Abstract: A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container, a shell, at least one agitator, at least one sparger, at least one gas filter inlet port for the sparger(s) and headspace overlay, at least one fill port, at least one harvest port, at least one sample port, and at least one probe. In examples, at least one controller may monitor and control one or more parameters associated with the single-use bioreactor A method to cultivate and propagate mammalian cells is also provided. The method may include cultivating under suitable conditions and in a suitable culture medium in a first single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a second single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a third single-use bioreactor, and cultivating the cells in the third bioreactor.

Abstract: A trocar coupling assembly includes a housing disposable in a tubular shaft of a surgical stapler. The housing has opposed openings defining a passage through the housing that is capable of receiving a trocar assembly therein. A release button is accessible through the tubular shaft for transitioning the trocar coupling assembly between a locked configuration and an unlocked configuration.

Abstract: A trocar assembly for releasable engagement with an adapter assembly of a surgical stapling instrument includes a trocar mechanism that includes a trocar member that is at least one of rotatable or articulable relative to a housing of the trocar assembly.

Abstract: An improved chip assembly for use in a stapling device includes a housing assembly receivable within a reload assembly. The housing assembly includes a base member defining a cavity and an identification assembly received within the cavity. The chip assembly further includes a plug assembly configured to selectively engage the base member. The plug assembly includes a housing, a wire extending from the housing, a seal member disposed within and extending from a distal end of the housing, and first and second contact members extending through the seal member and from the housing. The seal member is configured to be frictionally received within the base member to secure the plug assembly to the housing assembly in a fluid tight manner.

Abstract: A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container, a shell, at least one agitator, at least one sparger, at least one gas filter inlet port for the sparger(s) and headspace overlay, at least one fill port, at least one harvest port, at least one sample port, and at least one probe. In examples, at least one controller may monitor and control one or more parameters associated with the single-use bioreactor A method to cultivate and propagate mammalian cells is also provided. The method may include cultivating under suitable conditions and in a suitable culture medium in a first single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a second single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a third single-use bioreactor, and cultivating the cells in the third bioreactor.

Abstract: A surgical device includes an adapter assembly including a tubular housing having a proximal end portion configured to couple to a handle assembly, and a load sensing assembly disposed with the tubular housing. The load sensing assembly is configured to measure a load exerted on the tubular housing and includes: a sensor body including a pocket defined therein; a load sensor circuit disposed within the pocket and coupled to the sensor body; a signal processing circuit disposed within the pocket and electrically coupled to the load sensor circuit; a cover defining a cavity and disposed over the pocket and enclosing the load sensor circuit and the signal processing circuit therein, the cover being coupled to the sensor body thereby forming a first hermetic seal therebetween; and a thermal management material disposed within the cavity and in contact with the load sensor circuit and the signal processing circuit.

Abstract: A device for loading a trocar assembly with an adapter assembly of a surgical stapling instrument is provided. The trocar loading device includes a base member and an engagement member operatively secured to the base member. The base member defines a longitudinal passage for receipt of a trocar assembly and the engagement member releasably secures the trocar member within the base member. The base member includes an alignment feature for aligning the trocar assembly with an adapter assembly.

Abstract: A plug assembly for an electromechanical surgical system includes: a housing defining a proximal facing bore; a pair of electrical contacts disposed within the housing, each electrical contact including a distal end portion projecting distally from a distal end of the housing; and a proximal end portion disposed within the proximal facing bore of the housing; a ribbon cable having a distal end portion electrically connected to the proximal end portion of each of the pair of electrical contacts, and being disposed with the proximal facing bore of the housing; and an encapsulating material filling the proximal facing bore of the housing.

Abstract: A surgical device includes a handle assembly having a controller and an adapter assembly including a tubular housing having a proximal end portion configured to couple to the handle assembly and a distal end portion. The adapter assembly also includes a load sensing assembly disposed with the tubular housing. The load sensing assembly is configured to measure a load exerted on the tubular housing and includes: a sensor body having a pocket defined therein; a load sensor circuit disposed within the pocket and coupled to the sensor body; and a signal processing circuit disposed within the pocket and electrically coupled to the load sensor circuit. The load sensing assembly further includes a cover disposed over the pocket and enclosing the load sensor circuit and the signal processing circuit therein, the cover being coupled to the sensor body thereby forming a first hermetic seal therebetween.

Abstract: An adapter assembly for connecting a surgical loading unit to a handle assembly is provided. The adapter assembly includes a sleeve, a trocar assembly releasably securable within the sleeve, and a locking mechanism configured to releasably secure the trocar assembly within the sleeve.

Abstract: Surgical instruments include a first drive assembly having a first drive gear and a lockout mechanism positioned for releasable engagement with the first drive assembly to inhibit rotation of the first drive gear. The lockout mechanism includes a pawl and an actuator means for moving the pawl from a first position in engagement with the first drive gear to a second position spaced from the first drive gear.

Abstract: A method of encapsulating and hermetically sealing a printed circuit board of a flex cable includes: positioning a printed circuit board portion of a flex cable into a channel defined in a first mold half of a mold, the printed circuit board portion including a substrate and electronic components mounted on the substrate; mounting a second mold half onto the first mold half to enclose the channel of the first mold half and form a cavity within the mold; and filling the cavity of the mold with an encapsulation material through an inlet opening defined through the mold.

Abstract: An adapter assembly, for connecting a surgical device to an electromechanical handle assembly, includes a cavity and a seal. The cavity is configured to receive a pin connector assembly of an electrical assembly of the electromechanical handle assembly. The seal is disposed at least partially within the cavity and is configured to reduce an amount of fluid able to contact the electrical assembly of the electromechanical handle assembly.

Abstract: A tool assembly includes a cartridge assembly, a shell, and an anvil assembly. The shell houses the cartridge assembly and defines a passage. The shell includes alignment splines that are disposed within the passage and define channels between adjacent alignment splines. The anvil assembly includes an anvil and a center rod that extends from the anvil. The center rod defines a longitudinal axis and includes a first spline and second splines. The first spline includes a first leading facet that is configured to engage the alignment splines to clock the anvil assembly relative to the cartridge assembly. The second splines are radially spaced apart about the longitudinal axis. Each of the second splines includes a leading end that defines a plane that is substantially orthogonal to the longitudinal axis. The leading end is configured to crash with the alignments spines when the anvil assembly is misaligned with the cartridge assembly.

Abstract: The present disclosure relates to force sensors and force sensor substrates for use with surgical devices.

Abstract: A circular stapling device includes an anvil assembly and an adaptor assembly including a shell assembly. The adaptor assembly includes an anvil retainer including an asymmetric tip. The anvil assembly has a center rod, an anvil head supported on the center rod, and an alignment member. The center rod has a proximal portion and a distal portion and defines a channel that extends from the proximal portion to the distal portion. The alignment member is positioned within the channel and is configured to engage the asymmetric trocar tip of the anvil retainer of the adaptor when the anvil assembly is attached to the anvil retainer to properly align the anvil assembly with the shell assembly.

Abstract: The present disclosure relates to force sensors and force sensor substrates for use with surgical devices.

Abstract: A method of assembling a hermetically sealed printed circuit board includes: securing a first end portion of a wall of a cap to a substrate around an electrical contact region of the substrate, the wall including a second end portion disposed in an open configuration; mounting an electronic component to the electrical contact region of the substrate; and sealing the second end portion of the wall closed to form a hermetically sealed chamber between the substrate and the cap to encase the electronic component therein.

Abstract: A tool assembly includes a cartridge assembly, a shell, and an anvil assembly. The shell houses the cartridge assembly and defines a passage. The shell includes alignment splines that are disposed within the passage and define channels between adjacent alignment splines. The anvil assembly includes an anvil and a center rod that extends from the anvil. The center rod defines a longitudinal axis and includes a first spline and second splines. The first spline includes a first leading facet that is configured to engage the alignment splines to clock the anvil assembly relative to the cartridge assembly. The second splines are radially spaced apart about the longitudinal axis. Each of the second splines includes a leading end that defines a plane that is substantially orthogonal to the longitudinal axis. The leading end is configured to crash with the alignments spines when the anvil assembly is misaligned with the cartridge assembly.

Abstract: An apparatus for ensuring strain gauge accuracy including a handle assembly including a controller, an adapter assembly including a tubular housing having a proximal end portion configured to couple to the handle assembly and a distal end portion, a load sensing assembly configured to measure a load exerted on the tubular housing, and a signal processing circuit electrically coupled to the load sensing assembly, a memory coupled to the signal processing circuit, and a calibration assembly including a biasing member having a known spring rate stored as a force value in the memory, the calibration assembly configured to couple to the distal end portion of the adapter assembly. The signal processing circuit is configured to calibrate the adapter assembly with the calibration assembly attached thereto by calculating a correction factor based on a comparison a force of the spring member measured by the load sensing assembly to the force value.