Patents by Inventor David Tice

David Tice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BINDING MOLECULES SPECIFIC FOR HER3 AND USES THEREOF
    Publication number: 20160237162
    Abstract: Provided herein are antibodies and antigen binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various HER3 receptor related functions via ligand-dependent and/or ligand-independent mechanisms. Also provided are compositions with increased half-life, as well as compositions and methods for diagnosing and treating diseases associated with HER3 mediated signal transduction.
    Type: Application
    Filed: September 23, 2014
    Publication date: August 18, 2016
    Applicant: MedImmune, LLC
    Inventors: Partha S. Chowdhury, David Tice, Zhan Xiao, Philipp Steiner, Krista Kinneer, Marlon Rebelatto, Andrew Pierce
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20160215411
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: October 17, 2014
    Publication date: July 28, 2016
    Applicant: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • BINDING MOLECULES SPECIFIC FOR HER3 AND USES THEREOF
    Publication number: 20160159913
    Abstract: The present invention relates to antibodies and antigen binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various HER3 receptor related functions via ligand-dependent and/or ligand-independent mechanisms. Also provided are compositions with increased half-life. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER3 mediated signal transduction.
    Type: Application
    Filed: November 20, 2015
    Publication date: June 9, 2016
    Applicant: MEDIMMUNE LLC
    Inventors: Partha S. Chowdhury, David Tice, Zhan Xiao, Philipp Steiner, Krista Kinneer, Marlon Rebelatto
  • Device for pressure-driven plug transport comprising microchannel with traps
    Patent number: 9329107
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: May 3, 2016
    Assignee: THE UNIVERSITY OF CHICAGO
    Inventors: Rustem F Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20160051960
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: August 26, 2015
    Publication date: February 25, 2016
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song, Lewis Spencer Roach
  • Binding molecules specific for HER3 and uses thereof
    Patent number: 9220775
    Abstract: The present invention relates to antibodies and antigen binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various HER3 receptor related functions via ligand-dependent and/or ligand-independent mechanisms. Also provided are compositions with increased half-life. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER3 mediated signal transduction.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: December 29, 2015
    Assignee: MedImmune LLC
    Inventors: Partha S. Chowdhury, David Tice, Zhan Xiao, Philipp Steiner, Krista Kinneer, Marlon Rebelatto
  • TRAIL R2-specific multimeric scaffolds
    Patent number: 9212231
    Abstract: The present invention provides Tenascin-3 FnIII domain-based multimeric scaffolds that specifically bind to TRAIL Receptor 2 (TRAIL R2), a cell membrane receptor involved in apoptosis. The invention further provides engineered variants with increased affinity for the target, increased stability, and reduced immunogenicity. Furthermore, the present invention is related to engineered multivalent scaffolds as prophylactic, diagnostic, or therapeutic agents, and their uses against diseases caused by cells expressing TRAIL R2, in particular to a therapeutic use against cancer.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: December 15, 2015
    Assignee: MEDIMMUNE, LLC
    Inventors: Manuel Baca, Thomas Thisted, Jeffrey Swers, David Tice
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20150099264
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: October 7, 2014
    Publication date: April 9, 2015
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song, Lewis Spencer Roach
  • BINDING MOLECULES SPECIFIC FOR HER3 AND USES THEREOF
    Publication number: 20140363429
    Abstract: The present invention relates to antibodies and antigen binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various HER3 receptor related functions via ligand-dependent and/or ligand-independent mechanisms. Also provided are compositions with increased half-life. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER3 mediated signal transduction.
    Type: Application
    Filed: November 20, 2012
    Publication date: December 11, 2014
    Applicant: MedImmune LLC
    Inventors: Partha S. Chowdhury, David Tice, Zhan Xiao, Philipp Steiner, Krista Kinneer, Marlon Rebelatto
  • Device and method for pressure-driven plug transport and reaction
    Patent number: 8889083
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: November 18, 2014
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song, Lewis Spencer Roach, Jr.
  • Method of performing PCR reaction in continuously flowing microfluidic plugs
    Patent number: 8822148
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: September 2, 2014
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagliov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT
    Publication number: 20130101995
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: October 10, 2012
    Publication date: April 25, 2013
    Inventors: Ismagilov F. Rustem, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • TRAIL R2-SPECIFIC MULTIMERIC SCAFFOLDS
    Publication number: 20130096058
    Abstract: The present invention provides Tenascin-3 FnIII domain-based multimeric scaffolds that specifically bind to TRAIL Receptor 2 (TRAIL R2), a cell membrane receptor involved in apoptosis. The invention further provides engineered variants with increased affinity for the target, increased stability, and reduced immunogenicity. Furthermore, the present invention is related to engineered multivalent scaffolds as prophylactic, diagnostic, or therapeutic agents, and their uses against diseases caused by cells expressing TRAIL R2, in particular to a therapeutic use against cancer.
    Type: Application
    Filed: April 12, 2011
    Publication date: April 18, 2013
    Applicant: MedImmune, LLC
    Inventors: Manuel Baca, Thomas Thisted, Jeffrey Swers, David Tice
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT
    Publication number: 20120329171
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: July 31, 2012
    Publication date: December 27, 2012
    Inventors: Rustem F. Ismagliov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • Method for conducting reactions involving biological molecules in plugs in a microfluidic system
    Patent number: 8329407
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: December 11, 2012
    Assignee: The University of Chicago
    Inventors: Rustem F Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • Method for conducting an autocatalytic reaction in plugs in a microfluidic system
    Patent number: 8304193
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: November 6, 2012
    Assignee: The University of Chicago
    Inventors: Rustem F Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • Method for obtaining a collection of plugs comprising biological molecules
    Patent number: 8273573
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: September 25, 2012
    Assignee: The University of Chicago
    Inventors: Rustem F Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • Filter for a crankcase ventilation system
    Patent number: 8146545
    Abstract: An oil-collecting can (500) for a filter cartridge (300) comprises a plurality of capillary ribs (530) that are sized and shaped to contact filter media in the outlet chamber. The oil-collecting can (500) can be used in conjunction with a filter cartridge (300), which is installed in a filter assembly to encourage the downward flow of oil droplets. Such a filter assembly could be used, for example, in a crankcase ventilation system, to remove particulates and other contaminants from piston-bypass fumes.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: April 3, 2012
    Assignee: Parker-Hannifin Corporation
    Inventors: Ronald G. Frazier, Jr., David Tice
  • TOXIN CONJUGATED EPH RECEPTOR ANTIBODIES
    Publication number: 20110280892
    Abstract: The present invention relates to compositions and methods for inducing cell death or stasis in cancer cells or other hyperproliferative cells using anti-EphA2 or anti-EphA4 antibodies conjugated to toxins.
    Type: Application
    Filed: December 21, 2010
    Publication date: November 17, 2011
    Applicants: MedImmune, LLC, Seattle Genetics, Inc.
    Inventors: Michael S. Kinch, Herren Wu, Christine Bachy, David Tice, Changshou Gao, Peter D. Senter
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT
    Publication number: 20110177586
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: February 9, 2011
    Publication date: July 21, 2011
    Applicant: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng