Abstract: Provided herein are recombinant fusion polypeptides comprising one or more antigenic peptides (e.g., fused to a PEST-containing peptide) from cancer-associated proteins. The antigenic peptides can comprise one or more or all of an antigenic peptide comprising a recurrent cancer mutation, an antigenic peptide comprising a heteroclitic mutation, or an antigenic peptide fused to a ubiquitin protein. For example, provided herein are recombinant fusion polypeptides comprising two or more antigenic peptides (e.g., fused to a PEST-containing peptide), wherein each antigenic peptide comprises a recurrent cancer mutation, and wherein at least two of the antigenic peptides are fragments of the same cancer-associated protein. Also provided are nucleic acids encoding such fusion polypeptides, recombinant bacteria or Listeria strains comprising such fusion polypeptides or such nucleic acids, and cell banks comprising such recombinant bacteria or Listeria strains.

Abstract: A fuel system for an aircraft including a fuel tank for storing fuel during operation of the aircraft and a diffuser disposed inside the fuel tank. The diffuser is configured such that it forms part of a flow path configured to connect a fuel source to the inside of the fuel tank. The diffuser includes a wall which at least partially defines an internal space of the diffuser; an opening in the wall, which provides access to the internal space; and a blocking component configured to block the opening.

Abstract: A support member configured to support a first structure within an aperture of a second structure is disclosed. The support member comprises a bracket for attaching the support member to the second structure; and a funnel part. The diameter of the base of the funnel is less than or equal to the diameter of the aperture, and is substantially equal to the diameter of a part of the first structure to be supported by the support member.

Abstract: A fuel pipe assembly is disclosed including a connector having a socket and a lug arrangement extending from the socket, a pipe having a first end portion adapted to fit within the socket, and a retainer having first and second parts which together form a collar configured to retain a pipe. The retainer has an open condition in which a pipe is insertable, and a closed condition. The retainer also has a channel arranged, in the closed condition, to capture the lug arrangement.

Abstract: When coupling tubular parts by fitting, the seal interposed between them may roll on itself, be pinched or damaged. Now, a twisted or damaged seal no longer correctly ensures the seal-tightness and it is very difficult to detect this. The present application discloses a tool for installing a seal between two tubular parts, one male and one female, including a compression ring to encircle the male part and exert a compression on the seal before producing the join. The tool also includes a tongue that can be positioned at a chamfered surface of the female tubular part. The tongue makes it possible to offer the pre-compressed seal with the dimensions of the female part a continuous travel making it possible to prevent any twisting or other effect compromising the seal-tightness.

Abstract: A support member configured to support a first structure within an aperture of a second structure is disclosed. The support member comprises a bracket for attaching the support member to the second structure; and a funnel part. The diameter of the base of the funnel is less than or equal to the diameter of the aperture, and is substantially equal to the diameter of a part of the first structure to be supported by the support member.

Abstract: When coupling tubular parts by fitting, the seal interposed between them may roll on itself, be pinched or damaged. Now, a twisted or damaged seal no longer correctly ensures the seal-tightness and it is very difficult to detect this. The present application discloses a tool for installing a seal between two tubular parts, one male and one female, including a compression ring to encircle the male part and exert a compression on the seal before producing the join. The tool also includes a tongue that can be positioned at a chamfered surface of the female tubular part. The tongue makes it possible to offer the pre-compressed seal with the dimensions of the female part a continuous travel making it possible to prevent any twisting or other effect compromising the seal-tightness.

Abstract: A method for manufacturing a wafer on which are formed resonators, each resonator including, above a semiconductor substrate, a stack of layers including, in the following order from the substrate surface: a Bragg mirror; a compensation layer made of a material having a temperature coefficient of the acoustic velocity of a sign opposite to that of all the other stack layers; and a piezoelectric resonator, the method including the successive steps of: a) depositing the compensation layer; and b) decreasing thickness inequalities of the compensation layer due to the deposition method, so that this layer has a same thickness to within better than 2%, and preferably to within better than 1%, at the level of each resonator.

Abstract: A connector for connecting a pipe, such as a fuel pipe, to another fuel pipe or pipe terminal, having a first connector element including a first female sub-element and a concentric second female sub-element, a first seal seat positioned within the first female sub-element, a second seal seat positioned in the concentric second female sub-element, a first seal retained within the first seal seat, a second seal retained the second seal seat, and a second connector element providing a connection for a pipe at one end and connection to the first connector element at a second end.

Abstract: A substrate of the silicon-on-insulator type is formed from an initial substrate of the silicon-on-insulator type having a semiconductor film on top of a buried insulating layer itself situated on top of a carrier substrate. A localized modification of a thickness of the semiconductor film is made so as to form a semiconductor film having different thicknesses in different regions.

Abstract: A method of adjustment during manufacture of a capacitance of a capacitor supported by a substrate, the method including the steps of: a) forming a first electrode parallel to the surface of the substrate and covering it with a dielectric layer; b) forming, on a first portion of the dielectric layer, a second electrode; c) measuring the electrical signal between the first electrode and the second electrode, and deducing therefrom the capacitance to be added to obtain the desired capacitance; d) thinning down a second portion of the dielectric layer, which is not covered by the second electrode, so that the thickness of this second portion is adapted to the forming of the deduced capacitance; and e) forming a third electrode on the thinned-down portion and connecting it to the second electrode.

Abstract: A method for manufacturing a wafer on which are formed resonators, each resonator including, above a semiconductor substrate, a stack of layers including, in the following order from the substrate surface: a Bragg mirror; a compensation layer made of a material having a temperature coefficient of the acoustic velocity of a sign opposite to that of all the other stack layers; and a piezoelectric resonator, the method including the successive steps of: a) depositing the compensation layer; and b) decreasing thickness inequalities of the compensation layer due to the deposition method, so that this layer has a same thickness to within better than 2%, and preferably to within better than 1%, at the level of each resonator.

Abstract: A pipe connector is disclosed, comprising two connector elements, arranged for interconnection of two pipes, wherein one or both of the connector elements is formed from electrically resistive material so as to provide electrical resistance between the connected pipes.

Abstract: A method for manufacturing a bulk acoustic wave resonator, each resonator including: above a substrate, a piezoelectric resonator, and next to the piezoelectric resonator, a contact pad connected to an electrode of the piezoelectric resonator; and, between the piezoelectric resonator and the substrate, a Bragg mirror including at least one conductive layer extending between the pad and the substrate and at least one upper silicon oxide layer extending between the pad and the substrate, the method including the steps of: depositing the upper silicon oxide layer; and decreasing the thickness unevenness of the upper silicon oxide layer due to the deposition method, so that this layer has a same thickness to within better than 2%, and preferably to within better than 1%, at the level of each pad.

Abstract: A method of adjustment in the manufacture of a capacitance of a capacitor supported by a substrate, the method including the steps of: a) forming a first electrode parallel to the surface of the substrate and covering it with a dielectric layer; b) forming, on a first portion of the dielectric layer, a second electrode; c) measuring the capacitance between the first electrode and the second electrode, and deducing therefrom the capacitance to be added to obtain the desired capacitance; d) thinning down a second portion of the dielectric layer, which is not covered by the second electrode, so that the thickness of this second portion is adapted to the forming of the deduced capacitance; and e) forming a third electrode on the thinned-down portion and connecting it to the second electrode.

Abstract: A resonant device including a stack of a first metal layer, a piezoelectric material layer, and a second metal layer formed on a silicon substrate, a cavity being formed in depth in the substrate, the thickness of the silicon above the cavity having at least a first value in a first region located opposite to the center of the stack, having a second value in a second region located under the periphery of the stack and having at least a third value in a third region surrounding the second region, the second value being greater than the first and the third values.

Abstract: A coupling for fuel pipe includes a pipe end fitting, which includes a male outer surface including a groove and a female inner surface including a groove. The coupling includes a double-walled socket including a female outer socket and a male inner shaft. The pipe end fitting is accommodated in the region between the female outer socket and the male inner shaft. A first seal ring seals between the female inner surface and the male inner shaft. A second seal ring, which may be substantially coplanar with the first, seals between the male outer surface and the female outer socket of the double-walled socket. The coupling may be so arranged that the pipe end fitting and the double-walled socket are able to pivot relative to each other by up to at least ±2 degrees and are able to slide both towards and apart from each other.

Abstract: A pipe connector is disclosed, comprising two connector elements, arranged for interconnection of two pipes, wherein one or both of the connector elements is formed from electrically resistive material so as to provide electrical resistance between the connected pipes.

Abstract: A method of adjustment during manufacture of a capacitance of a capacitor supported by a substrate, the method including the steps of: a) forming a first electrode parallel to the surface of the substrate and covering it with a dielectric layer; b) forming, on a first portion of the dielectric layer, a second electrode; c) measuring the electrical signal between the first electrode and the second electrode, and deducing therefrom the capacitance to be added to obtain the desired capacitance; d) thinning down a second portion of the dielectric layer, which is not covered by the second electrode, so that the thickness of this second portion is adapted to the forming of the deduced capacitance; and e) forming a third electrode on the thinned-down portion and connecting it to the second electrode.

Abstract: A connector for connecting a pipe, such as a fuel pipe, to another fuel pipe or pipe terminal.