Abstract: The invention provides isolated primate cells preferably human cells that comprise a genetically engineered disruption in a beta-2 microglobulin (B2M) gene, which results in deficiency in MHC class I expression and function. Also provided are the method of using the cells for transplantation and treating a disease condition.

Abstract: Disclosed herein are methods of editing a gene in a cell that involve contacting the cell with a replication fork modulator, as well as edited cells and their methods of use.

Abstract: Apparatuses for storing, transmitting, and identifying changes in relation to, data are provided. One of these apparatuses is a server which includes a processor-implemented controller that receives data from a first electronic device external to the server, determines whether a user identification corresponding to a second electronic device external to the server matches a specified user identification, and transmits at least one portion of the data to the second electronic device based at least in part on a determination that the user identification matches the specified user identification.

Abstract: The invention provides isolated primate cells preferably human cells that comprise a genetically engineered disruption in a beta-2 microglobulin (B2M) gene, which results in deficiency in MHC class I expression and function. Also provided are the method of using the cells for transplantation and treating a disease condition.

Abstract: The invention provides isolated primate cells preferably human cells that comprise a genetically engineered disruption in a human leukocyte antigen (HLA) class II-related gene, which results in deficiency in MHC class II expression and function. This invention also provides isolated cells further comprising a genetically engineered disruption in a beta-2 microglobulin (B2M) gene, which results in HLA class I/class II deficiency. Also provided are the method of using the cells for transplantation and treating a disease condition.

Abstract: Apparatuses for storing, transmitting, and identifying changes in relation to, data are provided. One of these apparatuses is a server which includes a processor-implemented controller that receives data from a first electronic device external to the server, determines whether a user identification corresponding to a second electronic device external to the server matches a specified user identification, and transmits at least one portion of the data to the second electronic device based at least in part on a determination that the user identification matches the specified user identification.

Abstract: Apparatuses for storing, transmitting, and identifying changes in relation to, data are provided. One of these apparatuses is a server which includes a processor-implemented controller that receives data from a first electronic device external to the server, determines whether a user identification corresponding to a second electronic device external to the server matches a specified user identification, and transmits at least one portion of the data to the second electronic device based at least in part on a determination that the user identification matches the specified user identification.

Abstract: A display screen assembly is suitable for use in a digital device that lacks the processing power, memory, or both needed to carry out light-simulated bar code processing. The display screen assembly includes a display screen having a display area and mounted to a flexible circuit. The flexible circuit includes numerous conductive circuit traces including terminal ends, and various electronic components such as a controller and a screen driver. The various components may be covered by a cover layer, and the display screen including the display area may be covered by a sheet of transparent material. An LED may be generally positioned near an edge or corner of the display screen, and may be may be controlled by a digital device processor or by the controller on the flexible circuit, as desired, for producing light-simulated bar codes.

Abstract: Apparatuses for storing, transmitting, and identifying changes in relation to, data are provided. One of these apparatuses is a server which includes a processor-implemented controller that receives data from a first electronic device external to the server, determines whether a user identification corresponding to a second electronic device external to the server matches a specified user identification, and transmits at least one portion of the data to the second electronic device based at least in part on a determination that the user identification matches the specified user identification.

Abstract: The invention provides isolated primate cells preferably human cells that comprise a genetically engineered disruption in a human leukocyte antigen (HLA) class II-related gene, which results in deficiency in MHC class II expression and function. This invention also provides isolated cells further comprising a genetically engineered disruption in a beta-2 microglobulin (B2M) gene, which results in HLA class I/class II deficiency. Also provided are the method of using the cells for transplantation and treating a disease condition.

Abstract: This invention provides methods for obtaining targeted gene modification in vertebrate cells using parvoviral vectors, including adeno-associated virus (AAV). The parvoviral vectors used in the methods of the invention are capable of targeting a specific genetic modification to a preselected target locus in a cellular genome by homologous pairing.

Abstract: Various types of light source, including those in use in pixel based display devices, may be used for light-simulated bar codes. Liquid crystal displays (“LCD”) which utilize a backlight for screen brightness may, for example, be very effective for producing light-simulated bar codes because the entire backlight may be modulated to provide the desired light/dark sequence. Even displays which have no backlight, for example but not limited to OLED and LED displays, may be used for light-simulated bar codes. While the entire display may be used, single pixels or pixel groups of the displays of such displays may be used.

Abstract: A method and system for backing up and restoring personal data are provided. The method includes communicating with a first communication device over a first communication connection when the first communication device detects changes to personal data stored in a first communication device; receiving the changed personal data over the first communication connection; performing a backup function by receiving the changed personal data from the first communication device; automatically communicating with a second communication device that is associated with a same user account as a user account associated with the first communication device, over a second communication connection upon performing the backup function; and automatically performing a restore function by transmitting the changed personal data to the second communication device over the second communication connection upon performing the backup function.

Abstract: A method and system for backing up and restoring personal data are provided. The method includes establishing a first communication connection between the first communication device and an entity in a remote computer network upon detecting changes of personal data stored in a first communication device; communicating between the first communication device and the remote computer network entity an identity of an archival function to be performed over the first communication connection, wherein the archival function to be performed includes backing up the personal data; performing a backup function by receiving the changed personal data from the first communication device; establishing a second communication connection between a second communication device and the remote computer network entity; and performing a restore function using the second communication connection by transmitting the changed personal data from the remote computer network entity to the second communication device.

Abstract: The invention provides isolated primate cells preferably human cells that comprise a genetically engineered disruption in a beta-2 microglobulin (B2M) gene, which results in deficiency in MHC class I expression and function. Also provided are the method of using the cells for transplantation and treating a disease condition.

Abstract: A method and system for backing up and restoring personal data are provided. The method includes establishing a first communication connection between the first communication device and an entity in a remote computer network upon detecting changes of personal data stored in a first communication device; communicating between the first communication device and the remote computer network entity an identity of an archival function to be performed over the first communication connection, wherein the archival function to be performed includes backing up the personal data; performing a backup function by receiving the changed personal data from the first communication device; establishing a second communication connection between a second communication device and the remote computer network entity; and performing a restore function using the second communication connection by transmitting the changed personal data from the remote computer network entity to the second communication device.

Abstract: The present invention provides methods of generating a mammalian cell that is homozygous at a locus of interest, as well as cells made by the method. The present invention further provides methods of using the cells.

Abstract: Various types of light source, including those in use in pixel based display devices, may be used for light-simulated bar codes. Liquid crystal displays (“LCD”) which utilize a backlight for screen brightness may, for example, be very effective for producing light-simulated bar codes because the entire backlight may be modulated to provide the desired light/dark sequence. Even displays which have no backlight, for example but not limited to OLED and LED displays, may be used for light-simulated bar codes. While the entire display may be used, single pixels or pixel groups of the displays of such displays may be used.

Abstract: A display screen assembly is suitable for use in a digital device that lacks the processing power, memory, or both needed to carry out light-simulated bar code processing. The display screen assembly includes a display screen having a display area and mounted to a flexible circuit. The flexible circuit includes numerous conductive circuit traces including terminal ends, and various electronic components such as a controller and a screen driver. The various components may be covered by a cover layer, and the display screen including the display area may be covered by a sheet of transparent material. An LED may be generally positioned near an edge or corner of the display screen, and may be may be controlled by a digital device processor or by the controller on the flexible circuit, as desired, for producing light-simulated bar codes.

Abstract: A method and system for archiving and restoring data in a portable communication device. A first wireless communication connection is established between the communication device and a remote network capable of storing portable communication device data. The identity of an archival function to be performed is transmitted over the first communication connection. The indicated archival function is performed by transmitting data to or from the communication device. The function can be performed over the first wireless communication connection or a second wireless communication connection can be established for transmitting the information. The data can be converted by an upload converter into a format that is independent of the identity of the communication device. The converted data can be sent to other communication devices and reformatted for use by those devices. The first communication connection can be established by a communication device user or automatically.