Patents by Inventor David Thomas Davies

David Thomas Davies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diazabicyclooctanones as inhibitors of serine beta-lactamases
    Patent number: 11905286
    Abstract: The invention relates to a compound which is a diazabicyclooctanone of Formula (I) or a pharmaceutically acceptable salt thereof: wherein R is as defined herein. The compounds are useful in the treatment of bacterial infection, in particular they are useful in reducing bacterial resistance to antibiotics. They are also useful in the treatment of bacteria which express serine-?-lactamase enzymes, in combination with antibiotics.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: February 20, 2024
    Assignee: Antabio SAS
    Inventors: Simon Leiris, David Thomas Davies
  • COMBINATION THERAPY
    Publication number: 20240016941
    Abstract: The invention provides a combinations and pharmaceutical compositions comprising (i) a compound which is an indane according to Formula (I) or a pharmaceutically acceptable salt thereof; and (ii) one or more CFTR modulator; wherein R1, R2, R3, R4, n, Lk, (A), G and m are as defined herein. Also provided are therapeutic uses of such combinations and compositions in the treatment of conditions such as cystic fibrosis.
    Type: Application
    Filed: March 23, 2021
    Publication date: January 18, 2024
    Applicant: Antabio SAS
    Inventors: Martin Everett, Simon Leiris, David Thomas Davies, Nicolas Sprynski, Lilha Beyria, Thomas David Pallin, Andrew Peter Cridland, Toby Jonathan Blench, Richard Leonard Elliott, David Edward Clark
  • CHEMICAL COMPOUNDS
    Publication number: 20220315546
    Abstract: The invention relates to a compound which is a thiazole derivative of Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, , Z, L, X, m, n and p are as defined herein. The compounds are useful in the treatment and prevention of bacterial infection. The invention also relates to combinations of the compound of Formula (I) with further active agents.
    Type: Application
    Filed: March 4, 2022
    Publication date: October 6, 2022
    Applicant: Antabio SAS
    Inventors: David Thomas DAVIES, Simon LEIRIS, Nicolas SPRYNSKI, Martin EVERETT, Magdalena ZALACAIN
  • DIAZABICYCLOOCTANONES AS INHIBITORS OF SERINE BETA-LACTAMASES
    Publication number: 20220289747
    Abstract: The invention relates to a compound which is a diazabicyclooctanone of Formula (I) or a pharmaceutically acceptable salt thereof (I): wherein R is as defined herein. The compounds are useful in the treatment of bacterial infection, in particular they are useful in reducing bacterial resistance to antibiotics. They are also useful in the treatment of bacteria which express serine-?-lactamase enzymes, in combination with antibiotics.
    Type: Application
    Filed: August 8, 2019
    Publication date: September 15, 2022
    Applicant: Antabio SAS
    Inventors: Simon Leiris, David Thomas Davies
  • INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION
    Publication number: 20220112169
    Abstract: The invention relates to a compound which is an indane according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, L, n and p are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics.
    Type: Application
    Filed: July 25, 2019
    Publication date: April 14, 2022
    Applicant: Antabio SAS
    Inventors: Simon Leiris, David Thomas Davies, Martin Everett, Nicolas Sprynski, Lilha Beyria, Thomas David Pallin, Andrew Peter Cridland, Toby Jonathan Blench, Richard Leonard Elliott, David Edward Clark
  • Chemical compounds
    Patent number: 11299467
    Abstract: The invention relates to a compound which is a thiazole derivative of Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, Formula (A), Z, L, X, m, n and p are as defined herein. The compounds are useful in the treatment and prevention of bacterial infection. The invention also relates to combinations of the compound of Formula (I) with further active agents.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: April 12, 2022
    Assignee: ANTABIO SAS
    Inventors: David Thomas Davies, Simon Leiris, Nicolas Sprynski, Martin Everett, Magdalena Zalacain
  • INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION
    Publication number: 20210347748
    Abstract: The invention relates to a compound which is an indane according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, n and p are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics.
    Type: Application
    Filed: July 25, 2019
    Publication date: November 11, 2021
    Applicant: Antabio SAS
    Inventors: Simon Leiris, David Thomas Davies, Martin Everett, Nicolas Sprynski, Lilha Beyria, Thomas David Pallin, Andrew Peter Cridland, Toby Jonathan Blench, Richard Leonard Elliott, David Edward Clark
  • Chemical compounds as antibiotics
    Patent number: 11000511
    Abstract: The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p, q, L, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: May 11, 2021
    Assignee: Antabio SAS
    Inventors: Simon Leiris, David Thomas Davies, Martin Everett, Nicolas Sprynski, Jonathan Mark Sutton, Michael Steven Bodnarchuk, Thomas David Pallin, Andrew Peter Cridland, Toby Jonathan Blench, David Edward Clark, Richard Leonard Elliott, Lilha Beyria
  • CHEMICAL COMPOUNDS
    Publication number: 20200339526
    Abstract: The invention relates to a compound which is a thiazole derivative of Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, Formula (A), Z, L, X, m, n and p are as defined herein. The compounds are useful in the treatment and prevention of bacterial infection. The invention also relates to combinations of the compound of Formula (I) with further active agents.
    Type: Application
    Filed: July 20, 2018
    Publication date: October 29, 2020
    Applicant: Antabio SAS
    Inventors: David Thomas DAVIES, Simon LEIRIS, Nicolas SPRYNSKI, Martin EVERETT, Magdalena ZALACAIN
  • CHEMICAL COMPOUNDS AS ANTIBIOTICS
    Publication number: 20200155509
    Abstract: The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p, q, L, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions.
    Type: Application
    Filed: March 21, 2018
    Publication date: May 21, 2020
    Applicant: Antabio SAS
    Inventors: Simon LEIRIS, David Thomas DAVIES, Martin EVERETT, Nicolas SPRYNSKI, Jonathan Mark SUTTON, Michael Steven BODNARCHUK, Thomas David PALLIN, Andrew Peter CRIDLAND, Toby Jonathan BLENCH, David Edward CLARK, Richard Leonard ELLIOTT, Lilha BEYRIA
  • Tricyclic nitrogen containing compounds as antibacterial agents
    Patent number: 8389524
    Abstract: Tricyclic nitrogen containing compounds and their use as antibacterials. Z1 and Z2 are independently selected from CH and N.
    Type: Grant
    Filed: April 16, 2008
    Date of Patent: March 5, 2013
    Assignee: Glaxo Group Limited
    Inventors: David Evan Davies, David Thomas Davies, Ilaria Giordano, Alan Joseph Hennessy, Neil David Pearson
  • Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
    Patent number: 8071592
    Abstract: Bicyclic nitrogen containing compounds and their use as antibacterials.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: December 6, 2011
    Assignee: Glaxo Group Limited
    Inventors: Lluis Ballell, David Barros, Gerald Brooks, Julia Castro Pichel, Steven Dabbs, Robert A Daines, David Thomas Davies, Jose Maria Fiandor Roman, Israil Pendrak, Modesto J Remuiñan Blanco, Jason Anthony Rossi, Ilaria Giordano, Alan Joseph Hennessy, James B Hoffman, Graham Elgin Jones, Timothy James Miles, Neil David Pearson, Lihua(lily) Zhang
  • Substituted 1-Methyl-1H-Quinolin-2-Ones And 1-Methyl-1H-1,5-Naphthyridin-2-Ones As Antibacterials
    Publication number: 20100256124
    Abstract: Bicyclic nitrogen containing compounds and their use as antibacterials.
    Type: Application
    Filed: June 8, 2007
    Publication date: October 7, 2010
    Inventors: David Thomas Davies, Graham Elgin Jones, Neil David Pearson
  • COMPOUNDS
    Publication number: 20100197679
    Abstract: Bicyclic nitrogen containing compounds and their use as antibacterials
    Type: Application
    Filed: April 17, 2008
    Publication date: August 5, 2010
    Inventors: Christopher Barfoot, David Thomas Davies, Timothy James Miles, Neil David Pearson
  • Heterocyclic compounds, their preparation and their use as antibacterials
    Patent number: 7732460
    Abstract: Tricyclic nitrogen containing compounds of formula (I) and their use as antibacterials.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: June 8, 2010
    Assignee: Glaxo Group Limited
    Inventors: Nathalie Cailleau, David Thomas Davies, Alan Joseph Hennessy, Graham Elgin Jones, Timothy James Miles, Neil David Pearson
  • TRICYCLIC NITROGEN CONTAINING COMPOUNDS AS ANTIBACTERIAL AGENTS
    Publication number: 20100137282
    Abstract: Tricyclic nitrogen containing compounds and their use as antibacterials. Z1 and Z2 are independently selected from CH and N.
    Type: Application
    Filed: April 16, 2008
    Publication date: June 3, 2010
    Inventors: David Evan Davies, David Thomas Davies, Ilaria Giordano, Alan Joseph Hennessy, Neil David Pearson
  • Antimicrobial Compounds
    Publication number: 20100081650
    Abstract: Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.
    Type: Application
    Filed: November 17, 2009
    Publication date: April 1, 2010
    Inventors: Jeffrey Michael Axten, Robert A. Daines, David Thomas Davies, Timothy Francis Gallagher, Graham Elgin Jones, William Henry Miller, Neil David Pearson, Israil Pendrak
  • COMPOUNDS
    Publication number: 20100056502
    Abstract: Tricyclic nitrogen containing compounds and their use as antibacterials.
    Type: Application
    Filed: March 20, 2008
    Publication date: March 4, 2010
    Applicant: GLAXO GROUP LIMITED
    Inventors: Pamela Brown, Steven Dabbs, David Thomas Davies, Neil David Pearson
  • Antibacterial compounds
    Patent number: 7622481
    Abstract: Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: November 24, 2009
    Assignee: Glaxo Group Limited
    Inventors: Jeffrey Michael Axten, Robert A Daines, David Thomas Davies, Timothy Francis Gallagher, Graham Elgin Jones, William Henry Miller, Neil David Pearson, Israil Pendrak
  • DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES
    Publication number: 20090270374
    Abstract: Bicyclic nitrogen containing compounds and their use as antibacterials.
    Type: Application
    Filed: July 18, 2007
    Publication date: October 29, 2009
    Inventors: Llius Ballell, David Barros, Gerald Brooks, Julia Castro Pichel, Steven Dabbs, Robert A. Daines, David Thomas Davies, Jose Maria Fiandor Roman, Israil Pendrak, Modesto J. Remuinan Blanco, Jason Anthony Rossi, Ilaria Giordano, Alan Joseph Hennessy, James B. Hoffman, Graham Elgin Jones, Timothy James Miles, Neil David Pearson, Lihua(lily) Zhang