Abstract: The present disclosure provides bispecific proteins that bind to two antigens, as well as their compositions, uses, and methods of making.

Abstract: In a LED lamp having an optically transmissive enclosure and a base connected to the enclosure a plurality of LEDs are operable to emit light when energized through an electrical path from the base. A reflector has an enclosed wall shape and is disposed such that LEDs are mounted inside of and outside of the reflector. The reflector includes a reflective outer surface where in cross-section the reflective outer surface is disposed at an angle relative to the longitudinal axis of the lamp such that the reflective outer surface diverges away from the longitudinal axis as it extends away from the base. The reflective outer surface may be disposed at an angle of between approximately 83 and 89 degrees relative to the plane of the LEDs.

Abstract: A PWM dimmer includes a source terminal, a load terminal, a power stage, an interface, and control circuitry. The power stage is coupled between the source terminal and the load terminal and is configured to receive from the source terminal an AC supply signal and provide a pulsed AC load signal to the load terminal in response to a control signal. The AC supply signal has a sinusoidal envelope with a positive half-cycle and a negative half-cycle for each cycle. The pulsed AC load signal tracks the envelope and includes a plurality of pulses in the positive half-cycle and the negative half-cycle for each cycle. The interface is configured to receive dimming control information bearing on a dimming level from a user or remote terminal. The control circuitry is configured to receive the dimming control information from the interface and generate the control signal based on the dimming control information.

Abstract: A LED lamp includes an at least partially optically transmissive enclosure and a base. A LED assembly comprising at least one LED is located in the enclosure and is operable to emit light when energized through an electrical path from the base. A heat sink comprises a heat dissipating portion that is at least partially exposed to the ambient environment and a heat conducting portion that is thermally coupled to the at least one LED. The heat sink is connected to the base by a snap fit connector comprising a deformable first member on one of the base or heat sink engaging a second member on the other one of the heat sink and the base. A retention member holds the first member in engagement with the second member. A seal is positioned between the heat sink and the base, the seal being compressed between the heat sink and the base.

Abstract: A lighting wall controller can be a retrofit for existing light switches, and the lighting wall control replaces the conventional light switch and can still work as a conventional light switch or other power switch with “dumb” lights or appliances while providing the ability to control “smart” lights and/or other “smart” devices with voice commands. In addition to controlling lights and/or devices, voice commands can be used to provide information or actions back to the user in response to the voice command. The lighting wall controller thereby provides voice control functionality without requiring additional devices, such as additional voice control appliances.

Abstract: A LED lamp includes an elongated at least partially optically transmissive enclosure having a first end and a second end. LEDs are in the enclosure and are operable to emit light through the enclosure when energized through an electrical path. A first pin is mounted to the first end of the enclosure and a second pin mounted to the second end of the enclosure, the first pin and the second pin are in the electrical path. The LEDs are mounted on an LED board. A plurality of discrete braces are spaced along the length of the LED board and are mounted to the LED board. The braces support and position the LED board in the enclosure.

Abstract: A LED fixture is provided, the lamp comprising a LED board having a thermally conductive periphery, the LED board comprising at least one LED operable to emit light when energized through an electrical path from a base; and a heat sink assembly thermally coupled to the thermally conductive periphery.

Abstract: A PWM dimmer includes a source terminal, a load terminal, a power stage, an interface, and control circuitry. The power stage is coupled between the source terminal and the load terminal and is configured to receive from the source terminal an AC supply signal and provide a pulsed AC load signal to the load terminal in response to a control signal. The AC supply signal has a sinusoidal envelope with a positive half-cycle and a negative half-cycle for each cycle. The pulsed AC load signal tracks the envelope and includes a plurality of pulses in the positive half-cycle and the negative half-cycle for each cycle. The interface is configured to receive dimming control information bearing on a dimming level from a user or remote terminal. The control circuitry is configured to receive the dimming control information from the interface and generate the control signal based on the dimming control information.

Abstract: The present disclosure provides bispecific proteins that bind to two antigens, as well as their compositions, uses, and methods of making.

Abstract: A method and apparatus for generating a final dielectric etch compensation table and a final hard mask etch compensation table for either OPC or MPC process flows are provided. Embodiments include performing an overlap pattern classification on a wafer; calibrating a dielectric etch bias or a hard mask etch bias based on the pattern classification; comparing either a CD overlap of a via layer with a metal layer and a CD overlap of the via layer with a lower connecting metal layer or a CD overlap of the metal layer with an upper connecting via layer and a CD overlap of the metal layer with the via layer against a criteria; outputting final dielectric etch compensation and hard mask etch compensation tables to either OPC or MPC process flows; and repeating the steps of calibrating, comparing, and outputting for either the via layer or metal layer remaining.

Abstract: An enclosure is divided into first and second portions by a theoretical plane defined by a horizontal line. LEDs are mounted on an LED board in the enclosure and are operable to emit light when energized through an electrical path. A first pin is mounted to a first end of the enclosure and a second pin mounted to a second end of the enclosure, both pins being in the electrical path. Braces support the LED board and comprise first and second legs. The first leg and second leg extend to a first point and a second point of intersection of the plane and the internal surface of the enclosure, respectively. A first conductor connects the first pin to the LED board and a second conductor connects the second pin to the LED board. The first conductor and first pin and the second conductor and the second pin are one-piece.

Abstract: A LED lamp has a non-optically transmissive base connected to an optically transmissive enclosure. A LED assembly emits light when energized through an electrical path from the base. A portion of the heat sink and lamp electronics extend from the base and into the enclosure such that at least an upper portion of the heat sink extends into the interior volume defined by the enclosure. The LED assembly is supported on top of the heat sink such that the LEDs are disposed in the volume of the enclosure. An optic element extends over the LEDs and at least the portion of the heat sink. The size of the non-optically transmissive base of the lamp is reduced relative to the optically transmissive enclosure such that a greater ratio of optically transmissive view space to non-optically transmissive base is provided.

Abstract: In a LED lamp having an optically transmissive enclosure and a base connected to the enclosure a plurality of LEDs are operable to emit light when energized through an electrical path from the base. A reflector has an enclosed wall shape and is disposed such that LEDs are mounted inside of and outside of the reflector. The reflector includes a reflective outer surface where in cross-section the reflective outer surface is disposed at an angle relative to the longitudinal axis of the lamp such that the reflective outer surface diverges away from the longitudinal axis as it extends away from the base. The reflective outer surface may be disposed at an angle of between approximately 83 and 89 degrees relative to the plane of the LEDs.

Abstract: A solid-state lamp with an angular distribution optic is disclosed. Embodiments of the present invention can provide for improved luminous intensity distribution in the vertical plane for a vertically oriented solid-state lamp. A lamp according to some example embodiments of the invention includes at least one LED, an optically transmissive enclosure for the LED or LEDs, and a base. The lamp also includes a distribution optic conformably disposed in or on the base to conduct light for angularly distributed emission from the base of the lamp. In some embodiments, the lamp is dimensioned as a replacement for a candelabra type incandescent bulb. The distribution optic can be composed of any optical medium, and in some embodiments, may be from about 1 mm to about 5 mm thick. In some embodiments, the distribution optic is made of thermally conductive plastic.

Abstract: A LED lamp comprises an enclosure containing a reflective surface and an optically transmissive exit surface and a base. A LED assembly is mounted on a submount, is located in the enclosure and is operable to emit light when energized through an electrical path from the base. The submount comprises a connector portion having a first electrical contact that is in the electrical path. A first spring contact is electrically coupled to lamp electronics where the lamp electronics and the first spring contact are in the electrical path. A heat sink comprises a heat dissipating portion that is at least partially exposed to the ambient environment and a heat conducting portion that is thermally coupled to the LED assembly. The connector portion is inserted into the heat sink such that the first electrical contact creates an electrical contact coupling with the first spring contact.

Abstract: A method and apparatus for generating a final dielectric etch compensation table and a final hard mask etch compensation table for either OPC or MPC process flows are provided. Embodiments include performing an overlap pattern classification on a wafer; calibrating a dielectric etch bias or a hard mask etch bias based on the pattern classification; comparing either a CD overlap of a via layer with a metal layer and a CD overlap of the via layer with a lower connecting metal layer or a CD overlap of the metal layer with an upper connecting via layer and a CD overlap of the metal layer with the via layer against a criteria; outputting final dielectric etch compensation and hard mask etch compensation tables to either OPC or MPC process flows; and repeating the steps of calibrating, comparing, and outputting for either the via layer or metal layer remaining.

Abstract: Methods of treating humans or animals having various conditions are disclosed which include administering a cyclosporine component. Among the conditions treated are dry mouth syndrome, verruciform xanthoma, achlorhydria, mucous cysts, oral submucous fibrosis, oral nevi, cancer of the oral mucosa, maloplakia of the genito-urinary tract, vulvovaginitis, helicobacter pylori infection, duodenal ulcers, peptic ulcers, conditions affecting the uterus and appendicitis.