Patents by Inventor David Marks

David Marks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINES AND THERAPEUTIC USES THEREOF
    Publication number: 20180214427
    Abstract: 6-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 6-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
    Type: Application
    Filed: August 3, 2016
    Publication date: August 2, 2018
    Inventors: Sunil Kumar KC, David Mark Wallace, Jianguo Cao, Chandramouli Chiruta, John Hood
  • 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF
    Publication number: 20180207141
    Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
    Type: Application
    Filed: August 3, 2016
    Publication date: July 26, 2018
    Inventors: Sunil Kumar KC, David Mark Wallace, Jianguo Cao, Chandramouli Chiruta, John Hood
  • Configurable speech recognition system using a pronunciation alignment between multiple recognizers
    Patent number: 10032455
    Abstract: Techniques for combining the results of multiple recognizers in a distributed speech recognition architecture. Speech data input to a client device is encoded and processed both locally and remotely by different recognizers configured to be proficient at different speech recognition tasks. The client/server architecture is configurable to enable network providers to specify a policy directed to a trade-off between reducing recognition latency perceived by a user and usage of network resources. The results of the local and remote speech recognition engines are combined based, at least in part, on logic stored by one or more components of the client/server architecture.
    Type: Grant
    Filed: January 6, 2012
    Date of Patent: July 24, 2018
    Assignee: Nuance Communications, Inc.
    Inventors: Michael Newman, Anthony Gillet, David Mark Krowitz, Michael D. Edgington
  • 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF
    Publication number: 20180201624
    Abstract: Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
    Type: Application
    Filed: September 27, 2017
    Publication date: July 19, 2018
    Inventors: Sunil Kumar KC, David Mark Wallace, Jianguo Cao, Chandramouli Chiruta, John Hood
  • Machining fixture production
    Patent number: 10025288
    Abstract: Disclosed is a method of producing a machining fixture for fixedly holding a workpiece during machining of that workpiece. The method comprises: providing an initial machining fixture comprising a plurality of receiving elements for receiving the workpiece to be machined; determining a datum, the datum being dependent upon the relative positions of the receiving elements; determining positions and orientations of one or more reference surfaces with respect to the datum; measuring the surface of the initial machining fixture with respect to the datum; and, thereafter, controlling machining apparatus with respect to the datum to machine the initial machining fixture to form the one or more reference surfaces, thereby producing the machining fixture.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: July 17, 2018
    Assignee: BAE Systems plc
    Inventors: John Bickerstaff, David Mark Wilson
  • 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
    Patent number: 10023572
    Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: July 17, 2018
    Assignee: Samumed, LLC
    Inventors: Sunil Kumar KC, David Mark Wallace, Jianguo Cao, Chandramouli Chiruta, John Hood
  • Object production
    Patent number: 10025293
    Abstract: Disclosed is a method of producing an object, the method comprising: providing a workpiece comprising a plurality of attachment features for attaching the workpiece to a machining fixture; determining a datum, the datum being dependent upon the relative positions of the attachment features; measuring the surface of the workpiece with respect to the datum; providing the machining fixture; attaching, using the attachment features, the workpiece to the machining fixture; providing a digital model specifying the object including the attachment features; and, thereafter, using the measurements of the workpiece surface and the digital model, controlling machining apparatus with respect to the datum to machine the workpiece so as to produce the object as specified by the digital model.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: July 17, 2018
    Assignee: BAE Systems plc
    Inventors: John Bickerstaff, David Mark Wilson
  • Indazole inhibitors of the WNT signal pathway and therapeutic uses thereof
    Patent number: 10016406
    Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases due to mutations in Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: July 10, 2018
    Assignee: Samumed, LLC
    Inventors: John Hood, David Mark Wallace, Sunil Kumar KC
  • Modified polymerases for improved incorporation of nucleotide analogues
    Patent number: 10017750
    Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogs bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: July 10, 2018
    Assignee: ILLUMINA CAMBRIDGE LIMITED
    Inventors: Geoffrey Paul Smith, David Mark Dunstan Bailey, Raquel Maria Sanches-Kuiper, Harold Swerdlow, David James Earnshaw
  • Cleaning devices, systems and methods
    Patent number: 10016575
    Abstract: Cleaning systems and devices are provided for cleaning body-inserted tubes (e.g., endotracheal tubes, chest cleaning tubes). In one embodiment, a closed suction system includes a suction catheter having at least one deployable (e.g., inflatable) cleaning member at a distal portion of the suction catheter and at least one suction opening distal to the cleaning member. The closed suction system module may include a control unit at its proximal end adapted to facilitate operation in one of the following three operational states: i) a first operational state in which only the cleaning member is functional, ii) a second operational state in which only suction is functional, or iii) a third operational state in which neither suction nor the cleaning member is functional.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: July 10, 2018
    Assignee: ENDOCLEAR LLC
    Inventors: Brad Eugene Vazales, David Mark Chersky
  • 3-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF
    Publication number: 20180177787
    Abstract: Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
    Type: Application
    Filed: August 10, 2017
    Publication date: June 28, 2018
    Inventors: Sunil Kumar KC, David Mark Wallace, Jianguo Cao, Chandramouli Chiruta, John Hood
  • Closed suction cleaning devices, systems and methods
    Patent number: 10004863
    Abstract: A closed suction system module is provided. In one embodiment, the closed suction system module includes a coupling member configured to couple to a suction port of a multi-port manifold or endotracheal tube adapter (e.g., dual-port or tri-port adapter). In one embodiment, the closed suction system module includes a suction catheter configured to clean the interior surfaces of body-inserted tubes or artificial airways (alone or in addition to suctioning natural airways or portions of the respiratory tract or other body lumens). The suction catheter may include a cleaning portion at a distal portion of the suction catheter (e.g., near the distal end or tip of the suction catheter). In some embodiments, the cleaning portion includes at least one expandable cleaning member (e.g., balloon, sleeve, wiper).
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: June 26, 2018
    Assignee: ENDOCLEAR LLC
    Inventors: Brad Eugene Vazales, David Mark Chersky, Arthur A. Bertolero
  • Photo-electric receptacle luminaire integration point
    Patent number: 10003165
    Abstract: Provided is a receptacle for installation within a lighting fixture. The receptacle includes a platform (i) for exposure external to the lighting fixture and (ii) providing connectivity for coupling to an external control device and a base operationally coupled to the platform and including a first set of one or more nodes configured for coupling to a first set of wires.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: June 19, 2018
    Assignee: GE LIGHTING SOLUTIONS, LLC
    Inventors: David Mark Johnson, Matthew S. Mrakovich
  • Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
    Patent number: 9994563
    Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: June 12, 2018
    Assignee: Samumed, LLC
    Inventors: John Hood, David Mark Wallace, Sunil Kumar KC
  • INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF
    Publication number: 20180153873
    Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases due to mutations in Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
    Type: Application
    Filed: August 18, 2017
    Publication date: June 7, 2018
    Inventors: John Hood, David Mark Wallace, Sunil Kumar KC
  • RESOURCE PLANNING SYSTEM, PARTICULARLY FOR VEHICLE FLEET MANAGEMENT
    Publication number: 20180158145
    Abstract: A system for physical asset resource planning including a capital asset management (CAM) application server in data communication with a CAM report server and a CAM database server; the CAM application server is configured to: execute a life cycle module for generating an asset life cycle model based on user inputs customizing the model for each instance of its execution and to execute a life cycle calculator for generating an annual cost for an asset based on the life cycle model and on a dataset received from the CAM database server. A CAM report server is configured to: execute a presentation module for displaying results of the life cycle module and the life cycle calculator to a user. A CAM database server stores a plurality of datasets related to the assets and provides data to the CAM application and report servers.
    Type: Application
    Filed: December 1, 2016
    Publication date: June 7, 2018
    Inventors: David Mark Weigel, Marc Knight
  • Lactate Production Process
    Publication number: 20180155747
    Abstract: A process for producing alkyl R-lactate from an initial compound comprising substructure (I) is provided. The process involves producing an intermediate comprising R,R- and S,S-lactide from the initial compound, wherein the initial compound is subjected to stereoisomerisation conditions; and reacting at least a portion of the intermediate with an alkyl alcohol to produce a product comprising alkyl R-lactate, wherein alkyl R-lactate is produced in the presence of an enzyme. Also provided are processes for the production of R-lactic acid, oligomeric R-lactic acid, R,R-lactide, poly-R-lactic acid and stereocomplex lactic acid.
    Type: Application
    Filed: February 1, 2018
    Publication date: June 7, 2018
    Applicant: NatureWorks LLC
    Inventors: Edward Leslie Marshall, Alan Keasey, David Mark Sutton
  • Reactor assembly
    Patent number: 9987612
    Abstract: A reactor assembly is provided. The reactor assembly includes a substrate and a first catalytic layer provided on the substrate. The first catalytic layer further includes a first temperature zone configured to operate at a first temperature. The first catalytic layer further includes a second temperature zone extending from the first temperature zone. The second temperature zone is configured to operate at a second temperature. The second temperature is lower than the first temperature. The reactor assembly also includes a diffusion barrier coating provided on the first catalytic layer. The diffusion barrier coating is configured to regulate a diffusion of gas phase oxygen therethrough for controlling the first temperature with respect to the second temperature.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: June 5, 2018
    Assignee: Caterpillar Inc.
    Inventors: David Mark Ginter, Ling Deng, Wilce Damion Williams, Ronald G. Silver
  • Interface including a foam cushioning element
    Patent number: 9987450
    Abstract: A respiratory mask assembly includes a frame having a channel and a cushioning element including a clip portion adapted for interference seal and retention in the channel. The cushioning element includes an interfacing portion constructed from foam and having a wider width than the clip portion.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: June 5, 2018
    Assignee: ResMed Limited
    Inventors: Lee James Veliss, Renee Frances Doherty, Scott Alexander Howard, Alicia Kristianne Wells, Fiona Catherine Carroll, David Mark Gilliver, Brett Thomas Lindsay
  • 2-(1H-INDAZOL-3-YL)-3H-IMIDAZO[4,5-B]PYRIDINE AND THERAPEUTIC USES THEREOF
    Publication number: 20180148444
    Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
    Type: Application
    Filed: July 27, 2017
    Publication date: May 31, 2018
    Inventors: Sunil Kumar KC, David Mark Wallace, Jianguo Cao, Chandramouli Chiruta, John Hood