Patents by Inventor David W. Smith

David W. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220177845
    Abstract: This disclosure provides methods of making a megakaryocyte-erythroid progenitor cell (MEP), comprising differentiating a MEP precursor cell into a MEP in culture in the presence of an aryl hydrocarbon receptor (AhR) modulator. In some embodiments the AhR modulator is an AhR antagonist. In some embodiments the AhR modulator is an AhR agonist. In some embodiments the methods comprise culturing MEP precursor cells in the presence of an AHR antagonist and then culturing MEP precursor cells in the presence of an AHR agonist. In some embodiments the stem cell is a pluripotent stem cell. In some embodiments the MEP co-expresses CD41 and CD235. In some embodiments the number of MEPs produced in the culture increases exponentially. Methods of making a red blood cell (RBC) by culturing a MEP in the presence of an AhR modulator are also provided. Methods of making a megakaryocyte and/or a platelet, comprising culturing a MEP in the presence of an AhR modulator are also provided.
    Type: Application
    Filed: August 20, 2021
    Publication date: June 9, 2022
    Inventors: George J. Murphy, David H. Sherr, Sarah S. Rozelle, Brenden W. Smith
  • Publication number: 20220151637
    Abstract: A system includes a first device, a second device, and garment. The garment has an elastic region that is configured to receive the first and second devices so that, when the garment is worn by a subject, the first and second devices are positioned at a respective one of a pair of neck veins of the subject. The first and second devices and/or the elastic region apply a compressive pressure to the pair of neck veins while the garment is worn.
    Type: Application
    Filed: December 23, 2021
    Publication date: May 19, 2022
    Inventors: David W. Smith, Kevin John Vititoe, Jamison Joseph Float, Chad Michael Leeder
  • Publication number: 20220073315
    Abstract: A knockdown, portable lift is relatively compact and lightweight for transport and use where there is no existing means for lifting a load between a lower surface and an upper surface or where the existing means cannot be used. Components of the lift are stored in a base portion of the lift and are assembled on site for forming a lift frame extending between the upper and lower surfaces. A platform and drive assembly are supported on the lift frame and are driven together up and down tracks on each side of the lift frame using a rotary drive, such as a hand crank or electric motor, to power the drive assembly. The drive assembly is operable by a person on or off the platform from either the upper or lower surface or traversing stairs over which the platform is moving. The drive assembly incorporates a unique overspeed braking system and a unique clutch arrangement.
    Type: Application
    Filed: September 29, 2021
    Publication date: March 10, 2022
    Inventor: David W. SMITH
  • Patent number: 11167954
    Abstract: A knockdown, portable lift is relatively compact and lightweight for transport and use where there is no existing means for lifting a load between a lower surface and an upper surface or where the existing means cannot be used. Components of the lift are stored in a base portion of the lift and are assembled on site for forming a lift frame extending between the upper and lower surfaces. A platform and drive assembly are supported on the lift frame and are driven together up and down tracks on each side of the lift frame using a rotary drive, such as a hand crank or electric motor, to power the drive assembly. The drive assembly is operable by a person on or off the platform from either the upper or lower surface or traversing stairs over which the platform is moving. The drive assembly incorporates a unique overspeed braking system and a unique clutch arrangement.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: November 9, 2021
    Assignee: ADAPTIVE CONCEPTS LTD.
    Inventor: David W Smith
  • Publication number: 20210268219
    Abstract: A respiratory interface device is provided that includes a cushion and a faceplate. The cushion is structured to be coupled to the faceplate. The faceplate includes a peripheral end and a number of custom features. The cushion is coupled to the faceplate adjacent the faceplate peripheral end.
    Type: Application
    Filed: May 19, 2021
    Publication date: September 2, 2021
    Inventors: JONATHAN SAYER GRASHOW, LAUREN PATRICIA CHODKOWSKI, DAVID W. SMITH
  • Publication number: 20210198430
    Abstract: Skin-contact products with a transpiration function such as medical devices or medicinal products, of which face masks, aspirators, ventilators, breast pumps or wound dressings are examples are described especially a skin-contact product with a transpiration function with an improved microclimate at a patient interface material -skin contact area. In an embodiment a material system is described that comprises a hydrophobic silicone base material and a hydrophilic silicone material that is combined with the hydrophobic base material.
    Type: Application
    Filed: March 9, 2021
    Publication date: July 1, 2021
    Inventors: Nicolaas Petrus Willard, Mareike Klee, Lucas Beckers, Dirk Burdinski, Joyce Van Zanten, Willem Franke Pasveer, Biju Kumar Sreedharan Nair, David W. Smith, Cornelis Petrus Hendriks, Sima Asvadi
  • Patent number: 10975204
    Abstract: Skin-contact products with a transpiration function such as medical devices or medicinal products, of which face masks, aspirators, ventilators, breast pumps or wound dressings are examples are described especially a skin-contact product with a transpiration function with an improved microclimate at a patient interface material-skin contact area. In an embodiment a material system is described that comprises a hydrophobic silicone base material and a hydrophilic silicone material that is combined with the hydrophobic base material.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: April 13, 2021
    Inventors: Nicolaas Petrus Willard, Mareike Klee, Lucas Johannes Anna Maria Beckers, Dirk Burdinski, Joyce Van Zanten, Willem Franke Pasveer, Biju Kumar Sreedharan Nair, David W. Smith, Cornelis Petrus Hendriks
  • Patent number: 10842502
    Abstract: A system for reducing the damaging effects of radiant energy, blast, or concussive events includes applying pressure to at least one jugular vein to reduce the egress of blood from the cranial cavity during or before the incidence of the imparting event. Reducing blood outflow from the cranial cavity increases intracranial volume and/or pressure of the cerebrospinal fluid to reduce the risk of traumatic brain injury and injuries to the spinal column. Reducing blood outflow further increases the intracranial pressure and volume, and thereby increases the pressure and volume of the cochlear fluid, the vitreous humor and the cerebrospinal fluid to thereby reduce the risk of injury to the inner ear, internal structure of the eye and of the spinal column. In addition, increasing intracranial pressure and volume reduces the likelihood of brain injury and any associated loss of olfactory function.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: November 24, 2020
    Assignee: TBI INNOVATIONS, LLC
    Inventors: David W. Smith, Kevin John Vititoe, Jamison Joseph Float, Chad Michael Leeder, Joseph A. Fisher, John Stites
  • Patent number: 10829322
    Abstract: A device is provided for transferring bulk materials from a vehicle through a grate to a structure disposed below the grate. The device includes a plate disposed over the grate and defining an opening smaller than the grate. The device further includes a hopper configured to rest on the plate between the plate and the underside of the vehicle. The hopper defines a bottom opening configured for alignment with the opening in the plate and a top opening configured for alignment with a discharge spout on the vehicle and the top opening is larger than the bottom opening. The device further includes means for moving the hopper to an operating position in which the bottom and top openings are aligned with the opening in the plate and the discharge spout on the vehicle.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: November 10, 2020
    Assignee: Owens-Brockway Glass Container Inc.
    Inventor: David W Smith
  • Publication number: 20200187957
    Abstract: A method and device for reducing the damaging effects of radiant energy, blast, or concussive events includes applying pressure to at least one jugular vein to reduce the egress of blood from the cranial cavity during or before the incidence of the imparting event. Reducing blood outflow from the cranial cavity increases intracranial volume and/or pressure of the cerebrospinal fluid to reduce the risk of traumatic brain injury and injuries to the spinal column. Reducing blood outflow further increases the intracranial pressure and volume, and thereby increases the pressure and volume of the cochlear fluid, the vitreous humor and the cerebrospinal fluid to thereby reduce the risk of injury to the inner ear, internal structure of the eye and of the spinal column. In addition, increasing intracranial pressure and volume reduces the likelihood of brain injury and any associated loss of olfactory function.
    Type: Application
    Filed: November 13, 2019
    Publication date: June 18, 2020
    Inventors: David W. Smith, Kevin John Vititoe, Jamison Joseph Float, Chad Michael Leeder
  • Patent number: 10682087
    Abstract: An apparatus, module, methods and systems for automated, standardized assessment and analysis of a human olfactory system's odor detection ability as an indicator or predictor of cognitive impairment or change in cognitive health, and other health conditions such as diabetes. Notably, the present invention is operable for use across all age groups of humans and provides quantitative detection and analysis of a human olfactory system's detection ability compared to a relevant demographic population.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: June 16, 2020
    Assignee: Olfaxis, LLC
    Inventors: David W. Smith, Jesse S. Eberdt, III
  • Patent number: 10499928
    Abstract: A method and device for reducing the damaging effects of radiant energy, blast, or concussive events includes applying pressure to at least one jugular vein to reduce the egress of blood from the cranial cavity during or before the incidence of the imparting event. Reducing blood outflow from the cranial cavity increases intracranial volume and/or pressure of the cerebrospinal fluid to reduce the risk of traumatic brain injury and injuries to the spinal column. Reducing blood outflow further increases the intracranial pressure and volume, and thereby increases the pressure and volume of the cochlear fluid, the vitreous humor and the cerebrospinal fluid to thereby reduce the risk of injury to the inner ear, internal structure of the eye and of the spinal column. In addition, increasing intracranial pressure and volume reduces the likelihood of brain injury and any associated loss of olfactory function.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: December 10, 2019
    Assignee: TBI INNOVATIONS, LLC
    Inventors: David W. Smith, Kevin John Vititoe, Jamison Joseph Float, Chad Michael Leeder
  • Patent number: 10413303
    Abstract: A method and device for reducing the damaging effects of radiant energy, blast, or concussive events includes applying pressure to at least one jugular vein to reduce the egress of blood from the cranial cavity during or before the incidence of the imparting event. Reducing blood outflow from the cranial cavity increases intracranial volume and/or pressure of the cerebrospinal fluid to reduce the risk of traumatic brain injury and injuries to the spinal column. Reducing blood outflow further increases the intracranial pressure and volume, and thereby increases the pressure and volume of the cochlear fluid, the vitreous humor and the cerebrospinal fluid to thereby reduce the risk of injury to the inner ear, internal structure of the eye and of the spinal column. In addition, increasing intracranial pressure and volume reduces the likelihood of brain injury and any associated loss of olfactory function.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: September 17, 2019
    Assignee: TBI INNOVATIONS, LLC
    Inventors: David W. Smith, Kevin John Vititoe, Jamison Joseph Float, Chad Michael Leeder, Joseph A. Fisher
  • Patent number: 10342550
    Abstract: A first embodiment can be a device comprising a means to reduce SLOSH energy absorption in a fluid containing organism by reducing the flow of one or more outflow vessels of the cranium by compressing said vessels.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: July 9, 2019
    Assignee: TBI INNOVATIONS, LLC
    Inventors: David W. Smith, Joseph A. Fisher
  • Publication number: 20190193994
    Abstract: A knockdown, portable lift is relatively compact and lightweight for transport and use where there is no existing means for lifting a load between a lower surface and an upper surface or where the existing means cannot be used. Components of the lift are stored in a base portion of the lift and are assembled on site for forming a lift frame extending between the upper and lower surfaces. A platform and drive assembly are supported on the lift frame and are driven together up and down tracks on each side of the lift frame using a rotary drive, such as a hand crank or electric motor, to power the drive assembly. The drive assembly is operable by a person on or off the platform from either the upper or lower surface or traversing stairs over which the platform is moving. The drive assembly incorporates a unique overspeed braking system and a unique clutch arrangement.
    Type: Application
    Filed: August 24, 2016
    Publication date: June 27, 2019
    Inventor: David W SMITH
  • Publication number: 20190069961
    Abstract: A method and system for performing invasive procedures includes a surgical robot which is controlled by a guidance system that uses time of flight calculations from RF transmitters embedded in the robot, surgical instrument, and patient anatomy. Sensors around the room detect RF transmissions emitted by the RF transmitters and drive the robot according to a preprogrammed trajectory entered into the guidance system.
    Type: Application
    Filed: August 24, 2018
    Publication date: March 7, 2019
    Inventors: David W. Smith, Regina DeSanctis-Smith, Alan M. Pitt, Nicholas Theodore, Neil Crawford
  • Patent number: 10172678
    Abstract: A method and system for performing invasive procedures includes a surgical robot which is controlled by a guidance system that uses time of flight calculations from RF transmitters embedded in the robot, surgical instrument, and patient anatomy. Sensors around the room detect RF transmissions emitted by the RF transmitters and drive the robot according to a preprogrammed trajectory entered into the guidance system.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: January 8, 2019
    Assignee: GLOBUS MEDICAL, INC.
    Inventors: David W. Smith, Regina DeSanctis-Smith, Alan M. Pitt, Nicholas Theodore, Neil Crawford
  • Publication number: 20180361096
    Abstract: A respiratory interface device (10) is provided that includes a cushion (30) and a faceplate (12). The cushion is structured to be coupled to the faceplate. The faceplate includes a peripheral end (18) and a number of custom features (60). The cushion is coupled to the faceplate adjacent the faceplate peripheral end.
    Type: Application
    Filed: December 15, 2016
    Publication date: December 20, 2018
    Inventors: JONATHAN SAYER GRASHOW, LAUREN PATRICIA CHODKOWSKI, DAVID W. SMITH
  • Patent number: 9987020
    Abstract: A first embodiment can be a method to reduce SLOSH energy absorption within an organism by reducing the inelastic collisions. A fluid containing organism can utilize an embodiment of the method wherein one or more of reversibly increasing pressure within the organs or cells, reversibly increasing the volume within the organs or cells, reversibly altering vascular, molecular, or cell wall stiffness, or reversibly altering vascular, molecular, or cell wall configuration within said organism may reduce these collisions.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: June 5, 2018
    Assignee: TBI INNOVATIONS, LLC
    Inventor: David W. Smith
  • Publication number: 20180133419
    Abstract: A pressure support system for delivering a flow of breathing gas to a patient includes a pressure generating base unit including a gas flow generator and a controller, a patient interface device for delivering the flow of breathing gas to the airway of the patient, and a degradation monitor apparatus including a control unit and an indicator apparatus. The controller is structured to generate data indicative of a degradation metric based on use of the pressure support system and to communicate the data indicative of the degradation metric to the degradation monitor apparatus. The control unit of the degradation monitor apparatus is structured to cause the indicator apparatus to generate a human perceptible indication based on the data indicative of the degradation metric when the degradation metric indicates that a component of the patient interface device demonstrates at least a threshold level of degradation.
    Type: Application
    Filed: April 25, 2016
    Publication date: May 17, 2018
    Inventors: ROBERT WILLIAM BAIKO, DAVID W. SMITH