Abstract: Systems and methods for securing an ultrasound probe of a wearable ultrasound system to a patient at a desired position are provided. The method includes affixing a first side of a pad to a patient or ultrasound probe. The pad includes the first side that is tacky and a second side that is moistened. The second side becomes tacky when moisture is absorbed and/or evaporates. The method includes manipulating the ultrasound probe to the desired position with respect to the patient with the pad between the ultrasound probe and the patient. The second side of the pad that is moistened provides a provisional slidable surface for manipulating the ultrasound probe. The method includes securing a fixture to the ultrasound probe and the patient. The fixture includes a probe attachment portion that is secured to the ultrasound probe and a patient attachment portion that is secured to the patient.

Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue to cause altered activity at a synapse between a neuron and a non-neuronal cell.

Abstract: Various methods and systems are provided for an ultrasound-mediated therapy system. In one example, a method includes for one or more therapeutic ultrasound beams of a plurality of therapeutic ultrasound beams delivered to a therapy region of interest (ROI) via an ultrasound probe, identifying a respective location of the one or more therapeutic ultrasound beams relative to the therapy ROI based on: a respective modeled beam profile, a respective live two-dimensional (2D) image of the therapy ROI acquired with the ultrasound probe, a respective position of the ultrasound probe, and a known prior location of the therapy ROI, calculating a cumulative therapeutic ultrasound dose received at each sub-region of the therapy ROI based on the respective location of the one or more therapeutic ultrasound beams; and outputting an indication of the cumulative therapeutic ultrasound dose received at each sub-region of the therapy ROI for display on a display device.

Abstract: A computer-implemented method, system, and computer program product for generating a safest route for travel. Inputs as to a starting point (e.g., home) and a destination (e.g., grocery store) are received. Road network characteristics and operational measures are obtained in connection with the starting point and the destination. Road network characteristics refer to the features or qualities regarding roadways. Operational measures refer to the features or characteristics of safety involved in traveling along the roadways. The safest route to travel to the destination is then generated using a trained machine learning model using the obtained road network characteristics and the operational measures in connection with the starting point and the destination.

Abstract: An ultrasound imaging system and method for determining a measurement of an optic nerve sheath are provided. The ultrasound imaging system and method may include controlling an ultrasound probe to acquire three-dimensional (3D) ultrasound data of the optic nerve sheath. The ultrasound imaging system and method may include determining the measurement of the optic nerve sheath based on the 3D ultrasound data. The ultrasound imaging system and method may include controlling the display to display information related to the measurement of the optic nerve sheath.

Abstract: An antibody or antigen binding fragment thereof that binds to a Fn14, wherein the antibody or antigen binding fragment thereof is an antagonist and non-agonist of Fn14.

Abstract: Various methods and systems are provided for an ultrasound-mediated therapy system. In one example, a method includes for one or more therapeutic ultrasound beams of a plurality of therapeutic ultrasound beams delivered to a therapy region of interest (ROI) via an ultrasound probe, identifying a respective location of the one or more therapeutic ultrasound beams relative to the therapy ROI based on: a respective modeled beam profile, a respective live two-dimensional (2D) image of the therapy ROI acquired with the ultrasound probe, a respective position of the ultrasound probe, and a known prior location of the therapy ROI, calculating a cumulative therapeutic ultrasound dose received at each sub-region of the therapy ROI based on the respective location of the one or more therapeutic ultrasound beams; and outputting an indication of the cumulative therapeutic ultrasound dose received at each sub-region of the therapy ROI for display on a display device.

Abstract: Various methods and systems are provided for an ultrasound-mediated therapy system. In one example, a method includes for one or more therapeutic ultrasound beams of a plurality of therapeutic ultrasound beams delivered to a therapy region of interest (ROI) of a patient via an ultrasound probe, identifying a respective location of the one or more therapeutic ultrasound beams relative to the therapy ROI of the patient based on one or more images of the therapy ROI acquired via the ultrasound probe; calculating a cumulative therapeutic ultrasound dose received at each sub-region of the therapy ROI based on the respective location of the one or more therapeutic ultrasound beams; and displaying a representation of the cumulative therapeutic ultrasound dose received at each sub-region of the therapy ROI on a display device.

Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue to cause altered activity at a synapse between a neuron and a non-neuronal cell.

Abstract: A packer for anchoring and sealing to a tubular in a well, the packer including a packer element, an anchoring arrangement, a setting mechanism and a release mechanism. The release mechanism holds a thin-walled section of tubing in the packer in tension using a biasing mechanism. On severing the tubing, the bias releases an engagement mechanism which allows the anchor arrangement and the packing element to move relative to the body and thereby unset the packer. An embodiment of a dual bore packer is described. A method of well isolation is described, with an assembly including the dual bore packer. The primary bore forms the short string and a secondary bore forms the long string. By severing the short string the integrity of the long string is maintained to pull lower devices on the long string and the short string does not require tension below the packer to release.

Abstract: An antibody or antigen binding fragment thereof that binds to a Fn14, wherein the antibody or antigen binding fragment thereof is an antagonist and non-agonist of Fn14.

Abstract: The combination of specific immunoglobulins plus activated Bifidobacteria strains or other beneficial bacteria is described with the designed efficacy to colonize unstable microbiome communities in humans or other animals, restoring the keystone Bifidobacteria strains or other beneficial bacteria to compositional and functional importance in the intestine and improve overall health and reduce pathogenic infections in the host. Secretory immunoglobulin A (SIgA), when bound via specific glycans to select commensal bacteria grown on human milk oligosaccharides (HMOs), enhances the colonization potential of commensals through protection from intestinal digestion, enhancing attachment, and dampening host immune response.

Abstract: A packer for anchoring and sealing to a tubular in a well, the packer including a packer element, an anchoring arrangement, a setting mechanism and a release mechanism. The release mechanism holds a thin-walled section of tubing in the packer in tension using a biasing mechanism. On severing the tubing, the bias releases an engagement mechanism which allows the anchor arrangement and the packing element to move relative to the body and thereby unset the packer. An embodiment of a dual bore packer is described. A method of well isolation is described, with an assembly including the dual bore packer. The primary bore forms the short string and a secondary bore forms the long string. By severing the short string the integrity of the long string is maintained to pull lower devices on the long string and the short string does not require tension below the packer to release.

Abstract: The present invention relates to the use of contrast-enhanced ultrasound using microbubble-based ultrasound contrast agents to accomplish noninvasive subharmonic aided pressure estimation (SHAPE) in a region of interest (ROI) of a subject. The method of the invention provides a non-invasive, direct, and accurate method for pressure estimation.

Abstract: A cleaning system and method use an ultrasound probe, a coupling mechanism, and a controller to clean equipment of a vehicle system. The ultrasound probe enters into an engine. The ultrasound probe emits ultrasound pulses and the coupling mechanism provides an ultrasound coupling medium between the ultrasound probe and one or more components of the engine. The controller drives the ultrasound probe to deliver the ultrasound pulse through the coupling medium to a surface of the one or more components of the engine. The ultrasound probe delivers the ultrasound pulse to remove deposits from the one or more components of the engine.

Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.

Abstract: Some embodiments of the invention include a composition and method for treating dysbiosis in infants. The composition may include a mixture of activated bifidobacteria and a complex oligosaccharide wherein the complex oligosaccharide may be derived from a human or non-human source.

Abstract: Compositions comprising at least two non-pathogenic microbes are described herein. The non-pathogenic microbes may be from a first species capable of internalizing and/or metabolizing dietary glycans and/or from a second species capable of consuming and metabolizing free sugar monomers. Methods of making and use in treating and/or preventing the overgrowth of pathogenic bacteria in mammals are also described herein.

Abstract: Some embodiments of the invention include a composition and method for treating dysbiosis in infants. The composition may include a mixture of activated bifidobacteria and a complex oligosaccharide wherein the complex oligosaccharide may be derived from a human or non-human source.

Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.