Abstract: A compound which is an arylimidazolyl isoxazole of formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer.

Abstract: Apparatus and methods of forming boxes from template blanks includes moving the blank forward on a drive line while one or more side panel fingers raise and lower various side panels of the blank in an alternating fashion. One or more holders maintain the side panels in position as the blank moves forward on the drive line. The raised and lowered side panels rigidify various panels from which they extend. The rigidified panels may be less susceptible to bending along false scores that extend transversely across the blank during folding and bending steps of the box forming process.

Abstract: A machine for forming packing templates includes a infeed system that can feed multiple feeds of sheet material into the machine without repositioning the infeed system or forming creases or bends in the sheet material. The machine also includes a separation and cutting systems with one or more cutting tables and biased knives that cut the sheet material packaging templates. The machine also includes creasing roller(s) that forms creases in the sheet material. The machine also includes a system for reducing or eliminating the impact of irregularities in the sheet material.

Abstract: A compound which is an isoxazolyl imidazopyridine of formula (I): wherein: R0 and R, which are the same or different, are each H or C alkyl; R9? and R9?, which are the same or different, are each H or F; X is -(alk)n-, -alk-C(?O)—NR—, -alk-NR—C(?O)— or -alk-C(?O)—; R1 is selected from —S(?O)2R? and a 4- to 7-membered heterocyclic group which is unsubstituted or substituted; R2 and R2?, which are the same or different, are each H or C1-6 alkyl; or R2 and R2? form, together with the C atom to which they are attached, a C3-6 cycloalkyl group; R3 and R3?, which are the same or different, are each H, C1-6 alkyl, OH or F; R4 is phenyl or a 5- to 12-membered N-containing heteroaryl group and is unsubstituted or substituted; alk is C1-6 alkylene; R? is C1-6 alkyl; and n is 0 or 1; or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer.

Abstract: A compound which is a benzimidazole of formula (I): wherein X is a 5-membered heteroaryl group selected from the following: or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer.

Abstract: An elevator system has a central control unit for generating control signals and/or processing sensor signals and controlling functions of the system, a plurality of field devices distributed inside a structure accommodating the system, preferably along an elevator shaft, and a field bus system for interchanging the signals between the control unit and the field devices. Each field device outputs sensor signals generated by a sensor and/or receives control signals to be implemented by an actuator. Data packets including the signals are interchanged in a serial manner between the control unit and all field devices in a summation frame method using a closed ring topology. Each field device has a driver to insert the sensor signals into the data packet or to remove the control signals from the data packet. Data and signal transmission is thereby carried out quickly and safely in a safety circuit of the elevator system.

Abstract: A hybrid rotary cone drill bit includes a plurality of legs. A bearing shaft extends from each leg, and a rotary cone is rotationally coupled to each bearing shaft. At least one rotary cone includes a nose row of cutting structures, an inner row of cutting structures, and a gage row of cutting structures. The nose row and the inner row of cutting structures are formed of milled teeth. The gage row of cutting structures is formed of cutter inserts.

Abstract: A monitoring device for an elevator system is used with an assembly device for assembling a shaft retrofit and a method for monitoring an assembly platform. The monitoring device monitors movements of an elevator car and includes a sensor system for detecting a movement variable and at least one analysis device that evaluates the detected movement variable and compares it to a threshold. If the threshold is exceeded, a signal output is triggered to actuate a brake/catching device. The monitoring device selects the threshold from specified thresholds based on a state of the monitoring device. The specified thresholds include at least one normal operation threshold, and the monitoring device indicates a normal state as soon as specified connection elements are connected to it. The monitoring device further contains a checking routine for determining a state of the monitoring device, and selects the threshold from specified thresholds based on the state.

Abstract: A compound which is a benzimidazolyl isoxazole of formula (I): wherein: R0 and R, which are the same or different, are each H or C1-6 alkyl; R9, R9 and R9, which are the same or different, are each H or F; X is -(alkn-, -alk-C(?O)—NR—, -alk-NR—C(?O)— or -alk-C(?O)—; R1 is selected from —S(?O)2R?; a 4- to 6-membered, C-linked heterocyclic group which is unsubstituted or substituted; and an N-linked spiro group of the following formula: R2 and R2?, which are the same or different, are each H or C1-6 alkyl, or R2 and R2? form, together with the C atom to which they are attached, a C3-6 cycloalkyl group; R3 and R3, which are the same or different, are each H, C1-6 alkyl, OH or F; R4 is phenyl or a 5- to 12-membered, N-containing heteroaryl group and is unsubstituted or substituted; alk is C1-6 alkylene; R? is C1-6 alkyl; and n is 0 or 1; or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer.

Abstract: A method and an equipment for monitoring the movement of an elevator car detect an acceleration of the elevator car and a travel speed or a travel distance of the elevator car and an integrated travel speed is calculated from the detected acceleration. In that case, the detected travel speed or the travel speed derived from the detected travel distance is used as a start variable of an integration cycle. In addition, the integrated travel speed is compared with at least one predetermined limit speed and a safety measure is triggered if exceeding of the predetermined limit speed is established.

Abstract: A compound which is a benzimidazolyl isoxazole of formula (I): wherein: R0 and R, which are the same or different, are each H or C1-6 alkyl; R9, R9 and R9, which are the same or different, are each H or F; X is -(alkn-, -alk-C(?O)—NR—, -alk-NR—C(?O)— or -alk-C(?O)—; R1 is selected from —S(?O)2R?; a 4- to 6-membered, C-linked heterocyclic group which is unsubstituted or substituted; and an N-linked spiro group of the following formula: R2 and R2?, which are the same or different, are each H or C1-6 alkyl, or R2 and R2? form, together with the C atom to which they are attached, a C3-6 cycloalkyl group; R3 and R3, which are the same or different, are each H, C1-6 alkyl, OH or F; R4 is phenyl or a 5- to 12-membered, N-containing heteroaryl group and is unsubstituted or substituted; alk is C1-6 alkylene; R? is C1-6 alkyl; and n is 0 or 1; or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer.

Abstract: A compound which is an isoxazolyl imidazopyridine of formula (I): wherein: R0 and R, which are the same or different, are each H or C alkyl; R9? and R9?, which are the same or different, are each H or F; X is -(alk)n-, -alk-C(?O)—NR—, -alk-NR—C(?O)— or -alk-C(?O)—; R1 is selected from —S(?O)2R? and a 4- to 7-membered heterocyclic group which is unsubstituted or substituted; R2 and R2?, which are the same or different, are each H or C1-6 alkyl; or R2 and R2? form, together with the C atom to which they are attached, a C3-6 cycloalkyl group; R3 and R3?, which are the same or different, are each H, C1-6 alkyl, OH or F; R4 is phenyl or a 5- to 12-membered N-containing heteroaryl group and is unsubstituted or substituted; alk is C1-6 alkylene; R? is C1-6 alkyl; and n is 0 or 1; or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer.

Abstract: In an elevator installation, an elevator car is movably arranged alongside guide rails and the elevator car is equipped with a brake system with preferably two safety brakes. A movement monitoring system monitors the movement parameters of the elevator car and triggers corresponding warnings or safety measures, if permissible threshold values are exceeded or it provides determined adjusted movement parameters to an elevator control. The movement monitoring system determines a first movement parameter in a time interval and detects an acceleration of the elevator car. The movement monitoring system determines the time interval for determining the adjusted movement parameter as a function of the detected acceleration.

Abstract: A test method is applied to an elevator system having a control unit and at least one bus node. The bus node has a first microprocessor and a second microprocessor and the control unit and the bus node communicate by a bus. Furthermore, the first microprocessor and the second microprocessor are connected without interruption by a signal line. The test method includes the steps: a specification signal is transmitted by the control unit to the first microprocessor, the first microprocessor transmits the signal to the second microprocessor, and the second microprocessor provides the signal for the control unit. Finally, the control unit verifies whether the provided signal corresponds to a signal expected by the control unit. The elevator system includes a monitoring device for carrying out the test method.

Abstract: An elevator system has a drive, a car, a plurality of safety function components for providing safety functions at various positions, and a safety monitoring system with a plurality of safety monitoring units for monitoring all of the safety function components. The monitoring units have an input interface for reading in data or signals and an output interface for outputting control signals to an assigned member of the safety function components, at least some of the monitoring units being connected via data exchange channels. The monitoring units are organized in a master-slave hierarchy, with one unit designed as a master unit, and at least one other unit designed as a slave unit. The decentralized and distributed monitoring units, each having data processing capability, and the master-slave organization result in the elevator system exhibiting a high security level with low cabling complexity and cost expenditure, in particular for high rise elevators.

Abstract: The present invention relates inter alia to a compound of formula (I) and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compounds.

Abstract: The present invention relates inter alia to a compound of formula (I) and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compounds.

Abstract: An elevator includes a drive, a car operatively connected to the drive to traverse along a travel path, at least one guide rail positioned along the travel path to guide the car, a safety brake arranged on the car to exert a braking force on the guide rail, and a safety system. The safety system includes a first safety control unit and a second safety control unit that monitor a safety condition of the elevator. The first safety control unit outputs a stop signal to the drive, in particular to a drive brake and/or to a frequency converter of the drive, and the second safety control unit outputs a trigger signal to the safety brake to bring the elevator into a proper safety condition when an impermissible safety condition of the elevator is detected.

Abstract: A method of checking the functional capability of at least one safety element of a safety circuit of an elevator installation utilizes a first processing unit and a second processing unit for the at least one safety element. The at least one safety element is connected with a control unit by a communications network. At least one signal is provided by the first processing unit on the basis of at least one communication from the control unit. The at least one provided signal is detected by the second processing unit connected with the first processing unit and is communicated to the control unit by way of the communications network. The at least one communicated signal is checked for the validity thereof by the control unit.

Abstract: The present invention relates inter alia to a compound of formula (I) and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compounds.