Abstract: Access to content of a secured document can be restricted and systems and methods are provided for obtaining access to the content of a secured document. An electronic device in communication with one or more displays and one or more input devices, receives, from a sender device, a secured document including content. In some examples, in response to receiving the secured document, one or more prompts for one or more respective inputs for accessing the secured document can be displayed. While displaying the one or more prompts one or more respective inputs can be detected. In response to detecting the one or more respective inputs, and in accordance with a determination that the one or more respective inputs satisfy one or more criteria, including a criterion that is satisfied when the one or more respective inputs authenticate a user, obtaining access to the content of the secured document.

Abstract: Some examples of the disclosure are directed to systems and methods for communicating image sensor data to a computer system using one or more media links that allow for image sensor data to be displayed within a three-dimensional environment. In some examples, while presenting a three-dimensional environment that includes an electronic device that is communicatively coupled to an image sensor (e.g., a camera, or some other imaging device) within the three-dimensional environment, the electronic device utilizes a visual code displayed on the electronic device to establish a communication link with the image sensor receiving an indication to display image sensor data from the image sensor that is communicatively coupled to the electronic device. In some examples, while presenting a three-dimensional environment that includes a first pre-defined location within the three-dimensional environment, the electronic device facilitates the user to choose an image sensor to display at the pre-defined location.

Abstract: Systems and methods detailed herein include roof simulation and design, and roof construction based on such simulations and designs. To minimize material and part waste, as well as enable improved construction efficiency by augmenting computer-aided design tools with functionality to arrange roofing accessories for an optimal layout and to arrange staging of the roofing accessories in advance of or during construction for efficient construction, embodiments detailed herein improve computer-aided design tools for roof design, e.g., via a plug-in, extension, add-on or other modification, to enable the computer-aided design tools to create, from a computer-aided design drawing or other image of a roof, a roof layout, a staging layout and/or a bill-of-materials.

Abstract: A method and system for monitoring using a sub-slab sensor assembly for a building having a slab includes a housing, a first air quality sensor coupled to the housing and generating a first air quality signal for air above the slab, a second air quality sensor coupled to the housing and generating a second air quality signal for air below the slab and a pressure sensor coupled to the housing. The pressure sensor generates a pressure signal corresponding to the pressure below the slab. A position sensor generates a position signal corresponding to a location of the sensor. A network interface communicates the first air quality signal, the second air quality signal or the pressure signal, or warning signals corresponding thereto and the position signal to a network.

Abstract: A smart shopping cart identifies items using cameras and sensors. The cart captures images of items within its storage area and applies machine-learning models, such as a barcode detection model, an OCR model, and an image embedding model, to generate identifier predictions. These predictions are processed using an efficient selection algorithm, which may involve majority voting, weighted voting, or linear regression, to select the most accurate identifier. The cart updates its display and user interface with the identified item. The process may be performed primarily by the CPU to enhance computational efficiency, avoiding the latency associated with GPU data transfer. Additional techniques, such as circular buffers and frame skipping, are employed to further optimize resource usage.

Abstract: An electronic device displays a widget dashboard user interface in a three-dimensional environment, displays a representation of a physical tool to as guidance for indicating a location of the physical tool relative to a location associated with video feed, displays suggestions for changing a pose of a camera to a predetermined pose based on image data detected while the camera previously had the predetermined pose, displays a live camera feed and image data and scrubs through the image data in accordance with changes to a pose of the camera relative to a physical object, displays live stereoscopic camera feed with special effects, detects and responds to inputs for virtually annotating portions of objects, and/or displays models of objects and detects and responds to input for rotating and/or viewing the model from different depth positions within the model.

Abstract: An electronic device displays a widget dashboard user interface in a three-dimensional environment, displays a representation of a physical tool to as guidance for indicating a location of the physical tool relative to a location associated with video feed, displays suggestions for changing a pose of a camera to a predetermined pose based on image data detected while the camera previously had the predetermined pose, displays a live camera feed and image data and scrubs through the image data in accordance with changes to a pose of the camera relative to a physical object, displays live stereoscopic camera feed with special effects, detects and responds to inputs for virtually annotating portions of objects, and/or displays models of objects and detects and responds to input for rotating and/or viewing the model from different depth positions within the model.

Abstract: Disclosed here is a method of identifying novel CRISPR effectors, comprising: identifying sequences in a genomic or metagenomic database encoding a CRISPR array; identifying one or more Open Reading Frames (ORFs) in said selected sequences within 10 kb of the CRISPR array; discarding all loci encoding proteins which are assigned to known CRISPR-Cas subtypes and, optionally, all loci encoding a protein of less than 700 amino acids; and identifying putative novel CRISPR effectors, and optionally classifying them based on structure analysis.

Abstract: A method for estimating and reducing high-frequency torsional oscillations (HFTO) during a downhole drilling operation includes estimating an HFTO propensity of an initial BHA configuration using a model that relates the HFTO propensity to at least a rock strength of a subterranean formation, a radius or diameter of the borehole, a drill bit body density, and a drill bit body radius or diameter. The estimated HFTO propensity is compared with an HFTO propensity threshold. The model is used to select a modified drill bit or bottom hole assembly (BHA) configuration that reduces the estimated HFTO propensity to a value below the HFTO propensity threshold. The modified drill bit or BHA configuration has an increased polar moment of inertia as compared to the initial drill bit or BHA configuration.

Abstract: The method may include providing one or more content item recommendations, by opening a content recommendation session for a selected user, retrieving some user data for the selected user from a first storage resource, obtaining content information concerning content available from content sources, using the user data and the content information to generate a content item recommendation for the user and providing the content item recommendation to the user. The user data for the selected user may be stored at contiguous physical locations at the first storage resource.

Abstract: The method may include providing one or more content item recommendations, by opening a content recommendation session for a selected user, retrieving some user data for the selected user from a first storage resource, obtaining content information concerning content available from content sources, using the user data and the content information to generate a content item recommendation for the user and providing the content item recommendation to the user. The user data for the selected user may be stored at contiguous physical locations at the first storage resource.

Abstract: Disclosed are compounds that possess inhibitory activity against FAK. Also disclosed are pharmaceutical compositions containing the compounds and methods of using the compounds to treat cancer mediated by aberrant FAK activity.

Abstract: A bit to detect drill bit metamorphism (DBM) may include a bit head. A bit to detect DBM may include at least one cutting element connected to the bit head. A bit to detect DBM may include a temperature sensor on or in the at least one cutting element. A bit to detect DBM may include an electronics module in communication with the temperature sensor. A bit to detect DBM may include a wiring conduit from the at least one cutting element and through at least a portion of the bit head to the electronics module.

Abstract: This invention, in embodiments, relates to a roofing system that includes a roof deck, a plurality of tapered insulation panels applied onto the roof deck, at least one non-tapered insulation panel applied onto the plurality of tapered insulation panels, and a membrane layer applied onto the at least one non-tapered insulation panel. This invention, in embodiments, further relates to a roof assembly kit that includes a plurality of tapered insulation panels and instructions for installation, as well as a method of installing such a roofing system.

Abstract: Some embodiments relate to a roofing structure. The roofing structure comprises a plurality of roofing membranes positioned on a roofing substrate. Each of the plurality of roofing membranes comprises an edge portion that abuts or overlaps with, or is adjacent to, an edge portion of another roofing membrane, so as to define a plurality of seams between adjacent roofing membranes. The roofing structure further comprises a plurality of standing seam structures positioned over the plurality of seams so as to conceal the plurality of seams.

Abstract: Disclosed are bifunctional compounds (degraders) that target Wee1 tyrosine kinase for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat disease.

Abstract: Systems and methods of injecting hydrate inhibiting chemicals into a gaseous fuel line of a burner are described. One system includes: an oilfield burner; a gaseous fuel line connected to the oilfield burner; a storage tank containing hydrate-inhibiting chemicals; a hydrate-inhibiting chemical supply line connected between the storage tank and the gaseous fuel line; and a control valve connected to control flow in the hydrate-inhibiting chemical supply line in response to the operation of the oilfield burner. A kit may be provided with at least the hydrate-inhibiting chemical supply line and control valve.

Abstract: Some examples of the disclosure are directed to systems and methods for communicating image sensor data to a computer system using one or more media links that allow for image sensor data to be displayed within a three-dimensional environment. In some examples, while presenting a three-dimensional environment that includes an electronic device that is communicatively coupled to an image sensor (e.g., a camera, or some other imaging device) within the three-dimensional environment, the electronic device utilizes a visual code displayed on the electronic device to establish a communication link with the image sensor receiving an indication to display image sensor data from the image sensor that is communicatively coupled to the electronic device. In some examples, while presenting a three-dimensional environment that includes a first pre-defined location within the three-dimensional environment, the electronic device facilitates the user to choose an image sensor to display at the pre-defined location.

Abstract: This invention, in embodiments, relates to a roofing system that includes a roof deck, a plurality of tapered insulation panels applied onto the roof deck, at least one non-tapered insulation panel applied onto the plurality of tapered insulation panels, and a membrane layer applied onto the at least one non-tapered insulation panel. This invention, in embodiments, further relates to a roof assembly kit that includes a plurality of tapered insulation panels and instructions for installation, as well as a method of installing such a roofing system.

Abstract: A system for monitoring pressure within a volume defined by a wall has a housing and a manometer coupled to the housing having fluid therein. The manometer is coupled to the volume and has a fluid level corresponding to a pressure within the volume. A pressure sensor is coupled to the housing and is coupled to volume. The pressure sensor generates a pressure signal corresponding to the pressure within the volume. A controller is coupled to the pressure sensor and is programmed to compare the pressure signal to a threshold and programmed to generate an indicator based on comparing.