Abstract: The invention relates to a compound which is a diazabicyclooctanone of Formula (I) or a pharmaceutically acceptable salt thereof (I): wherein R is as defined herein. The compounds are useful in the treatment of bacterial infection, in particular they are useful in reducing bacterial resistance to antibiotics. They are also useful in the treatment of bacteria which express serine-?-lactamase enzymes, in combination with antibiotics.

Abstract: Implantable devices for fixation of curved bone such as the pelvic ring pubic symphysis and acetabulum, and methods for the use of the devices are disclosed. The implantable devices are convertible between a flexible state and a rigid state, and include an elongate structure having a proximal bone interface, a main body, and a distal bone interface. In a flexible state, the devices may be inserted along, and conform to a curved pathway, and in the rigid state, the devices may support the mechanical loads required to fixate a fracture.

Abstract: Embodiments include systems and method for performing state driven bi-directional synchronization in a reflection database architecture. A set of changes to a series of data fields can be received at a first database, the set of changes being part of a first process flow. The first database can be a reflection of a second database over a partition. State driven synchronization can be performed by a bi-directional synchronization engine for at least a portion of the series of data fields between the first database and the second database. The bi-directional synchronization engine can be configured to bi-directionally synchronize data between the first database and the second database based at least in part on detecting a boundary state at one or more of the first database and the second database.

Abstract: Trust systems and methods include receiving a request from a first user, wherein the request is to a second user and relates to the second user sharing verified facts, attributes, and other pertinent information used by the first user in determining a level of trust to be afforded to the second user; providing the request to the second user for consent and for data acquisition related to the request; performing data acquisition responsive to the consent to obtain data; determining a response to the request based on the data; and providing the response to the first user, wherein the response is a minimum subset or derivative of the data required to answer the request so that the data is only shared with the first user on a limited basis.

Abstract: A spheroidal framework having sensors is mounted to a multi-rotor aircraft with elastic members and adjustable aircraft mounts whereby transmission of vibration from the aircraft to the framework is dampened and whereby the framework's position relative to the aircraft's center of gravity may be changed by selectively tensioning the elastic members and by adjusting the position of the aircraft mounts.

Abstract: Implantable devices for fixation of curved bones such as the pelvic ring pubic symphysis and acetabulum, and methods for the use of the devices are disclosed. The implantable devices are convertible between a flexible state and a rigid state using a shape locking section. The implantable devices further include a main body and a distal bone interface. In a flexible state, the devices may be inserted along, and conform to a curved pathway, and in the rigid state, the devices may support the mechanical loads required to fixate a fracture.

Abstract: A smoking substitute device is configured to record and store user data that is generated during operation of the device. Analyzing the user data can provide the user with useful information regarding their use of the smoking substitute device as well as useful information regarding the operational performance of the device. Typically, the analysis of the data would be conducted by a remote device and the smoking substitute device therefore includes a communication interface to connect and communicate with the remote device. The smoking substitute device and method of managing the smoking substitute device allows user data to be deleted from the device upon identification of a reset operation wherein the reset operation is able to be triggered from the connected remote device and/or the smoking substitute device. Providing a function to delete user data upon identification of a reset operation provides the user with some control over their information.

Abstract: The present disclosure relates to an aerosol delivery device and system, e.g., a smoking substitute device and system. In particular an aerosol delivery device, comprising: a source of power, for providing power to a heater; a first charging connection, for charging the source of power, located at a first end of the aerosol delivery device; and a second charging connection, for charging the source of power.

Abstract: A system and method are disclosed for analyzing the maturity of one or more supply chain entities according to competencies of an omni-channel retailer. The one or more supply chain entities including a retail manager that assesses the one or more supply chain entities according to one or more competencies and determines one or more maturity gaps associated with the one or more competencies. The retail manger further identifies one or more transition projects that fill the one or more maturity gaps and roadmaps one or more transition activities that generate the one or more identified transition projects. The one or more supply chain entities further adjusts an inventory of one or more products at least partially based on the one or more roadmapped transition activities.

Abstract: Systems and methods presented herein include an evacuation deterrence system that includes a vehicle having a member configured to deter evacuation of passengers from the vehicle. The evacuation deterrence system also includes an evacuation deterrence device configured to latch onto the member of the vehicle. The evacuation deterrence device includes an elongated main body, a handle portion, a latch mechanism configured to latch onto the member of the vehicle, an actuation mechanism configured to actuate the latch mechanism, and a positioning mechanism configured to fix a first location of the elongated main body relative to the vehicle. The elongated main body is configured to be extended relative to the vehicle when the first location of the elongated main body is fixed relative to the vehicle via the positioning mechanism.

Abstract: A security apparatus for securing a portable electronic device to an immovable object includes a locking head including a first part having a first base portion configured to be inserted into an opening of the portable electronic device, a second part that is separate from the first part, the second part having a second base portion configured to be inserted into the opening, and an aperture formed through the first part and the second part. The security apparatus also includes a cable threaded through the aperture to inhibit separation of the first part from the second part and removal of the locking head from the opening. The cable is configured to engage the immovable object.

Abstract: A method for changing between a multiplicity of discrete transmission ratio stages in a motorcycle gearbox is provided. In response to a shift demand, during the torque-transmitting connection of a drive shaft of the drive machine to a gearbox input shaft, a gear-selection drum of the transmission is rotatable from a first shifting position to an intermediate position which is situated between the first and a second shifting position, before shifting to the second shift position. In the intermediate position, no drive torque can be transmitted from the gearbox input shaft to a gearbox output shaft. During the gear selection drum movement from the first shifting position and the intermediate position, the drum may be rotated to a rest position in which drive torque can be transmitted from the gearbox input shaft to a gearbox output shaft.

Abstract: Devices and techniques are generally described for using user feedback to determine routing decisions in a speech processing system. In various examples, first data representing a first utterance may be received. Second data representing a first semantic interpretation of the first utterance may be determined. A first intent data processing application may be selected for processing the second data. Feedback data may be determined related to the first intent data processing application processing the second data. Third data representing a semantic interpretation of a second utterance may be received, wherein the first semantic interpretation is the same as the second semantic interpretation. A second intent data processing application may be determined for processing the third data based at least in part on the feedback data.

Abstract: Implantable devices for fixation of curved bone such as the pelvic ring pubic symphysis and acetabulum, and methods for the use of the devices are disclosed. The implantable devices are convertible between a flexible state and a rigid state, and include an elongate structure having a proximal bone interface, a main body, and a distal bone interface. In a flexible state, the devices may be inserted along, and conform to a curved pathway, and in the rigid state, the devices may support the mechanical loads required to fixate a fracture.

Abstract: Provenance analysis systems and methods. Datums representing relationships between entities can be stored in a knowledge store. Datums can be received from agents as agents perform activities. Activity records are be stored in a provenance graph, the activity record and associate received datums with any input datums used in the activity. Provenance subgraphs can 5 be retrieved by traversing the provenance graph for selected datums and presented through a user interface. Provenance subgraphs can be augmented with trust modifiers determined based on attributions, confidences, and refutations provided by a user. Trust modifiers can be propagated downstream to enable the addressing of junctions in variable confidence.

Abstract: Systems and methods for audience interaction in real-time multimedia applications are provided. In one embodiment, a method for a real-time video conference comprises, during the real-time video conference, receiving a media stream including audio and video from a remote computing system over a network, acquiring, video and audio of a user, detecting an event with a machine learning model in at least one of the video and the audio of the user, and transmitting an event detection message indicating the detected event and/or audio and video of the user to the remote computing system over the network. In this way, natural audience reactions may be automatically detected and shared.

Abstract: An apparatus for an aerosol generating device comprises a first housing member for at least partly defining a chamber for containing a heater arrangement for heating an aerosol generating material; and a second housing member attached to the first housing member via an attachment. The first housing member and the second housing member define therebetween a passageway into the chamber. The passageway is configured to allow an electrical connecting member for connecting to the heater arrangement to extend through the passageway. The apparatus also comprises a sealing arrangement arranged to seal the passageway. The attachment between the first housing member and the second housing member is configured to hold the first housing member and the second housing member in a configuration which causes the sealing arrangement to seal the passageway.

Abstract: Disclosed are processes for forming compositions comprising small domains of an active agent and a matrix material, and methods of using them. A suspension of an active agent, a matrix material, a first solvent, and a second solvent is formed at a temperature T1, heated to a temperature T2 and spray dried.