Abstract: A series of 2-imino-6-methylhexahydropyrimidin-4-one derivatives, and analogues thereof, substituted in the 6-position by an arylcarbonylaminophenyl or heteroarylcarbonylaminophenyl moiety, being potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood, are beneficial as pharmaceutical agents, especially in the treatment of malaria.

Abstract: Nuclear magnetic resonance (NMR) relaxation and/or diffusion measurements are used to deduce fluid compositional information such as a chain-length distribution, which may then be used to predict the true boiling points (TBP) of a sample of a complex hydrocarbon fluid mixture, such as a crude oil. The NMR measurements may be considered a fast and portable proxy measurement in estimating fluid TBP distributions in lieu of distillation methods, or the simulated distillation by gas chromatography.

Abstract: A series of substituted fused bicyclic imidazole derivatives of formula (I), including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments including inflammatory and autoimmune disorders, wherein i. a. A represents C—R1 or N; B represents C—R2 or N; D represents C—R3 or N; E represents C—R4 or N; Z represents —CH(R5)N(H)CH2R6, —CH(R5)N(H)S(O)2R6, —C(?CR5aR5b)N(H)C(O)R6, —CH(R5)R7, —CH(R5)N(H)R7 or —CH(R5)C(O)N(H)R7; R0 represents hydrogen or C1-6 alkyl.

Abstract: An integrated order management engine is disclosed that reduces the latency associated with managing multiple orders to buy or sell a plurality of financial instruments. Also disclosed is an integrated trading platform that provides low latency communications between various platform components. Such an integrated trading platform may include a trading strategy offload engine.

Abstract: A series of substituted fused bicyclic imidazole derivatives, including imidazo[1,2-a]pyridine derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Abstract: A device may include a capacitance sensor; an overlay positioned near the capacitance sensor, the overlay including a touch surface opposite to an underside of the overlay, where the underside is positioned near the capacitance sensor; a controller; memory in communication with the controller and including programmed instructions that, when executed, cause the controller to detect a proximity value of an object with a capacitance sensor, where a touch surface is located between the capacitance sensor and the object; determine a planar radial distance of the object away from a predetermined location on the touch surface; and change the proximity value based, at least in part, on the planar radial distance.

Abstract: Disclosed herein are methods and systems for the removal of volatile organic compounds, carbon monoxide and nitrogen oxides from off-gas, which systems comprise a source of ammonia, means for introducing ammonia into a catalytic article having an SCR functionality; a catalytic article having both an oxidation and an SCR functionality, the catalytic article comprising a catalyst substrate and a catalyst composition comprising at least one platinum group metal and/or at least one platinum group metal oxide, at least one oxide of titanium and at least one oxide of vanadium, wherein the washcoat is located in and/or on the walls of the catalyst substrate: means for measuring the amount of NOx and/or the ammonia slip between the outlet end of the catalytic article and the stack or at the stack, at least one carbon monoxide source, and means for introducing carbon monoxide into the catalytic article.

Abstract: A diaphragm for an audio transducer includes a first outer surface, a second outer surface opposing the first outer surface and a support structure. A skin defines at least one of the first and second outer surfaces of the diaphragm. The support structure is disposed on or within the skin.

Abstract: An example system is configured to: (i) receive data indicating a command to play back, via a playback device of a media playback system, media content; (ii) based on the data indicating the command, detect a first playback condition comprising a first user identity; (iii) identify, from one or more user accounts associated with the playback device, a first user account corresponding to the first user identity; (iv) based at least on (1) the command and (2) one or more properties of the first user account, determine first media content for playback by the playback device; and (v) cause the playback device to play back the first media content.

Abstract: A wall panel may have a rigid layer, a first insulation layer made from a two-part rigid urethane pour foam, and a second insulation layer made from a phase change material. The first insulation layer may be chemically bonded to the rigid layer and may also be bonded to the phase change layer. The first insulation layer may be positioned between the second insulation layer and the rigid layer. The rigid layer may be a finished surface or a veneer layer may be applied to the rigid layer.

Abstract: A framing system includes a first connection assembly that engages with a substrate. The first connection assembly includes a first connector and a track. At least one spring flange defined by the first connector engages with a fastener positioned along the substrate to maintain the first connection assembly in a fixed position relative to the substrate and to interconnect the substrate with the track. The framing system further includes a second connection assembly defining a second connector engaged to a stud. The second connection assembly engages with the first connection assembly to interconnect the stud with the track.

Abstract: A fluid pressure reducing valve apparatus includes a pressure reducing valve. The valve has: a body containing a fluid-flow chamber, a liquid supply orifice into the chamber, a liquid outlet from the chamber, a regulation plate opposed to the orifice, a spring acting to urge the plate towards the orifice, and a diaphragm between the plate and the body to close the chamber between them. A controllable motor drive acts between the body and an end of the spring remote from the plate. A flow meter is positioned downstream of the outlet. A controller is arranged to receive flow data from the flow meter and to control the motor drive for withdrawal of the remote end of the spring in accordance with flow rate measured by the flow meter. For an increase in demand flow, the plate is partially withdrawn to maintain downstream pressure on such increase and vice versa.

Abstract: Human lipoxygenases (LOXs) are a family of iron-containing enzymes involved in catalyzing the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive hydroxyeicosatetraenoic acid (HETE) metabolites. These eicosanoid signaling molecules are involved in a number of physiologic responses such as platelet aggregation, inflammation, and cell proliferation. Platelet-type 12-(S)-LOX (12-LOX) is of particular interest because of its demonstrated role in skin diseases, diabetes, platelet hemostasis, thrombosis, and cancer. Disclosed herein is the identification and medicinal chemistry optimization of a 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide-based scaffold. The compounds display nM potency against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases. In addition to possessing favorable ADME properties, the compounds also inhibit PAR-4 induced aggregation and calcium mobilization in human platelets, and reduce 12-HETE in mouse/human beta cells.

Abstract: System, method, and apparatus including receiving an identification of content played by a playback system and an identification of location of the playback system. A playlist of content is associated with the location. A request is received to retrieve the playlist of content and the requested playlist of content is sent to a playback system.

Abstract: The present application describes apparatus for supporting a mechanical hand, comprising a support member (200) pivotally coupled at a hinge axis (604) to a mounting member (700); and at least one leaf spring (707) configured to resist movement of the support member about the hinge axis. Apparatus for supporting a mechanical hand, comprising a lock arrangement (750) to lock the support member with respect to the mounting member in a rotational position about the hinge axis is also described.

Abstract: The present application describes a prosthetic or robot part (500), comprising at least one phalange member (532) pivotally coupled to a base (509) at a pivot axis; and a drive assembly to selectively move the phalange member about the pivot axis along a flexion/extension plane between an open position and a closed position, said drive assembly comprising a drive element (512) coupled to an actuator (506) and a driven element (514) coupled to the phalange member; wherein the driven element (514) is decouplable from the drive element (512) when the phalange member is caused to move in a first rotational direction about the pivot axis by an external force.

Abstract: A contact tip for a contact tonometer has a body including a contact surface, and a coating applied to the contact surface. The coating includes a light-activated material and a biocompatible water soluble adhesive for adhering the coating to the contact surface. The water soluble adhesive dissolves upon contact with the corneal tear film during a tonometric measurement, thereby releasing the light-activated material into the tear film. The present disclosure further provides a single-use tonometer contact tip product which includes a sterilized contact tip having the mentioned contact surface coating, and an opaque package containing the sterilized contact tip.

Abstract: A microfluidic probe includes a probe head with a processing surface that includes a first aperture and a second aperture. The probe further includes a liquid injection channel, which leads to the first aperture, and a liquid aspiration channel, which extends from the second aperture. The probe also includes a bypass channel, arranged so as to fluidly connect the liquid injection channel to the liquid aspiration channel, as well as a control channel. The latter fluidly connects to the bypass channel, hence forming a junction therewith, so as to define two portions of the bypass channel. These portions includes: a first portion that extends from the junction to the liquid injection channel; and a second portion that extends from that same junction to the liquid aspiration channel. The invention is further directed to methods of operation of a probe as described above, to process a surface.

Abstract: A wall panel may have a rigid layer, a first insulation layer made from a two-part rigid urethane pour foam, and a second insulation layer made from a phase change material. The first insulation layer maybe chemically bonded to the rigid layer and may also be bonded to the phase change layer. The first insulation layer may be positioned between the second insulation layer and the rigid layer. The rigid layer may be a finished surface or a veneer layer may be applied to the rigid layer.

Abstract: A series of 2-imino-6-methyltetrahydropyrimidin-4(1H)-one derivatives, substituted in the 6-position by a phenyl moiety which in turn is meta-substituted by an optionally substituted unsaturated fused bicyclic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsin V activity, are beneficial as pharmaceutical agents, especially in the treatment of malaria.