Abstract: An improved method is provided for treating a patient having a disorder responsive to PDE-4 inhibition by administering roflumilast. The improvement involves administering the roflumilast topically in a composition having a roflumilast release profile that produces in the patient a flattened plasma concentration time curve and a reduced Cmax relative to oral administration of a PDE4-inhibiting amount of roflumilast. Such disorders include inflammatory disorders such as inflammatory dermatoses, including psoriasis, atopic dermatitis and seborrheic dermatitis. Such disorders also include inflammatory diseases in a variety of organs, especially the lungs (asthma, COPD). Because of reduced side effects with topical administration due to the improved pharmacokinetics (PK) characteristics, it may be possible to provide higher systemic exposures (AUCs) with topical administration, resulting in greater therapeutic efficacy than with the oral route of administration.

Abstract: Methods of dewatering tailings, including tailings streams that may include a clay, ultra-fine particles, or both. The methods may include providing a tailings stream, dewatering the tailings stream with a dewatering apparatus to produce a first cake and a first residual effluent stream, contacting the first residual effluent stream with one or more additives, and dewatering the first residual effluent stream with a solid bowl centrifuge to produce a second cake and a second residual effluent stream. The methods may include providing a tailings stream, contacting the tailings stream with one or more additives, and dewatering the tailings stream with a solid bowl centrifuge to produce a first cake and a first residual effluent stream.

Abstract: An improved method is provided for treating a patient having a disorder responsive to PDE-4 inhibition by administering roflumilast. The improvement involves administering the roflumilast topically in a composition having a roflumilast release profile that produces in the patient a flattened plasma concentration time curve and a reduced Cmax relative to oral administration of a PDE4-inhibiting amount of roflumilast. Such disorders include inflammatory disorders such as inflammatory dermatoses, including psoriasis, atopic dermatitis and seborrheic dermatitis. Such disorders also include inflammatory diseases in a variety of organs, especially the lungs (asthma, COPD). Because of reduced side effects with topical administration due to the improved pharmacokinetics (PK) characteristics, it may be possible to provide higher systemic exposures (AUCs) with topical administration, resulting in greater therapeutic efficacy than with the oral route of administration.

Abstract: An improved method is provided for treating a patient having a disorder responsive to PDE-4 inhibition by administering roflumilast. The improvement involves administering the roflumilast topically in a composition having a roflumilast release profile that produces in the patient a flattened plasma concentration time curve and a reduced Cmax relative to oral administration of a PDE4-inhibiting amount of roflumilast. Such disorders include inflammatory disorders such as inflammatory dermatoses, including psoriasis, atopic dermatitis and seborrheic dermatitis. Such disorders also include inflammatory diseases in a variety of organs, especially the lungs (asthma, COPD). Because of reduced side effects with topical administration due to the improved pharmacokinetics (PK) characteristics, it may be possible to provide higher systemic exposures (AUCs) with topical administration, resulting in greater therapeutic efficacy than with the oral route of administration.

Abstract: Methods and systems for classification and recovery of certain solids from streams, such as liquid waste streams. Methods including classification with at least one solid bowl centrifuge, followed by a valorization procedure. The valorization procedure may be a flotation procedure, which may include a single-step or two-step procedure.

Abstract: An improved method is provided for treating a patient having a disorder responsive to PDE-4 inhibition by administering roflumilast. The improvement involves administering the roflumilast topically in a composition having a roflumilast release profile that produces in the patient a flattened plasma concentration time curve and a reduced Cmax relative to oral administration of a PDE4-inhibiting amount of roflumilast. Such disorders include inflammatory disorders such as inflammatory dermatoses, including psoriasis, atopic dermatitis and seborrheic dermatitis. Such disorders also include inflammatory diseases in a variety of organs, especially the lungs (asthma, COPD). Because of reduced side effects with topical administration due to the improved pharmacokinetics (PK) characteristics, it may be possible to provide higher systemic exposures (AUCs) with topical administration, resulting in greater therapeutic efficacy than with the oral route of administration.

Abstract: An improved a method of treating a patient having a disorder responsive to PDE-4 inhibition by administering roflumilast. The improvement involves administering the roflumilast topically in a composition having a roflumilast release profile that produces in the patient a flattened plasma concentration time curve and a reduced Cmax relative to oral administration of a PDE4-inhibiting amount of roflumilast. Such disorders include inflammatory disorders such as inflammatory dermatoses, including psoriasis, atopic dermatitis and seborrheic dermatitis. Such disorders also include inflammatory diseases in a variety of organs, especially the lungs (asthma, COPD). Because of reduced side effects with topical administration due to the improved pharmacokinetics (PK) characteristics, it may be possible to provide higher systemic exposures (AUCs) with topical administration, resulting in greater therapeutic efficacy than with the oral route of administration.

Abstract: An improved method is provided for treating a patient having a disorder responsive to PDE-4 inhibition by administering roflumilast. The improvement involves administering the roflumilast topically in a composition having a roflumilast release profile that produces in the patient a flattened plasma concentration time curve and a reduced Cmax relative to oral administration of a PDE4-inhibiting amount of roflumilast. Such disorders include inflammatory disorders such as inflammatory dermatoses, including psoriasis, atopic dermatitis and seborrheic dermatitis. Such disorders also include inflammatory diseases in a variety of organs, especially the lungs (asthma, COPD). Because of reduced side effects with topical administration due to the improved pharmacokinetics (PK) characteristics, it may be possible to provide higher systemic exposures (AUCs) with topical administration, resulting in greater therapeutic efficacy than with the oral route of administration.

Abstract: An improved a method of treating a patient having a disorder responsive to PDE-4 inhibition by administering roflumilast. The improvement involves administering the roflumilast topically in a composition having a roflumilast release profile that produces in the patient a flattened plasma concentration time curve and a reduced Cmax relative to oral administration of a PDE4-inhibiting amount of roflumilast. Such disorders include inflammatory disorders such as inflammatory dermatoses, including psoriasis, atopic dermatitis and seborrheic dermatitis. Such disorders also include inflammatory diseases in a variety of organs, especially the lungs (asthma, COPD). Because of reduced side effects with topical administration due to the improved pharmacokinetics (PK) characteristics, it may be possible to provide higher systemic exposures (AUCs) with topical administration, resulting in greater therapeutic efficacy than with the oral route of administration.

Abstract: Methods of dewatering tailings, including tailings streams that may include a clay, ultra-fine particles, or both. The methods may include providing a tailings stream, dewatering the tailings stream with a dewatering apparatus to produce a first cake and a first residual effluent stream, contacting the first residual effluent stream with one or more additives, and dewatering the first residual effluent stream with a solid bowl centrifuge to produce a second cake and a second residual effluent stream. The methods may include providing a tailings stream, contacting the tailings stream with one or more additives, and dewatering the tailings stream with a solid bowl centrifuge to produce a first cake and a first residual effluent stream.

Abstract: A fuel cell system including a fuel cell stack, separator and a scavenging reservoir. The fuel cell stack is configured to generate water and reusable fuel. The separator is downstream of and in fluid communication with the fuel cell stack. The separator is configured to separate the water from the reusable fuel. The scavenging reservoir is downstream of and in fluid communication with the separator. The scavenging reservoir is configured to receive the water from the separator. The scavenging reservoir includes an inlet portion, an outlet portion, and a middle portion positioned between the inlet and outlet portions. The middle portion includes a reservoir and a passageway extending there between. The passageway is configured to allow a fluid stream to flow there through when the reservoir is occupied by a frozen fluid.

Abstract: A shoe sole sanitizing assembly includes a housing that has a bottom wall, a top wall and a perimeter wall. The top wall has an opening extending therethrough. A cylinder is rotatably mounted to the housing and extends through the opening. An outer surface of the cylinder is comprised of an adsorptive material. A sanitizing fluid is positioned within the housing and the adsorptive material is in contact with the fluid. The sanitizing fluid coats the cylinder and applies the sanitizing fluid to a bottom of a shoe sole when the shoe sole is moved across the cylinder while the cylinder rotates relative to the housing.

Abstract: According to the present invention, an apparatus is provided that allows cutting an opening in a material, such as a wall or surface, while accurately controlling the depth of penetration so as not to damage or destroy any existing materials behind the wall or surface, and also without needing equal access behind the wall or surface. In a preferred embodiment of the invention, the apparatus includes a support block assembly having a thickness and at least one primary surface, the at least one primary surface defining a perimeter of the support block assembly; and one or more cutting blades coupled to the support block assembly in at least one location and extending away from the at least one primary surface, the one or more cutting blades being arranged in a closed plane orientation and each being coupled to the support block assembly such that the one or more cutting blades extend away from the at least one primary surface at an inset distance relative to the perimeter of the support block assembly.

Abstract: According to the present invention, an apparatus is provided that allows cutting an opening in a material, such as a wall or surface, while accurately controlling the depth of penetration so as not to damage or destroy any existing materials behind the wall or surface, and also without needing equal access behind the wall or surface. In a preferred embodiment of the invention, the apparatus includes a support block assembly having a thickness and at least one primary surface, the at least one primary surface defining a perimeter of the support block assembly; and one or more cutting blades coupled to the support block assembly in at least one location and extending away from the at least one primary surface, the one or more cutting blades being arranged in a closed plane orientation and each being coupled to the support block assembly such that the one or more cutting blades extend away from the at least one primary surface at an inset distance relative to the perimeter of the support block assembly.

Abstract: A vehicle system includes a controller configured to, in response to receiving a request to open a rear enclosure of a vehicle and data indicating that there is an object behind the vehicle, transmit one or more signals to open a door of a garage and inhibit opening the enclosure. The controller is also configured to, in response to the data indicating an absence of objects behind the vehicle, open the enclosure.

Abstract: An apparatus for delivering a primary fuel stream to a fuel cell stack is provided. The apparatus includes an ejector that is configured to receive the primary fuel stream from a fuel supply. The apparatus is further configured to receive the recirculated fuel stream from the fuel cell stack to provide a combined fluid stream for delivery to the fuel cell stack. The ejector includes an elastic conduit for varying a flow of the combined fluid stream based on a power level of the fuel cell stack.

Abstract: A fuel cell system including a fuel cell stack, separator and a scavenging reservoir. The fuel cell stack is configured to generate water and reusable fuel. The separator is downstream of and in fluid communication with the fuel cell stack. The separator is configured to separate the water from the reusable fuel. The scavenging reservoir is downstream of and in fluid communication with the separator. The scavenging reservoir is configured to receive the water from the separator. The scavenging reservoir includes an inlet portion, an outlet portion, and a middle portion positioned between the inlet and outlet portions. The middle portion includes a reservoir and a passageway extending there between. The passageway is configured to allow a fluid stream to flow there through when the reservoir is occupied by a frozen fluid.

Abstract: A modular fuel cell power system includes a coolant source, a reactant source and a plurality of fuel cell modules. Each of the fuel cell modules includes a fuel cell stack and a fluid distribution plant in fluid communication with the reactant source, coolant source and fuel cell stack. The fluid distribution plant controls the flow of reactant between the reactant source and fuel cell stack. The fuel cell stacks are configured to be selectively electrically connected.

Abstract: A fuel cell purge apparatus for a fuel cell system has a separator defining a chamber for receiving a recirculated fuel stream including a fluid and impurities. The apparatus has a drain conduit with an outer passage connected to the chamber. The outer passage forms a fluid trap to collect the fluid. The drain conduit also has an inner passage nested within the outer passage through the fluid trap for delivering the impurities to a purge valve. The inner passage has a free end extending into the chamber of the separator.

Abstract: A modular fuel cell power system includes a coolant source, a reactant source and a plurality of fuel cell modules. Each of the fuel cell modules includes a fuel cell stack and a fluid distribution plant in fluid communication with the reactant source, coolant source and fuel cell stack. The fluid distribution plant controls the flow of reactant between the reactant source and fuel cell stack. The fuel cell stacks are configured to be selectively electrically connected.