or determining a parameter of the event for setting a performance based on the received responses.

Abstract: An attenuator for high pressure fluid systems is provided. The attenuator includes a shielding stud including first and second ends, a cylindrical space extending therebetween, and a housing fixedly coupled to the first end. The attenuator includes a body disposed within the cylindrical space and defining a pressure chamber therein. The body includes an engaging wall extending axially beyond an opening to the pressure chamber and defines a sealing chamber therein. A seal head positioned within the sealing chamber is coupled to the body using a tensioner assembly coupled to the engaging wall. The seal head is engaged with the body first end to define a seal therebetween and an end cap is coupled to the second end of the shielding stud and the seal head. The end cap can apply a compressive force to the seal head to compress the seal head against the body and apply a tensile load to the shielding stud.

Abstract: This disclosure concerns compositions and methods for promoting transcription and translation of a nucleotide sequence in a plant or plant cell, employing a promoter and/or a 3?UTR from Zea mays Zrp2 gene. Some embodiments relate to a promoter from a Zea mays Zrp2 gene that is operably linked to a Zea mays Ubiquitin 1 intron and functions in plants to promote transcription of operably linked nucleotide sequences. Other embodiments relate to a 3? UTR from a Zea mays Zrp2 gene that functions in plants to terminate transcription of operably linked nucleotide sequences.

Abstract: Provided are deglycosylation methods designed to optimize the yield of a Veratrum alkaloid from Veratrum plant material and/or from an extract of Veratrum plant material.

Abstract: This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a Zea mays KN1 gene. Some embodiments relate to a promoter from a Zea mays KN1 gene that functions in plants to promote transcription of operably linked nucleotide sequences.

Abstract: Disclosed are compositions and methods useful for delivering targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to effect a beneficial therapeutic result. The disclosed targeting is useful for delivering therapeutic and detectable agents to diseased tissue in an animal.