Abstract: The invention provides an agent for preventing or treating a condition characterised by the presence of unwanted cells, the agent comprising: (i) a targeting moiety that is capable of targeting to the unwanted cells; and (ii) a T cell antigen, wherein the T cell antigen can be released from the targeting moiety by selective cleavage of a cleavage site in the agent in the vicinity of the unwanted cells.

Abstract: The invention provides molecule comprising: (i) a targeting moiety capable of directly or indirectly targeting to unwanted cells, and (ii) a further moiety that has a masked immune cell binding region so as to prevent binding of the further moiety to an immune cell, wherein the masked immune cell binding region is capable of being selectively unmasked when the molecule is in the vicinity of the unwanted cells so as to allow binding of the further moiety to an immune cell.

Abstract: A communication system includes a data source to receive a block of bits, a memory to store a set of distribution matchers. Each distribution matcher is associated with a probability mass function (PMF) to match equally likely input bits to a fixed number of output bits with values distributed according to the PMF of the distribution matcher. Each distribution matcher is associated with a selection probability, such that a sum of joint probabilities of all distribution matchers equals a target PMF. A joint probability of a distribution matcher is a product of PMF of the distribution matcher with the selection probability of the distribution matcher.

Abstract: The invention provides molecule comprising: (i) a targeting moiety capable of directly or indirectly targeting to unwanted cells, and (ii) a further moiety that has a masked immune cell binding region so as to prevent binding of the further moiety to an immune cell, wherein the masked immune cell binding region is capable of being selectively unmasked when the molecule is in the vicinity of the unwanted cells so as to allow binding of the further moiety to an immune cell.

Abstract: A method decodes an optical signal transmitted over an optical channel from a transmitter to a receiver. The receiver receives the transmitted optical signal to produce a digital signal which is filtered in the frequency domain for compensating static effects and/or dynamic effects. The filtering is performed in the frequency domain, while the frequency coefficients of the filter are updated in the time domain by updating at least some of time coefficients of the filter and transforming the time coefficients into the frequency domain.

Abstract: Methods and systems for decoding symbols transmitted over an optical channel having a cross-polarization modulation (XPolM) impairment, wherein an optical signal is polarized to encode the symbols on an x-polarization and an y-polarization before transmitted. The method including receiving the optical signal transmitted over the optical channel. Sampling the optical signal to produce a sequence of digital samples, wherein each digital sample includes a measurement of each polarization of the optical signal at an instance of time. Selecting a subset of the sequence of digital samples that includes a digital sample and neighboring digital samples on the sequence. Repeating the selecting and the determining for each digital sample remaining in the sequence of digital samples to produce a sequence of cross-talk coefficients; and decoding some of the symbols from the sequence of digital samples using cross-talk models with corresponding cross-talk coefficients, wherein method steps are performed using a processor.

Abstract: Methods and systems for decoding symbols transmitted over an optical channel having a cross-polarization modulation (XPolM) impairment, wherein an optical signal is polarized to encode the symbols on an x-polarization and an y-polarization before transmitted. The method including receiving the optical signal transmitted over the optical channel. Sampling the optical signal to produce a sequence of digital samples, wherein each digital sample includes a measurement of each polarization of the optical signal at an instance of time. Selecting a subset of the sequence of digital samples that includes a digital sample and neighboring digital samples on the sequence. Repeating the selecting and the determining for each digital sample remaining in the sequence of digital samples to produce a sequence of cross-talk coefficients; and decoding some of the symbols from the sequence of digital samples using cross-talk models with corresponding cross-talk coefficients, wherein method steps are performed using a processor.

Abstract: The invention provides molecule comprising: (i) a targeting moiety capable of directly or indirectly targeting to unwanted cells, and (ii) a further moiety that has a masked immune cell binding region so as to prevent binding of the further moiety to an immune cell, wherein the masked immune cell binding region is capable of being selectively unmasked when the molecule is in the vicinity of the unwanted cells so as to allow binding of the further moiety to an immune cell.

Abstract: A method for decoding a codeword transmitted over a channel demodulates data received over the channel to produce an initial estimate of belief messages for bits of the codeword and decodes the codeword using a belief propagation (BP) decoding that iteratively passes the belief messages between a set of variable nodes representing the bits of the codeword and a set of check nodes representing parity-check constraints on the bits of the codeword until a termination condition is met. The BP decoding selects a look-up table based on a probability of the belief messages and maps, using the look-up table, values of at least two incoming belief messages to values of at least one outgoing belief message that forms an incoming belief message in a subsequent iteration of the BP decoding.

Abstract: An optical data coding method includes at least steps of selecting a modulation scheme comprising an X-polarization constellation format having first and second amplitude rings with circular grids corresponding to predetermined phase angles and a Y-polarization constellation format having the first and second amplitude rings with the circular grids corresponding to the predetermined phase angles, arranging a first part of the symbol on a first circular grid of the first amplitude ring on the X-polarization constellation format, and arranging a second part of the symbol on a second circular grid of the second amplitude ring on the Y-polarization constellation format.

Abstract: A method decodes an optical signal transmitted over an optical channel from a transmitter to a receiver. The receiver receives the transmitted optical signal to produce a digital signal which is filtered in the frequency domain for compensating static effects and/or dynamic effects. The filtering is performed in the frequency domain, while the frequency coefficients of the filter are updated in the time domain by updating at least some of time coefficients of the filter and transforming the time coefficients into the frequency domain.

Abstract: A method receives the symbol transmitted over a channel, selects, from a constellation of codewords, a first codeword neighboring the received symbol and a set of second codewords neighboring the first codeword, and determines a relative likelihood of each second codeword being the transmitted symbol with respect to a likelihood of the first codeword being the transmitted symbol. Next, the method determines an approximation of a log-likelihood ratio (LLR) of each data bit in the received symbol as a log of a ratio of a sum of the relative likelihoods of at least some of the second codewords having the same value of the data bit to a sum of the relative likelihoods of at least some of the second codewords having different value of the data bit and decodes the received symbol using the LLR of each data bit.

Abstract: A method for decoding a codeword transmitted over a channel demodulates data received over the channel to produce an initial estimate of belief messages for bits of the codeword and decodes the codeword using a belief propagation (BP) decoding that iteratively passes the belief messages between a set of variable nodes representing the bits of the codeword and a set of check nodes representing parity-check constraints on the bits of the codeword until a termination condition is met. The BP decoding selects a look-up table based on a probability of the belief messages and maps, using the look-up table, values of at least two incoming belief messages to values of at least one outgoing belief message that forms an incoming belief message in a subsequent iteration of the BP decoding.

Abstract: The invention provides molecule comprising: (i) a targeting moiety capable of directly or indirectly targeting to unwanted cells, and (ii) a further moiety that has a masked immune cell binding region so as to prevent binding of the further moiety to an immune cell, wherein the masked immune cell binding region is capable of being selectively unmasked when the molecule is in the vicinity of the unwanted cells so as to allow binding of the further moiety to an immune cell.

Abstract: A method receives the symbol transmitted over a channel, selects, from a constellation of codewords, a first codeword neighboring the received symbol and a set of second codewords neighboring the first codeword, and determines a relative likelihood of each second codeword being the transmitted symbol with respect to a likelihood of the first codeword being the transmitted symbol. Next, the method determines an approximation of a log-likelihood ratio (LLR) of each data bit in the received symbol as a log of a ratio of a sum of the relative likelihoods of at least some of the second codewords having the same value of the data bit to a sum of the relative likelihoods of at least some of the second codewords having different value of the data bit and decodes the received symbol using the LLR of each data bit.

Abstract: A method generates constant modulus multi-dimensional modulations for coherent optical communications by first projecting points in a constellation of the code onto a Poincare sphere or its higher-dimensional hyper-sphere. By using meta-heuristic procedures, nonlinear programming and gradient search methods, constellation points in the hyper-sphere are optimized in certain criteria, such as maximizing the minimum Euclidean distance, minimizing the union bound, minimizing the bit-error rate, minimizing the required signal-to-noise ratio, maximizing the nonlinear fiber reach, maximizing the phase noise tolerance, and maximizing the mutual information. Some methods use parametric unitary space-time block codes such as Grassmannian packing, and filter impulse response as well as unitary rotation over adjacent code blocks to generate near-constant modulus waveform, not only at the symbol timing, but also over the entire time.

Abstract: A method for transmitting data over an optical super-channel partitions the data unequally into a set of data streams for transmission over the set of sub-channels of the super-channel, such that a size of a first data stream for transmission over a first sub-channel is different than a size of a second data stream of the data for transmission over a second sub-channel. The method encodes each data stream of the data with an error correction code (ECC) having different ECC rates to produce a set of encoded data streams and transmits concurrently the set of encoded data streams over the set of sub-channels of the super-channel. Accordingly, the method uses an adaptive ECC for optical super-channels, such that a first ECC rate for encoding the first data stream is different than a second ECC rate for encoding the second data stream.

Abstract: The embodiments of the invention provide methods to deal with problems of cycle slips, angular skew, and residual phase noise for high-speed optical communications employing any arbitrary high-order multi-dimensional modulation formats. The embodiments use a slip process analyzer, a skew angle estimator, and a phase noise variance estimator to provide feedforward soft-decision information of a carrier phase recovery (CPE) for more accurate likelihood calculation based on a high-order hidden Markov model (HMM). The log-likelihood calculation can be done jointly in dual polarization with joint Markov state transition. Some embodiments use a kernel filter or a particle filter for log-likelihood calculation.

Abstract: A variety of targeting moiety peptide epitope complexes (TPECs) are described in different embodiments. In each of the embodiments, however, a targeting moiety may be used to deliver the TPEC to an area of unwanted cells, allowing for a therapeutic effect to be delivered locally. The TPEC also contains a plurality of T-cell epitopes. The TPEC further comprises cleavage sites that release the T-cell epitopes from the targeting agent, and in some embodiments from each other, when they are in the microenvironment of the unwanted cells. Although the arrangement and number of T-cell epitopes varies in different embodiments described herein, once cleaved from the targeting agent (and any neighboring T-cell epitopes), the T-cell epitopes function by stimulating an immune response against the unwanted cells.

Abstract: The invention provides an agent for preventing or treating a condition characterized by the presence of unwanted cells, the agent comprising: (i) a targeting moiety that is capable of targeting to the unwanted cells; and (ii) a T cell antigen, wherein the T cell antigen can be released from the targeting moiety by selective cleavage of a cleavage site in the agent in the vicinity of the unwanted cells.