Abstract: A method, performed by one or more processors, may comprise receiving a query for performing one or more computational operations on one or more multi-dimensional data sets representing multi-dimensional time series data collected in real-time from one or more sensors associated with one or more technical systems. The method may also comprise identifying the location of the one or more multi-dimensional time series data sets in one or more databases, retrieving the one or more multi-dimensional time series data sets from the identified one or more databases, and performing the one or more computational operations on the retrieved one or more multi-dimensional time series data sets. The method may also comprise generating output based on the result of the one or more computational operations indicative of one or more states of the one or more technical systems with respect to time.

Abstract: Described are methods for subcutaneously administering a therapeutic composition comprising a RNAi agent for inhibiting Receptor for Advanced Glycation End-products (AGER or RAGE). The RAGE RNAi agents and RNAi agent conjugates disclosed herein inhibit the expression of an AGER gene when administered subcutaneously. Pharmaceutical compositions that include one or more RAGE RNAi agents, optionally with one or more additional therapeutics, are also described. Delivery of the described RAGE RNAi agents to pulmonary cells, in vivo, provides for inhibition of AGER gene expression and a reduction in membrane RAGE activity, which can provide a therapeutic benefit to subjects, including human subjects, for the treatment of various diseases including pulmonary inflammation diseases such as severe asthma. Subcutaneous delivery of the RAGE RNAi agents described herein can provide certain advantages over inhaled delivery.

Abstract: A waveguide for use in a virtual reality, VR, or augmented reality, AR, device, is disclosed. The waveguide comprising an input region configured to couple light into the waveguide so that it propagates under total internal reflection (TIR) within the waveguide, and an output region comprising optical structures configured to receive image bearing light from the input region. The output region comprises a plurality of zones having different diffraction to each other, the plurality of zones comprising diffraction efficiencies so as to reduce rainbow artefacts.

Abstract: A surgical device includes a power source and a motor coupled to the power source. The device also includes a drive shaft having a proximal drive shaft having a proximal end portion coupled to the motor and a distal end portion, a proximal index gear coupled to the distal end portion of the proximal drive shaft, a distal drive shaft having a proximal end portion and a distal end portion, a distal index gear coupled to the proximal end portion of the distal drive shaft, a spring member biasedly coupling the proximal index gear and the distal index gear. The device also includes a force measurement sensor configured to measure rotation of the proximal index gear and the distal index gear. The device further includes a controller coupled to the force measurement sensor and configured to determine a force applied to the drive shaft based on a difference between rotation of the proximal index gear and the distal index gear.

Abstract: A surgical device includes an end effector and a handle assembly operably coupled to the end effector. The end effector includes an anvil assembly and a cartridge assembly pivotally coupled to one another. The cartridge assembly includes a staple cartridge, a cartridge carrier, and a strain gauge. The cartridge carrier includes an elongated support channel configured to receive the staple cartridge, the elongated support channel defined by an inner first surface and a pair of inner second surfaces. The inner first surface includes a recess defined therein, and the strain gauge is disposed within the recess. The handle assembly includes a power-pack configured to receive sensor data from the strain gauge of the end effector and to control a function of the end effector in response to the sensor data.

Abstract: A surgical device includes a tool assembly and a handle assembly. The tool assembly includes a distal portion including a plurality of staples and an anvil assembly movable relative to the distal portion from an open position to a clamped position. The handle assembly includes an approximation mechanism coupled to the anvil assembly and configured to move the anvil assembly from the open position to the clamped position, a force sensor disposed at a distal end of the surgical device, and a controller. The force sensor is configured to sense a change in resistance indicating a force imparted on compressed tissue and on the approximation mechanism. The controller is configured to receive a signal indicative of a force measured by the force sensor and provide an indication of the sensed force.

Abstract: The present disclosure provides an improved scale inhibiting formulation that is effective, environmentally friendly, and does not add any organic compounds or traditional polymeric compounds to treated water. The scale inhibiting composition includes molecular clusters of polyammonium bisulfate (PABS), which can interact physically, chemically, or physio-chemically with one or more ions in the water or water-containing system being treated. That interaction inhibits scale accretion and/or removes previously formed scale.

Abstract: Aspects as described herein are directed to providing an enhanced user experience for consuming content on a computing device. Secondary computing devices, such as handheld smartphones and tablet-style computers, may be identified by a primary computing device, such as a set-top box. The secondary computing devices may be configured to receive actionable instructions from the primary computing device. An actionable event associated with content being outputted to a user via the primary computing device may be determined and an actionable instruction may be transmitted to the secondary computing device in response to the determined actionable event.

Abstract: Described herein is a computer implemented method for generating webpage data. The method includes processing a set of design element objects to generate a set of element-grid records, each record corresponding to a design element and including a unique column start, a unique column end, a column start offset and a column end offset. The set of element-grid records is processed to generate a webpage grid definition that defines a grid including a plurality of columns and a plurality of rows. A first design element and a second design element have a same horizontal start position and the webpage grid definition defines: a unique column start gridline for the first design element; a unique column start gridline for the second design element; and a zero-width first column between the first and second column gridlines.

Abstract: In one embodiment, a system for providing port occupancy management for a network connected device that includes a plurality of ports comprises: at least one port status input panel that comprises a plurality of manually operable port occupancy status selector switches, wherein each of the selector switches are associated with one or more of the ports; a control circuit coupled to the port status input panel, wherein the control circuit determines a port occupancy status for each of the ports based on signals initiated by the selector switches; a gateway coupled to the control circuit and configured to aggregate port occupancy status data for the network connected device based on the port occupancy status for each of the ports determined by the control circuit. The gateway executes at least one interface configured to provide the port occupancy status data to a remote system.

Abstract: Surgical instrument tracking systems, methods and devices are described. The system can include tracking devices configured to detect location events. The tracking device can include sensors, circuits, power sources, memories, and radio interface. The tracking devices can automatically determine a location of the tracking device when the tracking device detects a location event. The tracking device can automatically transmit the location and information related to the location event to a data analytics platform. The data analytics platform can allow a user to track multiple surgical instruments and surgical instrument tray in order to accurately determine when surgical instruments should be replaced, and how efficiently the surgical instruments are used.

Abstract: A system for calibrating a plurality of user sensors includes a calibration management system comprising a processor and a node services module and a plurality of calibration nodes disposed at a plurality of geographical locations. The processor is communicably coupled to the plurality of user sensors, the node services module, and the plurality of calibration nodes and operable to: provide calibration node information to a system associated with one of the plurality of user sensors and cause the calibration node to perform at least one calibration action after providing the calibration information, the calibration action may include performing an environmental measurement and/or providing a calibration reference signal to the user sensor. The processor is also operable to provide calibration results information containing results of the calibration action to the system associated with the one of the plurality of user sensors.

Abstract: Methods, systems, and computer storage media for providing a multi-attribute cluster-identifier that supports identifying malicious activity in computing environments. An instance of an activity having an attribute set can be assessed. The attribute set of the instance of the activity is analyzed to determine whether the instance of the activity is a malicious activity. The attribute set of the instance of the activity is compared to a plurality of multi-attribute cluster-identifiers of previous instances of the activity, such that, a determination that the instance of the activity is a malicious activity is made when the attribute set of the instance of the activity corresponds to an identified multi-attribute cluster-identifier. The identified multi-attribute cluster-identifier has a risk score and an attribute set that indicate a likelihood that the instance of the activity is a malicious activity. A visualization that identifies the instance of the activity as a malicious activity is generated.

Abstract: Disclosed herein are clusters compounds that include at least one substituted amine sulfate and at least one substituted amine bisulfate molecule. The substituted amine sulfate molecule and the substituted amine bisulfate molecule may each include an ammonium moiety with at least one alkyl substituent. Optionally, the alkyl substituent can include 1 to 20 carbon atoms, 1 to 10 carbon atoms, or 1 to 6 carbon atoms. For example, the alkyl substituent can be a methyl, ethyl, propyl, butyl, or pentyl group. In some examples, the substituted amine sulfate molecule and the substituted amine bisulfate molecule each include an ammonium moiety with at least two alkyl substituents. Optionally, the two alkyl substituents are the same. Alternatively, however, the two alkyl substituents can be different.

Abstract: Aspects as described herein are directed to providing an enhanced user experience for consuming content on a computing device. Secondary computing devices, such as handheld smartphones and tablet-style computers, may be identified by a primary computing device, such as a set-top box. The secondary computing devices may be configured to receive actionable instructions from the primary computing device. An actionable event associated with content being outputted to a user via the primary computing device may be determined and an actionable instruction may be transmitted to the secondary computing device in response to the determined actionable event.

Abstract: In one embodiment, a system for providing port occupancy management for a network connected device that includes a plurality of ports comprises: at least one port status input panel that comprises a plurality of manually operable port occupancy status selector switches, wherein each of the selector switches are associated with one or more of the ports; a control circuit coupled to the port status input panel, wherein the control circuit determines a port occupancy status for each of the ports based on signals initiated by the selector switches; a gateway coupled to the control circuit and configured to aggregate port occupancy status data for the network connected device based on the port occupancy status for each of the ports determined by the control circuit. The gateway executes at least one interface configured to provide the port occupancy status data to a remote system.

Abstract: A waveguide for use in a virtual reality, VR, or augmented reality, AR, device, is disclosed. The waveguide comprising an input region configured to couple light into the waveguide so that it propagates under total internal reflection (TIR) within the waveguide, and an output region comprising optical structures configured to receive image bearing light from the input region. The output region comprises a plurality of zones having different diffraction to each other, the plurality of zones comprising diffraction efficiencies so as to reduce rainbow artefacts.

Abstract: The present disclosure relates to a surgical device including an adapter assembly for selectively interconnecting an end effector and the device housing. The adapter assembly includes at least one drive converter assembly that converts and transmits a rotation of the rotatable drive shaft to an axial translation of at least one axially translatable drive member of the end effector. A first drive converter assembly includes a first drive element, a nut, an articulation sleeve, an articulation bearing, and an articulation link. Rotation of the rotatable drive shaft results in rotation of the first drive element. Rotation of the first drive element results in axial translation of the nut, the articulation sleeve, the articulation bearing, the articulation link, and the at least one axially translatable drive member of the end effector.

Abstract: A surgical apparatus is provided. The surgical apparatus includes a proximal body portion, a distal body portion selectively articulable relative to the proximal body portion at an articulation joint, and a first drive gear disposed within the distal body portion. The distal body portion has a diameter and a length. The length of the distal body portion is substantially the same as the diameter of the distal body portion.

Abstract: This disclosure relates to an articulation assembly configured for backlash compensation for use with surgical devices. The articulation assembly includes an articulation lever assembly configured to reduce axial backlash. The articulation assembly further includes an articulation joint configured to reduce lateral backlash.