Patents by Inventor David Needham
David Needham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230414637Abstract: The present disclosure provides prophylactic nasal and throat sprays that can be used to prevent initial infection of COVID19, its more contagious variants, and other respiratory viral infections, and the methods of making of the same. Data is given in a series of embodiments that show how niclosamide from one supplier (AK Sci), who's initial powder has a block-like morphology of what appears to be a high solubility polymorph, readily dissolves in pH buffers providing increased amounts in solution as the solution pH is increased. Unlike more conventional particulate drug materials, this provides 20 uM to 30 uM solutions of niclosamide at pH 8 for a prophylactic, preventative nasal spray that has rapid permeation through the nasal mucin and direct access to the underlying epithelial cells that the virus infects. At higher pH of 9.2 it can provide a 300 uM solution of niclosamide for throat spray to be used at first signs of early infection.Type: ApplicationFiled: November 9, 2021Publication date: December 28, 2023Inventor: David NEEDHAM
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Patent number: 10905665Abstract: Described are methods of treating a disease associated with dysregulation of the Wnt/Frizzled signaling pathway. The methods include identifying subjects in need of therapy, administering inhibitors of the Wnt/Frizzled signaling pathway, pharmaceutical compositions including the inhibitors, and methods of using the compounds and compositions for treating cancer, bacterial and viral infection, lupus, type II diabetes, nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD) in a subject.Type: GrantFiled: June 24, 2016Date of Patent: February 2, 2021Assignee: Duke UniversityInventors: Wei Chen, Robert A. Mook, Jr., Jiangbo Wang, Xiu-rong Ren, Minyong Chen, Lawrence S. Barak, Herbert Kim Lyerly, David Needham
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Publication number: 20200038350Abstract: Described are methods of treating a disease associated with dysregulation of the Wnt/Frizzled signaling pathway. The methods include identifying subjects in need of therapy, administering inhibitors of the Wnt/Frizzled signaling pathway, pharmaceutical compositions including the inhibitors, and methods of using the compounds and compositions for treating cancer, bacterial and viral infection, lupus, type II diabetes, nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD) in a subject.Type: ApplicationFiled: June 24, 2016Publication date: February 6, 2020Inventors: Wei Chen, Robert A. Mook, JR., Jiangbo Wang, Xiu-rong Ren, Minyong Chen, Lawrence S. Barak, Herbert Kim Lyerly, David Needham
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Patent number: 9492385Abstract: A liposome contains an active agent and has a gel-phase lipid bilayer membrane comprising phospholipid and a surface active agent. The phospholipids are the primary lipid source for the lipid bilayer membrane and the surface active agent is contained in the bilayer membrane in an amount sufficient to increase the percentage of active agent released at the phase transition temperature of the lipid bilayer, compared to that which would occur in the absence of the surface active agent. The surface active agent is present in the lipid bilayer membrane so as to not destabilize the membrane in the gel phase.Type: GrantFiled: December 10, 2008Date of Patent: November 15, 2016Assignee: Duke UniversityInventor: David Needham
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Patent number: 8691586Abstract: A method of forming bilayers of amphipathic molecules uses droplets of aqueous solution in a hydrophobic medium such as oil. A layer of amphipathic molecules such as a lipid is formed around the surfaces of the droplets. This may be achieved by providing the lipid in the oil and leaving the droplets for a time sufficient to form the layer. The droplets are brought into contact with one another so that a bilayer of the amphipathic molecules is formed as an interface between the contacting droplets. The bilayers may be used for a wide range of studies. The technique has numerous advantages including providing a long lifetime for the bilayers, allowing study of small volumes and allowing the construction of chains and networks of droplets with bilayers in between to study complex systems.Type: GrantFiled: September 7, 2012Date of Patent: April 8, 2014Assignee: ISIS Innovation LimitedInventors: John Hagen Pryce Bayley, Matthew Holden, Andrew John Heron, David Needham
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Patent number: 8512754Abstract: A composition comprising a glassified, stabilized particle preparation having a low water activity (between about 0.1 and 0.9) is provided. The preparations provide improved products with enhanced storage stability, less expensive cost of processing, and extended shelf life. The glassified, stabilized particle preparations are particularly efficacious in the preparation of perishable products, especially pharmaceutical agents, such as human blood and blood products (e.g., red blood cells). A single emulsion process comprising a 2-phase system for preserving food and pharmaceutical products is also provided. Stabilized biological products as glassified beads are also provided, as well as a method for rehydrating and/or reconstituting the glassified beads to provide useful and fully active reconstituted and/or rehydrated materials is also presented.Type: GrantFiled: September 2, 2011Date of Patent: August 20, 2013Inventor: David Needham
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Publication number: 20130146815Abstract: A method of forming bilayers of amphipathic molecules uses droplets of aqueous solution in a hydrophobic medium such as oil. A layer of amphipathic molecules such as a lipid is formed around the surfaces of the droplets. This may be achieved by providing the lipid in the oil and leaving the droplets for a time sufficient to form the layer. The droplets are brought into contact with one another so that a bilayer of the amphipathic molecules is formed as an interface between the contacting droplets. The bilayers may be used for a wide range of studies. The technique has numerous advantages including providing a long lifetime for the bilayers, allowing study of small volumes and allowing the construction of chains and networks of droplets with bilayers in between to study complex systems.Type: ApplicationFiled: September 7, 2012Publication date: June 13, 2013Applicant: ISIS INNOVATION LIMITEDInventors: John Hagen Pryce BAYLEY, Matthew Holden, Andrew John Heron, David Needham
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Patent number: 8268627Abstract: A method of forming bilayers of amphipathic molecules uses droplets of aqueous solution in a hydrophobic medium such as oil. A layer of amphipathic molecules such as a lipid is formed around the surfaces of the droplets. This may be achieved by providing the lipid in the oil and leaving the droplets for a time sufficient to form the layer. The droplets are brought into contact with one another so that a bilayer of the amphipathic molecules is formed as an interface between the contacting droplets. The bilayers may be used for a wide range of studies. The technique has numerous advantages including providing a long lifetime for the bilayers, allowing study of small volumes and allowing the construction of chains and networks of droplets with bilayers in between to study complex systems.Type: GrantFiled: July 26, 2007Date of Patent: September 18, 2012Assignee: ISIS Innovation LimitedInventors: John Hagen Pryce Bayley, Matthew Holden, Andrew John Heron, David Needham
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Publication number: 20120082715Abstract: A composition comprising a glassified, stabilized particle preparation having a low water activity (between about 0.1 and 0.9) is provided. The preparations provide improved products with enhanced storage stability, less expensive cost of processing, and extended shelf life. The glassified, stabilized particle preparations are particularly efficacious in the preparation of perishable products, especially pharmaceutical agents, such as human blood and blood products (e.g., red blood cells). A single emulsion process comprising a 2-phase system for preserving food and pharmaceutical products is also provided. Stabilized biological products as glassified beads are also provided, as well as a method for rehydrating and/or reconstituting the glassified beads to provide useful and fully active reconstituted and/or rehydrated materials is also presented.Type: ApplicationFiled: September 2, 2011Publication date: April 5, 2012Inventor: David Needham
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Patent number: 8013022Abstract: Disclosed is a multi-compartment medical device useful in the storage, processing and extended shelf life of perishable products, especially pharmaceutical, food and biological products. Particular biological materials processed according to the present methods are human blood and blood products (RBCs). Also disclosed are processes for preserving food, pharmaceutical and biological products for long-term storage and extended shelf life employing a process that reduces the hydration level of the material to less than native hydration levels of the specific product. The invention further provides stabilized biological products, such as in the form of glassified beads, prepared using a two-phase system according to the described processes that may be rehydrated and prepared for clinical use, and having essentially no loss of biological and/or pharmacological activity.Type: GrantFiled: April 27, 2007Date of Patent: September 6, 2011Inventors: Joseph DeAngelo, David Needham, Carroll Jones
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Patent number: 7901709Abstract: A liposome contains an active agent and has a gel-phase lipid bilayer membrane comprising phospholipid and a surface active agent. The phospholipids are the primary lipid source for the lipid bilayer membrane and the surface active agent is contained in the bilayer membrane in an amount sufficient to increase the percentage of active agent released at the phase transition temperature of the lipid bilayer, compared to that which would occur in the absence of the surface active agent. The surface active agent is present in the lipid bilayer membrane so as to not destabilize the membrane in the gel phase.Type: GrantFiled: April 12, 2005Date of Patent: March 8, 2011Assignee: Duke UniversityInventor: David Needham
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Publication number: 20100032627Abstract: A method of forming bilayers of amphipathic molecules uses droplets of aqueous solution in a hydrophobic medium such as oil. A layer of amphipathic molecules such as a lipid is formed around the surfaces of the droplets. This may be achieved by providing the lipid in the oil and leaving the droplets for a time sufficient to form the layer. The droplets are brought into contact with one another so that a bilayer of the amphipathic molecules is formed as an interface between the contacting droplets. The bilayers may be used for a wide range of studies. The technique has numerous advantages including providing a long lifetime for the bilayers, allowing study of small volumes and allowing the construction of chains and networks of droplets with bilayers in between to study complex systems.Type: ApplicationFiled: July 26, 2007Publication date: February 11, 2010Inventors: John Hagen Pryce Bayley, Matthew Holden, Andrew John Heron, David Needham
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Publication number: 20090117035Abstract: A liposome contains an active agent and has a gel-phase lipid bilayer membrane comprising phospholipid and a surface active agent. The phospholipids are the primary lipid source for the lipid bilayer membrane and the surface active agent is contained in the bilayer membrane in an amount sufficient to increase the percentage of active agent released at the phase transition temperature of the lipid bilayer, compared to that which would occur in the absence of the surface active agent. The surface active agent is present in the lipid bilayer membrane so as to not destabilize the membrane in the gel phase.Type: ApplicationFiled: December 10, 2008Publication date: May 7, 2009Inventor: David NEEDHAM
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Publication number: 20090087482Abstract: A liposome contains an active agent and has a gel-phase lipid bilayer membrane comprising phospholipid and a surface active agent. The phospholipids are the primary lipid source for the lipid bilayer membrane and the surface active agent is contained in the bilayer membrane in an amount sufficient to increase the percentage of active agent released at the phase transition temperature of the lipid bilayer, compared to that which would occur in the absence of the surface active agent. The surface active agent is present in the lipid bilayer membrane so as to not destabilize the membrane in the gel phase.Type: ApplicationFiled: December 10, 2008Publication date: April 2, 2009Inventor: David Needham
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Publication number: 20080043245Abstract: Apparatus, methods, and other embodiments associated with measuring multiple Fabry-Perot gaps to determine environmental parameters are described herein. In one embodiment, a system for measuring environmental parameters includes an optical fiber, a first reflective surface, a second reflective surface, a third reflective surface, and a light source. The first reflective surface is positioned proximate to a first end of the optical fiber. The second reflective surface is positioned to form a first Fabry-Perot gap between the first reflective surface and the second reflective surface. The third reflective surface is positioned to form a second Fabry-Perot gap between the second reflective surface and third reflective surface. The light source provides light to the optical fiber, wherein the optical fiber delivers light from the light source to the first Fabry-Perot gap and the second Fabry-Perot gap and the optical fiber receives reflected light from the first Fabry-Perot gap and the second Fabry-Perot gap.Type: ApplicationFiled: August 16, 2007Publication date: February 21, 2008Inventor: David Needham
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Publication number: 20070258960Abstract: Disclosed is a multi-compartment medical device useful in the storage, processing and extended shelf life of perishable products, especially pharmaceutical, food and biological products. Particular biological materials processed according to the present methods are human blood and blood products (RBCs). Also disclosed are processes for preserving food, pharmaceutical and biological products for long-term storage and extended shelf life employing a process that reduces the hydration level of the material to less than native hydration levels of the specific product. The invention further provides stabilized biological products, such as in the form of glassified beads, prepared using a two-phase system according to the described processes that may be rehydrated and prepared for clinical use, and having essentially no loss of biological and/or pharmacological activity.Type: ApplicationFiled: April 27, 2007Publication date: November 8, 2007Inventors: Joseph DeAngelo, David Needham, Carroll Jones
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Publication number: 20070064241Abstract: An algorithm and method for calculating an interferometric gap is disclosed that comprises providing an interferometric sensor having a first gap and an interferometric correlation element having a second gap placed in series with the first gap. A correlation burst waveform is generated having a plurality of features wherein the shape of the burst waveform evolves across the range of the second gap. Means are provided for tracking the features across the entire range of gaps and determining the dominant peak or dominant valley to determine the first gap.Type: ApplicationFiled: September 11, 2006Publication date: March 22, 2007Inventor: David Needham
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Patent number: 7017779Abstract: Frozen aerated edible product can be dispensed from single dose cartridges containing said frozen aerated edible product, using a portable dispenser comprising thermally insulated storing means for storing single dose cartridges containing said frozen aerated edible product, said thermally insulated storing means being adapted to be mounted on the back of a person, and dispensing means capable of holding a single dose cartridge containing said frozen aerated edible product outside the storing means, said dispensing means comprising discharge means capable of discharging frozen aerated edible product out of said single dose cartridge.Type: GrantFiled: July 30, 2003Date of Patent: March 28, 2006Assignee: Good Humor - Breyers Ice Cream, division of Conopco, Inc.Inventors: Alexander Aldred, Richard Henry Luck, David Needham, Paul Anthony Trusty
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Publication number: 20050244096Abstract: A signal conditioner to measure the length of an interferometric gap in a Fabry-Perot sensor (interferometer). The invention includes a light source, a Fabry-Perot interferometer capable of spanning a range of gaps in response to physical changes in the environment, a second interferometer that is placed in series with the Fabry-Perot interferometer which does not filter any particular wavelengths of light but acts as an optical cross-correlator, a detector for converting the correlated light signal into electronic signals, and an electronic processor which controls system elements and generates a signal indicative of the length of the gap spanned by the Fabry-Perot sensor.Type: ApplicationFiled: February 1, 2005Publication date: November 3, 2005Inventors: Larry Jeffers, John Berthold, Richard Lopushansky, David Needham
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Publication number: 20050191345Abstract: A liposome contains an active agent and has a gel-phase lipid bilayer membrane comprising phospholipid and a surface active agent. The phospholipids are the primary lipid source for the lipid bilayer membrane and the surface active agent is contained in the bilayer membrane in an amount sufficient to increase the percentage of active agent released at the phase transition temperature of the lipid bilayer, compared to that which would occur in the absence of the surface active agent. The surface active agent is present in the lipid bilayer membrane so as to not destabilize the membrane in the gel phase.Type: ApplicationFiled: April 12, 2005Publication date: September 1, 2005Inventor: David Needham