Abstract: Disclosed are RNA-targeting gene therapy compositions and methods for destroying or blocking toxic target CUG repeat RNA and treating DM1.

Abstract: The system provides a method and apparatus for sorting and displaying information from a BBS. The system provides a method of sorting and presenting messages from a BBS in a way so that the relationship in message threads can be easily observed and related messages can be identified. The system provides a way to view messages and map message threads in two and three dimensions so that the content of messages can be easily reviewed and the relationship between messages can be seen and followed. The system allows a user to enter into a message thread at any point and to then produce a visualization of the related threads and messages associated with each individual message. The system provides interfaces for either a linear or threaded BBS or even a hybrid BBS that is some combination of linear and threaded.

Abstract: The present invention features, inter alia, methods of treating (a) a patient who has been diagnosed with a hematopoietic cancer or (b) a population of patients who have been diagnosed with a hematopoietic cancer with a fixed dose of tamibarotene or a pharmaceutically acceptable salt thereof. The tamibarotene is administered daily, for a prescribed number of days, at 8-14 (e.g., 12 mg/day) regardless of the patient's weight or body surface area, and may be administered as the sole therapeutic agent or in combination with one or more of the additional therapeutic agents described herein.

Abstract: A method and an installation (10) for removing slag allows both slag removal and metal recovery from slag (60?) to be performed quickly and easily. The risk of slag fires is reduced.

Abstract: An orthopedic implant which generally includes a frame structure and a porous structure. Both the frame and porous structure at least partially define at least six surfaces which make a three-dimensional profile of the implant. The porous structure is positioned at least partially within the three-dimensional profile.

Abstract: A method and apparatus for testing and simulating an access control policy are disclosed. Evaluating an access control policy may be performed by utilizing a deny statement that causes the access request to be rejected despite actions indicated in the access request being authorized. Further, an independent simulation environment may be utilized for testing access control policy evaluation.

Abstract: An orthopedic implant which generally includes a frame structure and a porous structure. Both the frame and porous structure at least partially define at least six surfaces which make a three-dimensional profile of the implant. The porous structure is positioned at least partially within the three-dimensional profile.

Abstract: The present invention provides for the use of various compositions, including compounds of Formula (I) or (Ia), or a species thereof, and pharmaceutically acceptable salts, stereoisomers, and isotopic forms thereof in treating a proliferative disease such as cancer in a patient. Administration of a compound or pharmaceutical composition at a dose and conforming to a dosing regimen described herein is expected to inhibit cyclin-dependent kinase 7 (CDK7), and thereby, treat the cancer.

Abstract: The present specification discloses a sight mount used to attach or otherwise secure an optical sight to a firearm as well as methods of modifying a firearm to receive a sight mount disclosed herein.

Abstract: Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including once weekly administration. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including lipodystrophy, dyslipidemia, hyperlipidemia, overweight, obesity, hypothalamic amenorrhea, Alzheimer's disease, leptin deficiency, fatty liver disease or diabetes (including type I and type II). Additional diseases and disorders which can be treated by the compounds and methods described herein include nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD), metabolic syndrome X and Huntington's Disease.

Abstract: A device includes a processor and a memory. The processor effectuates operations including monitoring enterprise network traffic associated with one or more user device (UE). The processor further effectuates operations including comparing the enterprise network traffic to a UE profile associated with each of the one or more UE. The processor further effectuates operations including determining whether the comparison indicates that a predetermined threshold has been exceeded. The processor further effectuates operations including in response to the indication that the predetermined threshold has been exceeded, generating an alert, wherein exceeding the predetermined threshold is indicative of a denial of service attack on an enterprise network or an attempt to remove enterprise data via the one or more UE.

Abstract: A device includes a processor and a memory. The processor effectuates operations including monitoring enterprise network traffic associated with one or more user device (UE). The processor further effectuates operations including comparing the enterprise network traffic to a UE profile associated with each of the one or more UE. The processor further effectuates operations including determining whether the comparison indicates that a predetermined threshold has been exceeded. The processor further effectuates operations including in response to the indication that the predetermined threshold has been exceeded, generating an alert, wherein exceeding the predetermined threshold is indicative of a denial of service attack on an enterprise network or an attempt to remove enterprise data via the one or more UE.

Abstract: Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including once weekly administration. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including lipodystrophy, dyslipidemia, hyperlipidemia, overweight, obesity, hypothalamic amenorrhea, Alzheimer's disease, leptin deficiency, fatty liver disease or diabetes (including type I and type II). Additional diseases and disorders which can be treated by the compounds and methods described herein include nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD), metabolic syndrome X and Huntington's Disease.

Abstract: In one embodiment, a monitoring process modifies a class definition of an object of a monitored process to include an injected field. The monitoring process may then execute a first interception point of the monitored process, and sets, at the first interception point, the injected field to a given value. Upon executing a second interception point of the monitored process, the monitoring process can then read, at the second interception point, the given value in the injected field, and can use the given value at the second interception point for a corresponding correlation operation between the first interception point and the second interception point.

Abstract: The present specification discloses a sight mount used to attach or otherwise secure an optical sight to a firearm as well as methods of modifying a firearm to receive a sight mount disclosed herein.

Abstract: The present specification discloses systems, devices, and methods and uses provide a mounting system which includes rail and a bracket which is selectively secured to the rail. A bracket disclosed herein selectively and/or automatically secures or locks to a rail disclosed herein when positioned on the rail by actuating or triggering a locking mechanism disclosed herein to adopted a locked configuration. In addition, a bracket disclosed herein may be selectively removed from a rail by actuating or triggering a locking mechanism disclosed herein to adopted an unlocked configuration. The disclosed mounting systems, devices, and methods enable a device to be protected from impact and moisture exposure, enable a device to be securely mounted on a base, and/or enable a device to be quickly secured and removed from a base.

Abstract: The present specification discloses systems, devices, and methods and uses provide a mounting system which includes rail and a bracket which is selectively secured to the rail. A bracket disclosed herein selectively and/or automatically secures or locks to a rail disclosed herein when positioned on the rail by actuating or triggering a locking mechanism disclosed herein to adopted a locked configuration. In addition, a bracket disclosed herein may be selectively removed from a rail by actuating or triggering a locking mechanism disclosed herein to adopted an unlocked configuration. The disclosed mounting systems, devices, and methods enable a device to be protected from impact and moisture exposure, enable a device to be securely mounted on a base, and/or enable a device to be quickly secured and removed from a base.

Abstract: A device includes a processor and a memory. The processor effectuates operations including monitoring enterprise network traffic associated with one or more user device (UE). The processor further effectuates operations including comparing the enterprise network traffic to a UE profile associated with each of the one or more UE. The processor further effectuates operations including determining whether the comparison indicates that a predetermined threshold has been exceeded. The processor further effectuates operations including in response to the indication that the predetermined threshold has been exceeded, generating an alert, wherein exceeding the predetermined threshold is indicative of a denial of service attack on an enterprise network or an attempt to remove enterprise data via the one or more UE.

Abstract: An engine including a fuel tank, a carburetor, a speed control lever, and a transport valve. The carburetor includes a throttle valve movable between a first throttle position and a second throttle position. The speed control lever is coupled to the throttle valve and is movable between a first position corresponding to the first throttle position and a second position corresponding to the second throttle position. The transport valve is fluidly coupled between the fuel tank and the carburetor, and includes a valve element moveable between an open valve position allowing fuel flow between the fuel tank and the carburetor, and a closed valve position preventing fuel flow between the fuel tank and the carburetor. Movement of the speed control lever to the second position moves the valve element to the closed valve position to stop fluid flow between the fuel tank and the carburetor.

Abstract: An automatically adjusting auto gauge system comprises a servo motor that provides rotational motion; at least one of a gearbox and linear actuator driven by the one or more servo motors to transfer the rotational motor of the servo motor to linear motion; a group of roll former passes, each including a cam arm, an eccentric cam, a push rod, a top set of roll tooling, a bottom set of roll tooling; a bar operably coupled to the gearbox and the cam arms of the group of roll former passes, the bar driven by the gearbox to impart linear motion to the cam arms, which in turn imparts rotational motion to each eccentric cam, which in turn imparts linear motion, raising or lowering the top set of roll tooling via the push rod, adjusting a gap between the top and bottom sets of roll tooling.