Patents by Inventor David S. Newburg

David S. Newburg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of secretor, lewis and sialyl antigen levels in clinical samples as predictors of risk for disease
    Patent number: 9132143
    Abstract: An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
    Type: Grant
    Filed: September 23, 2014
    Date of Patent: September 15, 2015
    Assignees: The General Hospital Corporation, Instituto Nacional de Ciencias Medicas Y Nutricion, Children's Hospital Medical Care
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Inhibiting inflammation with milk oligosaccharides
    Patent number: 9034847
    Abstract: A method of inhibiting inflammation in a subject comprising the administration of milk oligosaccharides or glycoconjugates containing milk oligosaccharides is disclosed.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: May 19, 2015
    Assignees: Children's Hospital Medical Center, The General Hospital Corporation, Instituto Nacional de Ciencias Medicas Y Nutricion
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • USE OF SECRETOR, LEWIS AND SIALYL ANTIGEN LEVELS IN CLINICAL SAMPLES AS PREDICTORS OF RISK FOR DISEASE
    Publication number: 20150079055
    Abstract: An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
    Type: Application
    Filed: September 23, 2014
    Publication date: March 19, 2015
    Applicants: Children's Hospital Medical Center, The General Hospital Corporation, Instituto Nacional de Ciencias Medicas Y Nutricion
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Use of Secretor, Lewis and Sialyl Antigen Levels in Clinical Samples as Predictors of Risk for Disease
    Publication number: 20140140970
    Abstract: An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
    Type: Application
    Filed: October 2, 2013
    Publication date: May 22, 2014
    Applicants: Children's Hospital Medical Center, Instituto Nacional de Ciencias Medicas Y Nutricion, The General Hospital Corporation
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Use of secretor, lewis and sialyl antigen levels in clinical samples as predictors of risk for disease
    Patent number: 8574850
    Abstract: An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: November 5, 2013
    Assignees: Instituto Nacional de Ciencias Medicas Y Nutricion, The General Hospital Corporation, Children's Hospital Medical Center
    Inventors: Ardythe L. Morrow, Guillermo Ruiz-Palacios, David S. Newburg
  • COMPOSITION AND METHODS OF INHIBITING GASTROINTESTINAL PATHOGEN INFECTION
    Publication number: 20130012472
    Abstract: Compositions comprising a milk-derived oligosaccharide such as trifucosyl(1,2-1,2-1,3)-lacto-N-octoase (TFiLNO) and uses thereof for inhibiting invasion of gastrointestinal pathogen into intestinal epithelial cells or for treating an infectious disease (e.g., a disease caused by a gastrointestinal pathogen such as an ETEC) or an inflammatory diseases such as inflammatory bowel disease.
    Type: Application
    Filed: July 5, 2012
    Publication date: January 10, 2013
    Applicant: Boston College
    Inventors: David S. NEWBURG, Yingying HE
  • Use Of Purified 2'-Fucosyllactose, 3-Fucosyllactose and Lactodifucotetraose as Prebiotics
    Publication number: 20120294840
    Abstract: The invention provides compositions and methods for utilizing synthetic human milk oligosaccharides as prebiotics.
    Type: Application
    Filed: May 11, 2012
    Publication date: November 22, 2012
    Inventors: David S. Newburg, John M. McCoy, Massimo Merighi, Matthew Ian Heidtman, Zhuoteng Yu
  • Adiponectin for treatment of various disorders
    Patent number: 8314061
    Abstract: Methods for treating various disorders by orally administering adiponectin or a biologically active fragment thereof are described.
    Type: Grant
    Filed: January 9, 2007
    Date of Patent: November 20, 2012
    Assignees: Children's Hospital Medical Center, University of Massachusetts
    Inventors: Ardythe L. Morrow, Lisa J. Martin, David S. Newburg
  • INHIBITING INFLAMMATION WITH MILK OLIGOSACCHARIDES
    Publication number: 20120202753
    Abstract: A method of inhibiting inflammation in a subject comprising the administration of milk oligosaccharides or glycoconjugates containing milk oligosaccharides is disclosed.
    Type: Application
    Filed: July 2, 2010
    Publication date: August 9, 2012
    Applicants: Instituto Nacional de Ciencias Medicas Y Nutricion, The General Hospital Corporation d/b/a Massachusetts General Hospital, (CCHMC)
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • OLIGOSACCHARIDE COMPOSITIONS AND USE THEREOF IN THE TREATMENT OF INFECTION
    Publication number: 20110207659
    Abstract: Oligosaccharides and oligosaccharides linked to backbones such as proteins, methods for making such oligosaccharides and methods for using them to treat and/or prevent various disorders are described.
    Type: Application
    Filed: February 22, 2011
    Publication date: August 25, 2011
    Applicants: Children's Hospital Medical Center, University of Massachusetts, Instituto Nacional de Ciencias Medicas Y Nutricion
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • USE OF SECRETOR, LEWIS AND SIALYL ANTIGEN LEVELS IN CLINICAL SAMPLES AS PREDICTORS OF RISK FOR DISEASE
    Publication number: 20110177035
    Abstract: An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
    Type: Application
    Filed: January 14, 2011
    Publication date: July 21, 2011
    Inventors: Ardythe L. Morrow, Guillermo M. Ruiz-Palacios, David S. Newburg
  • Oligosaccharide compositions and use thereof in the treatment of infection
    Patent number: 7893041
    Abstract: Oligosaccharides and oligosaccharides linked to backbones such as proteins, methods for making such oligosaccharides and methods for using them to treat and/or prevent various disorders are described.
    Type: Grant
    Filed: December 6, 2004
    Date of Patent: February 22, 2011
    Assignees: Children's Hospital Medical Center, Instituto Nacional De Ciencias Medicas Y Nutricion, University of Massachusetts
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Use of secretor, Lewis and sialyl antigen levels in clinical samples as predictors of risk for disease
    Patent number: 7871785
    Abstract: An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1 , H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: January 18, 2011
    Assignees: Children's Hospital Medical Center, The General Hospital Corporation, Instituto Nacional De Ciencias Medicas y Nutricion
    Inventors: Ardythe L. Morrow, Guillermo M. Ruiz-Palacios, David S. Newburg
  • RAPID LATERAL FLOW GLYCAN-DETECTING DEVICE
    Publication number: 20100279308
    Abstract: A glycan-detecting device containing a sample pad, a membrane in communication with the sample pad, a labeled lectin, an immobilized lectin of the same type, and an immobilized antibody specific to the lectin.
    Type: Application
    Filed: March 8, 2010
    Publication date: November 4, 2010
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo Ruiz-Palacios
  • ADIPONECTIN FOR TREATMENT OF VARIOUS DISORDERS
    Publication number: 20090197806
    Abstract: Methods for treating various disorders by orally administering adiponectin or a biologically active fragment thereof are described.
    Type: Application
    Filed: January 9, 2007
    Publication date: August 6, 2009
    Inventors: Ardythe L. Morrow, Lisa J. Martin, David S. Newburg
  • Use of Secretor, Lewis and Sialyl Antigen Levels in Clinical Samples as Predictors of Risk for Disease
    Publication number: 20090191551
    Abstract: An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
    Type: Application
    Filed: September 5, 2008
    Publication date: July 30, 2009
    Inventors: Ardythe L. Morrow, Guillermo M. Ruiz-Palacios, David S. Newburg
  • Anti-viral composition and kit and use for treating rotavirus infection and diarrhea
    Patent number: 5667797
    Abstract: An anti-diarrheic product comprises a foodstuff and an anti-rotaviral agent such as human defatted fat globule membranes, the human milk macromolecular fraction, skim milk, curd, whey, the milk mucin complex, the 46 Kd app.MW glycoprotein, a polypeptide having an amino acid sequence having the rotavirus binding specificity of the 46 Kd app.MW HMFG glycoprotein or mixtures thereof. An anti-diarrheal kit comprises the anti-rotaviral agent of this invention and instructions for its use, and optionally a foodstuff. A method for inhibiting or countering rotavirus infection in mammalian cells comprises contacting the cells with an anti-rotaviral amount of the agent of this invention.
    Type: Grant
    Filed: April 1, 1996
    Date of Patent: September 16, 1997
    Assignees: Cancer Research Fund of Contra Costa, Senomed, Inc., The Johns Hopkins University School of Medicine
    Inventors: Jerry A. Peterson, David S. Newburg, Robert H. Yolken
  • Anti-diarrheic product and method of treating rotavirus-associated infection
    Patent number: 5505955
    Abstract: An anti-diarrheic product comprises a foodstuff and an anti-rotaviral agent such as human defatted fat globule membranes, the human milk macromolecular fraction, the milk mucin complex, the 46 Kd apparent MW glycoprotein, a polypeptide having the rotavirus-binding specificity of the 46 Kd apparent MW HMFG glycoprotein, mixtures thereof, or mixtures thereof, and optionally skim milk, curd, and/or whey. They product of the invention is provided also as an anti-diarrheal kit, with instructions for its use. The product of the invention has therapeutic and prophylactic application for inhibiting the onset of, or countering, rotavirus infection and/or diarrhea, in a subject, such as for example, infants and children (infantile gasteroenteritis), travellers, and immunodeficient persons, including HIV positive and transplant patients.
    Type: Grant
    Filed: January 23, 1995
    Date of Patent: April 9, 1996
    Assignees: Senomed, Inc., Cancer Research Fund of Contra Costa, The Johns Hopkins Univ. School of Medicine
    Inventors: Jerry A. Peterson, Robert H. Yolken, David S. Newburg