Abstract: A cleaning system and method use an ultrasound probe, a coupling mechanism, and a controller to clean equipment of a vehicle system. The ultrasound probe enters into an engine. The ultrasound probe emits ultrasound pulses and the coupling mechanism provides an ultrasound coupling medium between the ultrasound probe and one or more components of the engine. The controller drives the ultrasound probe to deliver the ultrasound pulse through the coupling medium to a surface of the one or more components of the engine. The ultrasound probe delivers the ultrasound pulse to remove deposits from the one or more components of the engine.

Abstract: A bioreactor control system comprises a batch server for controlling a bioreactor system in response to a recipe, a batch software system for generating a control sequence for the bioreactor system via the batch server for implementing the recipe, and a recipe conversion system that inputs the recipe into the batch software system. Preferably, the recipe conversion system reads a word processor file containing the recipe and interprets styles applied to text in the word processor file as indicating equipment and phases of the recipe to the recipe conversion system. Generally, the bioreactor system includes one or more bioreactors and additional hardware to perform the upstream and downstream processing. The document properties of the word processor file containing the recipe are applied as header information for the recipe input into the batch software system.

Abstract: The present invention provides a nucleic acid having activity to suppress expression of IRF5, a pharmaceutical composition comprising the nucleic acid, and a prophylactic or therapeutic drug containing the nucleic acid for autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and the like.

Abstract: The present invention provides galacto-oligosaccharide compositions that preferentially stimulate growth of specific Bifidobacterium species and subspecies.

Abstract: A testing member for eliciting blood samples is provided that can be rotatably mounted inside a cartridge and having a lancet for lancing a body part of a user. The lancet can protrude from an edge of the testing member. The testing member also can have a second blood collection part, and second contact pads, where the second contact pads being electrically connected to the second blood collection part, the second blood collection part and second contact pads together being configured to facilitate an analysis of the quantity of blood in a first blood sample in the second blood collection part. A blood analysis part and first contact pads can be included, where the first contact pads are electrically connected to the blood analysis part, the blood analysis part and first contact pads together being configured to facilitate an analysis of a second blood sample in the blood analysis part.

Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.

Abstract: The present invention includes a snap installation adaptor designed to be united with a handheld tool so that the union can permanently affix snaps onto fabric. The snap installation adaptor includes an upper portion with a cap node; a lower portion with a socket node; an intermediate portion connecting the upper and lower portions; and means for transferring external downward force from the handheld tool through the upper portion so that the cap node is forced to meet the socket node, thus permanently affixing a snap onto a piece of fabric between the upper and lower portions.

Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.

Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.

Abstract: A method for manufacturing a bioactive implant including the steps of (a) forming a mixture of an bioactive agent and a setting agent capable of transitioning from a flowable state to a rigid state; (b) converting the mixture into a flowable state; and (c) transitioning the mixture into a solid state in a shape of the implant.

Abstract: Embodiments of the present invention provide markers, phantoms, and associated methods of calibration which are suitable for use in both medical resonance imaging and radiographic imaging systems. A marker includes a first component having a first hydrogen proton density and a first mass density; and a second component having a second hydrogen proton density different than the first hydrogen proton density, and a second mass density different than the first mass density. The first and second components are non-magnetic.

Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.

Abstract: An augmented ceramic composite including aluminosilicate nanotubes may be added to a biocompatible polymer matrix. Aluminosilicate nanotubes have a surprisingly high biocompatibility, radio opaqueness, and suitability for storing therapeutic compounds for release over time. These surprising advantages make aluminosilicate nanotubes, such as halloysite nanotubes, a good candidate for use in various medical applications from bone and dental prosthetics to cancer treatment and prevention. Furthermore, unlike other additives, the addition of certain quantities of halloysite nanotubes increases the strength of the polymer matrix to which it is added.

Abstract: A testing member for eliciting blood samples is provided that can be rotatably mounted inside a cartridge and having a lancet for lancing a body part of a user. The lancet can protrude from an edge of the testing member. The testing member also can have a second blood collection part, and second contact pads, where the second contact pads being electrically connected to the second blood collection part, the second blood collection part and second contact pads together being configured to facilitate an analysis of the quantity of blood in a first blood sample in the second blood collection part. A blood analysis part and first contact pads can be included, where the first contact pads are electrically connected to the blood analysis part, the blood analysis part and first contact pads together being configured to facilitate an analysis of a second blood sample in the blood analysis part.

Abstract: Architecture for efficiently ensuring that data is stored to the desired destination datastore such as for replication processes. A copy of data (e.g., messages) sent to a datastore for storage is stored at an alternate location until a received signal indicates that the storage and replication was successful. As soon as the feedback signal is received, the copy is removed from the alternate location, and hence, improves input/output (I/O) and storage patterns. The feedback mechanism can also be used for monitoring the status of data transport associated with log shipping, for example, and taking the appropriate actions when storage (e.g., replication) is not being performed properly.

Abstract: Methods, systems, and techniques for determining the vertical alignment of an infrastructure corridor having a certain horizontal alignment involve using a processor to model the cost of constructing the infrastructure corridor as a function of cost variables that vary with the vertical alignment of the infrastructure corridor. The processor looks up the cost variables at vertical offsets corresponding to certain vertical alignments of the infrastructure corridor and determines the cost of constructing the length of road at elevations located between pairs of the vertical offsets by interpolating from the cost variables at the vertical offsets; the interpolation may be linear. The processor determines, subject to infrastructure corridor design constraints, the vertical alignment of the infrastructure corridor from the cost of constructing the infrastructure corridor at the vertical offsets.

Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.

Abstract: This invention provides nucleic acids and proteins involved in oligosaccharide modification in the species Bifidobacteria. The invention provides methods for utilizing the proteins of the invention to generate human milk oligosaccharides or oligosaccharide mimics. The invention also provides compositions containing the human milk oligosaccharides or oligosaccharide mimics and methods for use.

Abstract: Pre-biotic compositions containing oligosaccharides and probiotic compositions useful for treatment of a subject are provided herein. Also provided are methods for administering probiotic or pre-biotic compositions.

Abstract: Embodiments of an event-driven process management and automation system are disclosed. Such system may be particularly appropriate for a multi-tenant environment so that a single process handling flow may be generated for a given process. Because in a multi-tenant environment many different entities may desire to customize or optimize this process handling flow for their particular usage, modifications to the process flow may be easily handled by a non-technical user to realize process modification without incurring additional development costs. Using a multi-level hierarchical inheritance model in accordance with an embodiment of the present invention, a process may be standardized, with focused customization available on a macro and/or micro level.