Abstract: The invention relates to a DPP-IV inhibitor (preferably vildagliptin or a pharmaceutically acceptable salt thereof), and metformin or a pharmaceutically acceptable salt thereof, for use in treating type 2 diabetes. The invention also relates to the use of a DPP-IV inhibitor (preferably vildagliptin or a pharmaceutically acceptable salt thereof), and metformin or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for treating type 2 diabetes. The invention also relates to a method of treating type 2 diabetes using a DPP-IV inhibitor (preferably vildagliptin or a pharmaceutically acceptable salt thereof), and metformin or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to a DPP-IV inhibitor (preferably vildagliptin or a pharmaceutically acceptable salt thereof), and metformin or a pharmaceutically acceptable salt thereof, for use in treating type 2 diabetes. The invention also relates to the use of a DPP-IV inhibitor (preferably vildagliptin or a pharmaceutically acceptable salt thereof), and metformin or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for treating type 2 diabetes. The invention also relates to a method of treating type 2 diabetes using a DPP-IV inhibitor (preferably vildagliptin or a pharmaceutically acceptable salt thereof), and metformin or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to a DPP-IV inhibitor (preferably vildagliptin or a pharmaceutically acceptable salt thereof), and metformin or a pharmaceutically acceptable salt thereof, for use in treating type 2 diabetes. The invention also relates to the use of a DPP-IV inhibitor (preferably vildagliptin or a pharmaceutically acceptable salt thereof), and metformin or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for treating type 2 diabetes. The invention also relates to a method of treating type 2 diabetes using a DPP-IV inhibitor (preferably vildagliptin or a pharmaceutically acceptable salt thereof), and metformin or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to a DPP-IV inhibitor (preferably vildagliptin or a pharmaceutically acceptable salt thereof), and metformin or a pharmaceutically acceptable salt thereof, for use in treating type 2 diabetes. The invention also relates to the use of a DPP-IV inhibitor (preferably vildagliptin or a pharmaceutically acceptable salt thereof), and metformin or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for treating type 2 diabetes. The invention also relates to a method of treating type 2 diabetes using a DPP-IV inhibitor (preferably vildagliptin or a pharmaceutically acceptable salt thereof), and metformin or a pharmaceutically acceptable salt thereof.

Abstract: A slag agglomerator includes an inlet, an outlet and a plurality of obstacles. The inlet receives a flow of gas and slag droplets and the outlet allows the flow of gas and slag droplets to exit the agglomerator. The obstacles are oblique or perpendicular to the flow of gas and slag droplets and have an exterior surface containing a ceramic matrix composite.

Abstract: A method of assembling an injection device for use in a reactor injector feed assembly includes extending the injection device at least partially into a cavity. The injection device includes a plurality of substantially concentric conduits coupled to a modular tip that includes a plurality of cooling channels and a plurality of substantially annular nozzles defined therein. The method also includes coupling at least one coolant distribution device in flow communication with the plurality of cooling channels to facilitate removing heat from an outer surface of the injection device.

Abstract: An annular injector is described. The injector includes a first bayonet assembly and a second bayonet assembly each including a terminal end and a tip end. The second bayonet assembly is configured to be concentrically coupled at least partially about the first bayonet assembly. An outer diameter of the first bayonet assembly and an inner diameter of the second bayonet assembly vary at the tip end to define a first substantially annular nozzle. The first bayonet assembly includes a maximum outer diameter that is greater than a minimum inner diameter of the second bayonet assembly and at least a portion of at least one of the first bayonet assembly and the second bayonet assembly extends from the tip end to the terminal end. The injector includes a third bayonet assembly configured to be concentrically coupled at least partially about the second bayonet assembly to define a second substantially annular nozzle.

Abstract: A method of assembling a gasification reactor includes extending an injection device at least partially into the gasification reactor. The injection device includes a plurality of substantially concentric conduits coupled to a modular tip and at least one outer surface. The modular tip includes a plurality of cooling channels and a plurality of substantially annular nozzles defined therein. The method further includes forming at least one layer of insulation about at least a portion of the at least one outer surface to facilitate insulating at least a portion of the injection device from heat within the gasification reactor.

Abstract: A method of assembling an injection device for use in a reactor injector feed assembly includes extending the injection device at least partially into a cavity. The injection device includes a plurality of substantially concentric conduits coupled to a modular tip that includes a plurality of cooling channels and a plurality of substantially annular nozzles defined therein. The method also includes coupling at least one coolant distribution device in flow communication with the plurality of cooling channels to facilitate removing heat from an outer surface of the injection device.

Abstract: A method of assembling an injection device for use in a reactor injector feed assembly includes coupling a plurality of substantially concentric conduits to a modular tip. The method also includes coupling a first conduit of the reactor injector feed assembly to a modular tip and coupling a second conduit of the reactor injector feed assembly to the modular tip. The modular tip includes a first substantially annular nozzle and a second substantially annular nozzle defined therein. The first conduit and the first substantially annular nozzle are centered about an injection device centerline.

Abstract: An annular injector is described. The injector includes a first bayonet assembly and a second bayonet assembly each including a terminal end and a tip end. The second bayonet assembly is configured to be concentrically coupled at least partially about the first bayonet assembly. An outer diameter of the first bayonet assembly and an inner diameter of the second bayonet assembly vary at the tip end to define a first substantially annular nozzle. The first bayonet assembly includes a maximum outer diameter that is greater than a minimum inner diameter of the second bayonet assembly and at least a portion of at least one of the first bayonet assembly and the second bayonet assembly extends from the tip end to the terminal end. The injector includes a third bayonet assembly configured to be concentrically coupled at least partially about the second bayonet assembly to define a second substantially annular nozzle.

Abstract: An annular injector is described. The injector includes a first bayonet assembly and a second bayonet assembly each including a terminal end and a tip end. The second bayonet assembly is configured to be concentrically coupled at least partially about the first bayonet assembly. An outer diameter of the first bayonet assembly and an inner diameter of the second bayonet assembly vary at the tip end to define a first substantially annular nozzle. The first bayonet assembly includes a maximum outer diameter that is greater than a minimum inner diameter of the second bayonet assembly and at least a portion of at least one of the first bayonet assembly and the second bayonet assembly extends from the tip end to the terminal end. The injector includes a third bayonet assembly configured to be concentrically coupled at least partially about the second bayonet assembly to define a second substantially annular nozzle.

Abstract: A method of assembling an injection device for use in a reactor injector feed assembly includes extending the injection device at least partially into a cavity. The injection device includes a plurality of substantially concentric conduits coupled to a modular tip that includes a plurality of cooling channels and a plurality of substantially annular nozzles defined therein. The method also includes coupling at least one coolant distribution device in flow communication with the plurality of cooling channels to facilitate removing heat from an outer surface of the injection device.

Abstract: A slag agglomerator includes an inlet, an outlet and a plurality of obstacles. The inlet receives a flow of gas and slag droplets and the outlet allows the flow of gas and slag droplets to exit the agglomerator. The obstacles are oblique or perpendicular to the flow of gas and slag droplets and have an exterior surface containing a ceramic matrix composite.

Abstract: A method for gasifying a carbonaceous material includes supplying a main slurry flow to a main cavity of a two-stage slurry splitter, dividing the main slurry flow into secondary slurry flows that flow into secondary cavities extending from the main cavity at distal ends of first stage flow dividers, dividing each secondary slurry flow into tertiary slurry flows that flow into slurry injection tubes extending from each secondary cavity at distal ends or second stage flow dividers, injecting the tertiary slurry flows into a gasification chamber coupled to the injector module, impinging annular shaped sprays of a reactant onto corresponding ones of the tertiary slurry flows within the gasification chamber using annular impinging orifices in a face plate of the injector module, and cooling the face plate to withstand high temperatures and abrasion.

Abstract: A method for gasifying a carbonaceous material includes supplying a main slurry flow to a main cavity of a two-stage slurry splitter, dividing the main slurry flow into secondary slurry flows that flow into secondary cavities extending from the main cavity at distal ends of first stage flow dividers, dividing each secondary slurry flow into tertiary slurry flows that flow into slurry injection tubes extending from each secondary cavity at distal ends or second stage flow dividers, injecting the tertiary slurry flows into a gasification chamber coupled to the injector module, impinging annular shaped sprays of a reactant onto corresponding ones of the tertiary slurry flows within the gasification chamber using annular impinging orifices in a face plate of the injector module, and cooling the face plate to withstand high temperatures and abrasion.

Abstract: A gasifier injection module includes a two-stage slurry splitter and an injector face plate with a coolant system incorporated therein. The two-stage slurry splitter includes a main cavity into which a main slurry flow is provided. The main cavity includes a plurality of first stage flow dividers that divide the main slurry flow into a plurality of secondary slurry flows that flow into a plurality of secondary cavities that extend from the main cavity. Each secondary cavity includes a plurality of second stage flow dividers that divide each secondary slurry flow into a plurality of tertiary slurry flows that flow into a plurality of slurry injection tubes extending from the secondary cavities. The tertiary flows are injected as high pressure slurry streams into the gasification chamber via the slurry injection tubes. A reactant is impinged at high pressure, as an annular shaped spray, on each high pressure slurry stream via a plurality of annular impinging orifices incorporated into the injector face plate.

Abstract: A method of assembling an injection device for use in a reactor injector feed assembly includes extending the injection device at least partially into a cavity. The injection device includes a plurality of substantially concentric conduits coupled to a modular tip that includes a plurality of cooling channels and a plurality of substantially annular nozzles defined therein. The method also includes coupling at least one coolant distribution device in flow communication with the plurality of cooling channels to facilitate removing heat from an outer surface of the injection device.

Abstract: A method of assembling a gasification reactor includes extending an injection device at least partially into the gasification reactor. The injection device includes a plurality of substantially concentric conduits coupled to a modular tip and at least one outer surface. The modular tip includes a plurality of cooling channels and a plurality of substantially annular nozzles defined therein. The method further includes forming at least one layer of insulation about at least a portion of the at least one outer surface to facilitate insulating at least a portion of the injection device from heat within the gasification reactor.

Abstract: A method of assembling an injection device for use in a reactor injector feed assembly includes coupling a plurality of substantially concentric conduits to a modular tip. The method also includes coupling a first conduit of the reactor injector feed assembly to a modular tip and coupling a second conduit of the reactor injector feed assembly to the modular tip. The modular tip includes a first substantially annular nozzle and a second substantially annular nozzle defined therein. The first conduit and the first substantially annular nozzle are centered about an injection device centerline.