Abstract: Novel cholecystokinin antagonists useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment with use of nicotine, diazepam, alcohol, cocaine, coffee, or opioids. The compounds of the invention are also useful in treating and/or preventing panic. Also disclosed are pharmaceutical compositions and methods of treatment using the antagonists as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds in diagnostic compositions.

Abstract: The present invention is directed to compounds useful for the regulation of cholesterol of Formula I, methods for using them and pharmaceutical compositions thereof, ##STR1## wherein Ar and Ar.sup.1 are each independently selected from unsubstituted or substituted phenyl which substituents are from 1-5 in number and are each independently selected from alkyl, alkoxy, hydroxy, halogen, nitro, trifluoromethyl, COOH, and COOalkyl;X is --NH--, --O--, --S--, or --(CH.sub.2).sub.0-4 --, andR is hydrogen, alkyl, or phenyl.

Abstract: Sulfhydryl containing peptides having the formulaX--A.sub.1 --A.sub.2 --A.sub.3 --A.sub.4 --A.sub.5 --Yinhibit the formation of Lp(a) and thus are useful for treating vascular diseases such as coronary heart disease, myocardial infarction, ischemic stroke, cervical atherosclerosis, cerebral infarction, and restenosis.

Abstract: Pharmaceutically useful compounds having ACAT inhibitory activity of the formula ##STR1## wherein n is 0, 1, or 2, for X other than tetrazole and n=2 then R.sub.2 .dbd.R.sub.3 .dbd.H; R.sub.1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, a heteroaromatic group or a hydrocarbon group having from one to 18 carbon atoms; R.sub.2 and R.sub.3 are hydrogen, halo, hydroxy, alkyl, alkenyl, cycloalkyl, phenyl, substituted phenyl, a heteroaryl, or form a spiroalkyl group; X is a heteromonocyclic 5-membered ring containing one to four heteroatoms, said heteroatoms being nitrogen, oxygen or sulfur, and combination thereof; and R.sub.4 is a hydrocarbon group having from one to 20 carbon atoms are described as well as methods of their manufacture.

Abstract: Plasma levels of Lp(a) are lowered by administering an isothiazolone having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het.

Abstract: Pharmaceutically useful compounds having ACAT inhibitory activity of the formula ##STR1## wherein n is 0, 1, or 2, for X other than tetrazole and n=2 then R.sub.2 .dbd.R.sub.3 .dbd.H; R.sub.1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, a heteroaromatic group or a hydrocarbon group having from one to 18 carbon atoms; R.sub.2 and R.sub.3 are hydrogen, halo, hydroxy, alkyl, alkenyl, cycloalkyl, phenyl, substituted phenyl, a heteroaryl, or form a spiroalkyl group; X is a heteromonocyclic 5-membered ring containing one to four heteroatoms, said heteroatoms being nitrogen, oxygen or sulfur, and combination thereof; and R.sub.4 is a hydrocarbon group having from one to 20 carbon atoms are described as well as methods of their manufacture.

Abstract: Acoustic surveillance of objects and human traffic in a spatial zone of a financial transaction device is used to detect movement within the zone. Several specific types of detected movement defined as abnormal trigger an alert to a remote monitoring station. The alerts are automatically prioritized using rule-based criteria. Enhanced surveillance of the alert site by audio links as well as site alert history information are provided.

Abstract: A dross compression apparatus utilizes a substantially hemispheric shaped receptacle in a dross collector and a complementing compression head which is provided with ribs to form grooves in the material formed between the head and the receptacle. The material formed between the head and the receptacle is substantially a shell comprised of an inner layer of aluminum oxide and outer layers of aluminum. The grooves in the shell enable the material to be more easily processed as the shell is readily broken for crushing. The compression head may be applied more than once to the aluminum dross and may be rotated between applications causing multiple grooves and increased decanting of aluminum. The compression head is provided with a water cooling system which more rapidly cools the aluminum dross and reduces the thermite reaction. The cast steel compression head reduces the air flow to the cooling dross thereby reducing the amount of oxygen available, oxidation and the thermite reaction.

Abstract: A digital data processing system wherein large amounts of digital data are transferred from a source that is coupled to the internal bus of a host CPU to a data receiving device by cooperation between the host CPU and a microprocessor. A multiplexer has one of its input ports coupled to the host bus and its output port coupled by way of what is called a non-real-time bus to one or more devices that may be destinations for large amounts of data and need to be under at least periodic or non-real-time control by the microprocessor. Another bus, called a real-time bus, couples the microprocessor to another input port of the multiplexer. All digital devices that require real-time control by the microprocessor are coupled to the real-time bus. For data transfer, the microprocessor causes the multiplexer to couple the host bus to the non-real-time bus at which time the processor suspends control over the non-real-time devices but maintains control over the devices coupled to the real-time bus.

Abstract: In a nuclear imaging system the digitized x and y coordinates of gamma ray photon emission events address memory locations corresponding to the coordinates. The respective locations are incremented each time they are addressed so at the end of a selected time or event count period the locations contain digital values or raw data corresponding to the intensity of pixels comprising an image frame. The raw data for a frame is coupled to one input of an arithmetic logic unit (ALU) whose output is coupled to a display controller memory. The output of the controller memory is coupled to another ALU input with a feedback bus and is also coupled to a further signal processing circuit which includes means for converting processed data to analog video signals for television display.

Abstract: A refrigerated semitrailer truck for both long and local delivery of frozen foods in a hot environment is disclosed which utilizes both a liquid nitrogen unit and a mechanical refrigeration unit with an automatic control system. The system automatically turns the liquid nitrogen off when the temperature is above 30.degree. F., below -10.degree. F., or when an access door to the insulated truck is open. The liquid nitrogen also operates as a standby unit at all temperatures above -10.degree. F. in the event of a malfunction of the mechanical unit.