Abstract: The present invention relates to combinations of a H3 antagonist and an antidepressant, which exhibit a synergistic wake promoting activity.

Abstract: A system, method, and computer program for enabling a user to edit and access local and remote objects via a virtual drive, including objects synchronized to a plurality of synchronization clients. A virtual drive is displayed on the user's local client device with all objects, which a user has synchronized to a synchronization server. A user is able to access and edit any object displayed in the virtual drive. In response to detecting a change in an object in the virtual drive, the object is updated on the synchronization server. All remote clients of the user or of any other users who have access to the changed folder are identified and notified of the change. In response to the change being a change to content within the folder, the content of the folder is automatically updated on any identified remote clients that have a corresponding folder.

Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2?-halo-1-1?-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.

Abstract: A system and method for displaying images of internal anatomy includes an image processing device configured to provide high resolution images of the surgical field from low resolution scans during the procedure. The image processing device digitally manipulates a previously-obtained high resolution baseline image to produce many representative images based on permutations of movement of the baseline image. During the procedure a representative image is selected having an acceptable degree of correlation to the new low resolution image. The selected representative image and the new image are merged to provide a higher resolution image of the surgical field. The image processing device is also configured to provide interactive movement of the displayed image based on movement of the imaging device, and to permit placement of annotations on the displayed image to facilitate communication between the radiology technician and the surgeon.

Abstract: A fluid control valve for a faucet includes a body, a stem, a moveable disc, and at least one stationary disc. The stem is rotatably coupled to the body. The moveable disc is coupled to the stem and is configured to rotate with the stem. The at least one stationary disc is coupled to the body below the moveable disc. The fluid control valve is configured to be biased in an axial direction against a retaining element within a valve body by an incoming supply of fluid through the at least one stationary disc, so as to retain the fluid control valve within the valve body along the axial direction.

Abstract: A telemark ski binding has a toe retainer pivotally coupled to a base. A lock assembly of the binding has an actuator assembly. The lock assembly is adjustable between a locked configuration and an unlocked configuration. The binding further has a heel retainer rotatably coupled to the toe retainer. When the lock assembly is in the unlocked configuration, the toe retainer is unlocked, and the toe retainer and heel retainer are both rotatable together substantially inline, relative to the base, around a first center point. When the lock assembly is in the locked configuration, the toe retainer is locked, and the toe retainer is restrained from rotating relative to the base. The heal retainer is rotatable relative to the toe retainer around a second center point. The second center point is at a different location from said first center point.

Abstract: A method includes generating a new entigen group regarding trusted new information. The method further includes generating entigen groups from phrases of a document and determining whether an entigen group of the entigen groups has a most likely meaning similar to a most likely meaning of the new entigen group. When the entigen group has a most likely meaning similar to the most likely meaning of the new entigen group, the method further includes updating the entigen group based on the new entigen group. When the entigen groups do not include an entigen group having a most likely meaning similar to the most likely meaning of the new entigen group, the method further includes updating the entigen groups to include the new entigen group.

Abstract: A detection device for detecting that a source is sold-out for a beverage dispenser, the beverage dispenser dispensing from the source via a valve controlled by a solenoid. A circuit board is configured to be positioned on the valve proximal to the solenoid. A detector is coupled to the circuit board, where the solenoid creates a magnetic field when dispensing from the valve, and where the detector detects the magnetic field created by the solenoid and consequently produces an electrical output. A control system is coupled to the circuit board in communication with the detector. The control system is configured to access threshold data and to compare the electrical output of the detector to the threshold data. The control system indicates that the source is sold-out based upon the comparison of the electrical output to the threshold data.

Abstract: Provided are systems, methods, and devices for identifying correct satellite signals to improve the accuracy of a satellite navigation system. In some embodiments, identifying correct satellite signals may include receiving a plurality of satellite signals; demodulating the satellite signals to extract a first plurality of parameters; determining a first subset of parameters from the first plurality of parameters, wherein the first subset of parameters is based on a first geographic location; determining a second subset of parameters from a second plurality of parameters outside the first subset, the second plurality of parameters comprising one or more parameters of the first plurality of parameters outside the first subset, wherein the second subset of parameters is based on a second geographic location; and identifying an exemplary subset from the first subset and the second subset, wherein the exemplary subset comprises parameters corresponding to correct satellite signals.

Abstract: The issue-discovery services described herein may access data from the messaging platform and/or the issue-tracking platform to automatically determine issue attributes for creating a new issue in the issue-tracking platform based on activity in the messaging platform. The issue-discovery service may provide or otherwise be associated with a user input element presented on a client device (e.g., presented in the chat user interface), which allows a user of the client device to provide a user input to create a new issue in the issue-tracking platform based on activity in the chat channel. The user input may identify content associated with the chat channel (e.g., one or more messages displayed in the chat user interface) for use in creating the new issue in the issue-tracking platform.

Abstract: Techniques and systems for determining locations of devices using location data sources are provided. For example, a network device, method, and computer-program product may be provided. In one example, a method may include receiving, on a computing device, a request to locate a device, wherein the request includes an identifier of the device. The method may further include receiving a communication from the device, wherein the communication includes the identifier of the device, and obtaining a location of the device. The method may further include transmitting the location of the device and the identifier of the device to a server, wherein the server is configured to use the location of the device and the identifier of the device to send a response to the requestor of the request.

Abstract: Users are enabled to define and modify mappings between (1) gestures and (2) actions performed by one or more computing devices in response to a device detecting performance of a gesture. A generalized gesture-to-action mapping framework allows users to intuitively define and modify such mappings. In response to a device detecting the performance of a particular gesture, one or more devices may cause the execution of one or more device actions based on a set of user-defined gesture-to-action mappings.

Abstract: A prosthesis system comprises plates that can be positioned against vertebrae and a selected resilient core that can be positioned between the plates to allow the plates to articulate. The selected resilient core can be chosen from a plurality of cores in response to patient characteristics, such as age and/or intervertebral mobility, such that the prosthesis implanted in the patient is tailored to the needs of the patient. The plurality of cores may comprise cores with different resiliencies, and one of the cores can be selected such that the upper and lower plates articulate with the desired shock absorbing resiliency and/or maximum angle of inclination when the one selected core is positioned between the plates.

Abstract: A differential arrangement having a gear stage that includes at least one input element and at least two output elements is provided. The at least one output element is connected to at least one electrical device in order to distribute torque.

Abstract: A pressure compensated solenoid valve with fluid flow force balancing is provided. The solenoid valve includes an armature and a valve plunger arranged to transport hydraulic fluid from a supply end of a valve plunger to an upper end of the armature facilitating a resultant upper fluid force that acts upon the upper end of the armature to balance a resultant lower fluid force that acts on the supply end of the valve plunger. The solenoid valve includes a poppet that is configured as a pressure-relief valve for maintaining a minimum fluid pressure within an actuation fluid gallery. An inlet fluid force of the poppet is balanced by an outlet fluid force of the poppet.

Abstract: The instant invention provides compounds of formulas Ia and Ib which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.

Abstract: A fly rod including sensors and methods of using the same are provided, particularly where the sensors assist the user in casting or in logging data associated with fishing activities. In a described embodiment, the fly rod comprises: a handle portion that includes a butt end; a center shaft portion that extends from the handle portion; a tip portion that extends from the shaft portion and includes a tip; a first movement sensor disposed in the tip portion; and a second movement sensor spaced apart from the first sensor.

Abstract: A method and a system for joint data augmentation and classification learning, where an augmentation network learns to perform transformations and a classification network is trained. A set of labelled images is received. During an inner loop iteration, an augmentation network applies a transformation on a given labelled image of the set to obtain a transformed image. The classification network classifies the transformed image to obtain a predicted class, and a training loss is determined based on the predicted class and the respective label. The parameters of the classification network are updated based on the classification loss. During an outer loop iteration, the classification network classifies another labelled image of the set to obtain another predicted class, and a validation loss is determined based on the other predicted class and the respective label. The parameters of the augmentation network are updated based on the validation loss.