Patents by Inventor David Tice

David Tice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20190030538
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: August 20, 2018
    Publication date: January 31, 2019
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • Device and method for pressure-driven plug transport and reaction
    Patent number: 10118174
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: November 6, 2018
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • Method for Conducting an Autocatalytic Reaction in Plugs in a Microfluidic System
    Publication number: 20180304268
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: March 20, 2018
    Publication date: October 25, 2018
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • Device and method for pressure-driven plug transport and reaction
    Patent number: 10105703
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: October 23, 2018
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • Method for Conducting Reactions Involving Biological Molecules in Plugs in a Microfluidic System
    Publication number: 20180272351
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: March 20, 2018
    Publication date: September 27, 2018
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • Device and method for pressure-driven plug transport and reaction
    Publication number: 20180272352
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: March 20, 2018
    Publication date: September 27, 2018
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • BINDING MOLECULES SPECIFIC FOR ASCT2 AND USES THEREOF
    Publication number: 20180273617
    Abstract: This disclosure provides ASCT2-binding molecules, e.g., anti-ASCT2 antibodies, and antigen-binding fragments thereof. In certain aspects, the ASCT2-binding molecules are conjugated to cytotoxic drugs, e.g., ASCT2 antibody-drug conjugates (ADCs). In certain aspects, the anti-ASCT2 antibodies and fragments thereof can be hybridoma-derived murine monoclonal antibodies, and humanized versions thereof. In certain aspects, the ASCT2-binding molecules bind specifically to cells expressing ASCT2, and in some instances, are internalized into the cells. In addition, this disclosure provides compositions and methods for diagnosing and treating diseases or disorders characterized by ASCT2 overexpression, e.g., certain types of cancer. In a particular embodiment, the disclosure provides methods for treating cancer using ASCT2 ADCs.
    Type: Application
    Filed: November 10, 2016
    Publication date: September 27, 2018
    Inventors: Nabendu Pore, Martin J. Borrok III, Emil F. Michelotti, David A. Tice, Robert E. Hollingsworth, Chien-Ying Chang, Partha Chowdhury
  • Binding molecules specific for HER3 and uses thereof
    Patent number: 10040857
    Abstract: The present invention relates to antibodies and antigen binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various HER3 receptor related functions via ligand-dependent and/or ligand-independent mechanisms. Also provided are compositions with increased half-life. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER3 mediated signal transduction.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: August 7, 2018
    Assignee: MEDIMMUNE, LLC
    Inventors: Partha S. Chowdhury, David Tice, Zhan Xiao, Philipp Steiner, Krista Kinneer, Marlon Rebelatto
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20180193838
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: January 3, 2018
    Publication date: July 12, 2018
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20180193837
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: January 3, 2018
    Publication date: July 12, 2018
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20180154362
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: November 29, 2017
    Publication date: June 7, 2018
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • Device and method for pressure-driven plug transport and reaction
    Patent number: 9968933
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: May 15, 2018
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • Device and method for pressure-driven plug transport and reaction
    Patent number: 9889446
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: February 13, 2018
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20170368551
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: August 10, 2017
    Publication date: December 28, 2017
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20170361321
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: August 10, 2017
    Publication date: December 21, 2017
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • Device and method for pressure-driven plug transport and reaction
    Patent number: 9839893
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: December 12, 2017
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song, Lewis Spencer Roach
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20170232440
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: May 4, 2017
    Publication date: August 17, 2017
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • Method of crystallization in aqueous plugs flowing in immiscible carrier-fluid in microfluidic system
    Patent number: 9592506
    Abstract: A method of crystallization is disclosed, the method comprises the steps of providing a microfluidic system comprising at least three channels having at least one junction; providing within the at least three channels a continuously flowing water-immiscible carrier-fluid, a continuously flowing first aqueous fluid comprising a crystallization target, and a continuously flowing second aqueous fluid comprising a precipitant; forming at least one plug comprising the first and second aqueous fluids by partitioning the aqueous fluids with the flowing carrier-fluid at the junction of the at least three channels, flowing the at least one plug through an outlet port into a tubing, and stopping the flow of the at least one plug in the tubing, wherein the crystallization target forms a crystal in the tubing.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: March 14, 2017
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • Device and method for pressure-driven plug transport and reaction
    Patent number: 9579622
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: February 28, 2017
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song, Lewis Spencer Roach
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20160288124
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: March 31, 2016
    Publication date: October 6, 2016
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng