Abstract: The present invention provides a method for protecting against UV radiation-induced skin damage. Specifically, compositions including dapsone are administered to provide UV protection. The dapsone compositions may be administered orally, or by other parenteral routes, such as topically, transdermally, by inhalation, and the like.

Abstract: The present invention relates to a pharmaceutical delivery device for application of a pharmaceutical to mucosal surfaces. The device comprises an adhesive layer and a non-adhesive backing layer, and the pharmaceutical may be provided in either or both layers. Upon application, the device adheres to the mucosal surface, providing localized drug delivery and protection to the treatment site. The kinetics of erodability are easily adjusted by varying the number of layers and/or the components.

Abstract: The present invention relates to a pharmaceutical delivery device for application of a pharmaceutical to mucosal surfaces. The device comprises an adhesive layer and a non-adhesive backing layer, and the pharmaceutical may be provided in either or both layers. Upon application, the device adheres to the mucosal surface, providing localized drug delivery and protection to the treatment site. The kinetics of erodability are easily adjusted by varying the number of layers and/or the components.

Abstract: The present invention provides bioerodible, water-soluble pharmaceutical carriers for ocular (e.g., transconjunctival or transcorneal) delivery of pharmaceuticals for either systemic or local therapy.

Abstract: A thermal zone demand controlled air conditioning fan coil unit using dual cascade arranged heat pumps, chilled water, or a combination of chilled water and hot water, with or without back up electric resistance heat strips, and having an air circulation system for circulating air to and from a plurality of thermal zones and including a conditioned air chamber having first and second heat exchange refrigerant coils or direct or reversed cycle water coils being connected in refrigerant circulating relation respectively with the heat pumps, chilled water coil. A plurality of thermal zone blowers conduct conditioned air from the conditioned air chamber to respective thermal zones of a building space. Electronic controller circuitry of the system is coupled for thermal demand control of the heat pumps and the thermal zone blowers for operation of the first heat pump during average thermal load and for operation of both heat pumps during greater thermal load.

Abstract: A thermal zone demand controlled air conditioning fan coil unit using dual cascade arranged heat pumps, chilled water, or a combination of chilled water and hot water, with or without back up electric resistance heat strips, and having an air circulation system for circulating air to and from a plurality of thermal zones and including a conditioned air chamber having first and second heat exchange refrigerant coils or direct or reversed cycle water coils being connected in refrigerant circulating relation respectively with the heat pumps, chilled water coil A plurality of thermal zone blowers conduct conditioned air from the conditioned air chamber to respective thermal zones of a building space. Electronic controller circuitry of the system is coupled for thermal demand control of the heat pumps and the thermal zone blowers for operation of the first heat pump during average thermal load and for operation of both heat pumps during greater thermal load.

Abstract: A system 10 is provided for supplying air to a fuel cell 12 for use within a vehicle 14. The system 10 includes a conventional storage tank 16 which receives and stores hydrogen gas at a relatively high pressure, an expander unit 18, a compressor unit 20, pressure regulators 22, 24, a valve 26, a controller 30, and vehicle sensors 32, and a secondary compressor 34. The system 10 selectively channels pressurized hydrogen gas through expander unit 18 which lowers the pressure of the hydrogen gas and rotatably drives compressor 20. By utilizing the potential energy within the hydrogen gas to drive compressor 20, system 10 conserves energy and improves the overall fuel economy of the vehicle 14.

Abstract: A system 10 is provided for recovering the potential energy of a hydrogen gas fuel supply within a fuel cell powered vehicle 14. The system 10 includes a conventional storage tank 16 which receives and stores hydrogen gas at a relatively high pressure, an expander 18, a compressor 20, a motor/generator 76 which selectively generates electrical power and torque, pressure regulators 22, 24, a valve 26, an electrical charge storage device or battery 28, a controller 30, vehicle sensors 32 and electrical switches or switching module 34. The system 10 selectively channels pressurized hydrogen gas through expander 18 which lowers the pressure of the hydrogen gas, rotatably drives compressor 20 and generates electricity. Controller 30 causes the generated electricity to be selectively communicated to electrical accessories 72, and/or to battery 28 by use of switching module 34, based upon vehicle attribute data received from sensors 32.

Abstract: The present invention pertains to microparticles of a lipid-binding protein such as defatted albumin or microparticles of such a protein having a non-natural lipid profile are useful in therapy, e.g., as a vehicle for gene therapy, and in imaging.

Abstract: A system 10 is provided for recovering the potential energy of a hydrogen gas fuel supply within a fuel cell powered vehicle 14. The system 10 includes a conventional storage tank 16 which receives and stores hydrogen gas at a relatively high pressure, an energy conversion unit or assembly 18, a compressor unit or assembly 20, pressure regulators 22, 24, a valve 26, an electrical charge storage device or battery 28, a controller 30, vehicle sensors 32 and electrical switches or switching module 34. The system 10 selectively channels pressurized hydrogen gas through energy conversion unit 18 which lowers the pressure of the hydrogen gas and generates electricity. Controller 30 causes the generated electricity to be selectively communicated to compressor 20, electrical accessories 72, and/or to battery 28 by use of switching module 34, based upon vehicle attribute data received from sensors 32.

Abstract: Removal of lipid from lipid-bound protein such as human serum albumin to produce defatted protein enhances ability of the protein to bind therapeutic agents for use as a carrier for the therapeutic agent. The defatted protein may be reloaded with cationic and/or anionic lipids such as fatty acids, e.g. DC-Chol, to modify charge, hydrophilicity or hydrophobicity of the defatted protein to further enhance ability of the defatted protein to bind a therapeutic agent. A reloaded lipid itself may be a therapeutic agent. The defatted protein may be produced as microparticles by spray-drying. Defatting can be achieved by removing fatty acids with acidified activated charcoal, or by solvent extraction. A complex of DNA and a microparticle of defatted protein containing a cationic or anionic lipid molecule can be used for gene therapy. Defatted albumin may be reloaded with aminocaprylic acid to provide a microparticle for binding DNA for parenteral delivery.

Abstract: A system 10 is provided for recovering the potential energy of a hydrogen gas fuel supply within a fuel cell powered vehicle 14. The system 10 includes a conventional storage tank 16 which receives and stores hydrogen gas at a relatively high pressure, an energy conversion unit or assembly 18, a compressor unit or assembly 20, pressure regulators 22, 24, a valve 26, an electrical charge storage device or battery 28, a controller 30, vehicle sensors 32 and electrical switches or switching module 34. The system 10 selectively channels pressurized hydrogen gas through energy conversion unit 18 which lowers the pressure of the hydrogen gas and generates electricity. Controller 30 causes the generated electricity to be selectively communicated to compressor 20, electrical accessories 72, and/or to battery 28 by use of switching module 34, based upon vehicle attribute data received from sensors 32.

Abstract: A system 10 is provided for supplying air to a fuel cell 12 for use within a vehicle 14. The system 10 includes a conventional storage tank 16 which receives and stores hydrogen gas at a relatively high pressure, an expander unit 18, a compressor unit 20, pressure regulators 22, 24, a valve 26, a controller 30, and vehicle sensors 32, and a secondary compressor 34. The system 10 selectively channels pressurized hydrogen gas through expander unit 18 which lowers the pressure of the hydrogen gas and rotatably drives compressor 20. By utilizing the potential energy within the hydrogen gas to drive compressor 20, system 10 conserves energy and improves the overall fuel economy of the vehicle 14.

Abstract: Microcapsules having a wall thickness of no more than 500 nm, and a bulk density of no more than 0.2 g.cm−3, are suitable for therapeutic or diagnostic use. They are aerodynamically light, and can be used for delivery to the lung, or diagnosis by ultrasound.

Abstract: A system 10 is provided for ventilating hydrogen gas from a vehicle 12 which includes one or more fuel cells 14. System 10 includes a control module or controller 16, vehicle sensors 20, several fans 22, and several hydrogen gas sensors 18 which are operatively and communicatively coupled to a hydrogen gas detection module 26. Hydrogen gas detection module 26, sensors 20 and fans 22 are each communicatively connected to controller 16. Controller 16 is effective to selectively and periodically activate fans 22 in response to signals received from module 26 (e.g., sensors 18) and sensors 20, thereby substantially preventing hydrogen gas from pocketing or collecting in areas of vehicle 12.

Abstract: A hinge is disclosed which has a barrel 12 which is screw threaded at least at its ends. A grub screw 16 is inserted into one end of the barrel and can be screwed into and out of the barrel to adjust the relative height of a pin 22 inserted into the barrel to enable the height of a gate to be adjusted. The hinge can be used as a left or right hand hinge by simply inverting the hinge and screwing the grub screw 16 into the appropriate end of the hinge. An intermediate element 70 may be included to adjust for misalignment of the gates. The intermediate element has an eccentric bore 73 and the element can be rotated within the barrel 12 and locked to the pin 22 to adjust the pivot point of the pin 22 in the barrel 12 and thereby adjust for any misalignment of the hinge.