Patents by Inventor David Newsome

David Newsome has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS, COMPOSITIONS AND KITS FOR INCREASING GENOME EDITING EFFICIENCY
    Publication number: 20220106615
    Abstract: Methods of editing a target genomic region(s), methods of repairing of a DNA break via a HDR pathway, methods of inhibiting or suppressing repair of a DNA break via a NHEJ pathway, and methods of modifying expression of a gene(s) or protein(s) comprise administering to one or more cells that include one or more target genomic regions, a genome editing system and a DNA protein-kinase (DNA-PK) inhibitor disclosed herein. Kits and compositions for editing a target gene comprise a genome editing system and a DNA-PK inhibitor disclosed herein.
    Type: Application
    Filed: August 20, 2021
    Publication date: April 7, 2022
    Inventors: Norzehan Abdul-Manan, David A. Newsome, Jacque Zwahlen
  • METHOD FOR TREATING CANCER USING A COMBINATION OF DNA-DAMAGING AGENTS AND DNA-PK INHIBITORS
    Publication number: 20220088043
    Abstract: Described herein are methods of treating a proliferative disease in a subject by administering a DNA-damaging agent and between about 8 and about 48 hours later administering to the subject a DNA-PK inhibitor. Exemplary DNA-PK inhibitors are represented by Formula (B-I): and by pharmaceutically acceptable salts thereof, wherein R1, Q, Ring A, and Ring B are as defined herein.
    Type: Application
    Filed: July 29, 2021
    Publication date: March 24, 2022
    Inventors: Diane Boucher, Shawn M. Hillier, Wanjung Tsai, Brian Hare, William Markland, David A. Newsome, Marina S. Penney
  • Methods, compositions and kits for increasing genome editing efficiency
    Patent number: 11124805
    Abstract: Methods of editing a target genomic region(s), methods of repairing of a DNA break via a HDR pathway, methods of inhibiting or suppressing repair of a DNA break via a NHEJ pathway, and methods of modifying expression of a gene(s) or protein(s) comprise administering to one or more cells that include one or more target genomic regions, a genome editing system and a DNA protein-kinase (DNAPK) inhibitor disclosed herein. Kits and compositions for editing a target gene comprise a genome editing system and a DNAPK inhibitor disclosed herein.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: September 21, 2021
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Norzehan Abdul-Manan, David A. Newsome, Jacque Zwahlen
  • Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors
    Patent number: 11110108
    Abstract: Described herein are methods of treating a proliferative disease in a subject by administering a DNA-damaging agent and between about 8 and about 48 hours later administering to the subject a DNA-PK inhibitor. Exemplary DNA-PK inhibitors are represented by Formula (B-I): and by pharmaceutically acceptable salts thereof, wherein R1, Q, Ring A, and Ring B are as defined herein.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: September 7, 2021
    Assignee: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Diane M. Boucher, Shawn M. Hillier, Wanjung Tsai, Brian Hare, William Markland, David A. Newsome, Marina S. Penney
  • METHOD FOR TREATING CANCER USING A COMBINATION OF DNA-DAMAGING AGENTS AND DNA-PK INHIBITORS
    Publication number: 20200016181
    Abstract: Described herein are methods of treating a proliferative disease in a subject by administering a DNA-damaging agent and between about 8 and about 48 hours later administering to the subject a DNA-PK inhibitor. Exemplary DNA-PK inhibitors are represented by Formula (B-I): and by pharmaceutically acceptable salts thereof, wherein R1, Q, Ring A, and Ring B are as defined herein.
    Type: Application
    Filed: September 27, 2017
    Publication date: January 16, 2020
    Inventors: Diane M. Boucher, Shawn M. Hillier, Wanjung Tsai, Brian Hare, William Markland, David A. Newsome, Marina S. Penney
  • METHODS, COMPOSITIONS AND KITS FOR INCREASING GENOME EDITING EFFICIENCY
    Publication number: 20190225990
    Abstract: Methods of editing a target genomic region(s), methods of repairing of a DNA break via a HDR pathway, methods of inhibiting or suppressing repair of a DNA break via a NHEJ pathway, and methods of modifying expression of a gene(s) or protein(s) comprise administering to one or more cells that include one or more target genomic regions, a genome editing system and a DNA protein-kinase (DNAPK) inhibitor disclosed herein. Kits and compositions for editing a target gene comprise a genome editing system and a DNAPK inhibitor disclosed herein.
    Type: Application
    Filed: July 13, 2017
    Publication date: July 25, 2019
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Norzehan Abdul-Manan, David A. Newsome, Jacque Zwahlen
  • Zinc-Monocysteine Complex and Method Of Using Zinc-Cysteine Complexes
    Publication number: 20120071552
    Abstract: A method of providing zinc to a subject in need of treatment includes administering to the subject an effective amount of a zinc-cysteine complex. The zinc-cysteine complex is preferably a zinc-monocysteine complex. The complexes of zinc-cysteine of the present invention increase the activity of antioxidant enzymes catalase and glutathione peroxidase, and the antioxidant protein metallothionein. The complexes of zinc-cysteine of the present invention protect retinal pigment epithelial cells from increasing hydrogen peroxide concentrations.
    Type: Application
    Filed: November 29, 2011
    Publication date: March 22, 2012
    Inventors: David A. Newsome, David Tate
  • Zinc-monocysteine complex and method of using zinc-cysteine complexes
    Patent number: 8067627
    Abstract: A method of providing zinc to a subject in need of treatment includes administering to the subject an effective amount of a zinc-cysteine complex. The zinc-cysteine complex is preferably a zinc-monocysteine complex. The complexes of zinc-cysteine of the present invention increase the activity of antioxidant enzymes catalase and glutathione peroxidase, and the antioxidant protein metallothionein. The complexes of zinc-cysteine of the present invention protect retinal pigment epithelial cells from increasing hydrogen peroxide concentrations.
    Type: Grant
    Filed: January 26, 2010
    Date of Patent: November 29, 2011
    Inventors: David A. Newsome, David Tate
  • GASTRORETENTIVE ORAL HIGH DOSE ZINC PREPARATIONS
    Publication number: 20110212189
    Abstract: A sustained-release zinc composition preferably includes potassium bicarbonate. A method of providing zinc to a subject in need of treatment includes administering to the subject an effective amount of a sustained-release zinc composition which preferably includes potassium bicarbonate.
    Type: Application
    Filed: November 1, 2010
    Publication date: September 1, 2011
    Applicant: ADEONA PHARMACEUTICALS, INC.
    Inventors: George J. BREWER, Steve H. KANZER, David A. NEWSOME
  • Zinc-monocysteine complex and method of using zinc-cysteine complexes
    Publication number: 20100324322
    Abstract: A method of providing zinc to a subject in need of treatment includes administering to the subject an effective amount of a zinc-cysteine complex. The zinc-cysteine complex is preferably a zinc-monocysteine complex. The complexes of zinc-cysteine of the present invention increase the activity of antioxidant enzymes catalase and glutathione peroxidase, and the antioxidant protein metallothionein. The complexes of zinc-cysteine of the present invention protect retinal pigment epithelial cells from increasing hydrogen peroxide concentrations.
    Type: Application
    Filed: January 26, 2010
    Publication date: December 23, 2010
    Inventors: David A. Newsome, David Tate, JR.
  • Zinc-monocysteine complex and method of using zinc-cysteine complexes
    Patent number: 7652161
    Abstract: A method of providing zinc to a subject in need of treatment includes administering to the subject an effective amount of a zinc-cysteine complex. The zinc-cysteine complex is preferably a zinc-monocysteine complex. The complexes of zinc-cysteine of the present invention increase the activity of antioxidant enzymes catalase and glutathione peroxidase, and the antioxidant protein metallothionein. The complexes of zinc-cysteine of the present invention protect retinal pigment epithelial cells from increasing hydrogen peroxide concentrations.
    Type: Grant
    Filed: January 9, 2007
    Date of Patent: January 26, 2010
    Inventors: David A. Newsome, David Tate
  • Dilation enhancer with pre-medicated contact lenses
    Patent number: 7346389
    Abstract: A contact lens with a conductive outer shell (one electrode of a two-electrode electrophoresis device) and a preferably soft, preferably disposable contact lens for contacting a patient's eye, assists in delivering dilation drops or other medicaments to a patient's eye. Advantageously, the lens is used with a relatively small hand-held power source. Electrophoresis can be used to help deliver dilation drops more rapidly, regardless of the delivery apparatus used for the electrophoresis.
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: March 18, 2008
    Inventor: David A. Newsome
  • Zinc-monocysteine complex and method of using zinc-cysteine complexes
    Publication number: 20070129432
    Abstract: A method of providing zinc to a subject in need of treatment includes administering to the subject an effective amount of a zinc-cysteine complex. The zinc-cysteine complex is preferably a zinc-monocysteine complex. The complexes of zinc-cysteine of the present invention increase the activity of antioxidant enzymes catalase and glutathione peroxidase, and the antioxidant protein metallothionein. The complexes of zinc-cysteine of the present invention protect retinal pigment epithelial cells from increasing hydrogen peroxide concentrations.
    Type: Application
    Filed: January 9, 2007
    Publication date: June 7, 2007
    Inventors: David NEWSOME, David TATE
  • Zinc-monocysteine complex and method of using zinc-cysteine complexes
    Patent number: 7164035
    Abstract: A method of providing zinc to a subject in need of treatment includes administering to the subject an effective amount of a zinc-cysteine complex. The zinc-cysteine complex is preferably a zinc-monocysteine complex. The complexes of zinc-cysteine of the present invention increase the activity of antioxidant enzymes catalase and glutathione peroxidase, and the antioxidant protein metallothionein. The complexes of zinc-cysteine of the present invention protect retinal pigment epithelial cells from increasing hydrogen peroxide concentrations.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: January 16, 2007
    Inventors: David A. Newsome, David Tate
  • Dilation enhancer with pre-mediated contact lenses
    Patent number: 7151960
    Abstract: A contact lens with a conductive outer shell (one electrode of a two-electrode electrophoresis device) and a preferably soft, preferably disposable contact lens for contacting a patient's eye, assists in delivering dilation drops or other medicaments to a patient's eye. Advantageously, the lens is used with a relatively small hand-held power source. Electrophoresis can be used to help deliver dilation drops more rapidly, regardless of the delivery apparatus used for the electrophoresis.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: December 19, 2006
    Inventor: David A. Newsome
  • Method and system for testing RAM redundant integrated circuits
    Publication number: 20060168488
    Abstract: System and method of testing a packaged random access memory (RAM) redundant integrated circuit die comprising: identifying a failed element in the redundant RAM of the packaged integrated circuit die; and replacing the failed element with a redundant element in the redundant RAM of the packaged integrated circuit die.
    Type: Application
    Filed: January 26, 2005
    Publication date: July 27, 2006
    Inventors: J. Hill, Todd Mellinger, David Newsome
  • Method and apparatus for generating a multiphase clock
    Publication number: 20050264337
    Abstract: A multiphase clock generating apparatus includes a clock generator providing an M-clock having a frequency M times that of a received reference clock. Divider circuitry is coupled to provide an alignment signal having 1/M the frequency of the M-clock. A recovery circuit recovers up to M distinct clocks from the M-clock in accordance with the alignment signal. The recovered clocks have substantially an N•180°/M phase difference from each other, wherein N?1.
    Type: Application
    Filed: April 22, 2005
    Publication date: December 1, 2005
    Inventors: Daniel Berkram, Perry Wyatt, David Newsome
  • METHOD AND APPARATUS FOR GENERATING A QUADRATURE CLOCK
    Publication number: 20050127973
    Abstract: A quadrature clock generating apparatus includes a clock generator providing a double clock having a frequency that is twice that of a received reference clock. Divider circuitry is coupled to provide an alignment signal having half the frequency of the double clock. A recovery circuit recovers a first clock and a second clock from the double clock in accordance with the alignment signal. The first and second clocks have substantially a 90° phase difference.
    Type: Application
    Filed: December 10, 2003
    Publication date: June 16, 2005
    Inventors: Perry Wyatt, Daniel Berkram, David Newsome
  • Flash recovery timer and warning device, with recorder
    Patent number: 6863399
    Abstract: A flash recovery timer and warning device is a hand-held electronic device using a bright flash to create a temporary glare-type vision blur to the eye to be tested and a target and timer to determine the amount of time required for the eye to recover after the flash. The device has a voice chip that, in addition to the timer display, warns that the vision recovery time is unusually flash recovery times are recorded and stored in the device. Other clinical applications may be useful.
    Type: Grant
    Filed: March 18, 2003
    Date of Patent: March 8, 2005
    Inventor: David A. Newsome
  • Zinc-monocysteine complex and method of using zinc-cysteine complexes
    Publication number: 20040122088
    Abstract: A method of providing zinc to a subject in need of treatment includes administering to the subject an effective amount of a zinc-cysteine complex. The zinc-cysteine complex is preferably a zinc-monocysteine complex. The complexes of zinc-cysteine of the present invention increase the activity of antioxidant enzymes catalase and glutathione peroxidase, and the antioxidant protein metallothionein. The complexes of zinc-cysteine of the present invention protect retinal pigment epithelial cells from increasing hydrogen peroxide concentrations.
    Type: Application
    Filed: June 30, 2003
    Publication date: June 24, 2004
    Inventors: David A. Newsome, David Tate