Patents by Inventor David Needham

David Needham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050186183
    Abstract: Disclosed is a multi-compartment medical device useful in the storage, processing and extended shelf life of perishable products, especially pharmaceutical, food and biological products. Particular biological materials processed according to the present methods are human blood and blood products (RBCs). Also disclosed are processes for preserving food, pharmaceutical and biological products for long-term storage and extended shelf life employing a process that reduces the hydration level of the material to less than native hydration levels of the specific product. The invention further provides stabilized biological products, such as in the form of glassified beads, prepared using a two-phase system according to the described processes that may be rehydrated and prepared for clinical use, and having essentially no loss of biological and/or pharmacological activity.
    Type: Application
    Filed: December 8, 2004
    Publication date: August 25, 2005
    Inventors: Joseph DeAngelo, David Needham, Carroll Jones
  • Patent number: 6793952
    Abstract: A process for the production of a frozen food product comprising Anti-freeze peptides, wherein the conditions are chosen such that the ice-crystals in the product have an aspect ratio of from 1.9 to 3.
    Type: Grant
    Filed: July 9, 1997
    Date of Patent: September 21, 2004
    Assignee: Good Humor-Breyers Ice Cream, division of Conopco, Inc.
    Inventors: Richard Anthony Fenn, David Needham, Keith Smallwood
  • Patent number: 6726925
    Abstract: A liposome contains an active agent and has a gel-phase lipid bilayer membrane comprising phospholipid and a surface active agent. The phospholipids are the primary lipid source for the lipid bilayer membrane and the surface active agent is contained in the bilayer membrane in an amount sufficient to increase the percentage of active agent released at the phase transition temperature of the lipid bilayer, compared to that which would occur in the absence of the surface active agent. The surface active agent is present in the lipid bilayer membrane so as to not destabilize the membrane in the gel phase.
    Type: Grant
    Filed: December 9, 1999
    Date of Patent: April 27, 2004
    Assignee: Duke University
    Inventor: David Needham
  • Publication number: 20040031808
    Abstract: Frozen aerated edible product can be dispensed from single dose cartridges containing said frozen aerated edible product, using a portable dispenser comprising thermally insulated storing means for storing single dose cartridges containing said frozen aerated edible product, said thermally insulated storing means being adapted to be mounted on the back of a person, and dispensing means capable of holding a single dose cartridge containing said frozen aerated edible product outside the storing means, said dispensing means comprising discharge means capable of discharging frozen aerated edible product out of said single dose cartridge.
    Type: Application
    Filed: July 30, 2003
    Publication date: February 19, 2004
    Applicant: Good Humor-Breyers Ice Cream, Division of Conopco Inc.3
    Inventors: Alexander Aldred, Richard Henry Luck, David Needham, Paul Anthony Trusty
  • Patent number: 6497244
    Abstract: A fluid flow proportioning device including spool type valve elements (12,14,16) opposite end portions of which reciprocate in oppositely disposed and spaced apart valve block halves (100,102). So that the fluids being proportioned can never mix within the device despite the spool portions being devoid of sealing element within the cylindrical bores (13,15,17) in which they are slideable, central portions (21) of the valve elements are of smaller diameter than the diameters of the cylindrical bores (13,15,17) in which the valve elements are located, and resilient seals (105) encircle the portions (21) where they extend outwards from the valve block halves.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: December 24, 2002
    Inventor: David Needham
  • Publication number: 20020102298
    Abstract: A liposome contains an active agent and has a gel-phase lipid bilayer membrane comprising phospholipid and a surface active agent. The phospholipids are the primary lipid source for the lipid bilayer membrane and the surface active agent is contained in the bilayer membrane in an amount sufficient to increase the percentage of active agent released at the phase transition temperature of the lipid bilayer, compared to that which would occur in the absence of the surface active agent. The surface active agent is present in the lipid bilayer membrane so as to not destabilize the membrane in the gel phase.
    Type: Application
    Filed: February 26, 2002
    Publication date: August 1, 2002
    Inventor: David Needham
  • Publication number: 20010048962
    Abstract: A process for the production of a frozen food product comprising AFP, wherein the conditions are chosen such that the ice-crystals in the product have an aspect ratio of from 1.9 to 3.
    Type: Application
    Filed: July 9, 1997
    Publication date: December 6, 2001
    Applicant: RICHARD ANTHONY FENN
    Inventors: RICHARD ANTHONY FENN, DAVID NEEDHAM, KEITH SMALLWOOD
  • Publication number: 20010039969
    Abstract: A fluid flow proportioning device including spool type valve elements (12,14,16) opposite end portions of which reciprocate in oppositely disposed and spaced apart valve block halves (100,102).
    Type: Application
    Filed: February 15, 2001
    Publication date: November 15, 2001
    Inventor: David Needham
  • Patent number: 6296870
    Abstract: Liposomes formulations are designed to maximize the amount of poorly water-soluble active agent that can be carried by the liposome. Liposomes containing active agent in the lipid bilayer of the liposome, and/or entrapped within the liposome interior space in a micellar preparation are described. Methods of making such liposomes are presented.
    Type: Grant
    Filed: February 3, 1998
    Date of Patent: October 2, 2001
    Assignee: Duke University
    Inventors: David Needham, Ranjit S. Sarpal
  • Patent number: 6210611
    Abstract: A method for producing a gas microbubble comprises subjecting the gas microbubble to isothermal conditions or cooling conditions such that the lipid-containing shell cools at a rate ranging from about 100° C./min. to about 103° C./min., and wherein said subjecting step transforms the lipid-containing shell from a liquid state to a solid state.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: April 3, 2001
    Assignee: Duke University
    Inventors: David Needham, Dennis Heejong Kim
  • Patent number: 6200598
    Abstract: Temperature sensitive liposomes containing active agents are described. The liposomes comprise phospholipids and a surface active agent, such as a lysolipid, that increases the amount of active agent released by the liposome at the phase transition temperature of the liposome. Such liposomes are useful in methods of administering active agents using mild hyperthermic conditions.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: March 13, 2001
    Assignee: Duke University
    Inventor: David Needham
  • Patent number: 6143321
    Abstract: Liposomes formulations are designed to maximize the amount of poorly water-soluble active agent that can be carried by the liposome. Liposomes containing active agent in the lipid bilayer of the liposome, and/or entrapped within the liposome interior space in a micellar preparation are described. Methods of making such liposomes are presented.
    Type: Grant
    Filed: October 19, 1998
    Date of Patent: November 7, 2000
    Assignee: Duke University
    Inventors: David Needham, Ranjit S. Sarpal
  • Patent number: 6096867
    Abstract: Plant anti freeze proteins can advantageously be incorporated into frozen confectionery products, provided they have the capability of limiting the growth of ice crystals
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: August 1, 2000
    Assignee: Good Humor-Breyers Ice Cream, Division of Conopco, Inc.
    Inventors: Louise Jane Byass, Donald Frank Darling, Charlotte Juliette Doucet, Richard Anthony Fenn, Peter John Lillford, Andrew John McArthur, David Needham, Christopher Sidebottom, Keith Smallwood, Margaret Felicia Smallwood
  • Patent number: 5882679
    Abstract: Liposomes contain active agents which are aggregated with a lipid surfactant. The composition of the liposome membrane stabilizes the membrane against the disruptive effects of the active agent-surfactant aggregate contained therein.
    Type: Grant
    Filed: August 5, 1998
    Date of Patent: March 16, 1999
    Assignee: Duke University
    Inventor: David Needham
  • Patent number: 5827533
    Abstract: Liposomes contain active agents which are aggregated with a lipid surfactant. The composition of the liposome membrane stabilizes the membrane against the disruptive effects of the active agent-surfactant aggregate contained therein.
    Type: Grant
    Filed: February 6, 1997
    Date of Patent: October 27, 1998
    Assignee: Duke University
    Inventor: David Needham
  • Patent number: 5472726
    Abstract: Stable gas cells having d,32 average particle size below 20 .mu.m are used in ice confections to provide creaminess, whiteness and flavor enhancement.
    Type: Grant
    Filed: December 1, 1993
    Date of Patent: December 5, 1995
    Assignee: Good Humor Corporation
    Inventors: Rodney D. Bee, David Needham, Keith Smallwood