Abstract: Processes to make compounds, including N-acylsulfonamide apoptosis promoters are disclosed.

Abstract: A substrate handling system and method in which an air chuck produces a film of air between the substrate and the air chuck, a magnetic chuck attracts the substrate to the air chuck, and an actuator subsystem moves the magnetic chuck closer to and away from the air chuck to alternately pick up a substrate and release the substrate.

Abstract: A process for the preparation of neuraminidase inhibitors having structural formula (28) 1

Abstract: The present invention discloses a process for the synthesis of reverse hydroxamate matrix metalloproteinase (MMP) inhibitors.

Abstract: The instant invention provides a process for the synthesis of matrix metalloproteinase inhibitors.

Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2′-substituted and optionally 4″-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.

Abstract: A method and system to determine an alignment of a workpiece, with respect to a tool, by backlighting the workpiece. The workpiece includes fiducials, and the backlighting results in electromagnetic radiation passing through the fiducial. The electromagnetic energy emerging from the fiducial defines an emergent flux. A circumference of the emergent flux is ascertained, and the alignment is determined as a function of the circumference.

Abstract: A method of using a variety of sonic transmissions is utilized to determine fluid level in a well. It is known that wells replenish fluid at different rates even in the same formation or well field. Maximum production at minimum pumping cost is achieved for a given well.

Abstract: The instant invention provides a process for the synthesis of matrix metalloproteinase inhibitors.

Abstract: The instant invention provides a process for the selective N-formylation of N-hydroxylamines.

Abstract: The instant invention provides a process for the synthesis of matrix metalloproteinase inhibitors.

Abstract: The instant invention provides a process for the selective N-formylation of N-hydroxylamines.

Abstract: A preload hydrostatic bearing includes a pad, a diaphragm and an adjustable member. The pad has a bearing structure, an inlet manifold, and a plurality of orifices. The orifices direct a fluid, such as air, from the inlet manifold toward the bearing surface. The diaphragm is mounted on the pad, and the adjustable member, which extends in an axial direction, is coupled proximate one end to a center portion of the diaphragm. The diaphragm transfers a preload in the axial direction to the adjustable member. This preload hydrostatic bearing has a high repeatability of performance, because a single diaphragm replaces prior art mechanical coupling devices, such as ball bearings, conical seats and spring washers, which undesirably are sources of friction and hysteresis.

Abstract: The instant invention provides a process for the selective N-formylation of N-hydroxylamines.

Abstract: A method of using a variety of sonic transmissions is utilized to determined fluid level in a well. It is known that wells replenish fluid at different rates even in the same formation or well field. The fluid levers, which may be determined include water and petroleum. The sonic signals may be transmitted through the annulus in a well where the medium is a gas such as methane. The sonic signals may be also be transmitted through the casing or tubing of the well, which is typically steel pipe. Signals are generated, reflected, received, and converted into data. The data is then utilized to determine an initial liquid level P2, a no liquid pumpable state P0, and to activate the pump to pump the liquid, and inactivate the pump at a liquid level P1 above the no liquid pumpable state P0. [Maximum production at minimum pumping cost is achieved for a given well.

Abstract: Disclosed are 9-hydrazone erythromycin and 9-azine erythromycin derivatives and the processes for making the same. The compounds are useful intermediates for conversion into 6-O-alkyl erythromycin. Also disclosed are the processes for converting the compounds into 6-O-alkyl erythromycin.

Abstract: An articulated platform mechanism includes a base, a mounting frame including a platform, the frame having multiple attach portions; a mounting attached to each of the attach portions; a series of cams each having at least one cam surface; a series of cam followers; a series of drive motors; one of each of the cams or one of each of the followers being attached to each one of the mountings, the other of the cams and the followers being in rolling association with respective ones of each cam or cam follower; and wherein each motor drives a respective cam or follower not attached to the mountings, to actuate the platform in vertical lift, tilt front-to-back and tilt left-to-right.

Abstract: A method for the systematic and efficient synthetic preparation and identification of metabolites of a pharmaceutical product in order to study possible toxic and/or otherwise biologically-active metabolites of such pharmaceutical products as early and conveniently as possible in the very expensive drug development process, comprising adding samples of the pharmaceutical product to a series of combinations of a synthetic metalloporphyrin (SMP) with a synthetic metalloporphyrin-co-oxidizing reagent in the presence of a suitable solvent, under specified conditions, in a manner such that each sample of pharmaceutical product is reacted with a different combination of synthetic metalloporphyrin, SMP-co-oxidizing reagent and solvent, followed by separation and isolation of the resulting oxidative products, then confirmation of the identity of metabolites from the pre-identified oxidative products by appropriate animal model studies, and subjecting the actual metabolites prepared in larger quantities by the above m

Abstract: Disclosed are 9-hydrazone erythromycin and 9-azine erythromycin derivatives and the processes for making the same. The compounds are useful intermediates for conversion into 6-O-alkyl erythromycin. Also disclosed are the processes for converting the compounds into 6-O-alkyl erythromycin.