Abstract: A cognate specification system manages and enforces digital, canonical representations of entities that are added to and in the system by creating a composite entity key (“EntityKey”) that uniquely and immutably identifies each entity within the system, and that is created based upon the attributes of the entity rather than being arbitrarily assigned. Entities may be organized into various types or cognates, each associated with distinct sets of attributes. A physical or digital referent may be added to the system as an entity by specifying attributes. In such a system, any entity, whether a physical or digital referent, a process, or other type, is uniquely and verifiably identifiable, and may be linked to or associated with other entities, allowing users of the system to produce and access specification granularity beyond traditional approaches focused on systems interoperability.

Abstract: One nonlimiting variation of a detection arrangement includes one or more sensors each structured to detect at least one biochemical substance indicative of biochemistry of one or more target insect species and provide a corresponding sensor signal, a controller responsive to the sensor signal of each of the one or more sensors to determine if the one or more insect species are present and generate a corresponding output signal, and an indicator responsive to the output signal to indicate the presence of the one or more insect species.

Abstract: This invention relates to compounds that can be used to treat viral infections. The compounds are papain-like protease (PLpro) inhibitors.

Abstract: A shoulder-immobilizing apparatus includes a forearm sling. The forearm sling is configured to receive an elbow, forearm and wrist of a first arm of a user and includes a first fastener configured for fastening a posterior strap to a proximal portion adjacent to the elbow, a second fastener configured for fastening an anterior strap to a distal portion adjacent to the wrist, and a contralateral strap holder. The contralateral strap holder includes a circumferential shoulder strap configured to wrap around a shoulder of a second arm of the user to form a substantially ellipsoid opening that seats against a pectoral region, a scapular region and one of an underarm region or a lateral outside portion of the shoulder of the user's second arm. The posterior and anterior straps each have swivel fasteners rotatably coupled to respective posterior and anterior portions of the circumferential shoulder strap. Related methods are also provided.

Abstract: Methods and systems for classification and recovery of certain solids from streams, such as liquid waste streams. Methods including classification with at least one solid bowl centrifuge, followed by a valorization procedure. The valorization procedure may be a flotation procedure, which may include a single-step or two-step procedure.

Abstract: Support braces and methods of manufacturing the same are disclosed. A support brace includes a flexible fabric substrate and an elastomeric member disposed on the surface of the flexible fabric substrate. The elastomeric member is disposed so as to apply pressure non-uniformly about a limb or joint of the wearer, in a pattern selected to divert pain and/or reduce loads on the joint. The flexible fabric substrate can include regions having different levels of elasticity, to provide different levels of compression to different parts of the joint or limb in addition to the compression provided by the elastomeric member. The elastomeric member can be deposited, screen printed, injection molded, or otherwise applied to the fabric substrate, optionally without adhesive.

Abstract: Methods and devices for providing noninvasive electrotherapy and electrical stimulation are described herein. In one aspect, a device for noninvasive electrotherapy includes wireless communication circuitry configured to receive pulse generation control signals wirelessly transmitted from a computing device. The device can include pulse generation circuitry configured to deliver electrical waveforms according to instructions encoded in the pulse generation control signals. The computing device can include a cellular telephone device, a portable media player, a personal digital assistant, a tablet computer, or an internet access device.

Abstract: Support braces and methods of manufacturing the same are disclosed. A support brace includes a flexible fabric substrate and an elastomeric member disposed on the surface of the flexible fabric substrate. The elastomeric member is disposed so as to apply pressure non-uniformly about a limb or joint of the wearer, in a pattern selected to divert pain and/or reduce loads on the joint. The flexible fabric substrate can include regions having different levels of elasticity, to provide different levels of compression to different parts of the joint or limb in addition to the compression provided by the elastomeric member. The elastomeric member can be deposited, screen printed, injection molded, or otherwise applied to the fabric substrate, optionally without adhesive.

Abstract: An orthopedic walking boot includes a housing configured to encompass at least a user's foot, a mechanically adjustable ramp insert including a ramp surface and disposed in the housing, an adjusting mechanism configured to adjust an elevation angle of the ramp surface, and a mechanically adjustable lift configured to cause the mechanically adjustable ramp insert to descend within the housing as the ramp surface is elevated such that vertical displacement of the user's foot caused by elevation of the ramp surface is substantially attenuated. Related methods are also provided.

Abstract: This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-?-lactamase inhibitors.

Abstract: Embodiments of systems are disclosed herein to detect tampering and/or provide evidence of tampering without human interaction or oversight. In the disclosed embodiments, tampering is detected and tamper evidence is provided by incorporating at least one tamper-evident assembly and at least one processing device within an enclosure. The tamper-evident assembly includes a tamper-evident fastener having an integrated circuit (IC) chip, which is embedded within the tamper-evident fastener and configured to transmit a data signal through the tamper-evident fastener to the at least one processing device when the tamper-evident fastener is coupled to a surface of the enclosure to secure a point of entry on the enclosure. In some embodiments, the at least one processing device is configured to detect tampering and/or provide evidence of tampering when the data signal transmitted from the IC chip is not received.

Abstract: This invention relates to the synthesis of compounds that can be used to treat bacterial infections in combination with other antibacterial agents, and more specifically in combination with a class of antibacterial agents known as carbapenems. The compounds resulting from the novel methods of the present invention are enzyme inhibitors and more particularly are metallo-?-lactamase inhibitors.

Abstract: An orthopedic walking boot includes a housing configured to encompass at least a user's foot, a mechanically adjustable ramp insert including a ramp surface and disposed in the housing, an adjusting mechanism configured to adjust an elevation angle of the ramp surface, and a mechanically adjustable lift configured to cause the mechanically adjustable ramp insert to descend within the housing as the ramp surface is elevated such that vertical displacement of the user's foot caused by elevation of the ramp surface is substantially attenuated. Related methods are also provided.

Abstract: Support braces and methods of manufacturing the same are disclosed. A support brace includes a flexible fabric substrate and an elastomeric member disposed on the surface of the flexible fabric substrate. The elastomeric member is disposed so as to apply pressure non-uniformly about a limb or joint of the wearer, in a pattern selected to divert pain and/or reduce loads on the joint. The flexible fabric substrate can include regions having different levels of elasticity, to provide different levels of compression to different parts of the joint or limb in addition to the compression provided by the elastomeric member. The elastomeric member can be deposited, screen printed, injection molded, or otherwise applied to the fabric substrate, optionally without adhesive.

Abstract: Embodiments of systems are disclosed herein to detect tampering and/or provide evidence of tampering without human interaction or oversight. In the disclosed embodiments, tampering is detected and tamper evidence is provided by incorporating at least one tamper-evident assembly and at least one processing device within an enclosure. The tamper-evident assembly includes a tamper-evident fastener having an integrated circuit (IC) chip, which is embedded within the tamper-evident fastener and configured to transmit a data signal through the tamper-evident fastener to the at least one processing device when the tamper-evident fastener is coupled to a surface of the enclosure to secure a point of entry on the enclosure. In some embodiments, the at least one processing device is configured to detect tampering and/or provide evidence of tampering when the data signal transmitted from the IC chip is not received.

Abstract: Embodiments of systems and methods are disclosed to detect tampering and/or provide cryptographic evidence of tampering. Tampering is detected and tamper evidence is provided by incorporating at least one tamper-evident assembly and at least one processing device within an enclosure housing a host device. The tamper-evident assembly includes one or more tamper-evident fasteners, each having an identification chip, which stores a unique identifier corresponding to the tamper-evident fastener and transmits the unique identifier through the tamper-evident fastener to the at least one processing device when the tamper-evident fastener is coupled to a surface of the enclosure to secure a point of entry on the enclosure. The processing device may detect tampering and/or provide cryptographic evidence of tampering when a hash of the unique identifier(s) detected when the host device is in use does not match a hash of the unique identifier(s) detected before the host device is used.

Abstract: This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-?-lactamase inhibitors.

Abstract: This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-?-lactamase inhibitors.

Abstract: This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-?-lactamase inhibitors.

Abstract: Methods and devices for providing noninvasive electrotherapy and electrical stimulation are described herein. In one aspect, a device for noninvasive electrotherapy includes wireless communication circuitry configured to receive pulse generation control signals wirelessly transmitted from a computing device. The device can include pulse generation circuitry configured to deliver electrical waveforms according to instructions encoded in the pulse generation control signals. The computing device can include a cellular telephone device, a portable media player, a personal digital assistant, a tablet computer, or an internet access device.