Abstract: A cooling drink holder assembly includes a sleeve that has a compartment is integrated inside of the sleeve. The compartment is filled with a cooling gel to cool the beverage container when the beverage container is inserted into said sleeve. A first ring is coupled to the sleeve and a plurality of couplers is each coupled to the first ring. A second ring is included and a plurality of engagements is integrated into the second ring. Each of the couplers on the first ring releasably engages a respective one of the engagements for suspending the sleeve on an arm rest of a chair. In this way the sleeve can store the beverage container when the beverage container is extended through the arm rest of the chair.

Abstract: The invention provides RGS6 antagonists and methods for their use in treating the effects of alcohol consumption.

Abstract: The invention provides RGS6 antagonists and methods for their use in treating the effects of alcohol consumption.

Abstract: A shredder feeder has a first receiving post configured to receive a roll of first material, second and third receiving posts respectively configured to receive first and second rolls of second material, and a pair of guideposts that form an outlet of the shredder feeder therebetween. The respective guideposts are positioned to respectively direct the second material from the first and second rolls toward the first material from the roll of first material so that the first material is interposed between the second material from the first roll of second material and the second material from the second roll of second material when the first material and the second materials from the first and second rolls of second material pass concurrently through the outlet.

Abstract: G-protein coupled receptors are a diverse group that are the target of over 50% of marketed drugs. Activation of these receptors results in the exchange of bound GDP for GTP in the G? subunit of the heterotrimeric G-protein. The G? subunit dissociates from the ?/? subunits and both proceed to affect downstream signaling targets. The signal terminates by the hydrolysis of GTP to GDP and is regulated by Regulators of G-protein Signaling (RGS) proteins that act as GTPase Activating Proteins (GAPs). This makes RGS proteins potentially desirable targets for “tuning” the effects of current therapies as well as developing novel pharmacotherapies. The present invention provides a convenient assay for identifying modulators of RGS proteins that can be adapted for high throughput screening utilizing the colorimetric dye, malachite green, to detect free phosphate in the presence of a test compound.

Abstract: A wheelchair assembly for propelling a wheelchair is provided. The wheelchair has front wheels and rear wheels and a pair of armrests. The wheelchair assembly comprises a first gear wheel secured to each rear wheel and a second gear wheel secured to each armrest. The second gear wheel is positioned directly over the first gear wheel with the second gear wheel being completely encased by a cover. A chain is secured over and between the first and second gear wheels and extends from an opening in the cover. Rotatable handles are attached to each armrest with each having a grasping portion extending Upward. A control linkage extends between the handles and the second gear wheels and mounted to and under the armrest such that rotation of the handles also rotates the second gear wheels with the control linkage being perpendicular to the line formed between the first and second gear wheels.

Abstract: A shredder feeder has a first receiving post configured to receive a roll of first material, second and third receiving posts respectively configured to receive first and second rolls of second material, and a pair of guideposts that form an outlet of the shredder feeder therebetween. The respective guideposts are positioned to respectively direct the second material from the first and second rolls toward the first material from the roll of first material so that the first material is interposed between the second material from the first roll of second material and the second material from the second roll of second material when the first material and the second materials from the first and second rolls of second material pass concurrently through the outlet.

Abstract: A shredder feeder has a first receiving post configured to receive a roll of first material, second and third receiving posts respectively configured to receive first and second rolls of second material, and a pair of guideposts that form an outlet of the shredder feeder therebetween. The respective guideposts are positioned to respectively direct the second material from the first and second rolls toward the first material from the roll of first material so that the first material is interposed between the second material from the first roll of second material and the second material from the second roll of second material when the first material and the second materials from the first and second rolls of second material pass concurrently through the outlet.

Abstract: A shredder feeder has a first receiving post configured to receive a roll of first material, second and third receiving posts respectively configured to receive first and second rolls of second material, and a pair of guideposts that form an outlet of the shredder feeder therebetween. The respective guideposts are positioned to respectively direct the second material from the first and second rolls toward the first material from the roll of first material so that the first material is interposed between the second material from the first roll of second material and the second material from the second roll of second material when the first material and the second materials from the first and second rolls of second material pass concurrently through the outlet.

Abstract: A drink mixing glass which is graduated in a manner uniquely adapted to provide a prescribed volume of a drink mixture while compensating for the presence of water in the mixture attributable to the melting of ice which normally occurs during the drink mixing process. In an exemplary embodiment of the present invention, the graduations included on the mixing glass are adapted to facilitate the pouring of one or more martinis which are each of a volume of approximately seven ounces, inclusive of the presence of water from ice which melts during the drink mixing process.

Abstract: An electronic points system that allows consumers to redeem online those points that were earned offline is described. In one implementation, the offline-online points system is applied to a soft drink bottle caps program. A soft drink company is sponsoring a promotions program where certain bottle caps are worth so many points. A consumer buys a soft drink bottle at a local store. The lucky consumer discovers that he is the beneficiary of a winning bottle cap, and in particular, a bottle cap that is worth N points. Instead of redeeming this winning bottle cap in the traditional way, the consumer logs onto the soft drink company's website and registers his bottle cap code. Thereafter, after registration, the consumer can redeem these points for any merchandise that is available for purchase with these points at any participating company's online store.

Abstract: A memory card comprising a leadframe which includes a main frame defining a peripheral side. Extending toward the peripheral side of the main frame is a first set of leads, while extending away from the peripheral side is a second set of leads which are disposed in juxtaposed relation to respective ones of the leads of the first set. Positioned upon the main frame and electrically connected to the leads of the first and second sets is an electrical subassembly. A package body at least partially encapsulates the leadframe and the electrical subassembly. Portions of the leads of the first and second sets are exposed within the package body and mimic the structural and functional attributes of the fifty pin connector of a conventional CF card.

Abstract: An electronic points system that allows consumers to redeem online those points that were earned offline is described. In one implementation, the offline-online points system is applied to a soft drink bottle caps program. A soft drink company is sponsoring a promotions program where certain bottle caps are worth so many points. A consumer buys a soft drink bottle at a local store. The lucky consumer discovers that he is the beneficiary of a winning bottle cap, and in particular, a bottle cap that is worth N points. Instead of redeeming this winning bottle cap in the traditional way, the consumer logs onto the soft drink company's website and registers his bottle cap code. Thereafter, after registration, the consumer can redeem these points for any merchandise that is available for purchase with these points at any participating company's online store.

Abstract: A package for an integrated circuit device, having a die, a die pad, leads, bond wire, and an encapsulant. The lower surfaces of the die pad and the leads are provided with stepped profiles. Structures extending from lateral sides of the leads are formed to prevent the leads from being pulled horizontally from the package. Encapsulant material fills beneath the recessed, substantially horizontal surfaces of the die pad and the leads, and thereby prevents the die pad and the leads from being pulled vertically from the package body. Other portions of the die pad and the leads are exposed within the package for connecting the package externally.

Abstract: Methods for making packages and leadframes are enclosed. The package includes a die, a die pad, leads, bond wires, and an encapsulant. The lower surfaces of the die pad and leads are provided with a stepped profile by an etching step that etches partially through the thickness of a peripheral portion of the die pad, and also etches partially through the thickness of portions of the leads. Encapsulant material is applied by molding or liquid encapsulation techniques. The encapsulant material fills in beneath the recessed, substantially horizontal surfaces of the die pad and leads formed by the above-described partial etching step, and thereby prevents the die pad and leads from being pulled vertically from the package body. Other surface of the die pad and leads are not covered during the encapsulation step, but rather remain exposed at the lower surface of the package for connecting the package externally.

Abstract: Packages for an integrated circuit device and methods and leadframes for making such packages are disclosed. The package includes a die, a die pad, leads, bond wires, and an encapsulant. The lower surfaces of the die pad and leads are provided with a stepped profile by an etching step that etches partially through the thickness of a peripheral portion of the die pad, and also etches partially through the thickness of portions of the leads. Encapsulant material fills in beneath the recessed, substantially horizontal surfaces of the die pad and leads formed by the above-described etching step, and thereby prevents the die pad and leads from being pulled vertically from the package body. Other portions of the die pad and leads are exposed at the lower surface of the package for connecting the package externally. A metal leadframe for making an encapsulated package includes an outer frame. A die pad is within and connected to the frame.