Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: Methods for loading a module on a plurality of device types without modification includes initializing an application native to the client device, the application including a web browser; determining a module to be loaded on the application, the module written in a web-based format and having a set of dependencies indicated within a code thereof; and loading the determined module on the web browser for recognition by the application native to the client device. The loading the determined module on the web browser includes loading the set of dependencies of the module.

Abstract: Systems and methods for cleaning and maintaining artificial airways sized for insertion within pediatric or neonatal patients (e.g., external diameters of less than 5 mm) are disclosed. The system includes a multi-port ventilator manifold configured to couple to a ventilation source, thereby forming a ventilator circuit with the patient. The manifold includes an occluder configured to advantageously reduce an amount of dead space in the manifold so as to prevent loss of positive end expiratory pressure of the ventilator circuit and reduce the likelihood of broncho-pulmonary dysplasia of the patient, or even premature death.

Abstract: An improved sexual aid device, the device including a semi-rigid base member for insertion into a woman's vagina. The semi-rigid flexible base member has a shape generally conforming to the shape of a male penis, and a top section secured to the semi-rigid base member. The top section includes an inflatable bladder, a foam member or a removable member. The top section receives the male penis. The device also may include a second curved external member which is a continuous extension from the base member, such that the device can simultaneously stimulate a woman's vagina and clitoris. Alternatively, the top section may include a removable member, and the device may include one more stimulation means.

Abstract: A valve assembly comprising a valve guide and one or more weights coupled to and/or integral with the valve guide. The valve assembly may further comprising a valve body and a valve stem connecting the valve body to the valve guide. The valve assembly may be disposed in a fluid end of a positive displacement pump that is operated to flow a wellbore servicing fluid into a wellbore.

Abstract: A respiratory mask for continuous positive airway pressure treatment includes a cushion adapted to be positioned against the face of a patient. The cushion is configured in a gasket arrangement around an entrance to the airways of the patient. The cushion is constructed from a polyurethane foam and has a thickness of greater than about 5 mm.

Abstract: In an embodiment, an auxiliary-power-supply unit includes a connector and a controller configured to power a microgrid from a battery in response to determining that the connector is plugged into an outlet of the microgrid, and that the microgrid is uncoupled from a power grid. For example, the connector plugs into a wall outlet of a microgrid in, e.g., a home, and provides, from the battery during a power outage, auxiliary power to the microgrid and, therefore, provides auxiliary power to one or more devices, such as appliances, lights, computers, or televisions, that are connected to the microgrid.

Abstract: A delivery device for intravenous delivery of microparticles to a patient. The delivery device is fluidly connectable to (i) a first source of an injection medium and (ii) a second source of an injection medium. The delivery device includes: a first fluid inlet fluidly connectable to the first source of the injection medium, a fluid outlet, a fluid mixer fluidly connecting the first fluid inlet to the fluid outlet, a second fluid inlet fluidly connectable to the second source of the injection medium, and a source of microparticles fluidly connecting the second fluid inlet to the fluid mixer. When fluid flows from the second source of the injection medium into the delivery device: the second injection medium fluidly drives microparticles from the source of microparticles into the fluid mixer, and the fluid outlet dispenses to the patient an injection medium that includes the microparticles.

Abstract: The present invention relates to a method of capturing and stabilising volatile thiol malodour generated on the human skin, comprising steps of: i) contacting the human skin with a substrate, ii) absorbing said thiol into the substrate, and iii) reacting said thiol with a thiol-capture agent. The invention also relates to a method of quantifying said thiol, a method of assessing the deodorizing performance of a cosmetic composition on the human skin.

Abstract: The present invention provides novel engineered reverse transcriptase enzymes that afford beneficial improvements in thermal stability, processivity, cDNA yields and elimination of secondary enzymatic activity. The present invention also provides methods for amplifying template nucleic acids using such reverse transcriptase enzymes. This invention addresses deficiencies in the current state of the art reverse transcriptase enzymes in RNA detection and analysis including deficiencies in detection sensitivity, specificity, side enzyme activities, enzyme stability and synthesis capacity, especially when using template nucleic acids ranging in length, secondary structure and nucleotide content.

Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.

Abstract: A visual warning assembly, configured to make a warning from one vehicle to another vehicle. The visual warning assembly has a case with a front face joined to a base and an antenna. A channel display window, a channel selector button, a power button, a green lighted button, a yellow lighted button and a red lighted button, arranged on the front face. A mounting ball is magnetically joined to the base. A microcontroller is electrically coupled to the green lighted button, the yellow lighted button, and the red lighted button. The microcontroller is programmed with instructions to: receive a communication from a second visual warning assembly. Then, engage one member of a lighted button set consisting of the red button, the yellow button, and the green button creating an indicating light. Finally, receiving a signal from a user making the indicating light an activated button.

Abstract: Disclosed herein are methods and systems for integrating an enterprise's structured and unstructured data to provide users and enterprise applications with efficient and intelligent access to that data. In accordance with exemplary embodiments, the generation of feature vectors about unstructured data can be hardware-accelerated by processing streaming unstructured data through a reconfigurable logic device, a graphics processor unit (GPU), or chip multi-processor (CMP) to determine features that can aid clustering of similar data objects.

Abstract: A respiratory mask for continuous positive airway pressure treatment includes a cushion adapted to be positioned against the face of a patient. The cushion is configured in a gasket arrangement around an entrance to the airways of the patient. The cushion is constructed from a polyurethane foam and has a thickness of greater than about 5 mm.

Abstract: A consumer product having a sensor for controlling the operation of the consumer product, a system and method including the consumer product and a sensor are provided. The system and method including a central communication unit capable of receiving incoming signals and sending outgoing instructions from the consumer product and sensor. The central communication unit communicably connected with a memory configured to store an algorithm. The sensor has a cross-linked carbon nanotube network comprising: a plurality of carbon nanotubes; and at least one linker that covalently links adjacent carbon nanotubes. The algorithm controls the consumer product based on incoming signals sent from the sensor to the central communication unit.

Abstract: This application provides a computer-implemented method for providing notifications. The method includes creating and storing a geofenced area associated with a mobile device and a location that has a healthcare facility in a data store and outputting a notification to the mobile device when the mobile device is within the geofenced area. The notification may include that the location offers at least one healthcare service that can be received on an unscheduled basis, where in the facility that the at least one healthcare service is offered, whether or not the healthcare service is covered by a patient's insurance, the cost of the healthcare service, the out-of-pocket cost by the patient of the healthcare service, wait time at the facility for the healthcare service, and when the patient should not receive the healthcare service for other medical reasons.

Abstract: Methods for laser bonding optical elements to substrates and optical assemblies are disclosed. According to one embodiment, a method of bonding an optical element to a substrate includes disposing at least one optical element onto a surface of the substrate, electrostatically affixing the at least one optical element to the surface of the substrate, and directing a laser beam into the at least one optical element. The laser beam heats an interface between at least one optical element and the substrate to a temperature that is higher than a lowest temperature of the optical element change temperature and the substrate change temperature, thereby forming a bond between at least one optical element and the substrate at a bond area. The laser beam has a fluence that does not modify the substrate at areas of the substrate that are outside of the at least one optical element.

Abstract: In one embodiment, a method includes negotiating, by a networking device, a security association with a peer and receiving, by the networking device, an Internet Protocol (IP) packet from the peer. The IP packet includes an outer IP header, an ESP header, a protocol header, data, an ESP trailer, and ESP authentication data. The method further includes performing, using an IP Security (IPSec) authentication algorithm, authentication checks for the outer IP header, the ESP header, the protocol header, the data, the ESP trailer, and the ESP authentication data of the IP packet.

Abstract: Dialog based testing is performed in conjunction with a three-dimensional (3D) virtual reality (VR) system including at least one loudspeaker, a microphone, and a 3D VR headset having a display for displaying 3D VR video and a gaze tracker integrated with the headset. The dialog based testing includes: rendering a 3D avatar via the display of the 3D VR headset; engaging in a dialog including causing the rendered 3D avatar to make utterances in accordance with the branching dialog script and receiving responses to the utterances from a test subject wearing the 3D VR headset including at least verbal responses received via the microphone and gaze activity recorded by the gaze tracker and traversing the branching dialog script including selecting branches of the branching dialog script based at least on the verbal responses received via the microphone; and grading the test subject based on the responses.

Abstract: This document provides oilseed plants (e.g., pennycress plants) having increased levels of one or more saturated fatty acids, increased levels of one or more polyunsaturated fatty acids (PUFAs), altered (e.g., increased or decreased) levels of oleic acid, and/or altered (e.g., increased or decreased) levels of erucic acid. For example, oilseed plants having reduced polypeptide levels and/or reduced polypeptide activity of one or more polypeptides involved in triglyceride synthesis (e.g., diacylglycerol O-acyltransferase 1 (TAG1) can have increased levels of stearic acid, increased levels of one or more PUFAs, altered levels of oleic acid, and/or altered levels of erucic acid. Also provided herein are methods and materials for making and using oilseed plants having increased levels of one or more saturated fatty acids, increased levels of one or more PUFAs, altered levels of oleic acid, and/or altered levels of erucic acid.