Abstract: The technology described implements attestation programs that employ “code reuse” techniques. In particular, the technology relates to auto-generating attestation programs for, among other aspects, detecting whether a program has been modified. In one non-limiting example, the technology uses a tool that scans a software program (e.g., a video game) code for usable code sequences. The tool can automatically combine code sequences to generate a large number of attestation programs of different variety (e.g., memory checks, hashing).

Abstract: Provided herein are automated apparatus and methods for the identification of microorganisms in various samples. The disclosure solves existing challenges encountered in identifying and distinguishing various types of microorganisms, including viruses and bacteria in a timely, efficient, and automated manner by library preparation and sequencing.

Abstract: Described are compounds and compositions for transdifferentiation of glioblastoma cells to antigen presenting cells. Methods of using the compounds and compositions to treat glioblastoma and to induce an immune response against a glioblastoma are also described.

Abstract: Provided herein are automated apparatus for the identification of microorganisms in various samples. The disclosure solves existing challenges encountered in identifying and distinguishing various types of microorganisms, including viruses and bacteria in a timely, efficient, and automated manner by sequencing.

Abstract: Provided herein are automated apparatus and methods for the identification of microorganisms in various samples. The disclosure solves existing challenges encountered in identifying and distinguishing various types of microorganisms, including viruses and bacteria in a timely, efficient, and automated manner by library preparation and sequencing.

Abstract: Described herein are AAV particles having capsid proteins with amino acid substitutions that confer increased affinity for and transduction of glioma cells. The disclosed capsid proteins may be used in conjunction with any therapeutic transgene for treatment of cancer, including in the manufacture of an AAV particle. Also described are methods of identifying AAV variants having increased affinity for and transduction of specific tumor cell types.

Abstract: The subject disclosure relates to techniques for positioning an autonomous vehicle for sensor calibration. A process of the disclosed technology can include steps for positioning an autonomous vehicle along a first axis on a platform in a predetermined environment using guide rails, positioning the autonomous vehicle along a second axis on the platform using one or more elevated platform features, inserting one or more lifting alignment pins of a lifting mechanism into one or more sockets located on an underbody of the autonomous vehicle, and positioning the autonomous vehicle along a third axis using the lifting mechanism. Systems and machine-readable media are also provided.

Abstract: Disclosed herein are chemotherapeutic methods for the treatment of cancer in humans. In at least one specific embodiment, the method can include administering a therapeutic effective amount of one or more p38 inhibitor compound or salt thereof to a human. The method can also include administering a therapeutic effective of one or more IL-6 inhibitor or one or more IL-6 receptor inhibitor or salt thereof to the human. The method can also include administering a therapeutic effective amount of one or more cytotoxic compound or salt thereof to the human.

Abstract: The subject invention pertains to a Molecular Cell Diary System (MCDS), which allows identification of the history of somatic alterations in the cell. MCDS comprises one or more combinations of a DNA cutter and a DNA writer expressed under the control of a promoter controlled a cellular event of interest. The DNA cutter and the DNA writer are in a combination are co-expressed when an even of interest occurs. The DNA cutter creates double strand breaks (DSB) in a target DNA in a sequence specific manner and the DNA writer incorporates DNA sequences in the DSB. The endogenous DNA repair machinery synthesizes repairs the DSB. As such, the combination of the DNA cutter and the DNA writer modifies the target DNA and leaves “marks” of the occurrence of the cellular event of interest. These marks are sequenced and the cellular event history of the cell is deciphered.

Abstract: The subject technology provides solutions for performing extrinsic sensor calibration for vehicle sensors, such as environmental sensors deployed in an autonomous vehicle (AV) context. In some aspects, the disclosed technology relates to a sensor localization system that is configured to: perform a scan, using a 3D scanner, to collect surface data associated with an autonomous vehicle (AV), analyze the surface data to identify a coordinate origin of the AV, and calculate a position of at least one or more AV sensors based on the surface data. Methods and computer-readable media are also provided.

Abstract: Methods and kits treating a subject with a checkpoint inhibitor are provided by detecting expression levels of one or more biomarkers (e.g., cytokines and cytotoxic genes, immune cell functional regulators, naïve immune cell markers, regulatory T cell factors, and immune inhibitory receptors) in immune cells of a patient or subject with a condition (e.g., cancer) before and after exposure of tumor cells to alternating electric fields. Kits comprising nucleic acid probes for detecting the one or more biomarkers are also provided.

Abstract: Provided herein are automated apparatus and methods for the identification of microorganisms in various samples. The disclosure solves existing challenges encountered in identifying and distinguishing various types of microorganisms, including viruses and bacteria in a timely, efficient, and automated manner by library preparation and sequencing.

Abstract: Provided herein are automated apparatus for the identification of microorganisms in various samples. The disclosure solves existing challenges encountered in identifying and distinguishing various types of microorganisms, including viruses and bacteria in a timely, efficient, and automated manner by sequencing.

Abstract: Provided herein are automated apparatus for the identification of microorganisms in various samples. The disclosure solves existing challenges encountered in identifying and distinguishing various types of microorganisms, including viruses and bacteria in a timely, efficient, and automated manner by sequencing.

Abstract: Provided herein are fully-automated next-generation sequencing platforms and processes for detection of a target specimen (e.g., SARS-CoV-2) and for distinguishing infectious from non-infectious signals from the specimen. An analysis can provide simultaneous diagnosis and genomic surveillance of a multitude of distinct specimens in a sample information. The analysis can comprise distinguishing between infectious versus infectious specimens and provide a recommendation as to how infectious the sample can be. The information on can be used to better inform the status of a subject or a location with regards to infectivity from the specimen.

Abstract: The technology described implements attestation programs that employ “code reuse” techniques. In particular, the technology relates to auto-generating attestation programs for, among other aspects, detecting whether a program has been modified. In one non-limiting example, the technology uses a tool that scans a software program (e.g., a video game) code for usable code sequences. The tool can automatically combine code sequences to generate a large number of attestation programs of different variety (e.g., memory checks, hashing).

Abstract: Some examples herein provide for protection of data on a data path in a memory system in an integrated circuit. In an example, an integrated circuit includes a bit checker circuit, an Error Correcting Code (ECC) encoder circuit, an ECC decoder circuit, and a check bit generation circuit. The bit checker circuit is configured to check write data based on write-path check bit(s). The ECC encoder circuit is configured to generate a write encoded ECC value based on the write data. The write encoded ECC value is to be written to the memory with the write data. The ECC decoder circuit is configured to decode a read encoded ECC value and check read data based on the read encoded ECC value. The read encoded ECC value and read data are read from the memory. The check bit generation circuit is configured to generate read-path check bit(s) from the read data.

Abstract: Provided methods of inhibiting a glioblastoma stem-like cell (GSC), methods of treating a subject with glioblastoma, and methods of reprogramming an astrocyte to a glioblastoma stem-like cell (GSC).

Abstract: Provided herein are methods of assessing, detecting, monitoring the presence, or monitoring progression of cancer in a subject, or assessing or predicting prognosis or survival of a subject having cancer. Also provided are methods of measuring chromosomal accessibility of the chromosomal locus of cancer master regulator genes or downstream genes in the master regulator network, methods of measuring chromosomal DNA methylation at the chromosomal locus of cancer master regulator genes or downstream genes, and methods measuring chromosomal DNA methylation at the chromosomal locus of the promoter and/or regulatory regions of cancer master regulator genes or downstream genes.