Abstract: An ophthalmic device includes an optic including an optic axis and a closed-loop haptic structure coupled to the optic via a frame surrounding the optic, the closed-loop haptic structure including a closed loop extending from first and second attachment points to the frame. The closed loop includes a first hinge and a second hinge. The first hinge has a first section having a first component extending in a first angular direction, a second section having a second component extending in a second angular direction opposite to the first angular direction, and a first connecting section between the first section and the second section. The second hinge has a third section having a third component extending in the second angular direction, a fourth section having a fourth component extending in the first angular direction, the fourth section being connected to the second section to form the closed loop.

Abstract: This invention establishes a new paradigm for treatment of Parkinson's disease (PD) by eliminating senescent cells that reside in or around the site of the disease pathophysiology. Exposure of test subjects to the herbicide paraquat (PQ) increases the risk for developing Parkinson's disease. The data in this disclosure show that PQ induces a senescence arrest and SASP in astrocytes, in culture and in vivo in mice, and senescent cell markers were present in astrocytes in midbrain tissue from PD patients. In a transgenic mouse model, senescent cell ablation protected against PQ-induced PD-like neuropathology. Removal of senescent cells from affected sites using small molecule agents that specifically target senescent cells can help prevent or ameliorate signs and symptoms of the disease.

Abstract: A system and method for promoting and safeguarding the wellbeing of patients in relation to a fluid injection may obtain patient data; determine, based on the patient data, an initial risk prediction for a patient for a fluid injection to be administered to the patient, the initial risk prediction including a probability that the patient experiences at least one adverse event in response to the fluid injection; provide, to a user device, before the fluid injection is administered to the patient, the initial risk prediction; determine, after the fluid injection is started, sensor data associated with the patient; determine, based on the sensor data determined after the fluid injection is started, a current risk prediction including a probability that the patient experiences the at least one adverse event in response to the fluid injection; and provide, to the user device, the current risk prediction.

Abstract: A three-dimensional discretized computer model of a part in a three-dimensional discretized design space comprising three-dimensional geometrical elements is obtained. A signed distance field based on a geometry of the three-dimensional discretized computer model of the part as represented in the three-dimensional geometrical elements of the three-dimensional discretized design space is produced. At least one non-branching cooling channel in a portion of the three-dimensional discretized design space is generated.

Abstract: The invention pertains to a process for the production of crystalline carbon structure networks in a reactor 3 which contains a reaction zone 3b and a termination zone 3c, by injecting a thermodynamically stable micro-emulsion c, comprising metal catalyst nanoparticles, into the reaction zone 3b which is at a temperature of above 600° C., preferably above 700° C., more preferably above 900° C., even more preferably above 1000° C., more preferably above 1100° C., preferably up to 3000° C., more preferably up to 2500° C., most preferably up to 2000° C., to produce crystalline carbon structure networks e, transferring these networks e to the termination zone 3c, and quenching or stopping the formation of crystalline carbon structure networks in the termination zone by spraying in water d.

Abstract: Computing device(s) are configured for managing the reunification of students with parents during an emergency or a drill for a simulated emergency. The reunification of students with guardians may be managed through the operations of various user interfaces (UIs) presented on the device(s). Different UIs may be configured to support different personnel performing different roles in the reunification process. The UIs may include one or more of a student supervisor UI, a location supervisor UI, a runner UI, a guardian greeter UI, a reunification officer UI, or an incident commander UI. The various UIs enable different personnel to track the location and status of individuals, such as students and guardians, during various stages of a reunification process, enable personnel to dynamically update a centralized database with current information regarding the location and status of individuals, and view real time information regarding the location and status of individuals.

Abstract: In various example embodiments, a system and method for handling a replaced smart device are presented. A computer-implemented replaced device handler detects that a user's smart device was replaced with a new device of the same class and, in response, presents the user with an invitation to sell their old device that has been replaced. A replaced device handler may be provided in connection with an on-line trading platform.

Abstract: A realtime kernel supports realtime communications between communicants operating on respective network nodes. The realtime kernel handles the complex tasks of connecting to communicants, virtual areas, and other network resources, switching those connections in response to user inputs, and mixing realtime data streams. The realtime kernel enables developers to focus on developing high-level communications functionality instead of low-level plumbing code. The realtime kernel imposes relatively low computational resource requirements so that realtime communications performance can be achieved using a wide range of computing devices and network connections that currently are available.

Abstract: A three-dimensional computer model of a cooling mold for a part and a specification of an initial layout of one or more cooling channels integrated into the cooling mold is obtained. Data regarding temperatures of a cavity surface of the cooling mold in contact with the part is produced. Individual portions of the one or more cooling channels are moved toward hotter portions of the cavity surface, without moving any branch junctions of the one or more cooling channels and while keeping one or more diameters of the one or more cooling channels constant.

Abstract: In association with a virtual area, a first network connection is established with a first network node present in the virtual area and a second network connection is established with a second network node present in the virtual area. Based on stream routing instructions, a stream router is created between the first network node and the second network node. The stream router includes a directed graph of processing elements operable to receive network data, process the received network data, and output the processed network data. On the first network connection, an input data stream derived from output data generated by the first network node is received in association with the virtual area. The input data stream is processed through the stream router to produce an output data stream. On the second network connection, the output data stream is sent to the second network node.

Abstract: The present disclosure relates generally to a gaming system, device, and method supportive of a self-evolving, AI-based playstyle models. A gaming system, device, and method are provided that identify data associated with a gameplay session at a gaming device, provide the data to a machine learning network; receive an output from the machine learning network in response to the machine learning network processing the data using a playstyle model, the output including an indication associated with modifying the playstyle model; and modify the playstyle model based on the indication. The data includes at least one of: a gameplay decision received during the gameplay session; and an emotional state of a user in association with the gameplay decision.

Abstract: A vehicle, a method of controlling a vehicle, and a non-transitory computer readable storage medium are described. The vehicle can comprise a management and control system associated to onboard systems and/or to a driving input interface and/or to the engine and/or powertrain and/or to at least one wheel and/or to the chassis. The management and control system can: determine aggregated command outputs; detect one or more dynamic parameters exceeding a threshold safety value; selectively prioritize each of the aggregated command outputs based on one or more of the dynamic parameters to change from a user-selected driving mode to a safety driving mode; and change the prioritized safety driving mode back to the user-selected driving mode in response to the one or more of the dynamic parameters no longer exceeding the threshold safety value.

Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.

Abstract: The invention pertains to a process for the production of crystalline carbon nanofibre networks from pyrolysis oil in a furnace black reactor 3 which contains a reaction zone 3b and a termination zone 3c, by injecting a thermodynamically stable pyrolysis oil-comprising micro-emulsion c, comprising metal catalyst nanoparticles, into the reaction zone 3b which is at a temperature of above 600° C., preferably above 700° C., more preferably above 900° C., even more preferably above 1000° C., more preferably above 1100° C., preferably up to 3000° C., more preferably up to 2500° C., most preferably up to 2000° C., to produce crystalline carbon structure networks e, transferring these networks e to the termination zone 3c, and quenching or stopping the formation of crystalline carbon structure networks in the termination zone by spraying in water d.

Abstract: The present invention provides an article picking and placing system, the system comprising: —a first article picking tooling and a second article picking tooling, and an intermediate transportation unit configured in between an article infeed transportation unit and an article outfeed transportation unit; —a control unit for synchronizing the first and second article picking tooling such that (i) the first article picking tooling picks and/or forms a first configuration of articles from the infeed transportation unit for transfer to the intermediate transportation unit, thereby forming an intermediate configuration on said intermediate transportation unit, and (ii) the second picking tooling picks a second configuration of articles from said intermediate transportation unit for transfer to the outfeed transportation unit, wherein the second and intermediate article configurations are different relative to each other and each different from the first article configuration.

Abstract: A method for reducing the appearance of a skin pore in skin of a subject in need thereof is disclosed. The method can include topically applying to the skin pore a composition comprising effective amount of Albizia julibrissin bark extract, and hydrolyzed soy flour, wherein topical application of the composition reduces the appearance of the size of the skin pore.

Abstract: Apparatus and methods of managing a virtual area based on communicant capabilities are described. The communicant capabilities are updated based on rules in response to events in the virtual area. An action by one communicant can affect the capabilities of another communicant. Communicant capabilities can be stored in respective server-side proxies and the virtual area can be managed without transmitting any of the capabilities to the communicants' client network nodes. Capability-based permissions checks can be performed against communicant capabilities with wildcarded attribute fields.

Abstract: In some embodiments, data from multiple vehicle-based natural gas leak detection survey runs are used by computer-implemented machine learning systems to generate a list of natural gas leaks ranked by hazard level. A risk model embodies training data having known hazard levels, and is used to classify newly-discovered leaks. Hazard levels may be expressed by continuous variables, and/or probabilities that a given leak fits within a predefined category of hazard (e.g. Grades 1-3). Each leak is represented by a cluster of leak indications (peaks) originating from a common leak source. Hazard-predictive features may include maximum, minimum, mean, and/or median CH4/amplitude of aggregated leak indications; estimated leak flow rate, determined from an average of leak indications in a cluster; likelihood of leak being natural gas based on other indicator data (e.g. ethane concentration); probability the leak was detected on a given pass; and estimated distance to leak source.

Abstract: The present disclosure relates to compounds of Formula (I) which are multimeric forms of a monomeric binding peptide linearly bonded to PEG moieties to form the multimers. The multimeric forms stimulate angiogenesis and promote wound healing. The disclosure also includes pharmaceutical compositions comprising the multimers, including compositions suitable for topical or systemic administration.

Abstract: The present disclosure is directed to the use of microvirin-N in the detection of Mycobacterium tuberculosis infections.