Abstract: Provided is an oral soft gel capsule that includes a psychedelic compound. Also provided is a method of treating in a subject a disease or disorder ameliorated by a psychedelic compound, that includes orally administering to a subject an oral soft gel capsule that includes a therapeutically effective amount of the psychedelic compound. Also provided is a method of orally administering to a subject an oral soft gel capsule that includes a therapeutically effective amount of the psychedelic compound. Also provided is a method of orally administering to a subject an oral soft gel capsule that includes a low dose (e.g., microdose or sub-therapeutic dose) of the psychedelic compound.

Abstract: Provided herein are methods of treating or delaying the onset of Duchenne muscular dystrophy using modified antisense oligonucleotides.

Abstract: This disclosure relates to delivery vehicles comprising payload molecules, e.g., mRNA or gene editing therapeutics for the treatment of cystic fibrosis (CF). Nucleic acid therapeutics (e.g., mRNAs) for use in the invention, when administered in vivo, encode cystic fibrosis transmembrane conductance regulator (CFTR). Nucleic acid therapeutics (e.g., mRNAs) of the disclosure increase and/or restore deficient levels of CFTR expression and/or activity in subjects. Nucleic acid therapeutics (e.g., mRNAs) of the disclosure further decrease abnormal accumulation of ammonia associated with deficient CFTR activity in subjects.

Abstract: The present invention provides for a method for obtaining an oil extract of cannabis. The method includes: (a) contacting cannabis biomass and an edible oil; (b) pressing between a pair of plates to provide spent cannabis and an oil extract of cannabis; and (c) separating the spent cannabis biomass and the oil extract of cannabis.

Abstract: Films (ODFs) that include botanical extract are provided, as well as methods of making and using the same.

Abstract: Provided is an oral soft gel capsule that includes a psychedelic compound. Also provided is a method of treating in a subject a disease or disorder ameliorated by a psychedelic compound, that includes orally administering to a subject an oral soft gel capsule that includes a therapeutically effective amount of the psychedelic compound. Also provided is a method of orally administering to a subject an oral soft gel capsule that includes a therapeutically effective amount of the psychedelic compound. Also provided is a method of orally administering to a subject an oral soft gel capsule that includes a low dose (e.g., microdose or sub-therapeutic dose) of the psychedelic compound.

Abstract: The disclosure features a polynucleotide encoding a polypeptide, which polynucleotide comprises: a 5?UTR described herein; a coding region comprising a payload and a stop element described herein; and a 3?UTR described herein, and LNP compositions comprising the same. The polynucleotides and/or LNP compositions of the present disclosure can: increase the level and/or activity of the payload by increasing the half-life and/or duration of expression of the polynucleotide encoding the payload or of the payload polypeptide. Also disclosed herein are methods of treating a disease or disorder in a subject using the LNP compositions of the present disclosure.

Abstract: Disclosed are alkaline electrodeposition solutions and apparatus and methods for using such solutions to electroplate metal. During electroplating, the solutions may produce superconformal fill of metal in features such as features having a critical dimension of about 20 nm or less. The metal electroplating process may be used during integrated circuit fabrication. For example, it may be used to fill trenches and vias in partially fabricated integrated circuits. The electroplated metal may be copper. The copper may be electroplated on a substrate material that is less noble than copper.

Abstract: Provided herein is a topical antibiotic composition that includes an external antibiotic agent, one or more pharmaceutically acceptable excipients, and at least one of a cannabinoid, terpene, and flavonoid. Also provided is a method that includes topically administering to a skin surface of a subject (e.g., human) the topical antibiotic composition.

Abstract: Films (ODFs) that include botanical extract are provided, as well as methods of making and using the same.

Abstract: Various embodiments relate to methods, apparatus, and systems for forming an interconnect structure, or a portion thereof. The method may include contacting the substrate with a functionalization bath comprising a first solvent and a functionalization reactant to form a modified first material, and then depositing a second material on the modified first material through electroless plating, electroplating, chemical vapor deposition, or atomic layer deposition. The first material may be a dielectric material, a barrier layer, or a liner, and the second material may be a barrier layer or a barrier layer precursor, a liner, a seed layer, or a conductive metal that forms the interconnect of the interconnect structure, according to various embodiments.

Abstract: Disclosed are apparatus, systems, and methods for electroplating cobalt, nickel, and alloys thereof in interconnect features of partially or fully fabricated electronic devices. During electroplating, cobalt, nickel, or alloys thereof fill features by a bottom up electrofill mechanism. Examples of features that may be electrofilled with cobalt, nickel, or alloys thereof include micro TSVs, contacts for devices, and certain gates for transistors. Electroplating apparatus may include electroplating cells along with one or more instances of each of a post-electrofill module, an anneal chamber, a plasma pretreatment module, and a substrate pre-wetting module.

Abstract: The present invention provides for a method for obtaining an oil extract of cannabis. The method includes: (a) contacting cannabis biomass and an edible oil; (b) pressing between a pair of plates to provide spent cannabis and an oil extract of cannabis; and (c) separating the spent cannabis biomass and the oil extract of cannabis.

Abstract: Provided herein is a topical antibiotic composition that includes an external antibiotic agent, one or more pharmaceutically acceptable excipients, and at least one of a cannabinoid, terpene, and flavonoid. Also provided is a method that includes topically administering to a skin surface of a subject (e.g., human) the topical antibiotic composition.

Abstract: Provided is a catalytic washcoat having a catalyst component and an alumina binder, wherein the catalyst component includes an aluminosilicate molecular sieve having a beta (BEA) and/or chabazite (CHA) framework, and about 1 to about 10 weight percent of a base metal component comprising iron and/or copper, wherein said weight percent is based on the weight of the aluminosilicate molecular sieve.

Abstract: A method for controlling the application of aircraft wheel brakes including: controlling the application of a first wheel brake of an aircraft and a second wheel brake of the aircraft in dependence upon a determined relationship to control the time taken for the first wheel brake and the second wheel brake to reach respective specified temperatures. The relationship is determined between a first cooling characteristic of the first wheel brake, according to which the first wheel brake cools when in a first retracted position within the aircraft, and a second cooling characteristic of the second wheel brake, according to which the second wheel brake cools when in a second retracted position within the aircraft.

Abstract: The present invention is a composite solid propellant designed to operate in three distinct combustion regimes under various pressure states in the combustion chamber of a solid rocket motor. The design of this propellant facilitates desirable rocket motor operational characteristics, including throttleability, extinguishment, and self-destruction or detonability. The propellant contains ingredients that modify the propellant combustion characteristics to provide the desired behavior, including a surfactant and unaggregated, unagglomerated dispersed primary nanoparticles of aluminum in a polymer binder.

Abstract: Techniques are disclosed for managing power supplies and related power consumption alerts for a server based on the availability of redundant power supplies. When the system detects that a redundant power supply to a server has ceased to provide power, the system configures a new power consumption threshold for the remaining power supply. The new power consumption threshold is different than an initial power consumption threshold (if configured) when the redundant power supply was providing power. A power consumption threshold for triggering power consumption alerts for a power supply may be based on a number of power supplies actively providing power.

Abstract: A floor treatment device may include a body portion comprising one or more pumps, one or more spray outlets, and one or more reservoir receptacles configured to receive one or more reservoirs. The one or more pumps are operable to be activated and direct liquids to the spray outlets. The device may include swappable heads, each comprising a body connector configured to mate with a head connector of the body portion. In an embodiment, the head connector may include a sensor system and a controller communicatively connected to the sensor system. When one of swappable heads is connected to the body portion, the sensor system is configured to detect the identity of the swappable heads connected, and the controller is configured to selectively activate, based on the identity of the swappable heads, at least one of the one or more pumps.