Abstract: The disclosure herein relates to the development and production of novel antibodies and antigen binding fragments thereof that bind TL1A and that are useful in the treatment, prevention and diagnosis of a disease, disorder or inflammation including, for example, autoimmune diseases including rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, systemic lupus erythematosus, asthma, ulcerative colitis, Crohn's disease, psoriasis, primary biliary cirrhosis, primary biliary cholangitis, ankylosing spondylitis, and fibrosis including intestinal fibrosis, pulmonary fibrosis, and liver fibrosis. Some of the elements of final antibody structure being designed de novo by a computer system and its data training set without reference to a specific reference molecule.

Abstract: The disclosure herein relates to the development and production of novel antibodies and antigen binding fragments thereof that bind TL1A and that are useful in the treatment, prevention and diagnosis of a disease, disorder or inflammation including, for example, autoimmune diseases including rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, systemic lupus erythematosus, asthma, ulcerative colitis, Crohn's disease, psoriasis, primary biliary cirrhosis, primary biliary cholangitis, ankylosing spondylitis, and fibrosis including intestinal fibrosis, pulmonary fibrosis, and liver fibrosis. Some of the elements of final antibody structure being designed de novo by a computer system and its data training set without reference to a specific reference molecule.

Abstract: The present invention pertains to the field of imparting or increasing resistance against fungal pathogens, in particular soy-beanrust, in plants, plant parts, and/or plant cells. This is achieved by increasing the content of scopoletin, scopolin and/or, most preferably, scoparone (6,7-di-methoxycoumarin) in a plant, plant part and/or plant cell. This can in particular be achieved by establishing and/or increasing the expression of an OMT3 enzyme and an F6H1 protein in the respective plant, plant part and/or plant cell; a further way would be to apply a formulation or solution containing scopoletin and/or, most preferably, scoparone to the plant, plant part and/or plant cell. The invention correspondingly also provides proteins, enzymes, expression constructs, plants, plant parts and/or plant cells. In this respect the invention also provides variants of the OMT3 enzyme.

Abstract: The present disclosure provides methods, compounds and compositions that are relevant to DNA-repair and DNA-repair proteins such as tyrosyl-DNA phosphodiesterase 1 (TDP1) and type I topoisomerase (TOP1).

Abstract: The present invention relates to genes and materials for improving plant health, preferably against phytopathogenic microorganisms, and/or against coumarin-induced adverse effects on plant health. Furthermore, the invention pertains to methods and uses of such genes and mate-rials for creating correspondingly beneficial plant cells, plant parts and whole plants, and also relates to products obtained from such plants or plant parts.

Abstract: The present invention is directed to a modified clostridial neurotoxin comprising a botulinum neurotoxin A (BoNT/A) Hcc domain, wherein the Hcc domain comprises a modification of methionine 1144 (MI 144), and wherein the modification increases oxidative resistance of the modified clostridial neurotoxin when compared to an otherwise identical clostridial neurotoxin lacking the modification. Also provided are (inter alia) corresponding methods for producing the same, methods for selecting oxidation resistant clostridial neurotoxins, nucleic acids encoding the same, and therapeutic uses of said modified clostridial neurotoxins.

Abstract: The technology relates in part to binding molecules that specifically bind to a polypeptide that is the Isoform 2 of mesotheiin, or that specifically bind to an antigenic determinant (epitope) of the isoform 2 of mesotheiin, or that specifically bind to polypeptides containing an antigenic determinant (epitope) of the isoform 2 of mesotheiin, chimeric PD1 receptors that bind to PD ligands such as PDLs, to polynucleotides including vectors that encode such binding molecules, to ceils presenting such binding molecules and to methods of making such cells, to humanized forms of the binding molecules, and to methods of using such binding molecules, such as for treating cancers (e.g., ovarian cancers and mesotheliomas), including cancers in which the Isoform 2 of mesotheiin is specifically expressed and/or upregulated relative to normal tissues.

Abstract: The technology relates in part to binding molecules that specifically bind to a polypeptide that is the Isoform 2 of mesothelin, or that specifically bind to an antigenic determinant (epitope) of the isoform 2 of mesothelin, or that specifically bind to polypeptides containing an antigenic determinant (epitope) of the isoform 2 of mesothelin, chimeric PD1 receptors that bind to PD ligands such as PDLs, to polynucleotides including vectors that encode such binding molecules, to ceils presenting such binding molecules and to methods of making such cells, to humanized forms of the binding molecules, and to methods of using such binding molecules, such as for treating cancers (e.g., ovarian cancers and mesotheliomas), including cancers in which the Isoform 2 of mesothelin is specifically expressed and/or upregulated relative to normal tissues.

Abstract: A system includes a gas turbine system including a compressor, a combustor, a turbine, and an exhaust section. The system also includes multiple sensors coupled to components of the gas turbine system. The system further includes a controller communicatively coupled to the gas turbine system and the multiple sensors and configured to control operations of the gas turbine system, wherein the controller is configured to calculate a surrogate value for turbine exit Mach number based on the feedback from the multiple sensors and to utilize the surrogate value to derive a control action for the gas turbine system.

Abstract: Systems, methods, and apparatuses are described for determining compliance with a plurality of restrictions associated with one or more devices in an organization. First text indicating restrictions may be received, and second text indicating a current configuration of one or more devices may be received. Both sets of text may be processed by, e.g., removing a portion of the text based on a predetermined list of terms and simplifying the text using a lemmatization algorithm. A first vector and second vector may be generated based on the processed sets of text, and each vector may be weighted based on an inverse frequency of words in their respective text. Each vector may be normalized based on semantic analysis. The two vectors may be compared. Based on the comparison, third text corresponding to a portion of the second vector may be generated and transmitted to a third computing device.

Abstract: A machine for comminuting laminated glass members, such as automotive windshields and architectural glass, comprises infeed rollers feeding the member over a breaker bar, where an impactor assembly breaks the glass into small fragments and the plastic disposed between layers of the glass member into larger fragments, so that a size-based separation may be employed. The speed of the infeed rollers is controlled responsive to the thickness of the glass member.

Abstract: A vascular occlusion catheter for at least partial occlusion of a target vessel includes proximal and distal shafts, with an occlusion balloon connected therebetween. The proximal shaft has a proximal internal lumen, in fluid communication with the occlusion balloon. The distal shaft has a distal internal lumen. A hypotube having an internal lumen extends through the proximal lumen and the occlusion balloon and into communication with the distal lumen. The catheter includes at least one of (i) a distal sensor positioned within the distal lumen and facing an opening formed in the distal shaft, or (ii) the proximal shaft further includes a sensor lumen, and a proximal sensor is positioned within the sensor lumen and facing an opening formed in the proximal shaft. A display hub is mounted to the proximal shaft, and is electrically connected with the at least one of the distal sensor or the proximal sensor.

Abstract: A handgun simulation assembly that mates a virtual reality (VR) controller having a trigger finger button with a handgun grip and trigger in order to better simulate the feel of a typical handgun for a VR environment. The handgun simulation assembly includes a handgun body with a magazine release subassembly for transferring the depression of a magazine release button on the handgun grip to a translational action to depress the side button of the VR controller. Depressing the magazine release button can also cause a magazine weight suspended inside the handgun grip to at least partially drop downward in the handgun grip to simulate an actual magazine drop. By mating commercially available VR controllers with realistic handgun grips and triggers, users of the handgun simulation assembly are provided with a more realistic handgun experience when in a VR environment.

Abstract: A handgun simulation assembly that mates a virtual reality (VR) controller having a trigger finger button with a handgun grip and trigger in order to better simulate the feel of a typical handgun for a VR environment. The handgun simulation assembly includes a handgun body with a mating cradle that is designed to receive and hold a VR controller. The mating cradle has an engaged position where the VR controller is affixed to the handgun body and an unengaged position where the VR controller is released. When the mating cradle is in the engaged position, the VR controller can be oriented such that the trigger finger button is positioned downward, and the control pad is positioned rearward and facing the user. The mating cradle allows various subassemblies to access the buttons on the VR controller to provide a more realistic handgun experience when in a VR environment.

Abstract: A handgun simulation assembly that mates a virtual reality (VR) controller having a trigger finger button with a handgun grip and trigger in order to better simulate the feel of a typical handgun for a VR environment. The handgun simulation assembly includes a handgun body with a trigger translation subassembly for translating the horizontal motion of the trigger blade pull to a vertical translational action to depress the trigger finger button of the VR controller. A tensioning mechanism is incorporated in the trigger translation subassembly to simulate the feel of trigger resistance that is found in a physical handgun. By mating commercially available VR controllers with realistic handgun grips and triggers, users of the handgun simulation assembly are provided with a more realistic handgun experience when in a VR environment.

Abstract: Systems, methods, and apparatuses are described for determining compliance with a plurality of restrictions associated with one or more devices in an organization. First text indicating restrictions may be received, and second text indicating a current configuration of one or more devices may be received. Both sets of text may be processed by, e.g., removing a portion of the text based on a predetermined list of terms and simplifying the text using a lemmatization algorithm. A first vector and second vector may be generated based on the processed sets of text, and each vector may be weighted based on an inverse frequency of words in their respective text. Each vector may be normalized based on semantic analysis. The two vectors may be compared. Based on the comparison, third text corresponding to a portion of the second vector may be generated and transmitted to a third computing device.

Abstract: An occlusion catheter system includes a proximal hub having an inflation connection port and an inflation pathway. An inflation catheter member is connected to the proximal hub and has an inflation lumen. A stiffener member defines a longitudinal axis. The proximal end of the stiffener member is connected to the proximal hub. The stiffener member extends through a portion of the inflation lumen. An occlusion balloon has a proximal balloon end and a distal balloon end. A distal catheter member is positioned substantially on the longitudinal axis and is connected to the distal end of the stiffener member. An atraumatic tip is positioned on a distal end of the distal catheter member. The atraumatic tip has a substantially circular profile in a relaxed configuration. A pressure sensor is connected to the occlusion catheter system distally relative to the occlusion balloon and is connected to a processor by electrical wiring.

Abstract: Systems, methods, and apparatuses are described for determining compliance with a plurality of restrictions associated with one or more devices in an organization. First text indicating restrictions may be received, and second text indicating a current configuration of one or more devices may be received. Both sets of text may be processed by, e.g., removing a portion of the text based on a predetermined list of terms and simplifying the text using a lemmatization algorithm. A first vector and second vector may be generated based on the processed sets of text, and each vector may be weighted based on an inverse frequency of words in their respective text. Each vector may be normalized based on semantic analysis. The two vectors may be compared. Based on the comparison, third text corresponding to a portion of the second vector may be generated and transmitted to a third computing device.

Abstract: An anchoring device for use in retaining a railway rail fastening clip having first and second leg portions and a rail-bearing portion therebetween. The anchoring device includes a base member, an opening in the base member configured to receive a fastening component for fastening the anchoring device to an underlying foundation, and first and second clip-retaining sides extending from said base member with the first clip-retaining side being spaced apart from the second clip-retaining side so as to define a space therebetween for receiving the rail-bearing portion of the clip. Each clip-retaining side comprising upper and lower clip contact walls defining a passageway for receiving one of the leg portions, wherein the leg portions contact the clip contact walls of the respective clip-retaining sides as the clip moves from a wedged position towards an engaged position where the rail-bearing portion of the clip bears on the rail.