Abstract: The present invention relates to crystalline forms of 5-[5-[2-isopropylcyclopropyl]-6-methyl-pyridazin-3-yl]-1H-pyrimidine-2,4-dione, and pharmaceutical compositions comprising them, which inhibit the activity of CD73 and are useful for treating cancer.

Abstract: Utilizing a storage replica data structure includes receiving, at a hyper-kernel running on a computing node in a plurality of interconnected computing nodes, an indication of an operation pertaining to at least one of a guest physical memory address or a stable storage address. A guest operating system is run on a virtual environment that is defined by a set of hyper-kernels running on the plurality of interconnected computing nodes. It further includes updating a storage replica data structure. The storage replica data structure comprises a set of entries.

Abstract: A method for evaluating the deceleration law of a vehicle including an accelerator pedal, a brake pedal, and a powertrain including an engine, a gearbox and a unit for disconnecting the engine and gearbox, the deceleration law being defined for a discrete state of the powertrain. The method includes a first step of evaluating driving parameters, including measuring the speed (v) of the vehicle, evaluating the engaged gearbox ratio, evaluating the state of closure of the disconnecting unit, detecting the position of the accelerator pedal, detecting the position of the brake pedal, evaluating the slope (a) of the road on which the vehicle is traveling, evaluating the mass (m) of the vehicle. If the accelerator pedal is in a released position and if the brake pedal is in a released position, a second step including recording the speed (v) of the vehicle and the slope (a) of the road.

Abstract: Provided herein is an autonomous or semi-autonomous vehicle fleet comprising a plurality of electric autonomous vehicles for apportioned display of a media, operating autonomously and a fleet management module for coordination of the autonomous vehicle fleet. Each autonomous or semi-autonomous vehicle comprising a screen configured to display the media. Activation, deactivation, brightness modification, in combination with specific media selection enables more efficient media display.

Abstract: A device estimates an actual trajectory of a vehicle. The device is designed to determine a sequence of measured position values over a corresponding sequence of times by use of a position sensor. The device is further designed to determine a sequence of odometry values on the basis of sensor data from one or more vehicle sensors. The device is also designed to determine, as an estimation of the actual trajectory of the vehicle, a sequence of estimated pose values for the sequence of times and a systematic position offset for the sequence of measured position values so that an optimization criterion is improved, in particular is optimized at least locally.

Abstract: An assembly for opening or accessing an electronic communication and entertainment device holder for repair or replacement of its contents, including a latch which can be released by the contraction of an attached muscle wire actuator in response to a low current pulse sent by an attached wireless receiver.

Abstract: The present invention relates to substituted5-membered nitrogen containing heteroaryl compounds, such as triazole esters, where the heteroaryl ring is further substituted via a linking group such as —NH— with a cyclic group which in turn is substituted at the a-position. The present invention further relates to associated salts, solvates, prodrugs and pharmaceutical compositions, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.

Abstract: Disclosed herein is a method for the preparation of diarylmethane dyes and triarylmethane dyes, such as Isosulfan Blue, using electrochemistry. Further disclosed is Isosulfan Blue prepared from a process employing electrochemistry, compositions comprising the same, and use of the prepared Isosulfan Blue as an imaging agent.

Abstract: Molecules or salts thereof are provided, having the structure in Formula I, wherein n2 and n4 are the same or different and are independently 1, 2, or 3, and n3 is 1 to 20; X is oxygen, nitrogen, or sulfur; wherein R1, R2, R3, R4, R5, R6, and R7 are as described herein. Methods are also provided for the synthesis of and use of the provided molecules in applications for diagnostic testing.

Abstract: Embodiments include detection of physical events associated with a wireless network, where the detected physical events are associated with the measurable effects on radio signals between devices in the wireless network. The detected physical event and associated radio signal information is used to provide precise low cost time synchronization for a device in a network.

Abstract: In a network communications environment supporting realtime communications between respective network nodes of a user and other communicants in virtual areas each of which is associated with its own respective set of communicant members, a graphical user interface is provided in connection with the user's network node. The graphical user interface includes controls for establishing presence in respective ones of the virtual areas, managing realtime communications with other communicants in respective ones of the virtual areas, and presenting different views of communicants associated with the network communications environment.

Abstract: An apparatus for retaining a transmission line within a drill string component is disclosed. In one embodiment, such an apparatus includes a drill string component comprising a bore having an internal diameter. A slot is formed in the internal diameter to receive a transmission line. A first feature within the slot is configured to engage a corresponding second feature on the transmission line and thereby retain an end of the transmission line. A sleeve is inserted into the internal diameter to keep the transmission line within the slot. A corresponding system is also disclosed.

Abstract: A mobile processing system is disclosed for the removal of radioactive contaminants from nuclear process wastewater. The system is fully scalable, modular, and portable allowing the system to be fully customizable according to site-specific remediation requirements. It is designed to be both transported and operated from standard sized intermodal containers or custom designed enclosures for increased mobility between sites and on-site, further increasing the speed and ease with which the system may be deployed. Additionally, the system is completely modular wherein the various modules perform different forms or stages of wastewater remediation and may be connected in parallel and/or in series. Depending on the needs of the site, one or more different processes may be used. In some embodiments, one or more of the same modules may be used in the same operation.

Abstract: Provided herein are methods for the preparation of perfusable scaffolds for cell culture. These methods can comprise providing a bioink composition and a fugitive ink composition; chaotic printing the bioink composition and the fugitive ink composition to generate a microstructured precursor comprising a plurality of lamellar structures formed from the bioink composition; curing the bioink composition to form a cured scaffold precursor; and removing the fugitive ink from the cured scaffold precursor, thereby forming the perfusable scaffold. Also provided are scaffolds prepared by these methods as well as modular bioreactors incorporating these scaffolds.

Abstract: A system and method of improving facility performance and reliability includes the integrated use of feedstock property management, condition-based monitoring (CBM), neural network augmented predictions of the impacts of feedstock properties, and feedstock properties/plant operation databases used for machine learning applications. Sensors are used to identify feedstock properties and operating parameters throughout the facility. Understanding how feedstock properties impact facility performance over time allows the system to predict how feedstock properties will impact processing outputs so that adjustments to operating parameters may be made to improve facility performance.

Abstract: In some examples, a cabin pressure control and monitoring system includes an outflow valve and a manual control panel comprising a selector switch and configured to generate a signal, wherein a value encoded in the signal is dependent on a position of the selector switch. The cabin pressure control and monitoring system also includes a controller configured to receive the signal from the manual control panel, determine a target rate of change for a cabin pressure based on the value encoded in the signal, and control the outflow valve based on the target rate of change.

Abstract: An object recognition ingestion system is presented. The object ingestion system captures image data of objects, possibly in an uncontrolled setting. The image data is analyzed to determine if one or more a priori know canonical shape objects match the object represented in the image data. The canonical shape object also includes one or more reference PoVs indicating perspectives from which to analyze objects having the corresponding shape. An object ingestion engine combines the canonical shape object along with the image data to create a model of the object. The engine generates a desirable set of model PoVs from the reference PoVs, and then generates recognition descriptors from each of the model PoVs. The descriptors, image data, model PoVs, or other contextually relevant information are combined into key frame bundles having sufficient information to allow other computing devices to recognize the object at a later time.

Abstract: An apparatus for retaining a transmission line within a drill string component includes a drill string component comprising a bore having an internal diameter. A slot is formed in the internal diameter to receive a transmission line. A first feature within the slot is configured to engage a corresponding second feature on the transmission line and thereby retain an end of the transmission line. The first feature comprises a first angled surface configured to contact and engage a corresponding second angled surface of the second feature. The first and second angled surfaces are oriented such to keep the transmission line retained within the slot when tension is placed on the transmission line. A corresponding system is also disclosed.

Abstract: A CPA ultrashort pulse laser system is configured with a beam splitter dividing each ultrashort pulse from a seed laser into at least two replicas which propagate along respective replica paths. Each replica path includes an upstream dispersive element stretching respective replicas to different pulse durations. The optical switches are located in respective replica paths upstream or downstream from upstream dispersive elements. Each optical switch is individually controllable to operate at a high switching speed between “on” and “off” positions so as to selectively block one of the replicas or temporally separate the replicas at the output of the switching assembly. The replicas are so stretched that a train of high peak power ultrashort pulses each are output with a pulse duration selected from a fs ns range and peak power of up to a MW level.

Abstract: The present invention provides compounds of formula (I) or (Ia) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, B, n, R2, R3, R4, R5, and R6 are as defined herein.