Abstract: A therapeutic agent delivery device includes a disposable portion and a reusable portion that detachably carries the disposable portion. The reusable portion includes a drive mechanism having a guide, a rotary actuator, and a follower drivably coupled to the rotary actuator and movably coupled to the guide. The rotary actuator is actuatable to rotatably drive the follower, and the follower thereby follows the guide and translates the drive mechanism. The drive mechanism thereby translates a syringe assembly of the disposable portion from a stowed configuration to a deployed configuration.

Abstract: In one embodiment, a system for providing port occupancy management for a network connected device that includes a plurality of ports comprises: at least one port status input panel that comprises a plurality of manually operable port occupancy status selector switches, wherein each of the selector switches are associated with one or more of the ports; a control circuit coupled to the port status input panel, wherein the control circuit determines a port occupancy status for each of the ports based on signals initiated by the selector switches; a gateway coupled to the control circuit and configured to aggregate port occupancy status data for the network connected device based on the port occupancy status for each of the ports determined by the control circuit. The gateway executes at least one interface configured to provide the port occupancy status data to a remote system.

Abstract: A device for online gaming includes an actuation component and a controller communicatively coupled to a computer system. The controller is configured to perform operations including detecting an actuation of the actuation component, wherein the actuation component is associated with performing of an action in a video game executed by the computer system. Responsive to detecting the actuation, an instruction is provided to the computer system to perform the action, wherein, based on a current value of a timer, the computer system restricts the action from being performed. The timer, having been previously initiated based on a prior actuation of the actuation component, relates to a cooldown period during which the action cannot be repeated after the action is performed. Responsive to receiving a command from the computer system, a tactile effect is generated as an indication to a user that the action can be repeated.

Abstract: Surgical instrument tracking systems, methods and devices are described. The system can include tracking devices configured to detect location events. The tracking device can include sensors, circuits, power sources, memories, and radio interface. The tracking devices can automatically determine a location of the tracking device when the tracking device detects a location event. The tracking device can automatically transmit the location and information related to the location event to a data analytics platform. The data analytics platform can allow a user to track multiple surgical instruments and surgical instrument tray in order to accurately determine when surgical instruments should be replaced, and how efficiently the surgical instruments are used.

Abstract: Methods, systems, and computer storage media for providing a multi-attribute cluster-identifier that supports identifying malicious activity in computing environments. An instance of an activity having an attribute set can be assessed. The attribute set of the instance of the activity is analyzed to determine whether the instance of the activity is a malicious activity. The attribute set of the instance of the activity is compared to a plurality of multi-attribute cluster-identifiers of previous instances of the activity, such that, a determination that the instance of the activity is a malicious activity is made when the attribute set of the instance of the activity corresponds to an identified multi-attribute cluster-identifier. The identified multi-attribute cluster-identifier has a risk score and an attribute set that indicate a likelihood that the instance of the activity is a malicious activity. A visualization that identifies the instance of the activity as a malicious activity is generated.

Abstract: Disclosed herein are clusters compounds that include at least one substituted amine sulfate and at least one substituted amine bisulfate molecule. The substituted amine sulfate molecule and the substituted amine bisulfate molecule may each include an ammonium moiety with at least one alkyl substituent. Optionally, the alkyl substituent can include 1 to 20 carbon atoms, 1 to 10 carbon atoms, or 1 to 6 carbon atoms. For example, the alkyl substituent can be a methyl, ethyl, propyl, butyl, or pentyl group. In some examples, the substituted amine sulfate molecule and the substituted amine bisulfate molecule each include an ammonium moiety with at least two alkyl substituents. Optionally, the two alkyl substituents are the same. Alternatively, however, the two alkyl substituents can be different.

Abstract: A separable footwear article comprising an outsole oriented at a bottom of the footwear and configured for ground contact, the outsole comprising a first material, an upper portion comprising a second material different from the first material, and a welt positioned between the outsole and the upper. The welt is releasably coupled to the outsole with a first thread using a first stitching technique, and releasably coupled to the upper portion with a second thread using a second stitching technique. The outsole, the upper portion, and the welt are configured to be separated upon receipt of a pulling force upon the first thread and the second thread sufficient to remove the first thread and the second thread from the footwear article.

Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

Abstract: Aspects as described herein are directed to providing an enhanced user experience for consuming content on a computing device. Secondary computing devices, such as handheld smartphones and tablet-style computers, may be identified by a primary computing device, such as a set-top box. The secondary computing devices may be configured to receive actionable instructions from the primary computing device. An actionable event associated with content being outputted to a user via the primary computing device may be determined and an actionable instruction may be transmitted to the secondary computing device in response to the determined actionable event.

Abstract: In one embodiment, a system for providing port occupancy management for a network connected device that includes a plurality of ports comprises: at least one port status input panel that comprises a plurality of manually operable port occupancy status selector switches, wherein each of the selector switches are associated with one or more of the ports; a control circuit coupled to the port status input panel, wherein the control circuit determines a port occupancy status for each of the ports based on signals initiated by the selector switches; a gateway coupled to the control circuit and configured to aggregate port occupancy status data for the network connected device based on the port occupancy status for each of the ports determined by the control circuit. The gateway executes at least one interface configured to provide the port occupancy status data to a remote system.

Abstract: A method for determining residue coverage of a field includes receiving, with a computing system, a captured image depicting an imaged portion of a field from one or more imaging devices. Furthermore, the method includes determining, with the computing system, an image gradient orientation at each of a plurality of pixels within the captured image. Additionally, the method includes determining, with the computing system, a plurality of image gradient orientation densities associated with the captured image based on the determined image gradient orientations. Moreover, the method includes determining, with the computing system, a residue coverage parameter associated with the imaged portion of the field based on the determined plurality of image gradient orientation densities.

Abstract: A device for online gaming includes an actuation component and a controller communicatively coupled to a computer system. The controller is configured to perform operations including detecting an actuation of the actuation component, wherein the actuation component is associated with performing of an action in a video game executed by the computer system. Responsive to detecting the actuation, an instruction is provided to the computer system to perform the action, wherein, based on a current value of a timer, the computer system restricts the action from being performed. The timer, having been previously initiated based on a prior actuation of the actuation component, relates to a cooldown period during which the action cannot be repeated after the action is performed. Responsive to receiving a command from the computer system, a tactile effect is generated as an indication to a user that the action can be repeated.

Abstract: Energy-recovery systems and methods are described that can recover excess energy remaining in an electrical or electromagnetic system after the system performs a function during each operational cycle of the system. The recovered energy can be made available for the start of the next operational cycle. The energy-recovery circuits are suitable for high voltage and/or high current pulsed-power applications.

Abstract: A waveguide for use in a virtual reality, VR, or augmented reality, AR, device, is disclosed. The waveguide comprising an input region configured to couple light into the waveguide so that it propagates under total internal reflection (TIR) within the waveguide, and an output region comprising optical structures configured to receive image bearing light from the input region. The output region comprises a plurality of zones having different diffraction to each other, the plurality of zones comprising diffraction efficiencies so as to reduce rainbow artefacts.

Abstract: The present disclosure relates to a surgical device including an adapter assembly for selectively interconnecting an end effector and the device housing. The adapter assembly includes at least one drive converter assembly that converts and transmits a rotation of the rotatable drive shaft to an axial translation of at least one axially translatable drive member of the end effector. A first drive converter assembly includes a first drive element, a nut, an articulation sleeve, an articulation bearing, and an articulation link. Rotation of the rotatable drive shaft results in rotation of the first drive element. Rotation of the first drive element results in axial translation of the nut, the articulation sleeve, the articulation bearing, the articulation link, and the at least one axially translatable drive member of the end effector.

Abstract: The present application relates to silk fibroin-based hydrogels, methods for making and using the same.

Abstract: Systems and methods for controlling the motion of an autonomous are provided. In one example embodiment, a computer-implemented method includes obtaining data associated with an object within a surrounding environment of an autonomous vehicle. The data associated with the object is indicative of a predicted motion trajectory of the object. The method includes determining a vehicle action sequence based at least in part on the predicted motion trajectory of the object. The vehicle action sequence is indicative of a plurality of vehicle actions for the autonomous vehicle at a plurality of respective time steps associated with the predicted motion trajectory. The method includes determining a motion plan for the autonomous vehicle based at least in part on the vehicle action sequence. The method includes causing the autonomous vehicle to initiate motion control in accordance with at least a portion of the motion plan.

Abstract: A surgical apparatus is provided. The surgical apparatus includes a proximal body portion, a distal body portion selectively articulable relative to the proximal body portion at an articulation joint, and a first drive gear disposed within the distal body portion. The distal body portion has a diameter and a length. The length of the distal body portion is substantially the same as the diameter of the distal body portion.

Abstract: This disclosure relates to an articulation assembly configured for backlash compensation for use with surgical devices. The articulation assembly includes an articulation lever assembly configured to reduce axial backlash. The articulation assembly further includes an articulation joint configured to reduce lateral backlash.

Abstract: A surgical device with a powered in-line handle assembly that includes actuators for actuating and articulating an end effector of the surgical device allows for single handed operation of the surgical device. The handle assembly includes a battery that is received in a removable compartment in a battery cover to allow for removal and recycling of the battery following use. The handle assembly also includes a manual release mechanism that allows a firing rod assembly of the handle assembly to be manually retracted in emergency situations.