Abstract: The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.

Abstract: An ammonia converter and method are disclosed. The reactor can alter the conversion of ammonia by controlling the reaction temperature of the exothermic reaction along the length of the reactor to parallel the equilibrium curve for the desired product. The reactor 100 can comprise a shell 101 and internal catalyst tubes 109. The feed gas stream enters the reactor, flows through the shell 101, and is heated by indirect heat exchange with the catalyst tubes 109.

Abstract: Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing one or more tissues with irradiation.

Abstract: Embodiments of the invention provide a scalable method for analyzing a network. The method includes generating a data trace representative of the network, determining a topology for the network from the data trace, and sequentially analyzing each frame in the data trace to determine at least one of network errors, warnings, and metrics. The analysis of each frame generally includes analyzing a first protocol layer of the frame with a first expert engine, determining if a second protocol layer is present in the frame, passing the frame to a second expert engine, and passing the frame to additional expert engines if the frame contains additional protocol layers.

Abstract: Embodiments of the invention provide a method for analyzing a data trace representative of an FC network. The method includes determining a topology of the network, filtering the data trace for open commands that are not perceived by at least one analyzer positioned in communication with the network and eliminating devices associated with these open commands not received by an analyzer from further analysis, filtering the data trace for failed open commands and eliminating devices associated with the failed open commands from further analysis, and filtering the trace data for frames to destinations that are not received by the analyzer and eliminating devices associated with these frame from further analysis. The method further includes filtering frames transmitted when a loop is in closed state and eliminating devices associated with transmitting frames when a loop is closed from further analysis, and conducting error analysis of the network topology not eliminated by a filtering step.

Abstract: An ammonia converter is disclosed. The converter can alter the conversion of ammonia by controlling the reaction temperature of the exothermic reaction along the length of the reactor to parallel the equilibrium curve for the desired product. The converter can comprise a shell 101 and internal catalyst tubes 109. The feed gas stream enters the reactor, flows through the shell 101, and is heated by indirect heat exchange with the catalyst tubes 109.

Abstract: Disclosed is a high performance business framework and related tools and processes for describing how known high performance businesses derive performance contributions from three building blocks. The present invention provides methods and tools for researching, measuring and quantifying these three building blocks to enable assessments to be made of various companies in various industries and methods and tools for enabling these various companies to identify and adopt solutions that enable them to model themselves after high performers.

Abstract: A welding system comprising a welding-type power source and a protective cover for the welding-type power source. The protective cover may be comprised of a synthetic fabric and a polymeric fluid barrier. The protective cover may have a member secured to the synthetic fabric to enable a user to grip the member to lift the cover from the welding-type power source. The protective cover may have a plurality of eyelets to enable the cover to be drawn against the welding-type power source. The protective cover may comprise a portion adapted to receive an exhaust pipe of the welding-type power source. The portion of the cover adapted to receive the exhaust pipe may comprise a heat-resistant synthetic fabric.

Abstract: A retail merchandising apparatus affording assured automatic product rotation, labor-savings associated with reduced stocking times and the elimination for the need to manually rotate product. The apparatus also provides greatly enhanced permanent brand-identification, brand exposure and distinction from competitor's in the grocery aisle due to the product always being in an upright position throughout the loading and dispensing process and the superior graphic presence presented on the apparatus.

Abstract: A point-to-multipoint network arrangement, method of operation and related signals for a network comprising a head-end station and at least one subscriber station connected to the head-end by means of a shared medium high-speed point-to-multipoint network (preferably a passive optical network). The method involves transmitting data upstream using a packet-switched transport protocol (e.g. Ethernet) over TDMA. By using high-speed upstream transmission with relatively long time slots and relatively short guard bands, the need for complex ranging schemes is obviated.

Abstract: Methods are disclosed for sterilizing biological materials to reduce the level of active biological contaminants or pathogens such as viruses, bacteria, nanobacteria, yeasts, molds, mycoplasmas, ureaplasmas, prions and parasites. These methods involve the use of dipeptide stabilizers in methods of sterilizing biological materials with irradiation.

Abstract: Methods are disclosed for sterilizing preparations of digestive enzymes to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. These methods involve sterilizing preparations of digestive enzymes, such as trypsin, ?-galactosidase and iduronate-2-sulfatase, with irradiation.

Abstract: An ammonia converter system and method are disclosed. The reactor can alter the conversion of ammonia by controlling the reaction temperature of the exothermic reaction along the length of the reactor to parallel the equilibrium curve for the desired product. The reactor 100 can comprise a shell 101 and internal catalyst tubes 109. The feed gas stream enters the reactor, flows through the shell 101, and is heated by indirect heat exchange with the catalyst tubes 109. The catalyst tubes 109 comprise reactive zones 122 having catalyst and reaction limited zones 124 that can comprise inert devices that function to both separate the reactive zones, increase heat transfer area, and reduce the temperature of the reaction mixture as the effluent passes through the catalyst tube 109.

Abstract: An apparatus is provides which includes a frame configured to be supported by a customer-accessible lower shelf, the lower shelf being adapted to support a plurality of items, and an upper shelf supported by the frame at an angle thereto, the upper shelf also being adapted to support a plurality of items and having an opening at a lower end thereof, so that an item supported by the upper shelf drops onto the lower shelf, through the opening, after an item is removed from the lower shelf.

Abstract: One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.

Abstract: A grip for an extension pole has an opening at one end sized to receive the inboard end of the extension pole, and another opening at the other end communicating with a storage compartment inside the grip for storing at least a portion of an adaptor. A gripper inside the grip engages the adaptor when inserted into the storage compartment to prevent the adaptor from inadvertently falling out of the storage compartment.

Abstract: Methods are disclosed for sterilizing preparation of monoclonal immunoglobulins to reduce the level of active biological contaminants such as viruses, bacteria, yeasts, molds, mycoplasmas, prions and parasites.

Abstract: A sprinkler discharges a column of water downwardly onto a deflector that has a plurality of peripheral tines with a respective non-radial tapered notch separating each adjacent pair of tines. Opposed cutouts with tabs in the central portion of the deflector combine with the notches and with depressed peripheral tabs to produce a predetermined spray pattern.

Abstract: Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, spores, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing one or more tissues with irradiation.

Abstract: Methods are disclosed for sterilizing biological materials to reduce the level of one or more biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, single or multicellular parasites, and/or prions or similar agents responsible, alone or in combination, for TSEs. These methods involve the use of stabilizer mixtures in methods of sterilizing biological materials with irradiation.