Abstract: Compounds of Formula I, which are activators of long form cyclic nucleotide phosphodiesterase-4 (PDE4) enzymes (isoforms) are provided. Methods and uses of these compounds for the treatment or prevention of disorders requiring a reduction of second messenger responses mediated by cyclic 3?,5?-adenosine monophosphate (cAMP) are also described.

Abstract: A membrane including a block copolymer is presented. The block copolymer includes at least one block A including structural units having a formula (I), and at least one block B including structural units having a formula (II). A hollow-fiber membrane for hemodialysis or hemofiltration, and associated block copolymer are also presented.

Abstract: There is provided A method for producing an electrical impedance tomographic image of an acoustic field within a fluid, comprising the steps of: a) positioning a plurality of electrodes within a fluid; b) applying an electrical signal to each electrode within a first subset of electrodes, wherein the electrical signal applied to each electrode has a different carrier frequency and/or phase; c) measuring the electrical potential at each electrode within a second subset of electrodes; and d) processing the measured data to provide an acoustic map of the acoustic field at the required acoustic frequencies. There is also provided a system for producing an electrical impedance tomographic image of an acoustic field within a fluid using the method of any preceding claim, comprising a plurality of electrodes, a signal generator adapted to perform step (b), a device adapted to perform step (c), and a processor adapted to perform step (d).

Abstract: Exemplary embodiments provide methods, mediums, and systems for behavioral research. In some embodiments, a simulated environment may be created. The simulated environment may be displayed to a user on a proprietary display device which utilizes a proprietary data format for storing the simulated environment. Multiple different types of proprietary devices may be supported by providing a hardware agnostic canvas and translation logic. The hardware agnostic canvas may be stored in a neutral format that is not specific to a proprietary display device. The translation logic may translate the hardware agnostic canvas into a format that is interpretably by a proprietary display device, and may translate data gathered from the proprietary display device into a hardware neutral format for further analysis.

Abstract: In one embodiment, a personal flotation device that can be worn by a user includes an inflation system including an inflatable bladder, a gas-generating component configured to generate gas using a chemical reaction and inject the generated gas into the bladder to inflate it, and an actuator configured to activate the gas-generating component; a sensor configured to sense one or more physiological parameters of the user; and an inflation control system configured to receive physiological parameter data from the sensor, to determine whether or not the user is experiencing a medical event that places the user at risk of drowning, and, if the user is experiencing such a medical event, to signal the actuator to activate the gas-generating component so as to provide floatation to the user.

Abstract: A method is provided herein, the method includes: applying a sample comprising target nucleic acids to a sample application zone of a substrate; and flowing a nucleic acid amplification reaction mixture across a length of the substrate through the sample application zone to amplify the target nucleic acid forming a nucleic acid amplification product; wherein the target nucleic acid having a first molecular weight is substantially immobilized at the sample application zone and wherein the amplification product having a second molecular weight migrates away from the sample application zone. An associated device is also provided.

Abstract: A soldering tool, comprising nozzle shaped soldering tip and a hot gas feed channel that runs in the soldering tip, wherein the hot gas feed channel includes openings that provide a hot gas exhaust, and wherein the soldering tip as well as a portion of a soldering environment is heatable by the hot gas, characterized in that the soldering tip includes one or plural contact surfaces that have a surface structure which corresponds to a surface structure of a soldering object so that the soldering object is thermally contactable by the soldering tip with a minimum heat resistance, wherein a hot gas jet that passes through the openings is forced to perform at least one directional reversal or directional deflection by placement of the soldering tip and contacting the soldering object.

Abstract: Systems and method relating to machining parts include a CNC system, and a computer including a processor and a computer-readable medium, wherein the computer-readable medium encodes instructions including receiving, at the computer program, output data from a CNC machine that receives instructions of a Numerical Control (NC) program at a computer of the CNC machine, the instructions causing the CNC machine to i) manufacture a part, and ii) output the output data, parsing, by the computer program, the output data before completion of the manufacturing of the part by the CNC machine in accordance with the instructions of the NC program, selecting, by the computer program and based on one or more predetermined parameters, a set of data from the parsed output data; and providing, by the computer program to a remote system, the set of data for processing to facilitate machining using the CNC machine.

Abstract: In one embodiment, a personal flotation device that can be worn by a user includes an inflation system including an inflatable bladder and a gas-generating component, the gas-generating component being configured to generate gas using a chemical reaction and inject the generated gas into the bladder to inflate it, and an inflation control system configured to control activation of the gas-generating component.

Abstract: A method, system, and computer readable medium for tracking mileage. The method includes obtaining global positions of a mobile device and timestamps corresponding to the global positions, and detecting, based on the global positions and the timestamps, a completed trip having global positions and timestamps. The global positions include an origin and a destination. The method further includes categorizing, from location categories, the origin into an origin location category, categorizing, from location categories, the destination into a destination location category, and categorizing, based on the origin location category and the destination location category, the completed trip into a completed trip category from trip categories. The method further includes calculating mileage based on the global positions of the completed trip, and storing, for the completed trip, the mileage and the completed trip category.

Abstract: A method involves determining multiple temperatures of an object from spectral data collected from the object. The spectral data covers a plurality of wavelengths. The method comprises using a computer to (a) assign an initial value for residual radiation; (b) identify a black body profile that best fits the spectral data over the plurality of wavelengths; (c) remove radiation corresponding to the identified profile from the residual radiation; and (d) return to (b) until the residual radiation reaches a termination criterion.

Abstract: Exemplary embodiments provide methods, mediums, and systems for behavioral research. In some embodiments, a simulated environment may be created. The simulated environment may be displayed to a user on a proprietary display device which utilizes a proprietary data format for storing the simulated environment. Multiple different types of proprietary devices may be supported by providing a hardware agnostic canvas and translation logic. The hardware agnostic canvas may be stored in a neutral format that is not specific to a proprietary display device. The translation logic may translate the hardware agnostic canvas into a format that is interpretably by a proprietary display device, and may translate data gathered from the proprietary display device into a hardware neutral format for further analysis.

Abstract: Method for producing an electrical impedance tomographic image of an acoustic field within a fluid, comprising the steps of: a) positioning a plurality of electrodes within a fluid; b) applying an electrical signal to each electrode within a first subset of electrodes, wherein the electrical signal applied to each electrode has a different carrier frequency and/or phase; c) measuring the electrical potential at each electrode within a second subset of electrodes, wherein the electrical potential is measured using a potential divider or a Wheatstone bridge; and d) processing the measured data to provide an acoustic map of the acoustic field at the required acoustic frequencies. There is also provided a system for producing an electrical impedance tomographic image of an acoustic field within a fluid using this method.

Abstract: The invention relates to an electrical connector element for contacting a conductive structure arranged on a flat carrier wherein the contacting is performed by a thermally bonded connecting material, wherein devices for fixing an advantageously flexible conductor are arranged on one side, wherein the connector element is configured as a soldering base or soldering bridge with a connector portion, characterized in that at least a portion of the soldering base or of the soldering bridge that is to be connected with the conductive structure is configured as a fanned area and includes at least two bars that are offset from each other by a slot.

Abstract: A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.

Abstract: A rapid detection method of a target biomolecule comprising an antigenic moiety is provided. The method includes providing a source biological sample comprising the target biomolecule; contacting the source biological sample to an ion-exchange medium; eluting the captured-target biomolecule from the ion-exchange medium as an eluate, and loading the eluate to a rapid diagnostic testing device comprising an antibody. The eluate comprises a concentrated form of the biomolecule in a solution having a salt concentration greater than 150 mM. A concentration of the target biomolecule in the eluate is in a range from about 2× to 25× compared to a concentration of the biomolecule in the source biological sample. The target biomolecule binds to the antibody under the salt concentration of greater than 150 mM. A device for rapid detection of target biomolecule is also provided.

Abstract: An electrospinning approach is disclosed for generating a dissolvable formulation of a reagent of interest in a nanoscale fiber medium. In one embodiment, the nanoscale fibers can incorporate and stabilize biological agents of interest, such as for storage at room temperature for extended periods. In one implementation, the fibers can be produced in a continuous manner and dissolve rapidly.

Abstract: The invention relates to the treatment of impulsivity-related disorders, such as a substance-related addiction, a behavioural addiction, relapse to a substance-related or behavioural addiction, a habit or impulsive disorder, an emotional unstable personality disorder, intentional self harm, an eating disorder, a dopamine agonist-induced impulse control disorder, or attention deficit hyperactivity disorder (ADHD) by administering a compound of Formula I or a salt thereof to a subject; Formula (I) wherein: E is S or Se; R1 and R2 are optional substituents, and are at each occurrence independently selected from: (1) a halogen, which is preferably selected from F, CI and Br; (2) C1-C4 alkyl, such as C1-C2 alkyl or C1 alkyl, optionally substituted with one or more halogen atoms, each of which is preferably selected from F, CI and Br; and (3) C1-C4 alkoxy, such as C1-C2 alkoxy or C1 alkoxy; optionally substituted with one or more halogen atoms, each of which is preferably selected from F, CI and Br; m is an integer

Abstract: An electrospinning approach is disclosed for generating a dissolvable formulation of a reagent of interest in a nanoscale fiber medium. In one embodiment, the nanoscale fibers can incorporate and stabilize biological agents of interest, such as for storage at room temperature for extended periods. In one implementation, the fibers can be produced in a continuous manner and dissolve rapidly.