Abstract: The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to HbS modulators of formula (I) or tautomers thereof, or pharmaceutically acceptable salts of said modulators or tautomers thereof, wherein X, Y, R2 and R3 are as defined in the description. HbS modulators are potentially useful in the treatment of a wide range of disorders, including sickle cell disease (SCD).

Abstract: The present application relates to processing of Cannabis material, particularly on a large scale, such as at an industrial level Cannabis is typically a controlled and regulated substance, and has traditionally been processed in low quantities. A human-based manual and/or labour-intensive processing implementation is not scalable, and is therefore infeasible at an industrial level. Disclosed herein are systems and methods for facilitating industrial-scale processing of Cannabis material.

Abstract: A laundry appliance includes a cabinet having a top panel that defines an aperture for selectively accessing a treatment chamber defined within the cabinet. A lid is rotationally operable relative to the aperture of the top panel between open and closed positions. Hinge assemblies extend between the lid and the top panel. The hinge assemblies include a first hinge assembly. A second hinge assembly is selectively retractable into the lid to a retracted position. A biasing member biases the second hinge assembly out to an extended position. At least the second hinge assembly is operable to the retracted position to bypass a portion of the top panel to define an installed position where the first and second hinge assemblies are engaged with respective hinge receptacles of the top panel.

Abstract: Disclosed herein are systems and methods for safe electric power delivery protection within a high-risk area while maintaining electric power availability in non-faulted areas. Fault signals from wireless sensors are used at a recloser to block reclosing onto a faulted high-risk zone. Fault signals from wireless sensors are used at a recloser to permit reclosing when the reclosing operation will not close onto a fault location within the high-risk zone. Portions of the power system may be selectively openable by sectionalizers. When a fault is reported by a wireless sensor as being on a portion of the power system selectively openable, a recloser may be permitted to attempt a reclose operation affecting the high-risk zone and the selectively openable portion.

Abstract: This application includes a compound of Formula I or a pharmaceutically acceptable salt thereof; wherein the variables R1a, R1b, R2, R3, X, Y and Z are as defined herein, pharmaceutical compositions comprising the compounds of Formula I and methods of treatment comprising administering to a patient in need thereof a compound of Formula I for the treatment of transthyretin amyloidosis and diseases related thereto.

Abstract: This disclosure provides connectors for smart windows. A smart window may incorporate an optically switchable pane. In one aspect, a window unit includes an insulated glass unit including an optically switchable pane. A wire assembly may be attached to the edge of the insulated glass unit and may include wires in electrical communication with electrodes of the optically switchable pane. A floating connector may be attached to a distal end of the wire assembly. The floating connector may include a flange and a nose, with two holes in the flange for affixing the floating connector to a first frame. The nose may include a terminal face that present two exposed contacts of opposite polarity. Pre-wired spacers improve fabrication efficiency and seal integrity of insulated glass units. Electrical connection systems include those embedded in the secondary seal of the insulated glass unit.

Abstract: A fabric treatment machine has a cabinet housing. A lid enables access inside the cabinet. Fabric treatment components such as a drum are positioned inside the cabinet housing. A panel on the cabinet housing includes an opening to receive the lid. At least one hinge spacer couples with the panel to receive a shaft of a slow close hinge on the lid. The at least one hinge spacer includes a socket portion and a flange portion. The socket portion inserts into an aperture in the panel. The socket portion includes a bore with at least one flat side to receive a mating shaft from the slow closing hinge. The hinge shaft has at least one flat surface. The flange portion covers the panel around the socket.

Abstract: Described herein are techniques of training a machine learning model and performing inference using an analog processor. Some embodiments mitigate the loss in performance of a machine learning model resulting from a lower precision of an analog processor by using an adaptive block floating-point representation of numbers for the analog processor. Some embodiments mitigate the loss in performance of a machine learning model due to noise that is present when using an analog processor. The techniques involve training the machine learning model such that it is robust to noise.

Abstract: Systems and methods for determining how to dispatch power to a property from a generator are provided. According to certain aspects, a controller associated with the generator may retrieve or access a set of data indicating time of use rates associated with utility power, performance characteristics of the generator, and/or energy usage data. Based on the data, the controller may determine a set point corresponding to when it may be beneficial to dispatch generator power to the property instead of utility power. At the set point, the controller may facilitate supplementing power from utility power with power from the generator. Additionally, the controller may collect usage and performance data associated with dispatch of the generator power.

Abstract: A refrigerator includes an outer wrapper, a fresh food compartment defined by a liner within the wrapper and separated from an interior of the outer wrapper at least along a first side wall of the fresh food compartment to define a void, and a door at least partially enclosing an opening to the fresh food compartment when in a closed position. A door compartment is positioned along the door. The refrigerator further includes an evaporator compartment positioned at least partially within the fresh food compartment and a duct in fluid communication with the evaporator compartment at a first end thereof and in communication with the door compartment a second end thereof. The duct has a first portion that extends laterally from the first end along a portion of the evaporator compartment and a second portion extending through the void along the first side wall of the fresh food compartment.

Abstract: The present application relates to the production of cannabis products, particularly on a large scale, such as at an industrial level. Cannabis is typically a controlled and regulated substance, and so inventory control, security, and traceability of the cannabis may need to be provided. A human-based manual and/or labour-intensive implementation is not scalable, and is therefore infeasible at an industrial level. Disclosed herein are computer systems for inventory control, security systems, and computer methods for facilitating traceability from a cannabis product back to a batch of cannabis plants.

Abstract: Methods, systems, and devices for analyzing vibration data to determine and mitigate an occurrence of an anomaly at an industrial asset. A device may obtain and preprocess vibration data, which may include grouping the vibration data according to respective time intervals, and the device may filter the grouped data to obtain the most recent measurement readings. The device may use an anomaly detection algorithm to detect outliers in the datasets for each group of vibration data and compare an amplitude of the outliers to a threshold for the respective group. The device may determine that the vibration data includes an anomaly based on quantities of outliers in first and second subsets of the vibration data that are within a detection window. The device may generate a report including an indication of the anomaly and transmit the report to an operator or engineer for the facility.

Abstract: An operable panel for an appliance includes a top panel that defines a hinge receptacle. A lid includes a hinge housing. A hinge is disposed within the hinge housing and extends between the lid and the top panel. A retainer includes a cap and a resilient portion. The retainer partially surrounds the hinge and the cap encloses the hinge housing. The resilient portion of the retainer biases the hinge toward the cap and the hinge receptacle.

Abstract: The present invention is directed to an acrylic polymer prepared from a reaction mixture comprising: (i) an ethylenically unsaturated monomer comprising hydroxyl functional groups; (ii) an ethylenically unsaturated monomer comprising polydialkylsiloxane groups; (iii) an ethylenically unsaturated monomer comprising carboxylic acid functional groups or amine functional groups; and (iv) a reactive diluent that is reactive with the ethylenically unsaturated monomer (iii). The reactive diluent (iv) is present initially in the reaction mixture as a medium in which the monomers polymerize. The present invention is further directed to aqueous polymeric dispersions prepared therefrom and aqueous, curable film-forming compositions prepared from the dispersions. The curable film-forming compositions are low VOC and are useful in methods of mitigating dirt build-up on a substrate.

Abstract: Systems and methods for determining how to dispatch power to a property from a generator are provided. According to certain aspects, a controller associated with the generator may retrieve or access a set of data indicating time of use rates associated with utility power, performance characteristics of the generator, and/or energy usage data. Based on the data, the controller may determine a set point corresponding to when it may be beneficial to dispatch generator power to the property instead of utility power. At the set point, the controller may facilitate supplementing power from utility power with power from the generator. Additionally, the controller may collect usage and performance data associated with dispatch of the generator power.

Abstract: An operable panel for an appliance includes a top panel that defines a hinge receptacle. A lid includes a hinge housing. A hinge is disposed within the hinge housing and extends between the lid and the top panel. A retainer includes a cap and a resilient portion. The retainer partially surrounds the hinge and the cap encloses the hinge housing. The resilient portion of the retainer biases the hinge toward the cap and the hinge receptacle.

Abstract: The present application relates to the production of cannabis products, particularly on a large scale, such as at an industrial level. Cannabis is typically a controlled and regulated substance, and so inventory control, security, and traceability of the cannabis may need to be provided. A human-based manual and/or labour-intensive implementation is not scalable, and is therefore infeasible at an industrial level. Disclosed herein are computer systems for inventory control, security systems, and computer methods for facilitating traceability from a cannabis product back to a batch of cannabis plants.

Abstract: The present application relates to the production of cannabis products, particularly on a large scale, such as at an industrial level. Cannabis is typically a controlled and regulated substance, and so inventory control, security, and traceability of the cannabis may need to be provided. A human-based manual and/or labour-intensive implementation is not scalable, and is therefore infeasible at an industrial level. Disclosed herein are computer systems for inventory control, security systems, and computer methods for facilitating traceability from a cannabis product back to a batch of cannabis plants.

Abstract: This disclosure provides connectors for smart windows. A smart window may incorporate an optically switchable pane. In one aspect, a window unit includes an insulated glass unit including an optically switchable pane. A wire assembly may be attached to the edge of the insulated glass unit and may include wires in electrical communication with electrodes of the optically switchable pane. A floating connector may be attached to a distal end of the wire assembly. The floating connector may include a flange and a nose, with two holes in the flange for affixing the floating connector to a first frame. The nose may include a terminal face that present two exposed contacts of opposite polarity. Pre-wired spacers improve fabrication efficiency and seal integrity of insulated glass units. Electrical connection systems include those embedded in the secondary seal of the insulated glass unit.

Abstract: A decorative component with a light emitting finish includes a transmissive portion including a resin material configured to carry light through the transmissive portion. A plateable portion is attached to the transmissive portion and includes a resin material configured to receive a metal material via electroplating. The plateable portion overlays a portion of the transmissive portion. A metal finish portion is applied to the plateable portion, and the metal finish portion overlays the plateable portion. A plurality of openings are defined by gaps in the finish portion and the plateable portion. Light carried by the transmissive portion exits the component through the openings.