Abstract: Aspects of the disclosure relate to mRNAs comprising a relatively low abundance of cytidine: adenosine (CA) dinucleotides that benefit from increased stability relative to mRNAs containing more CpA dinucleotides. The disclosure also relates to methods of modifying an mRNA sequence to improve stability. In some aspects, the disclosure relates to mRNAs comprising modified mRNA sequences with relatively reduced numbers of CpA dinucleotides, and compositions comprising mRNAs with relatively reduced numbers of CpA dinucleotides.

Abstract: The disclosure provides coronavirus mRNA vaccines, including vaccines directed against spike proteins of one or more variant strains of SARS-COV-2, as well as methods of using the vaccines.

Abstract: A semi-solid oral dosage form that includes one or more excipients, an active ingredient, and a polymer. The polymer encapsulates at least a portion of the active ingredient, and the portion of the active ingredient that is encapsulated does not come in direct contact with the one or more excipients present in the semi-solid oral dosage form. The semi-solid oral dosage form can be, e.g., an oral thin film (OTF) or gummy. Also provided is a method of orally administering the semi-solid oral dosage form, as well as methods of manufacturing the semi-solid oral dosage form.

Abstract: The present invention provides for a method for obtaining an oil extract of cannabis. The method includes: (a) contacting cannabis biomass and an edible oil; (b) pressing between a pair of plates to provide spent cannabis and an oil extract of cannabis; and (c) separating the spent cannabis biomass and the oil extract of cannabis.

Abstract: The disclosure provides coronavirus mRNA vaccines, including vaccines directed against spike proteins of one or more variant strains of SARS-CoV-2, as well as methods of using the vaccines.

Abstract: The present invention provides for a method for obtaining an oil extract of cannabis. The method includes: (a) contacting cannabis biomass and an edible oil; (b) pressing between a pair of plates to provide spent cannabis and an oil extract of cannabis; and (c) separating the spent cannabis biomass and the oil extract of cannabis.

Abstract: Provided herein is a topical sunscreen composition that includes an external sunscreen agent, one or more pharmaceutically acceptable excipients, and at least one of a cannabinoid, terpene, and flavonoid. Also provided is a method that includes topically administering to a skin surface of a subject (e.g., human) the topical sunscreen composition.

Abstract: The disclosure features a polynucleotide encoding a polypeptide, which polynucleotide comprises a 5? UTR, a coding region encoding a polypeptide, and a 3 UTR, and lipid nanoparticles comprising the same. The polynucleotides and/or lipid nanoparticles of the present disclosure can increase the level and/or activity of the polypeptide by increasing the half-life and/or duration of expression of the polynucleotide encoding the polypeptide. Also disclosed herein are methods of treating a disease or disorder in a subject using the lipid nanoparticles of the present disclosure.

Abstract: A midair warning device for warning a man lift operator of a hazard below. The midair warning device includes an attachment base adapted to be attached to a part of a building near a hazard to the man lift operator. The midair warning device includes a warning indicator connected to the attachment base so that the warning indicator is visible to the man lift operator near eye level of the man lift operator.

Abstract: The present invention provides for a chewable gummy containing ?-hydroxy ?-methylbutyric acid (HMB), a method of making and using the same, as well as the slurry used to form the chewable gummy.

Abstract: The present invention provides a water-soluble pouch, methods of manufacturing the same, as well as methods of orally administering the same.

Abstract: Provided herein are methods for detecting and/or measuring mRNA associated with ribosomes in a cell. The method can be used to assess potency and other characteristics of an miRNA drug product. Also provided are related products, including cells and reagents.

Abstract: Provided herein is a topical antibiotic composition that includes an external antibiotic agent, one or more pharmaceutically acceptable excipients, and at least one of a cannabinoid, terpene, and flavonoid. Also provided is a method that includes topically administering to a skin surface of a subject (e.g., human) the topical antibiotic composition.

Abstract: Films (ODFs) that include botanical extract are provided, as well as methods of making and using the same.

Abstract: This disclosure relates to mRNA therapy for the treatment of Fanconi anemia and related diseases, disorders or conditions. mRNAs for use in the invention, when administered in vivo, encode a Fanconi anemia, complementation group (FANC) protein such as FANCA, FANCC, or FANCG. mRNA therapies of the disclosure increase and/or restore deficient levels of a FANC protein such as FANCA, FANCC, or FANCG expression and/or activity in subjects.

Abstract: Provided herein is a topical sunscreen composition that includes an external sunscreen agent, one or more pharmaceutically acceptable excipients, and at least one of a cannabinoid, terpene, and flavonoid. Also provided is a method that includes topically administering to a skin surface of a subject (e.g., human) the topical sunscreen composition.

Abstract: This present invention is directed to a powder comprising a composite of primary nanoparticles of aluminum and/or aluminum oxide, the nanoparticle being separated from the others by an intervening organic or polymeric material, and formed into secondary particles that are substantially larger than the primary nanoparticles.

Abstract: Provided herein is a topical antibiotic composition that includes an external antibiotic agent, one or more pharmaceutically acceptable excipients, and at least one of a cannabinoid, terpene, and flavonoid. Also provided is a method that includes topically administering to a skin surface of a subject (e.g., human) the topical antibiotic composition.

Abstract: Provided herein is a topical analgesic composition that includes an external analgesic agent, one or more pharmaceutically acceptable excipients, and at least one of a cannabinoid, terpene, and flavonoid. Also provided is a method that includes topically administering to a skin surface of a subject (e.g., human) the topical analgesic composition.