Abstract: In one aspect, the present disclosure provides a formulation comprising a hyaluronidase enzyme and a therapeutically effective amount of an active ingredient. In another aspect, the present disclosure provides a method of administering a high volume of the formulation in a single administration to treat a disease or disorder in a subject.

Abstract: In one aspect, the present disclosure provides a formulation comprising a hyaluronidase enzyme and a therapeutically effective amount of an active ingredient. In another aspect, the present disclosure provides a method of administering a high volume of the formulation in a single administration to treat a disease or disorder in a subject.

Abstract: Embodiments of the present disclosure provide systems, methods, and non-transitory computer storage media for identifying malicious enterprise behaviors within a large enterprise. At a high level, embodiments of the present disclosure identify sub-graphs of behaviors within an enterprise based on probabilistic and deterministic methods. For example, starting with the node or edge having the highest risk score, embodiments of the present disclosure iteratively crawl a list of neighbors associated with the nodes or edges to identify subsets of behaviors within an enterprise that indicate potentially malicious activity based on the risk scores of each connected node and edge. In another example, embodiments select a target node and traverse the connected nodes via edges until a root-cause condition is met. Based on the traversal, a sub-graph is identified indicating a malicious execution path of traversed nodes with associated insights indicating the meaning or activity of the node.

Abstract: The present disclosure is directed to polypeptides capable of cleaving gluten proteins, e.g., gliadins, nucleic acid molecules encoding the same, pharmaceutical compositions comprising the same, and methods of use thereof for treating celiac sprue disease and/or non-celiac gluten sensitivity (NCGS).

Abstract: Devices, systems, and methods are provided for indoor localization. A self-driving vehicle may detect a first fiducial marker located at a first location within a building, wherein the first fiducial marker comprises first fiducial marker information associated with the first location. The self-driving vehicle may retrieve the first fiducial marker information from the first fiducial marker. The self-driving vehicle may generate localization information of the self-driving vehicle based on the first fiducial marker information. The self-driving vehicle may utilize the localization information to transition to a second location within the building, wherein the second location comprises a second fiducial marker.

Abstract: Disclosed herein are antibodies, pharmaceutical formulations for treating or preventing Alzheimer's disease, methods of treating or preventing Alzheimer's disease, and kits comprising pharmaceutical formulations for treating or preventing Alzheimer's Disease comprising an anti-A? protofibril antibody and anti-tau antibody.

Abstract: A method for demodulating an RF signal to polar in-phase and quadrature (IQ) components that includes converting an RF signal with an analog-to-digital converter and calculating the polar in-phase and quadrature (IQ) components of the RF signal as an IQ phasor phase angle and an IQ amplitude using a digital processor. The analog-to-digital converter uses a sampling rate, where, when the sampling rate used has sampling rates other than 3 times an RF carrier frequency of the RF signal, a digital logic circuit splines data to the sampling rate of 3 times the RF carrier frequency of the RF signal. The digital processor calculates the polar in-phase and quadrature (IQ) components of the RF signal as an IQ phasor phase angle and an IQ amplitude using addition, subtraction, multiplication, division, and absolute value.

Abstract: An on-demand glasswasher comprises a wash tank; a fluid level sensor assembly that includes an ultrasonic sensor assembly positioned within the wash tank; at least one microprocessor connected to the ultrasonic sensor assembly; and a memory device coupled to the at least one microprocessor, the memory device storing processor-executable instructions which, when executed by the at least one microprocessor, configure the microprocessor to receive, from the ultrasonic sensor assembly, ultrasonic signals; and analyze the ultrasonic signals to determine a level of fluid in the wash tank.

Abstract: A method for demodulating an RF signal to polar in-phase and quadrature (IQ) components that includes converting an RF signal with an analog-to-digital converter and calculating the polar in-phase and quadrature (IQ) components of the RF signal as an IQ phasor phase angle and an IQ amplitude using a digital processor. The analog-to-digital converter uses a sampling rate, where, when the sampling rate used has sampling rates other than 3 times an RF carrier frequency of the RF signal, a digital logic circuit splines data to the sampling rate of 3 times the RF carrier frequency of the RF signal. The digital processor calculates the polar in-phase and quadrature (IQ) components of the RF signal as an IQ phasor phase angle and an IQ amplitude using addition, subtraction, multiplication, division, and absolute value.

Abstract: Closed-loop geothermal systems operate by extracting heat from the reservoir and transporting it to the surface. To maintain high enough temperatures at the surface it is necessary to have significantly higher relative reservoir temperatures. While the thermal energy of the sub surface is abundant, reservoir rock is a natural insulator with a thermal conductivity of less than 20 BTU*in2/ft*hr*F. This low thermal conductivity prevents rapid regeneration of the reservoir temperature around the wellbore reducing the relative temperature below what is needed for electrical production. The Thermal Soak method uses time and multiple closed-loop wells to overcome the low thermal conductivity allowing for continuous production of heated fluid at surface.

Abstract: Example phototherapy systems, methods of using a phototherapy system, and methods of manufacturing a phototherapy system are described. An example phototherapy system includes a handle and a phototherapy light source. The phototherapy light source is attached to the handle, adapted to emit a light in a therapeutic wavelength, and includes a plasma lamp. The plasma lamp can be disposed between sheets of transparent material, including quartz. The phototherapy light source can be adapted to emit a light in a UVB wavelength between about 300 nanometers and about 320 nanometers and can have an output of between about 15 mW/cm2 and about 21 mW/cm2.

Abstract: The present disclosure provides a multi-layer body surface electrode. The multi-layer body surface electrode includes a first layer having a first diameter, a second layer having a second diameter, and a third layer having a third diameter. The second layer is positioned between the first layer and the third layer, and the second diameter is smaller than the first diameter and the third diameter.

Abstract: A push button safety injector includes a housing having a proximal end, a distal end spaced from the proximal end, and a longitudinal axis. An injection ram is positioned along the longitudinal axis and configured to actuate a fluid chamber. The injection ram is biased toward the distal end in an initial position. A sliding member is configured to retain the injection ram in the initial position. A safety member confines radial movement of the sliding member in the initial position and allows radial movement of the sliding member in an armed position. A button is moveable between an initial extended position and a depressed position. The button is engagable with the sliding member and configured to move the sliding member radially in the armed position. The sliding member releases the injection ram when the button is in the depressed position.

Abstract: A chirped radio frequency signal is transmitted across an area of a potential threat. A reflected radio frequency return signal from an open barrel of a weapon at a location within the area of the potential threat is received at an incident angle through an aperture. An antenna at a position in an antenna array detects the reflected radio frequency return signal received at the incident angle through the aperture. The position of the antenna within the antenna array corresponds to a direction from which the reflected radio frequency return signal originates.

Abstract: A chirped radio frequency signal is transmitted across an area of a potential threat. A reflected radio frequency return signal from an open barrel of a weapon at a location within the area of the potential threat is received at an incident angle through an aperture. An antenna at a position in an antenna array detects the reflected radio frequency return signal received at the incident angle through the aperture. The position of the antenna within the antenna array corresponds to a direction from which the reflected radio frequency return signal originates.

Abstract: This invention is new to the field in two ways: [1] it sends audio/video signals wirelessly between tablet computing devices and smartphones to projection devices instead of using attached cables, and [2] it does not require an app, a second computing device, a driver, a download, or a “jailbreak” of the computing device to function properly.

Abstract: A training device for training a user on the operation of an auto-injector that dispenses a medicament. A needle guard is slidable from a first extended position relative to a housing prior to operation of the training device, to a retracted position during operation of the training device, and to a second extended position after operation of the training device. An actuation assembly controls the movement of the needle guard from the retracted position to the second extended position. A lock locks the needle guard in the second extended position. A safety is proximate a proximal end of the housing and prevents movement of the needle guard from the first extended position to the retracted position in a storage position. The needle guard is moveable into the retracted position with the safety in an armed position. The safety resets the lock upon returning the safety to the storage position.

Abstract: A heater comprising: an outer tube having a first thermal expansion coefficient; an inner tube having a second thermal expansion coefficient that is less than the first thermal expansion coefficient, wherein the inner tube is disposed concentrically with the outer tube such that there is a space between the inner and outer tubes; a conductive powder disposed within the space between the inner and outer tubes; and two electrodes in electrical contact with the conductive powder such that when a potential is introduced between the electrodes, the conductive powder functions as a resistive heater whose resistance changes with temperature based on different degrees of thermal expansion of the inner and outer tubes.

Abstract: A method and system for a protection mechanism associated with a server to prevent execution of malicious code. The method includes identifying permissions of a set of files by the protection mechanism where the set of files are related to a request sent to the server, determining whether the request references any file in the set of files with inappropriate permissions, and blocking the request from being executed by a processing engine in response to determining the request is associated with at least one file with improper permissions.

Abstract: This invention is new to the field in two ways: [1] it sends audio/video signals wirelessly between tablet computing devices and smartphones to projection devices instead of using attached cables, and [2] it does not require an app, a second computing device, a driver, a download, or a “jailbreak” of the computing device to function properly.