Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: A circuit connector for a humidification system, the system comprising a base unit configured to be engaged by a humidification chamber. The circuit connector comprises an inlet to fluidly connect to an outlet of the humidification chamber to receive humidified gases therefrom, an outlet to sealably connect to or integral with a conduit for directing the humidified gases to a user, and an electrical terminal for electrically coupling the circuit connector to an electrical terminal associated with the base unit. The circuit connector may be releasably and lockably connectable to the outlet of the humidification chamber and/or orientation features may control orientation of component parts of the system as they are assembled.

Abstract: A frequency modulation continuous wave (FMCW)-based system configured to convert measurements of a linearly modulated wave from a time-domain into a frequency-domain to produce a non-linear frequency signal, where the non-linear frequency signal comprises a known linear component representing the desired linear modulation and an unknown non-linear component representing the non-linearity of the modulation. The FMCW-based system is further configured to determine coefficients of a basis function approximating a difference between the non-linear frequency signal and the linear frequency component in the frequency domain. The FMCW-based system is further configured to detect one or multiple spectrum peaks in the distorted beat signal with the distortion compensated according to the basis function with the determined coefficients to determine one or multiple distances to the one or multiple objects in the scene.

Abstract: A system for a target image reconstruction includes a stepped frequency transmitter configured to emit a stepped frequency waveform having different constant frequencies at different periods of time and a modulator configured to modulate the stepped frequency waveform emitted at each period of time with a modulation signal to output a modulated stepped frequency waveform with an increased bandwidth. The system includes a transceiver configured to transmit the modulated stepped frequency waveform to a target and to accept reflection of the modulated stepped frequency waveform reflected from the target, a mixer to interfere the unmodulated stepped frequency waveform and the reflection of the modulated stepped frequency waveform to produce a beat signal of the interference of the unmodulated stepped frequency waveform with the reflection of the modulated stepped frequency waveform, and a signal processor to reconstruct an image of the target from the beat signal.

Abstract: A system for a target image reconstruction includes a stepped frequency transmitter configured to emit a stepped frequency waveform having different constant frequencies at different periods of time and a modulator configured to modulate the stepped frequency waveform emitted at each period of time with a modulation signal to output a modulated stepped frequency waveform with an increased bandwidth. The system includes a transceiver configured to transmit the modulated stepped frequency waveform to a target and to accept reflection of the modulated stepped frequency waveform reflected from the target, a mixer to interfere the unmodulated stepped frequency waveform and the reflection of the modulated stepped frequency waveform to produce a beat signal of the interference of the unmodulated stepped frequency waveform with the reflection of the modulated stepped frequency waveform, and a signal processor to reconstruct an image of the target from the beat signal.

Abstract: An optical coherence tomography (OCT) system for profilometry measurements of a specimen with a lateral resolution across the profilometry measurements is provided. The OCT system includes a line-field generator, an interferometer, and a spectrometer. The line-field generator includes a filter arranged in a focal plane of a lens for spatially filtering extended line-field light into a line-field light of a width equal to the lateral resolution. The interferometer is configured to interfere the line-field light reflected from the specimen illuminated with a line-shaped focus with a reference signal of the line-field light to produce an interference pattern. The spectrometer configured to analyze spectral components of the interference pattern in a digital domain to produce the profilometry measurements of the specimen.

Abstract: The invention provides an agent for preventing or treating a condition characterised by the presence of unwanted cells, the agent comprising: (i) a targeting moiety that is capable of targeting to the unwanted cells; and (ii) a T cell antigen, wherein the T cell antigen can be released from the targeting moiety by selective cleavage of a cleavage site in the agent in the vicinity of the unwanted cells.

Abstract: A method for a target image reconstruction is provided. The method includes emitting stepped frequency waveforms having different constant frequencies at different periods of time, modulating the stepped frequency waveforms into frequency ranges each having a first frequency and a second frequency, wherein each of the stepped frequency waveforms are increased from the first frequency to the second frequency based on a range function, wherein the modulated stepped frequency waveforms are arranged with some sparsity factor.

Abstract: The present disclosure provides antibody tumor-targeting assembly complexes (ATTACs) for selectively activating desired immune cells in the tumor microenvironment.

Abstract: A frequency modulation continuous wave (FMCW)-based system includes an emitter to transmit at least one linearly modulated wave of radiation to a scene and a receiver to receive a reflection of the transmitted wave from one or multiple objects located at different locations in the scene. The system interferes a copy of the wave outputted by the emitter with the reflection of the transmitted wave received by the receiver to produce a beat signal with spectrum peaks corresponding to reflections from the different locations at the scene. The beat signal is distorted due to the non-linearity of the modulation.

Abstract: A communication system transmits an input block of bits over a communication channel using a prefix tree that maps a dyadic distribution of compositions of output symbols to prefixes of variable lengths. A path to each leaf of the prefix tree is defined by a prefix formed by a unique sequence of binary values of a length equal to a depth of the leaf. Each leaf is associated with a composition that has at least a number of unique permutations equals to two in a power of a length of a suffix of the block of input bits. The system selects a composition identified in the prefix tree by a prefix, permutes the selected composition according to a suffix, and transmits the permuted composition over a communication channel. The compositions are selected to reduce one or combination of energy and kurtosis of transmission.

Abstract: A method decodes an optical signal transmitted over an optical channel from a transmitter to a receiver. The method produces, from the transmitted optical signal, a digital signal including received data symbols and received pilot symbols and determines phase noise on the pilot symbols using a statistical probability distribution of phase noise on the optical channel and errors between phases of the received pilot symbols and the transmitted pilot signals. The method estimates phase noise on the data symbols using an interpolation of the phase noise on the pilot symbols and compensates the digital signal with the phase noise on the data symbols to produce a filtered signal with an equalized phase. The method demodulates and decodes the filtered signal to produce an estimate of the transmitted optical signal.

Abstract: A communication system transmits an input block of bits over a communication channel using a prefix tree that maps a dyadic distribution of compositions of output symbols to prefixes of variable lengths. A path to each leaf of the prefix tree is defined by a prefix formed by a unique sequence of binary values of a length equal to a depth of the leaf. Each leaf is associated with a composition that has at least a number of unique permutations equals to two in a power of a length of a suffix of the block of input bits. The system selects a composition identified in the prefix tree by a prefix in the input block of bits, permutes the selected composition according to a suffix in the input block of bits, and transmits the permuted composition over a communication channel.

Abstract: A variety of targeting moiety peptide epitope complexes (TPECs) are described in different embodiments. In each of the embodiments, however, a targeting moiety may be used to deliver the TPEC to an area of unwanted cells, allowing for a therapeutic effect to be delivered locally. The TPEC also contains a plurality of T-cell epitopes. The TPEC further comprises cleavage sites that release the T-cell epitopes from the targeting agent, and in some embodiments from each other, when they are in the microenvironment of the unwanted cells. Although the arrangement and number of T-cell epitopes varies in different embodiments described herein, once cleaved from the targeting agent (and any neighboring T-cell epitopes), the T-cell epitopes function by stimulating an immune response against the unwanted cells.

Abstract: A communication system includes a data source to receive a block of bits, a processor, a memory, in connection with the processor, to store a distribution matcher associated with a probability mass function (PMF) configured to match a block of equally likely input bits to a fixed number of output bits with values distributed according to the PMF of the distribution matcher using the processor. In this case, the distribution matcher contains a set of parallel binary distribution matchers which specify fully a target PMF, and a transmitter front end to transmit a block of shaped bits over a communication channel, such that bits in a sequence of the blocks of shaped bits are distributed according to the target PMF.

Abstract: A frequency modulation continuous wave (FMCW)-based system includes an emitter to transmit at least one linearly modulated wave of radiation to a scene and a receiver to receive a reflection of the transmitted wave from one or multiple objects located at different locations in the scene. The system interferes a copy of the wave outputted by the emitter with the reflection of the transmitted wave received by the receiver to produce a beat signal with spectrum peaks corresponding to reflections from the different locations at the scene. The beat signal is distorted due to the non-linearity of the modulation.

Abstract: A variety of targeting moiety peptide epitope complexes (TPECs) are described in different embodiments. In each of the embodiments, however, a targeting moiety may be used to deliver the TPEC to an area of unwanted cells, allowing for a therapeutic effect to be delivered locally. The TPEC also contains a plurality of T-cell epitopes. The TPEC further comprises cleavage sites that release the T-cell epitopes from the targeting agent, and in some embodiments from each other, when they are in the microenvironment of the unwanted cells. Although the arrangement and number of T-cell epitopes varies in different embodiments described herein, once cleaved from the targeting agent (and any neighboring T-cell epitopes), the T-cell epitopes function by stimulating an immune response against the unwanted cells.

Abstract: The invention provides an agent for preventing or treating a condition characterised by the presence of unwanted cells, the agent comprising: (i) a targeting moiety that is capable of targeting to the unwanted cells; and (ii) a T cell antigen, wherein the T cell antigen can be released from the targeting moiety by selective cleavage of a cleavage site in the agent in the vicinity of the unwanted cells.

Abstract: A method decodes an optical signal transmitted over an optical channel from a transmitter to a receiver. The method produces, from the transmitted optical signal, a digital signal including received data symbols and received pilot symbols and determines phase noise on the pilot symbols using a statistical probability distribution of phase noise on the optical channel and errors between phases of the received pilot symbols and the transmitted pilot signals. The method estimates phase noise on the data symbols using an interpolation of the phase noise on the pilot symbols and compensates the digital signal with the phase noise on the data symbols to produce a filtered signal with an equalized phase. The method demodulates and decodes the filtered signal to produce an estimate of the transmitted optical signal.

Abstract: An encoder for generating an optical data code from a symbol performs a symbol mapping and an encoding, wherein the symbol mapping performs providing a first constellation format having first and second amplitude rings with circular grids corresponding to phase angles, providing a second constellation format having the first and second amplitude rings with the circular grids corresponding to the phase angles, applying a first part of the symbol to one of the first and second constellation formats to represent the first part of the symbol by one of the first and second amplitude rings with one of the circular grids, and applying a second part of the symbol to another one of the first and second constellation formats to represent the second part of the symbol by one of the first and second amplitude rings with one of the circular grids. The first and the second constellation can be mapped to subcarrier modulation in three different ways.