Abstract: Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40 activity. Also provided are nucleic acid compositions comprising sequences coding for chimeric proteins that include an inducible CD40 peptide and an inducible pattern recognition receptor adapter or adapter fragment.

Abstract: A method includes instructing a gas control valve of a gas turbine system to open, thereby prefilling a fuel circuit of the gas turbine system with fuel, wherein the fuel circuit is initially filled with purge gas. The method also includes generating a model of the gas turbine system that simulates a modeled output of the gas turbine system based on a model input corresponding to a measured input to the gas turbine system. The method further includes receiving a measured output of the gas turbine system. The method also includes adjusting the model input such that the modeled output more closely matches the measured output when the measured output is not approximately equal to the modeled output. The method further includes instructing the gas control valve to open to prefill the fuel circuit during a subsequent prefill operation based at least in part on adjusting the model input.

Abstract: A method includes instructing a gas control valve to open to a first position, thereby sending fuel to a respective fuel circuit at a first flow rate, based on a first relationship between flow rate and a first set of operating parameters. The method also includes instructing the gas control valve to open to a second position, thereby adjusting the first flow rate of the fuel to the respective fuel circuit to a second flow rate, based on a set of output parameters. The method further includes determining a second relationship between adjusting the first flow rate and a second set of operating parameters. The method also includes instructing the gas control valve to open a third position, thereby sending the fuel to the respective fuel circuit at a third flow rate, based on the first relationship and the second relationship.

Abstract: A method includes instructing a purge valve of a gas turbine system to open, thereby purging a fuel circuit by filling the fuel circuit with purge gas, wherein the fuel circuit initially contains fuel. The method also includes generating a model of the gas turbine system that simulates a modeled output based on a model input corresponding to a measured input. The method further includes receiving a measured output of the gas turbine system. The method also includes adjusting the model input such that the modeled output more closely matches the measured output when the measured output is not approximately equal to the modeled output.

Abstract: An adapter for fitting to a drug delivery device, the adapter including: an outlet for communication with the mouth of a patient; an air flow path through the adapter along which air is drawn to the outlet by inhalation by the patient; an inlet adapted for connection to a mouthpiece of the drug delivery device; and an air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient. A drug delivery device having, in its body, an air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient.

Abstract: The technology relates generally to the field of immunology and relates in part to compositions and methods for controlling the proliferation of T cells, for example, therapeutic T cells. The methods further relate to compositions and methods for inducing an immune response in a subject.

Abstract: The technology relates in part to compositions comprising modified Caspase-9 polypeptides, compositions comprising nucleic acids coding for modified Caspase-9 polypeptides, chimeric modified Caspase-9 polypeptides, and methods of use thereof, including methods for cell therapy. Methods for cell therapy include modifying transfused cells to express an inducible modified Caspase-9 protein, with reduced basal activity in the absence of the inducer.

Abstract: A heavy-duty tire is described herein. The heavy duty tire includes a carcass, a tread located radially outward of the carcass, and a tread having a plurality of lugs. The lugs extend radially outward from an inner tread and are located between the first and second lateral tread edges. The tread further includes a first row of lugs extending from the tread lateral edge axially inwards toward the centerplane, and a second row of lugs extending from the opposite tread lateral edge and axially inwards toward the centerplane. The lugs of the first and second rows are separated by a plurality of shoulder grooves, wherein the first row of lugs are aligned with the second row of lugs, a center row of lugs located between a first and second offset lug, wherein all of the lugs in each row are aligned circumferentially.

Abstract: This invention relates to a rotary vane device and more particularly but not exclusively, to a rotary vane engine or pump. The invention also relates to a rotor assembly suitable for use in such a rotary vane device. The rotor assembly includes a cylindrical rotor body including a plurality of longitudinally extending receiving slots, the cylindrical rotor body further including a hollow core located radially inwardly of the receiving slots; and a plurality of vanes, with each vane being slidingly locatable inside a receiving slot. The rotor assembly is characterized in that the vanes are biased away from the cylindrical rotor by way of a magnet arrangement including vane magnets located in the vanes, and opposing rotor magnets located inside the hollow core of the rotor body.

Abstract: A videofluoroscopy device with a video and data management system. More particularly, it relates to a videofluoroscopy accessory device adapted to securely and removably attach to an X-ray head of a fluoroscopy system or device, and systems to manage the operation of the videofluoroscopy accessory device.

Abstract: The technology relates in part to methods for inducing partial apoptosis of cells that express an inducible caspase polypeptide. The technology further relates in part to methods for inducing partial apoptosis of cells that express an inducible modified caspase polypeptide, having a modified dose response curve to the multimeric ligand inducer. The technology also relates in part to methods for cell therapy using cells that express the inducible caspase polypeptide or the inducible modified caspase polypeptide, where the proportion of caspase polypeptide-expressing cells eliminated by apoptosis is related to the administered amount of the multimeric ligand inducer.

Abstract: A system includes a power generation system and a controller that controls the power generation system. The controller includes a processor that generates a model of the power generation system that estimates a value for a first parameter of the power generation system. The processor also receives a measured value of the first parameter. The processor further adjusts a correction factor of the model such that the estimated value of the first parameter output by the model is approximately equal to the measured value of the first parameter. The processor also generates a transfer function that represents the correction factor as a function of a second parameter of the power generation system. The processor further displays the transfer function along with one or more previously generated transfer functions to quantify degradation of the power generation system.

Abstract: A system includes a power generation system and a controller that controls the power generation system. The controller includes a processor that generates a model of the power generation system that estimates a value for a first parameter of the power generation system. The processor also receives a measured value of the first parameter. The processor further adjusts a correction factor of the model such that the estimated value of the first parameter output by the model is approximately equal to the measured value of the first parameter. The processor also generates a transfer function that represents the correction factor as a function of a second parameter of the power generation system. The processor further displays the transfer function along with one or more previously generated transfer functions to quantify degradation of the power generation system.

Abstract: Various embodiments include a system having: at least one computing device configured to tune a set of gas turbines (GTs) by performing actions including: commanding each GT in the set of GTs to a base load level, based upon a measured ambient condition for each GT; commanding each GT in the set of GTs to adjust a respective power output to match a nominal power output value, and subsequently measuring an actual emissions value for each GT; adjusting an operating condition of each GT in the set of GTs based upon a difference between the respective measured actual emissions value and a nominal emissions value at the ambient condition; and setting a target operating condition for each GT to match the adjusted operating condition after the adjusting of the operating condition.

Abstract: A method of augmenting power output by a gas turbine engine includes channeling fuel into the gas turbine engine at a predetermined fuel flow rate to generate a first power output. Steam is then injected into the gas turbine engine at a first steam flow rate, and a firing temperature bias is determined based at least on the first steam flow rate. The predetermined fuel flow rate is then adjusted based on the determined firing temperature bias such that the gas turbine engine generates a second power output greater than the first power output.

Abstract: The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions that are based on dendritic cells modified to express an inducible form of a co-stimulatory polypeptide.

Abstract: Various embodiments include a system having: at least one computing device configured to tune a set of gas turbines (GTs) by performing actions including: commanding each GT in the set of GTs to a base load level, based upon a measured ambient condition for each GT; commanding each GT in the set of GTs to adjust a respective power output to match a nominal power output value, and subsequently measuring an actual emissions value for each GT; adjusting an operating condition of each GT in the set of GTs based upon a difference between the respective measured actual emissions value and a nominal emissions value at the ambient condition; and setting a target operating condition for each GT to match the adjusted operating condition after the adjusting of the operating condition.

Abstract: A wireless apparatus may receive scheduling definitions from a networking device. The wireless apparatus may determine, from the scheduling definitions, downlink transmission times and to start a timer at one of the determined downlink transmission times. The wireless apparatus may discontinue reception at expiration of the timer. The wireless apparatus may also, in response to reception of a downlink transmission, transmit an acknowledgement and to discontinue reception before the timer has expired.

Abstract: A method and system for transferring between combustion modes in a gas turbine engine is provided. A processor generates data representative of an initial set of splits for providing at least one of fuel and air to at least one combustor in the gas turbine engine. A gas turbine engine model module generates data representative of at least one engine operating condition. A first split calculation module generates data representative of at least one set of active control splits to control the engine in a first combustion mode, using as an input the initial split data. A second split calculation module generates data representative of at least one set of passive control splits to control the engine in at least a second combustion mode. Transfer between combustion modes may be accomplished via use of at least one of the active control splits and the passive control splits.