Abstract: Described herein are AAV particles having capsid proteins with amino acid substitutions that confer increased affinity for and transduction of glioma cells. The disclosed capsid proteins may be used in conjunction with any therapeutic transgene for treatment of cancer, including in the manufacture of an AAV particle. Also described are methods of identifying AAV variants having increased affinity for and transduction of specific tumor cell types.

Abstract: Safety mechanisms are embedded into a System on a Chip (SoC) and are operable to detect faults present in the logic circuitry in the SoC. Various types of faults in logic circuitry can occur, for example, a bit stuck at 0 or 1, or a transient or temporary fault due to radiation impacting the SoC. SoC devices are required to meet certain automotive safety integrity standards. The most stringent automotive safety integrity level requires that 90% of random latent faults are detected in all relevant logic, including all safety mechanism. Examples disclosed include hardware based checkers and hardware or software based pattern generation methods that achieve high online fault coverage in safety mechanism circuitry used for functional safety. A hardware based safety mechanism monitors the logic circuitry during operation. Any time the safety mechanism detects any faults in the logic circuitry, a fault notification is propagated to upstream logic.

Abstract: A memory system that splits a data width (W) into N separate memories each of narrower width W/N is described. To protect a write enable (WE) signal, the WE signal is toggled and then stored in each of the N memories. A fault on the WE signal to any of the N memories results in its stored write detection bit being different from the write detection bits stored in the other N memories. This condition can then be detected upon any subsequent read by checking whether the write detection bits are equal. The memory system can also protect the address and control signals by generating parity bits that are stored in the N memories.

Abstract: Methods of reducing the viability of cancer cells, preventing cancer cells of a subject from developing resistance to TTFields, and restoring sensitivity of cancer cells to TTFields by recommending or prescribing a PTGER3 inhibitor to a subject and applying an alternating electric field to the cancer cells are provided. In some instances, sensitivity of cancer cells to TTFields can be restored with one or more PTGER3 inhibitors (e.g., NSAIDs, cox2 inhibitors).

Abstract: Embodiments herein describe a memory system with a data width (W) that is split into N separate memories each of narrower width W/N. To protect a write enable (WE) signal, the WE signal is toggled and then stored in each of the N memories. For example, toggle circuits can have states that toggle each time the WE signal goes high, indicated that a received data word should be stored in the N memories. A fault on the WE input to any of the N memories results in its stored toggle bit being different from the toggle bits stored in the other N memories. This condition can then be detected upon any subsequent read by checking whether the toggled bits are equal. The memory system can also protect the address and control signals by generating parity bits that are stored in the N memories.

Abstract: Systems and methods for vehicles to detect roadside shelters that can protect users from exposure to various weather conditions. Roadside shelter information can be mapped and added to a mapping database. Systems and methods are provided for live autonomous vehicle perception of viable shelters via machine learning. Shelter information can be incorporated into autonomous vehicle logic and decision-making for user pick-up, drop-off, delivery access, and any other user vehicle access. A user may prefer to wait for a vehicle underneath an awning or inside a bus stop shelter to avoid exposure to inclement weather. Vehicle sensors can be used for perception of roadside features.

Abstract: Methods and systems to detect a metastable condition and suppress/mask a signal during the metastable condition. The metastable condition may arise from asynchronous sampling. Techniques disclosed herein may be configured to enable asynchronous lock-stepping, where outputs of redundant circuit blocks of a first clock domain are received at input nodes of a second clock domain. In the second clock domain, logic states at the input nodes are compared to detect errors, and results of the comparison are masked during transitions at the input nodes. Masking may be constrained to situations where logic states at the input nodes differ.

Abstract: Safety mechanisms are embedded into a System on a Chip (SoC) and are operable to detect faults present in the logic circuitry in the SoC. Various types of faults in logic circuitry can occur, for example, a bit stuck at 0 or 1, or a transient or temporary fault due to radiation impacting the SoC. SoC devices are required to meet certain automotive safety integrity standards. The most stringent automotive safety integrity level requires that 90% of random latent faults are detected in all relevant logic, including all safety mechanism. Examples disclosed include hardware based checkers and hardware or software based pattern generation methods that achieve high online fault coverage in safety mechanism circuitry used for functional safety. A hardware based safety mechanism monitors the logic circuitry during operation. Any time the safety mechanism detects any faults in the logic circuitry, a fault notification is propagated to upstream logic.

Abstract: The disclosed technology provides solutions for efficiently and accurately identifying degraded suspension components. A method of the disclosed technology can include steps for associating a threshold measurement to a road feature; collecting sensor data from a sensor on an autonomous vehicle, wherein the sensor data includes a plurality of measurements associated with the road feature; identifying, from the sensor data, at least one measurement that is outside of the threshold measurement and indicative of a degraded suspension component of the autonomous vehicle; and identifying a location on the autonomous vehicle of the degraded suspension component based on the sensor data. Systems and machine-readable media are also provided.

Abstract: Aspects of the subject technology relate to systems, methods, and computer-readable media for maintaining a heating, ventilation, and air conditioning (HVAC) system in a vehicle. Factors associated with operation of an HVAC system in a vehicle are monitored. Input data generated by monitoring the factors are applied to a machine learning model. The machine learning model is configured to predict a health of the HVAC system in relation to the operation of the HVAC system in the vehicle. An output of the machine learning model that is indicative of the health of the HVAC system is accessed. Information associated with a likelihood that the HVAC system will fail in relation to a specific time is identified based on the output of the machine learning model.

Abstract: Methods of reducing the viability of cancer cells, preventing cancer cells of a subject from developing resistance to TTFields, and restoring sensitivity of cancer cells to TTFields by recommending or prescribing a PTGER3 inhibitor to a subject and applying an alternating electric field to the cancer cells are provided. In some instances, sensitivity of cancer cells to TTFields can be restored with one or more PTGER3 inhibitors (e.g., NSAIDs, cox2 inhibitors).

Abstract: The invention provides compositions comprising a ribonucleotide or ribonucleotides or a deoxyribonucleotide or deoxyribonucleotides encoding at least two cell fate determinants (CFD) selected from the group consisting of PBX2, ACTN2, POU2F1, HAND1, TRIM24, GATA4, PBX1, ZBTB39, HAND2, IKZF4, NROB2, NACA2, SMYD1, JUP, NEUROD1, CKMT2, TSHZ2, MITF, MYOCD, and PPARGC1B. The compositions are useful in the treatment of cardiac disorders and in reprogramming a mesenchymal stem cell (MSC) to an autologous induced cardiomyocyte (iCM).

Abstract: Provided herein are immunotherapy compositions for treating a subject with a glioblastoma, comprising a peptide formulation derived from at least one cancer or stemness factor, nanoparticles containing peptides derived from at least one cancer or stemness factor, dendritic cells containing peptides derived from at least one cancer or stemness factors, RNA coding at least one cancer or stemness factor, nanoparticles containing RNA coding at least one cancer or stemness factor, dendritic cells containing RNA coding at least one cancer factor or stemness factor, or an inhibitor of at least one cancer or stemness factor. Also provided are methods of inhibiting a glioblastoma stem-like cell (GSC), methods of treating a subject for glioblastoma, and methods of reprogramming an astrocyte to a glioblastoma stem-like cell (GSC) using such immunotherapy compositions.

Abstract: Methods and systems to detect a metastable condition and suppress/mask a signal during the metastable condition. The metastable condition may arise from asynchronous sampling. Techniques disclosed herein may be configured to enable asynchronous lock-stepping, where outputs of redundant circuit blocks of a first clock domain are received at input nodes of a second clock domain. In the second clock domain, logic states at the input nodes are compared to detect errors, and results of the comparison are masked during transitions at the input nodes. Masking may be constrained to situations where logic states at the input nodes differ.

Abstract: The technology described implements attestation programs that employ “code reuse” techniques. In particular, the technology relates to auto-generating attestation programs for, among other aspects, detecting whether a program has been modified. In one non-limiting example, the technology uses a tool that scans a software program (e.g., a video game) code for usable code sequences. The tool can automatically combine code sequences to generate a large number of attestation programs of different variety (e.g., memory checks, hashing).

Abstract: Provided herein are automated apparatus and methods for the identification of microorganisms in various samples. The disclosure solves existing challenges encountered in identifying and distinguishing various types of microorganisms, including viruses and bacteria in a timely, efficient, and automated manner by library preparation and sequencing.

Abstract: Described are compounds and compositions for transdifferentiation of glioblastoma cells to antigen presenting cells. Methods of using the compounds and compositions to treat glioblastoma and to induce an immune response against a glioblastoma are also described.