Patents by Inventor David Manning

David Manning has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
    Publication number: 20080207595
    Abstract: The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
    Type: Application
    Filed: July 17, 2006
    Publication date: August 28, 2008
    Applicant: AMR Technology, Inc.
    Inventors: Bruce Molino, Shuang Liu, Aruna Sambandam, Peter Guzzo, Min Hu, Congxiang Zha, Kassoum Nacro, David Manning, Matthew Isherwood, Kristen Fleming, Wenge Cui, Richard Olson
  • NOVEL PROCESSES FOR STEREOSELECTIVE SYNTHESIS OF TRANS ISATX247
    Publication number: 20080021197
    Abstract: The present invention relates to a process for preparation of a trans ISATX247 compound of the formula: where R1?H or D; R2?H or D; and R3?H or D, by application of organozirconium chemistry. The process involves reacting an acetyl cyclosporin aldehyde with an organozirconium reagent to provide acetyl cyclosporin diene (the acetate of trans ISATX247) and deacetylating the acetyl cyclosporin diene to produce the trans-isomer of ISATX247. The present invention also relates to a process for preparing the same trans ISATX 247 compound, using olefin cross metathesis. The process involves: olefin cross metathesis of acetyl cyclosporin A to afford acetyl cyclosporin ?,?-unsaturated aldehyde; Wittig reaction of the acetyl cyclosporin ?,?-unsaturated aldehyde to provide acetyl cyclosporin diene; and deacetylation of the acetyl cyclosporin diene to produce the trans ISATX247 compound.
    Type: Application
    Filed: July 26, 2005
    Publication date: January 24, 2008
    Inventors: Bruce Molino, Zhicai Yang, Jun-Ho Maeng, David Manning
  • Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
    Publication number: 20070021408
    Abstract: The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
    Type: Application
    Filed: July 17, 2006
    Publication date: January 25, 2007
    Applicant: AMR Technology, Inc.
    Inventors: Bruce Molino, Shuang Liu, Aruna Sambandam, Peter Guzzo, Min Hu, Congxiang Zha, Kassoum Nacro, David Manning, Matthew Isherwood, Kristen Fleming, Wenge Cui, Richard Olson
  • Pesticidal compositions
    Publication number: 20060247242
    Abstract: 5-Substituted-sulfonylaminopyrazole derivatives of formula (I): or salts thereof, wherein the various symbols are as defined in the description, and pesticidal compositions thereof, processes for their preparation, and methods for their use for the control of arthropods (including insects and arachnids) and helminths (including nematodes).
    Type: Application
    Filed: November 12, 2003
    Publication date: November 2, 2006
    Inventors: Uwe Döller, David Chou, Merwyn Steinsberger, Michael Maier, Anke Kuhlmann, Karl Seeger, David Hawkins, Stanley Gough, David Manning
  • Piperidine derivatives as subtype selective N-Methyl-D-Aspartate antagonists
    Patent number: 6642256
    Abstract: Described are piperidines of Formula I and pharmaceutically acceptable salts thereof. The compounds of Formula I are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, stroke, cerebral ischemia, central nervous system disorders, depression, trauma, hypoglycemia, neurodegenerative disorders, anxiety, migraine headache, convulsions, Parkinson's disease, aminoglycoside antibiotics-induced hearing loss, psychosis, glaucoma, CMV retinitis, opioid tolerance or withdrawal, pain, especially chronic pain, neuropathic pain, or surgical pain, or urinary incontinence.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: November 4, 2003
    Assignee: Warner-Lambert Company LLC
    Inventors: Brian Edward Kornberg, Russell Andrew Lewthwaite, David Manning, Sham Shridhar Nikam, Ian Leslie Scott
  • Piperidine derivatives as subtype selective N-methyl-D-aspartate antagonists
    Publication number: 20030018021
    Abstract: Described are piperidines of Formula I 1
    Type: Application
    Filed: November 30, 2001
    Publication date: January 23, 2003
    Inventors: Brian Edward Kornberg, Russell Andrew Lewthwaite, David Manning, Sham Shridhar Nikam, Ian Leslie Scott